References of "Bruyère, Olivier"
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See detailClinical settings in knee osteoarthritis: Pathophysiology guides treatment
Herrero-Beaumont, Gabriel; Roman-Blas, Jorge A; Bruyère, Olivier ULg et al

in Maturitas (2017), 96

Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with ... [more ▼]

Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with mechanical factors and systemic inflammation-associated metabolic syndrome lead to joint damage. Thus, the expression of a clinical phenotype in the early stages of OA relies on the main underlying pathway and predominant joint tissue involved at a given time. Moreover, OA often coexists with other morbidities in the same patient, which in turn condition the OA process. In this scenario, an appropriate identification of clinical phenotypes, especially in the early stages of the disease, may optimize the design of individualized treatments in OA. An ESCEO-EUGMS (European Union Geriatric Medicine Society) working group has recently suggested possible patient profiles in OA. Hereby, we propose the existence of 4 clinical phenotypes – biomechanical, osteoporotic, metabolic and inflammatory – whose characterization would help to properly stratify patients with OA in clinical trials or studies. Further research in this field is warranted. [less ▲]

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See detailRelevance of vitamin D in the pathogenesis and therapy of frailty.
Bruyère, Olivier ULg; Cavalier, Etienne ULg; Buckinx, Fanny ULg et al

in Current Opinion in Clinical Nutrition & Metabolic Care (2017), 20(1), 26-29

PURPOSE OF REVIEW: This article reviews recently published evidence regarding the role of vitamin D in the physiopathology of physical frailty in elderly populations and its role in the management of this ... [more ▼]

PURPOSE OF REVIEW: This article reviews recently published evidence regarding the role of vitamin D in the physiopathology of physical frailty in elderly populations and its role in the management of this geriatric condition. RECENT FINDINGS: Some recent studies have found a low level of 25-hydroxyvitamin D, considered the best marker of vitamin D status, in frail individuals. All prospective studies consistently report that low vitamin D status is associated with an increased risk of becoming frail. Recent studies also suggest that the relationship between vitamin D status and frailty is largely mediated by the development of sarcopenia. Very few well designed randomized controlled trials are available that assess the effectiveness of vitamin D supplementation in the prevention or management of frailty. In the absence of specific guidelines, a minimal serum 25-hydroxyvitamin D level of 75 nmol/l is proposed for frail elderly patients by some scientific societies. The doses necessary to reach this target are between 800 and 2000 IU/day. SUMMARY: Several studies suggest a potential effect of vitamin D on physical frailty but large clinical trials are lacking at this time to provide solid evidence of clinical benefit. [less ▲]

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See detailCross-cultural adaptation and validation of the Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire on lateral elbow tendinopathy for French-speaking patients
Kaux, Jean-François ULg; DELVAUX, François ULg; SCHAUS, Jean ULg et al

in Journal of Hand Therapy (2016), 29(4), 496-504

Background: The lateral elbow tendinopathy is a common injury in tennis players and physical workers. The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire was specifically designed to measure ... [more ▼]

Background: The lateral elbow tendinopathy is a common injury in tennis players and physical workers. The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire was specifically designed to measure pain and functional limitations in patients with lateral epicondylitis (tennis elbow). First developed in English, this questionnaire has since been translated into several languages. Objectives: The aims of the study were to translate and cross-culturally adapt the PRTEE questionnaire into French and to evaluate the reliability and validity of this translated version of the questionnaire (PRTEE-F). Methods: The PRTEE was translated and cross-culturally adapted into French according to international guidelines. To assess the reliability and validity of the PRTEE-F, 115 participants were asked twice to fill in the PRTEE-F, and once the Disabilities of Arm, Shoulder and Hand questionnaire (DASH) and the Short Form Health Survey (SF-36). Internal consistency (using Cronbach’s alpha), test-retest reliability (using intra-class correlation coefficient (ICC), Standard Error of Measurement (SEM) and Minimal Detectable Change (MDC)), and convergent and divergent validity (using the Spearman’s correlation coefficients respectively with the DASH and with some sub scales of the SF-36) were assessed. Results: The PRTEE was translated into French without any problems. PRTEE-F showed a good test-retest reliability for the overall score (ICC 0.86) and for each item (ICC 0.8-0.96) and a high internal consistency (Cronbach’s alpha = 0.98). The correlation analyses revealed high correlation coefficients between PRTEE-F and DASH (convergent validity) and, as expected, a low or moderate correlation with the divergent subscales of the SF-36 (discriminant validity). There was no floor or ceiling effect. Conclusions: The PRTEE questionnaire was successfully cross-culturally adapted into French. The PRTEE-F is reliable and valid for evaluating French-speaking patients with lateral elbow tendinopathy. [less ▲]

