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See detailA Validation of the French Version of the Attitudes to Aging Questionnaire (AAQ): Factor Structure, Reliability and Validity
Marquet, Manon ULg; Missotten, Pierre ULg; Schroyen, Sarah ULg et al

in Psychologica Belgica (in press)

Introduction: The Attitudes to Aging Questionnaire (AAQ) was developed to measure attitudes toward the aging process as a personal experience from the perspective of older people. The present study aimed ... [more ▼]

Introduction: The Attitudes to Aging Questionnaire (AAQ) was developed to measure attitudes toward the aging process as a personal experience from the perspective of older people. The present study aimed to validate the French version of the AAQ. Participants and methods: This study examined factor structure, acceptability, reliability and validity of the AAQ’s French version in 238 Belgian adults aged 60 years or older. In addition, participants provided information on demographics, self-perception of their mental and physical health (single items), quality of life (WHOQOL-OLD) and social desirability (DS-36). Results: Exploratory Factor Analysis produced a three-factor solution accounting for 36.9% of the variance. No floor or ceiling effects were found. The internal consistency, measured by Cronbach’s alpha coefficients for the AAQ subscales were 0.62 (Physical Change), 0.74 (Psychological Growth), and 0.75 (Psychosocial Loss). A priori expected associations were found between AAQ subscales, self-reported health and quality of life, indicating good convergent validity. The scale also showed a good ability to discriminate between people with lower and higher education levels, supporting adequate known-groups validity. Finally, we confirmed the need to control for social desirability biases when assessing self-reported attitudes toward one’s own aging. Conclusion: The data support the usefulness of the French version of the AAQ for the assessment of attitudes toward their own aging in older people. [less ▲]

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See detailThe link between self-perceptions of aging, cancer view and physical and mental health of older people with cancer: A cross-sectional study
Schroyen, Sarah ULg; Marquet, Manon ULg; Jerusalem, Guy ULg et al

in Journal of Geriatric Oncology (2016)

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has ... [more ▼]

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has never been studied in the elderly population. Similarly, even though it is established that a negative self-perception of aging has deleterious consequences on mental and physical health in normal aging, the influence in pathological contexts, such as oncology, has not been studied. The main aim of this study is thus to analyze the effect of these two stigmas on the health of elderly oncology patients. Materials and Methods 101 patients suffering from a cancer (breast, gynecological, lung or hematological) were seen as soon as possible after their diagnosis. Their self-perception of age, cancer view and health (physical and mental) was assessed. Results Multiple regressions showed that patients with a more negative self-perception of aging and/or more negative cancer view reported poorer global health. We also observed that negative self-perception of aging was associated with worse physical and mental health, whereas negative cancer views were only linked to worse mental health. No interaction was observed between these two stigmas, suggesting that their action is independent. Conclusion Older patients with cancer face double stigmatization, due to negative self-perception of aging and cancer, and these stigmas have impacts on global and mental health. Self-perception of aging is also linked to physical health. Longitudinal studies will be necessary to analyze the direction of the association between this double stigmatization and health. [less ▲]

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See detailNeuropsychiatric Inventory data in a Belgian sample of elderly persons with and without dementia
Squelard, Gilles ULg; Missotten, Pierre ULg; Paquay, Louis et al

in Clinical Interventions in Aging (2012), 2(7), 423-430

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 ... [more ▼]

Background/aims: This study assesses and compares prevalence of psychological and behavioral symptoms in a Belgian sample of people with and without dementia. Methods: A total of 228 persons older than 65 years with dementia and a group of 64 non- demented persons were assessed using the Neuropsychiatric Inventory (NPI) in 2004. Results: Within the group without dementia, the most frequent symptoms were depression, agitation, and irritability. Within the group with dementia, the most common symptoms were depression, irritability, apathy, and agitation. Prevalence of delusions (P [less ▲]

