References of "Brichant, Jean-François"
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See detailThe new Sfar journals are in place
Plaud, B; Lefrant, JY; BRICHANT, Jean-François ULg

in Current Anaesthesia and Critical Care (2016)

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See detailDevelopment and validation of a morphologic obstructive sleep apnea prediction score: The DES-OSA score
Deflandre, E.; Degey, S.; Brichant, Jean-Francois ULg et al

in Anesthesia and Analgesia (2016), 122(2), 363-372

BACKGROUND: Obstructive sleep apnea (OSA) is a common and underdiagnosed entity that favors perioperative morbidity. Several anatomical characteristics predispose to OSA. We developed a new clinical score ... [more ▼]

BACKGROUND: Obstructive sleep apnea (OSA) is a common and underdiagnosed entity that favors perioperative morbidity. Several anatomical characteristics predispose to OSA. We developed a new clinical score that would detect OSA based on the patient's morphologic characteristics only. METHODS: Patients (n = 149) scheduled for an overnight polysomnography were included. Their morphologic metrics were compared, and combinations of them were tested for their ability to predict at least mild, moderate-to-severe, or severe OSA, as defined by an apnea-hypopnea index (AHI) >5, >15, or >30 events/h. This ability was calculated using Cohen κ coefficient and prediction probability. RESULTS: The score with best prediction abilities (DES-OSA score) considered 5 variables: Mallampati score, distance between the thyroid and the chin, body mass index, neck circumference, and sex. Those variables were weighted by 1, 2, or 3 points. DES-OSA score >5, 6, and 7 were associated with increased probability of an AHI >5, >15, or >30 events/h, respectively, and those thresholds had the best Cohen κ coefficient, sensitivities, and specificities. Receiver operating characteristic curve analysis revealed that the area under the curve was 0.832 (95% confidence interval [CI], 0.762-0.902), 0.805 (95% CI, 0.734-0.876), and 0.834 (95% CI, 0.757-0.911) for DES-OSA at predicting an AHI >5, >15, and >30 events/h, respectively. With the aforementioned thresholds, corresponding sensitivities (95% CI) were 82.7% (74.5-88.7), 77.1% (66.9-84.9), and 75% (61.0-85.1), and specificities (95% CI) were 72.4% (54.0-85.4), 73.2% (60.3-83.1), and 76.9% (67.2-84.4). Validation of DES-OSA performance in an independent sample yielded highly similar results. CONCLUSIONS: DES-OSA is a simple score for detecting OSA patients. Its originality relies on its morphologic nature. Derived from a European population, it may prove useful in a preoperative setting, but it has still to be compared with other screening tools in a general surgical population and in other ethnic groups. © 2016 International Anesthesia Research Society. [less ▲]

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See detailLarge-scale signatures of unconsciousness are consistent with a departure from critical dynamics
Tagliazucchi, E.; Chialvo, D. R.; Siniatchkin, M. et al

in Journal of the Royal Society Interface (2016), 13(114),

Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. In this study, we arrive at a basic ... [more ▼]

Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. In this study, we arrive at a basic model explaining these observations based on the theory of phase transitions in complex systems. We studied the link between spatial and temporal correlations of large-scale brain activity recorded with functional magnetic resonance imaging during wakefulness, propofol-induced sedation and loss of consciousness and during the subsequent recovery. We observed that during unconsciousness activity in frontothalamic regions exhibited a reduction of long-range temporal correlations and a departure of functional connectivity from anatomical constraints. A model of a system exhibiting a phase transition reproduced our findings, as well as the diminished sensitivity of the cortex to external perturbations during unconsciousness. This framework unifies different observations about brain activity during unconsciousness and predicts that the principles we identified are universal and independent from its causes. © 2016 The Author(s) Published by the Royal Society. All rights reserved. [less ▲]

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See detailDistribution of Injectate and Sensory-Motor Blockade after Adductor Canal Block
Gautier, P. E.; Hadzic, A.; LECOQ, Jean-Pierre ULg et al

in Anesthesia and Analgesia (2016), 122(1), 279-282

BACKGROUND: The analgesic efficacy reported for the adductor canal block may be related to the spread of local anesthetic outside the adductor canal. METHODS: Fifteen patients undergoing knee surgery ... [more ▼]

BACKGROUND: The analgesic efficacy reported for the adductor canal block may be related to the spread of local anesthetic outside the adductor canal. METHODS: Fifteen patients undergoing knee surgery received ultrasound-guided injections of local anesthetic at the level of the adductor hiatus. Sensory-motor block and spread of contrast solution were assessed. RESULTS: Sensation was rated as "markedly diminished" or "absent" in the saphenous nerve distribution and "slightly diminished" in the sciatic nerve territory without motor deficits. Contrast solution was found in the popliteal fossa. CONCLUSIONS: The spread of injectate to the popliteal fossa may contribute to the analgesic efficacy of adductor canal block. © 2015 International Anesthesia Research Society. [less ▲]