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See detailValidity and reliability of the French translation of the VISA-A questionnaire for Achilles tendinopathy
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Disability & Rehabilitation (2016), 38(26), 2593-2599

Purpose The Victorian Institute of Sport Assessment – Achilles tendinopathy questionnaire (VISA-A) evaluates the clinical severity of Achilles tendinopathy. The aim of this study was to translate the VISA ... [more ▼]

Purpose The Victorian Institute of Sport Assessment – Achilles tendinopathy questionnaire (VISA-A) evaluates the clinical severity of Achilles tendinopathy. The aim of this study was to translate the VISA-A into French and to study the reliability and validity of this French version, the VISA-AF. Method The VISA-A was translated into French to produce the VISA-AF using a validated methodology in six steps. Thereafter, several psychometric properties of this French version such as test–retest reliability, internal consistency, construct validity and floor and ceiling effects were evaluated. Therefore, we recruited 116 subjects, distributed into 3 groups: pathological patients (n¼31), at-risk athletes (n¼63) and healthy people (n¼22). Results The final version of the VISAAF was approved by an expert committee. On a scale ranging from 0 to 100, the average scores of the VISA-AF obtained were 59 (± 18) for the pathological group, 99 (± 1) for the healthy group and 94 (± 7) for the at-risk group. The VISA-AF shows excellent reliability, low correlations with the discriminant subscales of the SF-36 and moderate correlations with the convergent subscales of the SF-36. Conclusions The French version of the VISA-A is equivalent to its original version and is a reliable and valid questionnaire for French-speaking patients with Achilles tendinopathy. [less ▲]

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See detailCROSS-CULTURAL TRANSLATION, VALIDITY AND RELIABILITY OF THE FRENCH VERSION OF THE « PAIN BELIEFS QUESTIONNAIRE »
Demoulin, Christophe ULg; Duvallon, Louise ULg; Roussel, N. et al

in Back to Specific Low Back Pain (2016, November)

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See detailA single group session of pain physiology education is effective to improve the understanding of neurophysiology of pain in patients with chronic low back pain
Demoulin, Christophe ULg; Brasseur, Pauline; Crielaard, Jean-Michel ULg et al

in Vleeming, Andry (Ed.) 9th Interdisciplinary World Congress on Low Back and Pelvic Girdle Pain - Progress in Evidence based diagnosis and treatment (2016, November)

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See detailSarcopenia in daily practice: assessment and management
Beaudart, Charlotte ULg; McCloskey, Eugène; Bruyère, Olivier ULg et al

in BMC Geriatrics (2016), 16(170),

Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools ... [more ▼]

Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools have been recommended to assess muscle mass, muscle strength and physical performance in clinical trials. Whilst these tools have proven to be accurate and reliable in investigational settings, many are not easily applied to daily practice. Methods: This paper is based on literature reviews performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group on frailty and sarcopenia. Face-to-face meetings were afterwards organized for the whole group to make amendments and discuss further recommendations. Results: This paper proposes some user-friendly and inexpensive methods that can be used to assess sarcopenia in real-life settings. Healthcare providers, particularly in primary care, should consider an assessment of sarcopenia in individuals at increased risk; suggested tools for assessing risk include the Red Flag Method, the SARC-F questionnaire, the SMI method or different prediction equations. Management of sarcopenia should primarily be patient centered and involve the combination of both resistance and endurance based activity programmes with or without dietary interventions. Development of a number of pharmacological interventions is also in progress. Conclusions: Assessment of sarcopenia in individuals with risk factors, symptoms and/or conditions exposing them to the risk of disability will become particularly important in the near future. [less ▲]

