References of "Becker, M"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailEffect of Beclomethasone Dipropionate and Dexamethasone Isonicotinate on Lung Function, Bronchoalveolar Lavage Fluid Cytology, and Transcription Factor Expression in Airways of Horses with Recurrent Airway Obstruction
Couetil, L.; Art, Tatiana ULg; de Moffarts, Brieuc et al

in Journal of Veterinary Internal Medicine (2006), 20

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of ... [more ▼]

Glucocorticoid (GC) therapy is recognized to be effective for the treatment of recurrent airway obstruction (RAO) in horses. Anti-inflammatory properties of GC are thought to be mediated by suppression of inflammatory gene expression via inhibition of transcription factors such as nuclear factor-kB (NF-kB) and activator protein-1 (AP-1). The purpose of this study was to evaluate the effect of low-dose inhaled beclomethasone dipropionate and injectable dexamethasone 21- isonicotinate on clinical signs, pulmonary function, airway cytology, and activity of NF-kB and AP-1 in bronchial cells of RAO-affected horses. Seven horses with RAO were exposed to moldy hay until they developed airway obstruction on 3 separate occasions. In a crossover design, they were then treated with a placebo (injection on day 1), inhaled beclomethasone (500 mg q12h for 10 days), or dexamethasone (0.06 mg/kg, IM on day 1) and monitored for 10 days. Pulmonary function, bronchoalveolar lavage fluid cytology, and NF-kB and AP-1 activity in bronchial brushing cells were measured before (day 1) and after treatment (day 10). Treatment with beclomethasone resulted in significantly improved pulmonary function of RAOaffected horses compared with placebo and dexamethasone treatments. However, none of the treatments had an effect on bronchoalveolar lavage fluid cytology or NF-kB and AP-1 activity. These findings reveal that, in a model of severe RAO, the benefits of low-dose inhaled beclomethasone on pulmonary function are not accompanied by a decrease in airway inflammatory cells or a suppression of transcription factors NF-kB and AP-1 DNA-binding activity. [less ▲]

Detailed reference viewed: 73 (13 ULg)
Full Text
Peer Reviewed
See detailTraining-induced changes in aerobic capacity assessed by VO2max and echocardiography in standardbred horses
Art, Tatiana ULg; De Moffarts, Brieuc; Sandersen, Charlotte ULg et al

in Lindsey, A. Abeyasekere; Frances, J.Barr (Eds.) Handbook of the 43rd Congress of the British Equine Veterinary Association (2004)

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailMyeloperoxydase concentration in bronchoalveolar lavage from healthy and heavy horses
Art, Tatiana ULg; Desmet, Christophe ULg; Lekeux, Pierre ULg et al

in Proceedings : 22nd Symposium of the Veterinary and Comparative Respiratory Society (2004)

Detailed reference viewed: 39 (12 ULg)
Full Text
Peer Reviewed
See detailEffects of glycopyrrolate inhalation on pulmonary function in heaves-affected horses in crisis
Art, Tatiana ULg; De Moffarts, Brieuc; Van Erck, Emmanuelle ULg et al

in Pflügers Archiv : European Journal of Physiology (2004), 447

Detailed reference viewed: 49 (4 ULg)
Full Text
Peer Reviewed
See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

Detailed reference viewed: 74 (16 ULg)
Full Text
Peer Reviewed
See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; De Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Pratique Vétérinaire Equine (2003), 35(139), 23-29

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ... [more ▼]

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ipratropium bromide have been tested. This study is to evaluate the efficacy of the synthetic antimuscarinic compound glycopyrrolate as a bronchodilator in horses. Respiratory crisis was induced in seven allergic horses by exposure to natural allergens. Prior to the study, it was established that the attack could be stopped using intravenous atropine sulphate. Pulmonary function tests (ventilation and arterial blood gas analysis) were performed on the horses before and then after aerosol administration of 1500 µg of glycopyrrolate (Robinul®). The attack was characterised by an increase in total pulmonary resis¬tance and maximum pleural pressure variation and by decreased compliance. This study demonstrates that glycopyrrolate exhibits affects that are just as rapid and effective as intravenous atropine or aerosol administration of 1200 µg dry powder Ipratropium. In addi¬tion the treatment was well tolerated and no side-effects were observed in contrast to those seen with intravenous administration of atro¬pine. Therefore this drug has an important role to play among the therapeutics available to practitioners for acute respiratory attacks in horses [less ▲]

Detailed reference viewed: 218 (13 ULg)
See detailCalibration and quality assessment of water vapor radiometer observations using radiosonde GPS and VLBI
Pottiaux, Eric; Becker, M.; Buerki, B. et al

Conference (2003)

Detailed reference viewed: 9 (0 ULg)
See detailThe Radcalwet observation campaign: relative and absolute calibration of WVR's
Pottiaux, Eric; Becker, M.; Buerki, B. et al

Conference (2003)

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailEffets fonctionnels respiratoires induits par l’inhalation du glycopyrrolate chez le cheval poussif en crise.
Art, Tatiana ULg; de Moffarts; Van Erck, Emmanuelle ULg et al

in Congrès de l'Association Vétérinaire Equine Française (AVEF) (2003)

Detailed reference viewed: 22 (7 ULg)