Effects of obesity on lung function and airway reactivity in healthy dogs.Manens, Jefferson ; ; Bernaerts, Frederique et alin Veterinary Journal (2011) The present study investigated the effects of bodyweight (BW) gain on respiratory function and airway responsiveness in healthy Beagles using barometric whole body plethysmography (BWBP). Six adult dogs ... [more ▼] The present study investigated the effects of bodyweight (BW) gain on respiratory function and airway responsiveness in healthy Beagles using barometric whole body plethysmography (BWBP). Six adult dogs were examined before and after a fattening diet. The high-energy diet induced a mean increase in BW of 41 ± 6%. BWBP basal parameters were recorded prior to airway reactivity testing (using increasing concentrations of histamine nebulisations). An airway responsiveness index (H-Penh300) was calculated as the histamine concentration necessary to reach 300% of basal enhanced pause (Penh, bronchoconstriction index). The same dogs underwent a doxapram hydrochloride (Dxp) stimulation testing 2 weeks later. Basal measurements showed that obese dogs had tidal volume per kg (TV/BW) that was significantly decreased whilst respiratory rate (RR) increased significantly. H-Penh300 decreased significantly in obese Beagles, indicating increased bronchoreactivity. Dxp administration induced a significant increase in TV/BW, minute volume per kg (MV/BW), peak inspiratory and expiratory flows per kg (PIF/BW and PEF/BW) in both normal and obese dogs although the TV/BW increase was significantly less marked in the obese group. In conclusion, obesity induced changes in basal respiratory parameters, increased bronchoreactivity and a blunted response to Dxp-induced respiratory stimulation. This combination of basal respiratory parameters, bronchoreactivity testing and pharmacological stimulation testing using non-invasive BWBP can help characterize pulmonary function and airway responsiveness in obese dogs. [less ▲] Detailed reference viewed: 41 (12 ULg) A model of subclinical chronic bronchitis induced by repeted nebulisations of bacterial lipopolysaccharideKrafft, Emilie ; ; Tual, Charlotte et alin 20th ECVIM Meeting - Toulouse - France - 9-12 septembre 2010 (2010, September 09) Detailed reference viewed: 18 (3 ULg) Respiratory functional assessment using barometric whole-body plethysmography in healthy growing and aging beagle dogsManens, Jefferson ; ; et alin ACVIM Meeting - Anaheim, Californie - 9-12 juin 2010 (2010, June 09) Detailed reference viewed: 4 (1 ULg) Activity of metalloproteinases MMP2 and MMP9 in matched serum and bronchoalveolar lavage fluid samples in a dog model of airway inflammationManens, Jefferson ; ; et alin 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08) Detailed reference viewed: 7 (2 ULg) Procollagen Type-III aminoterminal peptide in serum, bronchoalveolar lavage fluid and bronchial brush specimens in a model of chronic bronchitis in dogs; ; et al in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08) Detailed reference viewed: 1 (0 ULg) Characterisation of the acute and reversible airway inflammation induced by cadmium chloride inhalation in healthy dogs and evaluation of the effects of salbutamol and prednisolone.; ; Leemans, Jérôme et alin Veterinary Journal (2009), 179(3), 443-450 The aims of this study were firstly to characterise a model of subclinical and reversible bronchial inflammation induced by cadmium chloride inhalation in healthy dogs and then to examine the effect of ... [more ▼] The aims of this study were firstly to characterise a model of subclinical and reversible bronchial inflammation induced by cadmium chloride inhalation in healthy dogs and then to examine the effect of prednisolone or salbutamol treatment on the resulting bronchitis. The model characterisation and the effects of treatment were studied using clinical symptoms, haematology, thoracic radiography, bronchoscopy and bronchoalveolar lavage, barometric whole-body plethysmography and histamine broncho-provocation tests. In addition, the activity of matrix metalloproteinases (MMP)-2 and -9 were determined in serum and bronchoalveolar lavage fluid (BALF). Cadmium inhalation induced: (1) a transient bronchial inflammation, dominated by neutrophils; (2) a neutrophilia of the blood that persisted for up to 4weeks; (3) a transient increased bronchial reactivity, and (4) a significant increase in MMP-9 activity in the BALF. Prednisolone treatment reduced the influx of inflammatory cells into the BALF, but not significantly, had no effect on pulmonary function, and did not reduce of airway hypersensitivity. Salbutamol had almost no effect on any of the parameters investigated. [less ▲] Detailed reference viewed: 32 (9 ULg) Cellular composition of bronchial brushings obtained from dogs with experimental chronic bronchitis; Tual, Charlotte ; et alin 18th ECVIM Meeting - Gent - Belgique - 2-5 septembre 2008 (2008, September 02) Detailed reference viewed: 5 (0 ULg) Clinical and functional investigation in an experimental model of chronic bronchitis in dogs; ; et al in 18th ECVIM Meeting - Gent - Belgique - 2-5 septembre 2008 (2008, September 02) Detailed reference viewed: 6 (0 ULg) Therapeutic response in dogs with lymphoplasmacytic rhinitis: a retrospective study in 12 dogsManens, Jefferson ; ; Mercier, Elise et alin 25th Symposium of the Veterinary Comarative Respiratory Society - Purdue, USA 10-13 octobre 2007 (2007, October 10) Detailed reference viewed: 10 (1 ULg) Comparison of total cell count in bronchoalveolar lavage fluid obtained by manual haemocytometry versus automated cell counters, from healthy dogs and cats and dogs with bronchitisLavoué, Rachel ; Delvaux, François ; et alin 17th ECVIM Meeting - Budapest - Hongrie - Septembre 2007 (2007, September 13) Detailed reference viewed: 7 (2 ULg) Activity of metalloproteinases mmp2 and mmp9 in matched serum and bronchoalveolar lavage fluidsamples from dogs with chronic bronchitis cvresus recurrent infectious bronchopneumonia; ; et al in 17th ECVIM Meeting - Budapest - Hongrie - Septembre 2007 (2007, September 13) Detailed reference viewed: 3 (0 ULg) Effect of obesity on doxapram hydrochlorid-induced effects on whole body barometric plethysmography measurements in healthy Beagle dogs; Bernaerts, Frederique ; et alin 24th Symposium of the Veterinary Comarative Respiratory Society - Jena, Allemagne 8-10 octobre 2006 (2006, October 08) Detailed reference viewed: 8 (1 ULg) Investigation of airway reactivity by barometric whole body plethysmography in cats with spontaneous bronchial diseaseBernaerts, Frederique ; Merveille, Anne-Christine ; et alin 24th Symposium of the Veterinary Comarative Respiratory Society - Jena, Allemagne 8-10 octobre 2006 (2006, October) Detailed reference viewed: 6 (1 ULg) Investigation of the effect of salbutamol and prenisolone on lung function test in healthy dogs with experimentally induced airway inflammation; ; Bernaerts, Frederique et alin 16th ECVIM Meeting - Amsterdam - Nederlands - Septembre 2006 (2006, September) Detailed reference viewed: 4 (1 ULg) Effect of obesity in dogs on airway reactivity measured by barometric whole body plethysmographyBernaerts, Frederique ; ; et alin 16th ECVIM Meeting - Amsterdam - Nederlands - Septembre 2006 (2006, September) Detailed reference viewed: 8 (3 ULg) |
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