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See detailAdaptation interculturelles du questionnaire "Patient-Rated Tennis Elbow Evaluation" pour les patients francophones
Kaux, Jean-François ULg; DELVAUX, François ULg; SCHAUS, Jean ULg et al

in 9ème Congrès commun SFMES - SFTS (2016, September)

Contexte: L’épicondylite latérale est une blessure commune chez les joueurs de tennis et les travailleurs physiques pour qui il existe un questionnaire en anglais qui en évalue la sévérité. Le ... [more ▼]

Contexte: L’épicondylite latérale est une blessure commune chez les joueurs de tennis et les travailleurs physiques pour qui il existe un questionnaire en anglais qui en évalue la sévérité. Le questionnaire « Patient-Rated Tennis Elbow Evaluation » (PRTEE) mesure la douleur et l’incapacité fonctionnelle du coude chez les patients souffrant d’une épicondylite latérale. Le questionnaire a déjà été traduit en suédois, en turc, en québécois, en italien, en néerlandais et en grec. Objectifs : Le but de cette étude est de traduire et de réaliser une adaptation interculturelle du questionnaire PRTEE en français et d’en évaluer sa fiabilité et sa validité. Matériel et Méthodes : Le PRTEE a été adapté interculturellement en français selon les lignes directrices internationales. Les participants (n=115) ont rempli le PRTEE-F, deux fois avec un intervalle de 30 minutes, le questionnaire Disabilities of Arm, Soulier and Hand (DASH), et le Short Form Health Survey (SF-36) pour évaluer la fiabilité et la validité du PRTEE-F. La cohérence interne (avec l’alpha de Cronbach), la fidélité test-retest (avec la corrélation intra-classe (ICC)) et la validité de construit (avec le coefficient de corrélation de Spearman). Résultats : Le PRTEE-F montre une fidélité test-retest bonne pour le score total (ICC 0,83) et pour les différents items (ICC 0,71-0,9). La traduction française possède une cohérence interne élevée (0,98). La corrélation entre le PRTEE-F et le DASH est forte pour le score total (rs=0,92, p<0.001), pour le sous-total symptomatique (rs=0,86, p<0.001) et fonctionnel (rs=0,93, p<0.001). Le PRTEE-F possède une corrélation forte avec une partie des sous-échelles convergentes du SF-36 (PF, RP et BP). Il y a une corrélation faible ou modérée avec les sous-échelles divergentes du SF-36 (REm, MH, SF et VT). Il n’y a pas d’effet plancher et plafond. Conclusion : La version française du questionnaire PRTEE a été adaptée interculturellement avec succès, et cette étude a montré que le PRTEE-F est fiable et valide pour évaluer les patients francophones souffrant d’une épicondylite latérale. [less ▲]

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See detailMacro-economic factors influencing the architectural business model shift in the pharmaceutical industry
Dierks, Raphaela Marie Louisa ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg et al

in Expert Review of Pharmacoeconomics & Outcomes Research (2016), First online

Introduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its ... [more ▼]

Introduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its underlying business model. Despite significant articles in the press, there is little medical and economic evidence on the rationale driving the transformation from the traditional Research & Development (R&D) model to new alternative business models, such as Mergers & Acquisitions (M&A). The purpose of this review is to understand the macro-economic factors responsible for the revolution of the pharmaceutical business model, by understanding the needs, desires, new behavioral patterns, but also challenges within the industry. Considering these changes will be the key to possessing a competitive advantage over the market players. Areas covered: Existing literature on new macro-economic factors changing the pharmaceutical landscape has been reviewed to present a clear image of the current market environment. Expert commentary: Literature and media sources show that pharmaceutical companies are facing an architectural alteration in their business model, with more M&A deals and collaborations headlining the papers. Although Q1 2016 did show a major slowdown in M&A deals by volume since 2013 (with deal cancellations of Pfizer and Allergan, or the downfall of Valeant) pharmaceutical analysts remain confident that this shortfall was a consequence of the equity market volatility. It seems likely that the shift to an M&A model will become apparent during the remainder of 2016, with deal announcements such as Abbott Laboratories, AbbVie and Sanofi worth USD 45billion [1] showing the appetite of big pharma companies to shift from the fully vertical integrated business model to more horizontal business models. [less ▲]