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See detailImpact of place of residence on relationship between quality of life and cognitive decline in dementia
Missotten, Pierre ULg; Thomas, Philippe; Squelard, Gilles ULg et al

in Alzheimer Disease and Associated Disorders (2009), 23(4), 395-400

The aim of this descriptive study was to estimate and compare the association between cognitive decline and quality of life (QOL) for 2 groups of dementia patients differing by place of residence: home or ... [more ▼]

The aim of this descriptive study was to estimate and compare the association between cognitive decline and quality of life (QOL) for 2 groups of dementia patients differing by place of residence: home or institution. Each subject was placed within a specific subgroup according to their Mini-Mental State Examination (MMSE) score and was evaluated by a QOL proxy-assessment [Alzheimer Disease Related Quality of Life (ADRQL)] and a dependency assessment (Katz Activities of Daily Living classification). For the ‘‘at home’’ and ‘‘institution’’ groups, global and subscale ADRQL scores showed significant differences between the 5 MMSE subgroups. Place of residence and MMSE subgroups significantly affected global and subscale ADRQL scores. The MMSE 4 to 8, 9 to 13, and 14 to 18 subgroups had ADRQL global scores significantly better in the institution group than the at home group. In contrast, the MMSE 19 to 23 and 0 to 3 subgroups had similar ADRQL global scores in both places of residence. In conclusion, there is no direct relationship between cognitive decline and QOL, and QOL does not seem to be better at home compared with the institution. [less ▲]

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See detailPrévalences des troubles psychologiques et comportementaux de la démence en fonction du stade évolutif
Squelard, Gilles ULg; Missotten, Pierre ULg; Ylieff, Michel ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2009), 14(3), 22-31

Behavioural and psychological signs and symptoms - BPSD are clinical features of dementia. They have considerable impact on the daily life of patients and their caregivers. The aim of this study is to ... [more ▼]

Behavioural and psychological signs and symptoms - BPSD are clinical features of dementia. They have considerable impact on the daily life of patients and their caregivers. The aim of this study is to show the importance of these disorders in dementia semiology and to assess differences in their prevalence across levels of severity of dementia. The sample is made up of 160 subjects with dementia older than 65 years old. Diagnosis of dementia was based on DSM-IV criteria. BPSD were assessed with the NeuroPsychiatric Inventory-NPI and dementia staging was measured with Clinical Dementia Rating/Modified-CDR-M. Results show that prevalence of delusions is more important in severe dementia and that prevalence of agitation/ aggression is more important in profound dementia. These data may help to clarify objectives and treatment of BPSD. This study raises also some methodological problems with the NPI and underlines the importance to define the different disorders included in certain NPI domains accurately. [less ▲]

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See detailRelationship between quality of life and cognitive decline in dementia
Missotten, Pierre ULg; Squelard, Gilles ULg; Ylieff, Michel ULg et al

in Dementia & Geriatric Cognitive Disorders (2008), 25(6), 564-572

Aims: We aimed to examine the association of cognitive decline with quality of life (QoL) in dementia compared to controls and to determine variables associated with QoL. Methods: Every subject was placed ... [more ▼]

Aims: We aimed to examine the association of cognitive decline with quality of life (QoL) in dementia compared to controls and to determine variables associated with QoL. Methods: Every subject was placed within a specific group depending on their designation by the Mini Mental State Examination and evaluated by the Alzheimer’s Disease Related Quality of Life (ADRQL) and clinical assessments. Results: QoL for the mild dementia group was lower (p = 0.08) than that of controls. The very severe dementia group had a significantly lower QoL than the other dementia groups, which all had similar ADRQL scores. The only predictor of ADRQL scores was found to be the behavioral and psychological symptoms of dementia. Conclusion: There is no direct relationship between cognitive decline and QoL. [less ▲]

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See detailQuality of life in dementia: a 2-year follow-up study
Missotten, Pierre ULg; Ylieff, Michel ULg; Di Notte, David et al

in International Journal of Geriatric Psychiatry (2007), 22(12), 1201-1207

Objectives To examine the evolution of quality of life (QOL) in demented subjects at base-line, one and 2 years later and to determine clinical variables associated with QOL. Method Longitudinal study of ... [more ▼]

