References of "Bruyère, Olivier"
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See detailRetour au sport après plastie du ligament croisé antérieur : critères utilisés dans les cubs professionnels de football
Delvaux, François ULg; Rochcongar, P; Bruyère, Olivier ULg et al

in Science et Sports (in press)

Résumé Objectifs Analyser la démarche suivie par les médecins de clubs professionnels de football lorsqu’ils décident, en pratique quotidienne, d’autoriser le retour compétitif après plastie du ligament ... [more ▼]

Résumé Objectifs Analyser la démarche suivie par les médecins de clubs professionnels de football lorsqu’ils décident, en pratique quotidienne, d’autoriser le retour compétitif après plastie du ligament croisé antérieur chez un footballeur. Matériels et méthodes Trente-sept médecins responsables de clubs professionnels de football français et belges (Ligue 1, n = 15 ; Ligue 2, n = 14 ; Division 1 belge, n = 8) ont rempli un questionnaire à choix multiple concernant : (1) les critères utilisés afin de déterminer si un joueur est apte à reprendre la compétition après plastie du ligament croisé antérieur ; (2) l’importance relative de chacun de ces critères ; (3) le rôle éventuel d’intervenants spécifiques (kinésithérapeute…) dans cette décision. Résultats Plus de 80 % des médecins interrogés ont déclaré utiliser au moins huit critères (sur 17 proposés) afin d’évaluer la capacité d’un footballeur à reprendre la compétition après plastie du ligament croisé antérieur. Les trois critères considérés comme les plus déterminants étaient, par ordre d’importance : la stabilité dynamique du genou lors d’un exercice spécifique au football, la force musculaire et la récupération complète ou quasi complète d’amplitudes articulaires de flexion et d’extension de genou. Pour certains de ces critères (notamment la force musculaire), nous constatons cependant un manque de consensus sur les modalités pratiques d’évaluation, sur les paramètres ainsi que sur les valeurs-limites tolérées afin de garantir un retour sur terrain sécurisé. La prise en compte de l’avis du kinésithérapeute et du préparateur physique par une très nette majorité de médecins souligne l’importance d’un travail pluridisciplinaire. Conclusion L’utilisation de différents critères objectifs afin d’autoriser le retour compétitif après plastie du ligament croisé antérieur semble être une réalité dans le football professionnel. Des études supplémentaires devraient cependant contribuer à préciser les modalités des épreuves ainsi que des valeurs-seuils. ________________________________________ Summary Purpose To analyze how sport physicians decide, in their daily practice, when a professional soccer player with a reconstructed anterior cruciate ligament is able to get back to competitive activities. Materials and methods Thirty-seven physicians for professional French and Belgian soccer teams filled in a specific questionnaire dedicated to: (1) return-to-play criteria after anterior cruciate reconstruction; (2) the importance they assigned to each of these criteria in the return-to-play decision; (3) the potential role of professionals, such as physiotherapists or physical coaches in this decision. Results More than 80% of the respondents declared to use at least eight criteria in order to assess the player's ability to return to competitive soccer after anterior cruciate ligament reconstruction. The most important ones were (in order of importance): dynamic knee stability during a specific soccer exercise, muscle strength performance and normalization of knee flexion and extension ranges of motion. For most of these criteria (notably muscle strength), there was a lack of consensus about the choice of assessment parameters and the limit values allowing physicians to authorize or forbid the return-to-competition. A large majority of participants stated to take into consideration advices from physiotherapists or physical coaches for the return-to-play decision. Conclusion Sport physicians of professional soccer teams use relevant criteria to assess players’ ability to return to full sport after anterior cruciate ligament reconstruction. Further studies are required to determine the choice of assessment parameters and the limit values to assist physicians in return-to-play decisions. [less ▲]

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See detailClinical and biological determinants of sclerostin plasma concentration in hemodialysis patients
DELANAYE, Pierre ULg; KRZESINSKI, Jean-Marie ULg; Warling, Xavier et al

in Nephron. Clinical Practice (in press)

Background: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological ... [more ▼]

