Release and Innate detection of host cell DNA mediates the adjuvant effects of aluminum salts on adaptive responses

in Proceedings of the 1St Winter School Immunology (2012, January)

Interferon Response Factor-3 is essential for house dust mite-induced airway allergy

in Proceedings of the Belgian Thoracic Society Annual Meeting (2011, May 23)

Release and innate immune detection of host cell DNA mediate the adjuvant activity of aluminum salts

Conference (2011)

Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-γ Activity in Dendritic Cells

in Journal of Immunology (2011), 187(9), 4517-4529

Sirtuins are a unique class of NAD+-dependent deacetylases that regulate diverse biological functions such as aging, metabolism, and stress resistance. Recently, it has been shown that sirtuins may have ... [more ▼]

Sirtuins are a unique class of NAD+-dependent deacetylases that regulate diverse biological functions such as aging, metabolism, and stress resistance. Recently, it has been shown that sirtuins may have anti-inflammatory activities by inhibiting proinflammatory transcription factors such as NF-κB. In contrast, we report in this study that pharmacological inhibition of sirtuins dampens adaptive Th2 responses and subsequent allergic inflammation by interfering with lung dendritic cell (DC) function in a mouse model of airway allergy. Using genetic engineering, we demonstrate that sirtuin 1 represses the activity of the nuclear receptor peroxisome proliferator-activated receptor-γ in DCs, thereby favoring their maturation toward a pro-Th2 phenotype. This study reveals a previously unappreciated function of sirtuin 1 in the regulation of DC function and Th2 responses, thus shedding new light on our current knowledge on the regulation of inflammatory processes by sirtuins. [less ▲]

Self-DNA release mediates the adjuvant effect of aluminum salts

in Proceedings of the 4th meeting on Harnessing immunity to prevent and treat diseases (2011)

Les macrophages interstitiels, gardiens de l'homeostasie immune pulmonaire.

in Medecine Sciences : M/S (2010), 26(3), 229-31

IRF3 is required for induction of allergic airway inflammation by dendritic cells

Poster (2009)

IRF3 is required for induction of allergic airway inflammation by dendritic cells

Conference (2009)

A crucial role forlung interstitial macrophages in preventing airway allergy

in Short book of the Annual Congress of the European Respiratory Society (ERS), Vienne (2009)

Evaluation de l’efficacité du Caprofène lors de bronchoneumonie expérimentale bovine à Mannheimia haemolytica

in Revue de Médecine Vétérinaire (2007), 158(8-9), 418-424

M. haemolytica serotype A1 (formerly known as Pasteurella) is the most important and commonly isolated bacterial pathogen from fatal cases of bovine fibrinous pleuroneumonia. M. haemolytica and its two ... [more ▼]

M. haemolytica serotype A1 (formerly known as Pasteurella) is the most important and commonly isolated bacterial pathogen from fatal cases of bovine fibrinous pleuroneumonia. M. haemolytica and its two principal toxins, the lipopolysaccharides (LPS) and the leukotoxin (LktA) induce the recruitment, the activation and the necrosis of neutrophils involved in the pathogenicity of bovine pneumonic mannheimiosis (BPM). The objective of this study was to determine whether systemic therapy with carprofène (Rimadyl®*), a non-steroidal anti-inflammatory drug, improves the disease development in an acute experimental model of BPM. The experimental pathology was induced by trans-tracheal inoculation of M. haemolytica and toxins at T0. One hour post-inoculation, six calves were treated intravenously with carprofen (1,4 mg/kg) while six placebo-treated calves received dose-matched volumes of sterile saline. The clinical and biochemical parameters were measured at one (T+1), three (T+3) and seven (T+7) hours after inoculation. Disease scores for carprofen treated calves were significantly lower than those for placebo-treated controls six hours (T+7) after treatment. These results were associated to a significantly oxygen saturation decrease at T+3 and a significantly blood lactate increase at T+7 in the control calves. Moreover, pulmonary lesions were significantly less extensive than those in the control group. Taken together, this finding suggest that pharmacological modulation by carprofen of pulmonary inflammation after appearance of acute BPM clinical signs leads to calves’ health enhancement and reduces the extent of gross pneumonic lesion. [less ▲]