Objectives To examine the evolution of quality of life (QOL) in demented subjects at base-line, one and 2 years later and to determine clinical variables associated with QOL. Method Longitudinal study of a cohort of 127 subjects living at home or in a long-term care institution. A QOL measure (Alzheimer Disease Related Quality of Life; ADRQL) was administered three times. In addition, several clinical instruments (MMSE, IADL, ADL and CDR/M) were also administered. Results ADRQL data analysis did not reveal significant modifications of QOL over the 2-year period, whereas results from clinical instruments showed a significant deterioration. On the group, the variations of ADRQL scores were limited, with some improvement after the first year followed by some deterioration after the second year. On the other hand, ADRQL scores fluctuated every year by at least 10 points for more than 50% of subjects. With dementia evolution, it was observed that the clinical variables were more strongly correlated with ADRQL scores and were more significant predictors. This varied from 5.9% (MMSE) in 2002 to 40.01 % in 2004 (MMSE and CDR/M). Conclusions QOL did not develop in a strictly linear manner following the deterioration of clinical state. This suggests that the evolution of QOL is also determined by other variables relating to the physical and social environment of the patients. Their role seems particularly important for the mild to moderate stages of dementia. Copyright (c) 2007 John Wiley [less ▲]

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See detailEtude comparative de la qualité de vie de sujets déments en fonction de leur lieu de résidence et de leur état cognitif
Missotten, Pierre ULg; Di Notte, David; Thomas, Philippe et al

Poster (2007, June)

Classiquement, on affirme que la qualité de vie (QdV) des personnes démentes est meilleure au domicile qu’en institution. Toutefois, cette affirmation n’est guère étayée par des études comparatives ... [more ▼]

Classiquement, on affirme que la qualité de vie (QdV) des personnes démentes est meilleure au domicile qu’en institution. Toutefois, cette affirmation n’est guère étayée par des études comparatives utilisant un même instrument d’évaluation. En outre, il n’y a pas de consensus sur la nature des relations entre troubles cognitifs et QdV. Dans le cadre des études Qualidem (Paquay et al., 2004) et PIXEL (Thomas et al., 2006), la QdV de sujets déments et vulnérables a été évaluée au moyen de l’Alzheimer Disease Related Quality of Life (ADRQL; Rabins et al., 1999). Des analyses préliminaires ont démontré l’absence de différences significatives entre les populations Qualidem et PIXEL (variables âge, sexe, dépendance et QdV). L’échantillon total se compose de sujets majoritairement féminins âgés de 65 ans et plus. Tous les sujets déments ont un score MMSE compris entre 0 et 23 et sont répartis en 5 groupes: MMSE 0-3; 4-8; 9-13; 14-18 et 19-23. Tous les sujets vulnérables ont un score MMSE24 et se situent au stade évolutif normal de la Clinical Dementia Rating/Modified (CDR/M; Heymans et al., 1987). L’analyse des scores ADRQL ne met pas en évidence une diminution linéaire de la QdV en fonction de la sévérité des troubles cognitifs. Toutefois, le lieu de résidence influence le profil des scores. En institution (n déments=296; n vulnérables=12), ils diminuent au stade débutant de la démence (MMSE 19-23), se stabilisent dans les groupes MMSE 9-13 et 14-18 avant de s’abaisser fortement dans les groupe MMSE 4-8 et 0-3. Au domicile, (n déments=159; n vulnérables=14), on observe une phase de diminution dans les groupes MMSE 19-23 et 14-18 puis une phase de stabilisation dans les 3 derniers groupes. En conclusion, la QdV des sujets déments n’évolue pas linéairement en fonction de la dégradation de l’état cognitif. L’évolution différente des profils selon le lieu de résidence soulève la question de l’influence de la variable « informant » dans l’hétéro-évaluation de la QdV de personnes démentes. Au domicile, cet informant est l’aidant principal (soignant informel) alors qu’en institution, il s’agit d’un soignant formel. L’hypothèse de biais de surévaluation par le soignant formel et de sous-évaluation par le soignant informel peut donc être posée. [less ▲]