Background: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological data in hemodialyzed patients (HD), notably parathormone (PTH), biomarkers of bone turnover, vascular calcifications and mortality after 2 years. Methods: 164 HD patients were included in this observational study. The calcification score was assessed with the Kauppila method. Patients were followed for 2 years. Results: Median sclerostin levels were significantly (p < 0.0001) higher in HD versus healthy subjects (n = 94) (1,375 vs. 565 pg/ml, respectively). In univariate analysis a significant association (p < 0.05) was found between sclerostin and age, height, dialysis vintage, albumin, troponin, homocysteine, PTH, C-terminal telopeptide of collagen type I, bone-specific alkaline phosphatase and osteoprotegerin, but not with the calcification score. In a multivariate model, the association remained with age, height, dialysis vintage, troponin, homocysteine, phosphate, PTH, but also with vascular calcifications. Association was positive for all variables, except PTH and vascular calcifications. The baseline sclerostin concentration was not different in survivors and non-survivors. Conclusions: We confirm a higher concentration of sclerostin in HD patients, a positive association with age and a negative association with PTH. A positive association with phosphate, homocysteine and troponin calls for additional research. The clinical interest of sclerostin to assess vascular calcifications in HD is limited and no association was found between sclerostin and mortality. [less ▲]

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See detailLetter to the Editor.
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Seminars in arthritis and rheumatism (in press)

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See detailEvaluation of the impact of 6-month training by whole body vibration on the risk of falls among nursing home residents, observed over a 12-month period: a single blind, randomized controlled trial.
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Maquet, Didier ULg et al

in Aging Clinical & Experimental Research (in press)

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement ... [more ▼]

BACKGROUND: We have previously shown that short sessions of whole body vibration (WBV) were not able to significantly improve fall risk among nursing home residents but some trends towards an improvement of motor capacity were observed. OBJECTIVE: The objective of the present study was to evaluate the impact of 6-month training by WBV on functional and motor abilities among nursing home residents observed over a 12-month period. METHODS: Patients were randomized into two groups: the WBV group which received three training sessions every week composed of five series of 15 s of vibration at 30 Hz intensity for a period of 6 months and a control group with normal daily life. The impact of this training on the risk of falls was assessed blindly after 6 and 12 months by the Tinetti Test, the "Timed Up and Go" test and a quantitative evaluation of a 10-s walk performed with a tri-axial accelerometer. The occurrence of falls was also observed. RESULTS: 62 elderly healthy volunteers, (47 women and 15 men, mean age 83.2 +/- 7.9 years) were included in this study. There was no significant difference between the two groups regarding the Tinetti test (p = 0.75), the "Timed Up and Go" test (p = 0.19) and the Locometrix(R) test, except for the step length, measured by dual task (p < 0.01). No significant inter-group difference in the frequency of falls was observed during the 12 months of research. A total of 42 falls were recorded during the first 6 months of experimentation: 24 falls in the treated group and 18 in the control group (p = 0.60). During the next 6 months, 19 falls occurred: 8 falls in the treated group and 11 in the control group (p = 0.52). CONCLUSION: This study failed to establish the effectiveness of low doses of WBV, under the conditions used in our study, on functional and motor abilities of institutionalized elderly patients. However, given the positive results of other studies, further investigations, with modified therapeutic protocols, seem necessary to clarify the effects of WBV in the elderly. [less ▲]

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa; Bruyère, Olivier ULg et al

in European journal of public health (in press)

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost ... [more ▼]

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost-effectiveness of vitamin D and calcium supplementation in elderly women and men with osteoporosis and therefore to assess if this recommendation is justified in terms of cost-effectiveness. METHODS: A validated model for economic evaluations in osteoporosis was used to estimate the cost per quality-adjusted life-year (QALY) gained of vitamin D/calcium supplementation compared with no treatment. The model was populated with cost and epidemiological data from a Belgian health-care perspective. Analyses were conducted in women and men with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5). A literature search was conducted to describe the efficacy of vitamin D and calcium in terms of fracture risk reduction. RESULTS: The cost per QALY gained of vitamin D/calcium supplementation was estimated at euro40 578 and euro23 477 in women and men aged 60 years, respectively. These values decreased to euro7912 and euro10 250 at the age of 70 years and vitamin D and calcium supplementation was cost-saving at the age of 80 years, meaning that treatment cost was less than the costs of treating osteoporotic fractures of the no-treatment group. CONCLUSION: This study suggests that vitamin D and calcium supplementation is cost-effective for women and men with osteoporosis aged over 60 years. From an economic perspective, vitamin D and calcium should therefore be administrated in these populations including those also taking other osteoporotic treatments. [less ▲]

