  Separation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte.Fillet, Marianne  ; ; Fotsing, Lucas et alin Biomedical Chromatography : BMC (2000), 14(1), 12-3 Separation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte. Detailed reference viewed: 15 (9 ULg) Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes.Fillet, Marianne ; ; et alin Electrophoresis (1999), 20(9), 1907-15 The aim of the present work was to investigate the separation of nonsteroidal anti-inflammatory drugs (NSAIDs: niflumic acid, flufenamic acid, piroxicam, alclofenac, tiaprofenic acid, flurbiprofen ... [more ▼] The aim of the present work was to investigate the separation of nonsteroidal anti-inflammatory drugs (NSAIDs: niflumic acid, flufenamic acid, piroxicam, alclofenac, tiaprofenic acid, flurbiprofen, suprofen, ketoprofen, naproxen, indomethacin, carprofen, indoprofen, sulindac) in capillary electrophoresis (CE) using completely nonaqueous systems. The influence of different parameters such as nature and proportion of organic solvent (methanol, acetonitrile, 2-propanol), apparent pH (ranging from 7 to 9) and temperature (ranging from 25 to 40 degrees C) on selectivity and migration times were studied systematically in an uncoated fused-silica capillary. A nonaqueous electrolyte made of 50 mM ammonium acetate - 13.75 mM ammonia in methanol proved to resolve 11 NSAIDs at 25 degrees C and 13 NSAIDs at 36 degrees C, both within 13 min and without a modifier besides the methanol itself. The same buffer containing 30% acetonitrile provides a satisfactory separation for 13 NSAIDs within 14 min at 25 degrees C. [less ▲] Detailed reference viewed: 59 (0 ULg)Quantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis; Hubert, Philippe ; Crommen, Jacques et alin Journal of Pharmaceutical & Biomedical Analysis (1995), 13(4-5), 497-503 The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of ... [more ▼] The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of different parameters on migration times, peak symmetry, efficiency and resolution was studied; these parameters included the nature and concentration of the anionic and cationic components of the separation buffer. A buffer consisting of 75 mM glycine adjusted to pH 9.1 with triethanolamine was found to provide a very efficient and stable electrophoretic system for the CZE analysis of NSAIDs, giving RSD values of about 0.1 and 0.5% for the within-day reproducibility of migration times and peak areas, respectively at a concentration of 25 micrograms ml-1 (n = 5). Response was linear from 2-100 micrograms ml-1 for both sulindac and tiaprofenic acid, for which the LOQ values were 2.8 and 1.9 micrograms ml-1, respectively, using UV detection at 280 nm. Accuracy for each drug was 102-103%. [less ▲] Detailed reference viewed: 19 (1 ULg)Enantiomeric separations by capillary electrophoresis applications in pharmaceutical, biomedical and environmental analysis, chapitre #L-7Crommen, Jacques ; Fillet, Marianne ; et alin Buszewski, B. (Ed.) New analytical methods for environmental control and monitoring (1995) Detailed reference viewed: 4 (1 ULg)Automated HPLC analysis of diltiazem and desacetyldiltiazem in plasma using disposabele extraction cartridgesChiap, Patrice ; Hubert, Philippe ; et alin Journal de Pharmacie de Belgique (1992), 47 Detailed reference viewed: 8 (2 ULg)Separation and quantitative analysis of amino acids by capillary zone electrophoresis with indirect photometric detection; Ceccato, Attilio ; Hubert, Philippe et alin Journal de Pharmacie de Belgique (1992), 47 Detailed reference viewed: 4 (1 ULg)Indirect photometric detection of amino acids in capillary zone electrophoresis; Hubert, Philippe ; Crommen, Jacques in Journal de Pharmacie de Belgique (1991), 46 Detailed reference viewed: 4 (1 ULg) |
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