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See detailEtude comparative de la qualité de vie chez des sujets déments, MCI et vulnérables
Missotten, Pierre ULg; Di Notte, David; Squelard, Gilles ULg et al

Poster (2007, June)

L’étude de la qualité de vie (QdV) des personnes démentes suscite de plus en plus d’intérêt. Son évaluation soulève de nombreuses interrogations concernant son évolution au cours du processus démentiel ... [more ▼]

L’étude de la qualité de vie (QdV) des personnes démentes suscite de plus en plus d’intérêt. Son évaluation soulève de nombreuses interrogations concernant son évolution au cours du processus démentiel. Les facteurs explicatifs demeurent encore controversés. Dans le cadre de l’étude Qualidem (Paquay et al., 2004), nous avons évalué, sur une période de deux ans, la QdV de sujets déments (n=362) avec l’Alzheimer Disease Related Quality of Life-ADRQL (Rabins et al., 1999). Leur QdV initiale a été comparée à celle de sujets MCI (n=36) et vulnérables (n=124). Majoritairement féminines, les trois populations se composent de sujets âgés de 65 ans et plus résidant en institution ou au domicile. L’analyse des scores ADRQL globaux ( /100) montre que la QdV du groupe « déments » (65.89±17.06) est significativement inférieure à celle des groupes « MCI » (82.11±13.31) et « vulnérables » (75.64±20.44). MCI et vulnérables ne se différencient pas entre eux. Les scores ADRQL du groupe « déments » ne sont pas en relation avec le sexe, l’âge et le lieu de résidence (domicile/institution). Ils sont corrélés avec l’état cognitif (MMSE, CAMCOG), la dépendance (AIVJ, AVQ), les troubles psychologiques et comportementaux (CERAD/BRSD) et le stade évolutif (CDR-M). Le MMSE et la CERAD/BRSD ont un rôle explicateur (25.92%) sur la variance du critère « qualité de vie ». Le suivi du groupe déments (n=127) met en évidence une absence de modifications significatives de la QdV sur une période de 2 ans. Par contre, une dégradation de l’état clinique (MMSE, AIVJ, AVQ, CDR-M) s’observe. Celle-ci s’accompagne d’une augmentation du pouvoir explicateur des variables du tableau clinique (MMSE et CDR/M). En conclusion, la QdV du groupe « déments » n’est pas très nettement inférieure à celle des groupes « MCI » et « vulnérables ». De plus, elle demeure relativement stable sur une période de 2 ans malgré la dégradation du tableau clinique. Ces résultats confortent l’hypothèse selon laquelle l’évolution de la QdV ne serait pas uniquement déterminée par des paramètres neurodégénératifs mais également par des variables en lien avec les environnements physique et social au sein desquels la personne démente vit sa maladie. [less ▲]

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See detailEvaluation du stade évolutif de la démence par la Clinical Dementia Rating-Modified (CDR-M)
Ylieff, Michel ULg; Di Notte, David; Missotten, Pierre ULg et al

Poster (2006, September)

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See detailLe NPI NH chez des sujets âgés déments et non déments
Ylieff, Michel ULg; Di Notte, David; Missotten, Pierre ULg et al

Poster (2006, September)

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See detailLa qualité de vie de sujets âgés déments, MCI et vulnérables : évaluations transversale et longitudinale
Missotten, Pierre ULg; Ylieff, Michel ULg; Schuerch, Michael et al

Conference (2006, September)

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See detailSymptômes psychologiques et comportementaux dans les démences : définition, prévalence, étiologie
Ylieff, Michel ULg; Di Notte, David; Vezina, Jean et al

in Landreville, Philippe (Ed.) Symptômes comportementaux et psychologiques de la démence (2005)

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