Erythropoiesis in acromegaly : effect of GH or IGF-1 ? Data from the LAS (Liege Acromegaly Survey)

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 45

Age, GH and tumor size : the triangular relation in acromegaly. Data from the LAS (Liege Acromegaly Survey)

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 43

Caracteristicas de prolactinomas resisitentes a dosis estandar de cabergolina : un estudio multicentrico en 92 pacientes

in Abstract book - 54 Congreso Sociedad Espanola de Endocrinologia y nutrition (2012, May 23)

Prolactinomas Resistant to Standard Doses of Cabergoline : A multicenter study of 92 patients

in European Journal of Endocrinology (2012), 167

Clinical characterization of cabergoline resistant prolactinomas : a multicenter experience on 92 patients

in ENEA Munich - abstract book (2011, December)

Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line AIP Mutations and Pituitary Adenomas - An International Collaborative Study

in Journal of Clinical Endocrinology and Metabolism (2010), 95(11),

Context: AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated pituitary adenomas and less often in sporadic cases. The clinical and therapeutic features ... [more ▼]

Context: AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated pituitary adenomas and less often in sporadic cases. The clinical and therapeutic features of AIPmut-associated pituitary adenomas have not been studied comprehensively. Objective: The objective of the study was to assess clinical/therapeutic characteristics of AIPmut pituitary adenomas. Design: This study was an international, multicenter, retrospective case collection/database analysis. Setting: The study was conducted at 36 tertiary referral endocrine and clinical genetics departments. Patients: Patients included 96 patients with germline AIPmut and pituitary adenomas and 232 matched AIPmut-negative acromegaly controls. Results: The AIPmut population was predominantly young and male (63.5%); first symptoms occurred as children/adolescents in 50%. At diagnosis, most tumors were macroadenomas (93.3%); extension and invasion was common. Somatotropinomas comprised 78.1% of the cohort; there were also prolactinomas (n = 13), nonsecreting adenomas (n = 7), and a TSH-secreting adenoma. AIPmut somatotropinomas were larger (P = 0.00026), with higher GH levels (P = 0.00068), more frequent extension (P = 0.018) and prolactin cosecretion (P = 0.00023), and occurred 2 decades before controls (P < 0.000001). Gigantism was more common in the AIPmut group (P < 0.000001). AIPmut somatotropinoma patients underwent more surgical interventions (P = 0.00069) and had lower decreases in GH (P = 0.00037) and IGF-I (P = 0.028) and less tumor shrinkage with somatostatin analogs (P < 0.00001) vs. controls. AIPmut prolactinomas occurred generally in young males and frequently required surgery or radiotherapy. Conclusions: AIPmut pituitary adenomas have clinical features that may negatively impact treatment efficacy. Predisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility. [less ▲]

Caractérisation des facteurs associés à la perte d'expression de AIP dans les adénomes hypophysaires somatotropes

in Annales d'Endocrinologie (2010, September), 71(5), 406

Recherche de la mutation du gène CDKN1B dans les adénomes hypophysaires familiaux isolés (FIPA): analyse de 86 familles

in Annales d'Endocrinologie (2010, September), 71(5), 398

Cyclin dependent kinase inhibitor 1B (CDKN1B) gene mutations in FIPA

in European Neuroendocrine Association - Liège, 22-25 septembre 2010 (2010, September)

Caractérisation des facteurs associés à la perte d'expression de AIP dans les adénomes hypophysaires somatotropes

in 27ème Congrès de la Société Française d'Endocrinologie - Deauville, 29 septembre - 2 octobre 2010 (2010, September)