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See detailWhat mediates postoperative risk in obstructive sleep apnea: airway obstruction, nocturnal hypoxia or both ?
DEFLANDRE, Eric; BONHOMME, Vincent ULg; BRICHANT, Jean-François ULg et al

in Canadian Journal of Anaesthesia = Journal Canadien d'Anesthésie (2016)

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See detailPrevalence, characteristics and risk factors of chronic post surgical pain after laparoscopic colorectal surgery: retrospective analysis
JORIS, Jean ULg; GEORGES, MATHIEU; MEDJAHED, KAMEL et al

in European Journal of Anaesthesiology (2015)

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See detailTHE IMPLEMENTATION OF REGIONAL ANAESTHESIA BLOCK ROOMS IN BELGIUM: A NATIONAL SURVEY
BINDELLE, Simon ULg; LECOQ, Jean-Pierre ULg; Sermeus, Luc et al

in Regional Anesthesia & Pain Medicine (2015, September), 40(5), 162

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See detailEVALUATION OF CONTINUOUS SUPRASCAPULAR NERVE BLOCKADE IN THE TREATMENT OF REFRACTORY ADHESIVE CAPSULITIS : A RETROSPECTIVE STUDY
MUTSERS, Pierre ULg; LECOQ, Jean-Pierre ULg; GOFFIN, Pierre ULg et al

in Abstract Book du Residence Meeting de la Société Belge d'Anesthésie (2015, June 15)

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See detailRegional anesthesia: an extra-benefit for our patients
NINANE, Vincent ULg; LECOQ, Jean-Pierre ULg; FONTAINE, ROBERT et al

in Revue Médicale de Liège (2015)

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See detailObstructive sleep apnea and detection of non-adherence to CPAP in OSA: limits of the preanesthesia visit.
Deflandre, E.; Brichant, Jean-François ULg; Bonhomme, V.

in Minerva anestesiologica (2015)

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See detailImpairment of sciatic nerve function during adductor canal block
Gautier, Philippe; LECOQ, Jean-Pierre ULg; HARTSTEIN, Gary ULg et al

in Regional Anesthesia & Pain Medicine (2015)

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See detailEtat prothrombotique des patients atteints du syndrome d'apnées et d'hypopnées obstructives du sommeil
DEFLANDRE, E.; KEMPENEER, D.; BRICHANT, Jean-François ULg et al

in Praticien en Anesthésie Réanimation (Le) (2015)

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See detailConsciousness and complexity during unresponsiveness induced by propofol, xenon, and ketamine
Sarasso, S.; Boly, M.; Napolitani, M. et al

in Current Biology (2015), 25(23), 3099-3105

A common endpoint of general anesthetics is behavioral unresponsiveness [1], which is commonly associated with loss of consciousness. However, subjects can become disconnected from the environment while ... [more ▼]

A common endpoint of general anesthetics is behavioral unresponsiveness [1], which is commonly associated with loss of consciousness. However, subjects can become disconnected from the environment while still having conscious experiences, as demonstrated by sleep states associated with dreaming [2]. Among anesthetics, ketamine is remarkable [3] in that it induces profound unresponsiveness, but subjects often report ketamine dreams upon emergence from anesthesia [4-9]. Here, we aimed at assessing consciousness during anesthesia with propofol, xenon, and ketamine, independent of behavioral responsiveness. To do so, in 18 healthy volunteers, we measured the complexity of the cortical response to transcranial magnetic stimulation (TMS) - an approach that has proven helpful in assessing objectively the level of consciousness irrespective of sensory processing and motor responses [10]. In addition, upon emergence from anesthesia, we collected reports about conscious experiences during unresponsiveness. Both frontal and parietal TMS elicited a low-amplitude electroencephalographic (EEG) slow wave corresponding to a local pattern of cortical activation with low complexity during propofol anesthesia, a high-amplitude EEG slow wave corresponding to a global, stereotypical pattern of cortical activation with low complexity during xenon anesthesia, and a wakefulness-like, complex spatiotemporal activation pattern during ketamine anesthesia. Crucially, participants reported no conscious experience after emergence from propofol and xenon anesthesia, whereas after ketamine they reported long, vivid dreams unrelated to the external environment. These results are relevant because they suggest that brain complexity may be sensitive to the presence of disconnected consciousness in subjects who are considered unconscious based on behavioral responses. © 2015 Elsevier Ltd All rights reserved. [less ▲]

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See detailWhen diagnostic imaging is misleading: a case of subacute liver failure
KHELIFA, H.; SEIVERT, M.; COLARD, A. et al

in Revue Médicale de Liège (2015)

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See detailPreoperative Adherence to Continuous Positive Airway Pressure among Obstructive Sleep Apnea Patients
Deflandre; Degey, S; BONHOMME, Vincent ULg et al

in Minerva Anestesiologica (2015), 81(9), 960-7

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See detailAdherence to Continuous Positive Airway Pressure (CPAP) Therapy
Deflandre, Eric ULg; Degey, Stéphanie; BONHOMME, Vincent ULg et al

Poster (2014, October)

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See detailAdherence to Continuous Positive Airway Pressure (CPAP) Therapy
Deflandre, Eric ULg; Degey, Stéphanie; BONHOMME, Vincent ULg et al

Poster (2014, October)

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