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See detailOsteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Endocrine (in press)

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of ... [more ▼]

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they could have deleterious effects on the bone. Evidence from longitudinal, crosssectional, and prospective cohort studies suggests that the use of antidepressants at therapeutic doses is associated with decreased bone mineral density and increased fracture risk. The association between SSRIs use and fracture risk could potentially differ depending on dose, exposure duration, time of exposure, age, or sex. However, the risk of fracture declined rapidly after discontinuation of use of SSRIs. The evidence now seems sufficient to consider adding SSRIs to the list of medications that contribute to osteoporosis. In practice, assessment of risk factor for osteoporosis or fractures could be made taking into account age, gender, duration, and severity of depression, length of SSRI treatments, and other concurrent risk factors. [less ▲]

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (in press)

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See detaillES CHUTES DE LA PERSONNE AGEE
GILLAIN, Sophie ULg; ELBOUZ, Leila ULg; Beaudart, Charlotte ULg et al

in Revue Médicale de Liège (in press)

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (in press)

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailDabigatran Etexilate and Risk of Myocardial Infarction, Other Cardiovascular Events, Major Bleeding, and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Douxfils, Jonathan; Buckinx, Fanny ULg; Mullier, Francois et al

in Journal of the American Heart Association (in press)

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of ... [more ▼]

BACKGROUND: Signals of an increased risk of myocardial infarction (MI) have been identified with dabigatran etexilate in randomized controlled trials (RCTs). METHODS AND RESULES: We conducted searches of the published literature and a clinical trials registry maintained by the drug manufacturer. Criteria for inclusion in our meta-analysis included all RCTs and the availability of outcome data for MI, other cardiovascular events, major bleeding, and all-cause mortality. Among the 501 unique references identified, 14 RCTs fulfilled the inclusion criteria. Stratification analyses by comparators and doses of dabigatran etexilate were conducted. Peto odds ratio (ORPETO) values using the fixed-effect model (FEM) for MI, other cardiovascular events, major bleeding, and all-cause mortality were 1.34 (95% CI 1.08 to 1.65, P=0.007), 0.93 (95%CI 0.83 to 1.06, P=0.270), 0.88 (95% CI 0.79 to 0.99, P=0.029), and 0.89 (95% CI 0.80 to 1.00, P=0.041). When compared with warfarin, ORPETO values using FEM were 1.41 (95% CI 1.11 to 1.80, P=0.005), 0.94 (95%CI 0.83 to 1.06, P=0.293), 0.85 (95% CI 0.76 to 0.96, P=0.007), and 0.90 (95% CI 0.81 to 1.01, P=0.061), respectively. In RCTs using the 150-mg BID dosage, the ORPETO values using FEM were 1.45 (95% CI 1.11 to 1.91, P=0.007), 0.95 (95% CI 0.82 to 1.09, P=0.423), 0.92 (95% CI 0.81 to 1.05, P=0.228), and 0.88 (95% CI 0.78 to 1.00, P=0.045), respectively. The results of the 110-mg BID dosage were mainly driven by the RE-LY trial. CONCLUSIONS: This meta-analysis provides evidence that dabigatran etexilate is associated with a significantly increased risk of MI. This increased risk should be considered taking into account the overall benefit in terms of major bleeding and all-cause mortality. [less ▲]

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See detailMirabel: An integrated project for risk and cost/benefit analysis of peanut allergy
Crépet, A.; Papadopoulos, A.; Elegbede, C.F. et al

in Regulatory Toxicology & Pharmacology [=RTP] (2015), 71

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on ... [more ▼]