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See detailTraduction inter-culturelle et validation du Kujala Anterior Knee Pain Scale (AKPS) en français
Kaux, Jean-François ULg; Bornheim, Stephen ULg; Remy, Gaël et al

in 9ème Congrès commun SFMES - SFTS (2016, September)

Introduction : Le syndrome fémoro-patellaire est l'un des problèmes de genou les plus répandus qui se caractérise par une douleur antérieure du genou dans des activités mettant en charge l'articulation ... [more ▼]

Introduction : Le syndrome fémoro-patellaire est l'un des problèmes de genou les plus répandus qui se caractérise par une douleur antérieure du genou dans des activités mettant en charge l'articulation fémoro-patellaire. Le Kuala Anterior Knee Pain Scale (Kujala AKPS) est un questionnaire utilisé pour évaluer les symptômes subjectifs, tels que les limitations fonctionnelles et la douleur antérieure du genou. Le questionnaire a déjà été traduit et validé en portugais brésilien, en persan, en chinois, en turque, et en néerlandais. Le but de cette étude est de traduire ce questionnaire en français afin d'en évaluer sa fiabilité et sa validité. Matériel et méthode : La traduction et l’adaptation interculturelle du questionnaire a été adaptée selon les recommandations internationales qui se présentent en 6 étapes : traduction initiale, synthèse des traductions, traduction de retour vers la langue d’origine, comité d'experts, test de la version pré-finale et approbation du comité experts. Une fois la version française obtenue, les participants (n=101) ont remplis 2 fois le Kujula AKPS avec un intervalle de 7 jours, et le Short Form Health Survey (SF-36) afin d'en évaluer les propriétés psychométriques (la cohérence interne, la fidélité test-retest et la validité de construit). Résultats : Le Kujula AKPS montre une fidélité test-retest élevée pour le score total (ICC 0,97). La traduction française possède une cohérence interne élevée (0,87). Le Kujula AKPS possède une corrélation forte avec une partie des sous-échelles convergentes du SF-36 (PF, RP et BP). Il y a une corrélation faible ou modérée avec les sous-échelles divergentes du SF-36 (MH, SF et VT). Il n’y a pas d’effet plancher et plafond. Conclusion : La version française du questionnaire Kujula AKPS étant compréhensible, semble avoir une bonne adaptation interculturelle. Cette étude a démontré que le Kujula AKPS-F est fiable et valide pour les patients francophones souffrant d'un syndrome rotulien. [less ▲]

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See detailRelationship between frailty, physical performance and quality of life among nursing home residents: the SENIOR cohort
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Petermans, Jean ULg et al

in Aging Clinical and Experimental Research (2016), Epub ahead of print

Background The aim of this study was to assess the relationship between frailty and a large number of indicators related to physical and muscular performance as well as quality of life. Methods This is an ... [more ▼]

Background The aim of this study was to assess the relationship between frailty and a large number of indicators related to physical and muscular performance as well as quality of life. Methods This is an analysis of data collected at baseline in the Sample of Elderly Nursing home Individuals: an Observational Research (SENIOR) cohort including nursing home residents. Subjects are volunteer, oriented and able to walk (walking assistance allowed) nursing home residents in Belgium. A large number of demographic and clinical characteristics, including physical and muscular performance, were collected from each patient. The prevalence of frailty in this population was assessed using Fried’s definition. Results In total, 662 subjects are included in this analysis. The mean age of the sample is 83.2 ± 8.99 years, and 484 (73.1 %) are women. In this population of nursing home residents, the prevalence of frailty is 25.1 %, pre-frailty, 59.8 % and robustness, 15.1 %. Compared to non-frail subjects, frail subjects have lower physical and muscular performances and a lower quality of life. Conclusion Frailty, according to Fried’s definition, seems to be associated with several clinical indicators suggesting a higher level of disability and an increased propensity to develop major clinical consequences. Follow-up data of the SENIOR cohort will be helpful in confirming these findings, establishing cause–effect relationships and identifying the most predictive components of physical frailty for adverse outcomes in nursing homes. [less ▲]

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See detailThe role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club.
Cavalier, Etienne ULg; Bergmann, P.; Bruyère, Olivier ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2016), 27

The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state ... [more ▼]

