  Quaternary Indole Alkaloids from the Stem Bark of Strychnos Guianensis; Tits, Monique  ; et alin Phytochemistry (2000), 53(8), 1057-66 Two new quaternary alkaloids, 9-methoxy-Nb-methylgeissoschizol and guiachrysine together with the known compounds C-alkaloid O, fluorocurine, mavacurine, macusine B and C-profluorocurine, were isolated ... [more ▼] Two new quaternary alkaloids, 9-methoxy-Nb-methylgeissoschizol and guiachrysine together with the known compounds C-alkaloid O, fluorocurine, mavacurine, macusine B and C-profluorocurine, were isolated from Strychnos guianensis stembark. The structures of the compounds were elucidated on the basis of spectroscopic studies. [less ▲] Detailed reference viewed: 25 (4 ULg)New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja RootsFrederich, Michel ; Gillet, Marie-Claire ; Llabres, Gabriel et alin Planta Medica (2000), 66(3), 262-9 Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy ... [more ▼] Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38). [less ▲] Detailed reference viewed: 42 (13 ULg)New strictosidine beta-glucosidase from Strychnos mellodora; ; Tits, Monique et alin Plant Physiology & Biochemistry (2000), 38(3), 187-192 A stable strictosidine glucosidase was isolated from dried powdered material of Strychnos mellodora. The kinetic parameters Km and Vmax of the purified glucosidases from catharanthus roseus and S ... [more ▼] A stable strictosidine glucosidase was isolated from dried powdered material of Strychnos mellodora. The kinetic parameters Km and Vmax of the purified glucosidases from catharanthus roseus and S. mellodora towards strictosidine, dolichantoside and palicoside were determined and compared. [less ▲] Detailed reference viewed: 27 (2 ULg)Anti-inflammatory and chondroprotective activity of prodelphinidins isolated from Ribes nigrum leaves.Tits, Monique ; ; et alPoster (2000) Detailed reference viewed: 13 (0 ULg)10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos UsambarensisFrederich, Michel ; Tits, Monique ; Hayette, Marie-Pierre et alin Journal of Natural Products (1999), 62(4), 619-21 Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods ... [more ▼] Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods. Compound 1 was moderately active against two strains of Plasmodium falciparum in vitro. [less ▲] Detailed reference viewed: 193 (34 ULg)Strychnochrysine, a New Bisindole Alkaloid from the Roots of Strychnos Nux-Vomica; Tits, Monique ; et alin Journal of Natural Products (1998), 61(1), 139-41 The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was ... [more ▼] The reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was defined by detailed spectroscopic methods. [less ▲] Detailed reference viewed: 53 (25 ULg) |
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