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on exposure components such as the allergens present in foods and the consumption behaviour of allergic consumers and models to estimate the related risk need to be enriched. Mirabel proposes for the first time studying each risk component using an integrated approach in order to improve the quality of life of the allergic population. Field surveys were conducted in order to fill in the current gaps in unintentional allergen traces in food, allergic consumers’ food behaviour, threshold doses of allergic reaction, allergy symptoms and severity. The aim is also to propose methodological and operational tools to quantify allergic risk, to test management scenarios and to produce a cost/benefit analysis. Medical data on the peanut allergies of 785 patients were collected in the MIRABEL survey and 443 patients answered the food consumption questionnaire. The population surveyed was mostly paediatric – 86% were children under 16 years of age, with a high percentage of males (60%). This project will generate tangible results on peanut allergen exposure and risk which could be used in future risk assessment work and particularly to provide science-based guidance to set up concentration limits for peanut traces on packages. [less ▲]

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See detailÉpidémiologie de la lithiase urinaire en Province de Liège
Castiglione, Vincent ULg; JOURET, François ULg; Bruyère, Olivier ULg et al

Conference (2014, October 17)

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See detailÉpidémiologie de la lithiase urinaire en Province de Liège
Castiglione, Vincent ULg; Jouret, François ULg; Bruyère, Olivier ULg et al

in Néphrologie & Thérapeutique (2014, October 01)

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See detailEpidémiologie de la lithiase urinaire en Province de Liège
GADISSEUR, Romy ULg; Castiglione, Vincent ULg; JOURET, François ULg et al

in Néphrologie & Thérapeutique (2014, September), 10(5), 270

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See detailAdaptation interculturelle et validation du questionnaire VISA-P en français
Oppong-Kyei, Julian; Bruyère, Olivier ULg; Delvaux, François ULg et al

in 7ème Congrès National SFMES & SFTS 2014 (2014, September)

Introduction La tendinopathie patellaire est une affection musculo-squelettique très fréquentes chez le sportif et la plus fréquente au niveau du genou. Elle affecte le plus souvent des disciplines qui ... [more ▼]

Introduction La tendinopathie patellaire est une affection musculo-squelettique très fréquentes chez le sportif et la plus fréquente au niveau du genou. Elle affecte le plus souvent des disciplines qui nécessitent soit des impulsions et des sauts soit un travail important du quadriceps. Le Victorian Institute of Sports Assessment–Patellar (VISA-P) est un questionnaire permettant d’évaluer les symptômes et leurs retentissements sur les activités physiques quotidiennes et sportives de la tendinopathie patellaire (Jumper’s knee). Comme la plus part des questionnaires de ce type, le VISA-P fut originalement développé pour des patients anglophones et n'est donc pas adapté à une population francophone. En conséquence, l'objectif de cette étude sera de traduire, adapter et valider une version française fiable du VISA-P et d'en évaluer ses propriétés psychométriques. Matériel et méthode La traduction et l’adaptation interculturelle du VISA-P ont été réalisées selon les recommandations internationales (Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures). Ce processus s'est déroulé en 6 étapes : traductions initiales, synthèse des traductions, traduction de retour vers la langue d’origine, comité expert, test de la version pré-finale et approbation du comité expert. La version française finale obtenue fut ensuite l’objet d’une évaluation de certaines propriétés psychométriques telles que la fidélité test-retest, la cohérence interne, la validité de construit et les effets plancher et plafond. Nonante-deux sujets furent recruté au total afin de tester ces propriétés psychométriques. Trois groupes de sujets furent utilisés pour répondre conjointement aux VISA-P et à un questionnaire supplémentaire, le Medical Outcomes Survey Short Form 36 questionnaire (SF-36) pour la validité de construit : un groupe de sujets pathologiques principalement recrutés parmi les patients du Centre Hospitalier Universitaire de Liège (28), un groupe de sujets asymptomatiques (22) et un groupe de sportifs à risque recrutés dans divers clubs sportif (42). L'ensemble des participants ont été recrutés au sein de la province de Liège. Résultats Aucun sujet ne présenta de grosses difficultés à comprendre le questionnaire suite au test de la version pré-finale. Les différents membres du comité expert se montrèrent satisfait de la version finale et donnèrent donc leur approbation. La moyenne des scores obtenu est de 53 (± 17) pour le groupe pathologique, 99 (± 2) pour le groupe sain et 86 (± 14) pour le groupe à risque. Les corrélations entre le VISA-P et certaines mesures divergentes du SF-36 semblent donner des résultats faibles. Les coefficients de corrélation mesurés entre les scores du VISA-P et les items convergents du SF-36 paraissent être élevés. Aucun effet plancher ou plafond n'a pu être observer lors de l'évaluation des propriétés psychométriques du VISA-P dans le groupe pathologique. Conclusion La version française du VISA-P est donc être un questionnaire compréhensible, fiable et adapté aux patients francophones souffrant d'une tendinopathie patellaire supérieur. [less ▲]