The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state of the art on the use of these biomarkers in different clinical or physiological situations like in postmenopausal women, osteoporosis in men, in elderly patients, in patients suffering from bone metastasis, in patients with chronic renal failure, in pregnant or lactating women, in intensive care patients, and in diabetics. We also gave our considerations on the analytical issues linked to the use of these biomarkers, on potential new emerging biomarkers, and on the use of bone turnover biomarkers in the follow-up of patients treated with new drugs for osteoporosis. [less ▲]

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See detailValidity and reliability of the French translation of the Patient-Related Tennis Elbow Evaluation Questionnaire
Kaux, Jean-François ULg; DELVAUX, François ULg; SCHAUS, Jean ULg et al

in Crossing borders through sport science (2016, July)

Background: The lateral elbow tendinopathy is a common injury in tennis players and physical workers. The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire was created to measure pain and ... [more ▼]

Background: The lateral elbow tendinopathy is a common injury in tennis players and physical workers. The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire was created to measure pain and functional disabilities specifically reported in patient with lateral epicondylitis (tennis elbow). Developed in English, this questionnaire has since then been translated into several languages but not in French. Objectives: The aims of the study were to translate and cross-culturally adapt the PRTEE questionnaire into French and to evaluate the reliability and validity of this new version of the questionnaire (PRTEE-F). Methods: The PRTEE was cross-culturally adapted into French according to the international guidelines. To assess the reliability and validity of the PRTEE-F, 115 participants filled in the PRTEE-F twice, and the Disabilities of Arm, Shoulder and Hand questionnaire (DASH) and the Short Form Health Survey (SF-36) once. Internal consistency (with Cronbach’s alpha), test-retest reliability (with intra-class correlation (ICC)), convergent and divergent validity (by calculating the Spearman’s correlation coefficients with the DASH and some sub scales of the SF-36, respectively) were assessed. Results: The PRTEE was translated in French without problem. PRTEE-F showed a good test-retest reliability for the overall score (ICC 0.83) and for each items (ICC 0.71-0.9) and a high internal consistency (Cronbach’s alpha = 0.98). The correlation analyses revealed high correlation coefficients between PRTEE-F and DASH (good convergent validity) and, as expected, a low or moderate correlations with the divergent subscales of the SF-36 (discriminant validity). There was no floor or ceiling effect. Conclusions: The PRTEE questionnaire was successfully cross-culturally adapted into French the PRTEE-F is reliable and valid for evaluating the French-speaking patient with lateral elbow tendinopathy. [less ▲]

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See detailA review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes
Kucharz, E.J.; Kovalenko, V.; Szanto, S. et al

in Current Medical Research & Opinion (2016), 32(6), 997-1004

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm for knee osteoarthritis (OA) recommends symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) first line for the medium to long term management of OA, due to their ability to control pain, improve function, and delay joint structural changes. Among SYSADOAs, glucosamine is probably the most widely used intervention. In the present review of glucosamine for knee OA, we have investigated whether the evidence is greater for the patented crystalline glucosamine sulfate (pCGS) preparation (Rottapharm/Meda) than for other glucosamine formulations. Glucosamine is actually widely available in many forms, as the prescription-grade pCGS preparation, generic and over-the-counter formulations of glucosamine sulfate (GS) and food supplements containing glucosamine hydrochloride (GH), which vary substantially in molecular form, pharmaceutical formulation and dose regimens. Only pCGS is given as a highly bioavailable once daily dose (1500mg) with a proven pharmacological effect. pCGS consistently reaches the plasma levels of around 10 lM required to inhibit interleukin-1 induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction, compared with sub-therapeutic levels achieved with GH. It is evident, from careful consideration of the evidence base, that only the pCGS formulation of glucosamine reliably provides an effect size on pain that is higher than that of paracetamol and equivalent to that provided by non-steroidal antiinflammatory drugs. In comparison, the effect size on pain of non-crystalline GS preparations and GH from randomized controlled trials is repeatedly demonstrated to be zero. In addition, there is evidence that chronic administration of pCGS has disease-modifying effects, with a reduction in the need for total joint replacement surgery lasting for at least 5 years after treatment cessation. Consequently, the pCGS preparation (Rottapharm/Meda) is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression. [less ▲]

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