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See detailAdaptation interculturelle et validation du questionnaire VISA-A en français
Oppong-Kyei, Julian; Bruyère, Olivier ULg; Delvaux, François ULg et al

in 7ème Congrès National SFMES & SFTS 2014 (2014, September)

Introduction La tendinopathie d’Achille, dont la discipline athlétique implique une grosse activité de course à pied, représente une source de douleurs et de handicap. Cette pathologie fait actuellement l ... [more ▼]

Introduction La tendinopathie d’Achille, dont la discipline athlétique implique une grosse activité de course à pied, représente une source de douleurs et de handicap. Cette pathologie fait actuellement l'objet de nouvelles découvertes sur le plan de la physiopathologie permettant l'exploration de nouvelles pistes thérapeutiques. Dans le cadre de telles études, des échelles d’évaluation sont utilisées afin d'évaluer des phénomènes subjectifs ou complexes tels la douleur, la qualité de vie, le handicap, etc. Elles sont généralement composées de plusieurs items dont la cotation est combinée en un score global ou des sous scores dimensionnels. La majorité des échelles algo-fonctionnelles sont développés dans des pays anglophones et sont par conséquence uniquement pertinents pour des sujets parlant l’anglais. Ceci est la cas pour le Victorian Institute of Sports Assessment–Achilles (VISA-A), un questionnaire développé dans le but d'évaluer la sévérité des symptômes de la tendinopathie achilléenne. L’intérêt de ce mémoire est donc de valider une version française fiable de ce questionnaire. Matériel et méthode La traduction et l’adaptation interculturelle du VISA-A ont été réalisées selon les recommandations internationales (Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures). Ce processus s'est déroulé en 6 étapes : traductions initiales, synthèse des traductions, traduction de retour vers la langue d’origine, comité expert, test de la version pré-finale et approbation du comité expert. La version française finale obtenue fut ensuite l’objet d’une évaluation de certaines propriétés psychométriques telles que la fidélité test-retest, la cohérence interne, la validité de construit et les effets plancher et plafond. Pour ces évaluations, 116 sujets furent recruté et répartis en 3 groupes : un groupe de sujets pathologiques principalement recrutés parmi les patients du Centre Hospitalier Universitaire de Liège (31), un groupe de sujets asymptomatiques (22) et un groupe de sportifs à risque (63). Tous ces sujets durent également répondre à un questionnaire supplémentaire, le Medical Outcomes Survey Short Form 36 questionnaire (SF-36) pour la validité de construit. L'ensemble des participants ont été recrutés au sein de la province de Liège. Résultats Aucun sujets ne présenta de difficultés à comprendre le questionnaire suite au test de la version pré-finale. Les différents membres du comité expert se montrèrent satisfait de la version finale et donnèrent donc leur approbation. La moyenne des scores obtenus dans le groupe pathologique est de 59 (± 18), celle du groupe sain est de 99 (± 1) et celle du groupe à risque est de 94 (± 7). Aucun effet plancher ou plafond n'a pu être observer lors de l'évaluation des propriétés psychométriques du VISA-A (dans le groupe pathologique). Les corrélations entre le VISA-A et certaines mesures divergentes du SF-36 semblent être faibles. Les coefficients de corrélation mesurés entre les scores du VISA-A et les items convergents du SF-36 paraissent être élevé. Conclusion La version française du VISA-A est donc être un questionnaire compréhensible, fiable et adapté aux patients francophones souffrant d'une tendinopathie d'Achille. [less ▲]

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See detailOù il est question de se faire une idée juste de la réalité... (partie 1)
Bruyère, Olivier ULg

in Medi-Sphere (2014), 454

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