Evaluation of the impact of a 6-month training by whole body vibration on the risk of falls among nursing home residents

in Osteoporosis International (2013, April), 24(Suppl.1), 246-247

Quantitative gait assessment using an accelerometer technology as a predictive tool of falls among nursing home residents: a 6-month prospective study

in Osteoporosis International (2013, April), 24(Suppl.1), 210

Quantitative gait assessment using an accelerometer technology as a predictive tool of falls among nursing home residents: a 6-month prospective study

in Proceedings of the meeting (2013, February 22)

Relationship between use of antidepressants and risk of fractures: a meta-analysis

in Osteoporosis International (2013), 24

Summary It has been shown that antidepressants would have a direct action on bone metabolism and would be associated with increased fracture risk. Results from this large meta-analysis show that both ... [more ▼]

Summary It has been shown that antidepressants would have a direct action on bone metabolism and would be associated with increased fracture risk. Results from this large meta-analysis show that both SSRIs and TCAs are associated with a moderate and clinically significant increase in the risk of fractures of all types. Introduction This study seeks to investigate the relationship between use of antidepressants and the risk of fracture. Methods An exhaustive systematic research of case–control and cohort studies published or performed between 1966 and April 2011 that reported risk estimates of fracture associated with use of antidepressants was performed using MEDLINE, PsycINFO, and the Cochrane Systematic Review Database, manual review of the literature, and congressional abstracts. Inclusion, quality scoring, and data abstraction were performed systematically by three independent reviewers. Results A total of 34 studies (n01,217,464 individuals) were identified. Compared with non-users, the random effects pooled RR of fractures of all types, among antidepressant users, were 1.39 (95%CI 1.32–1.47). Use of antidepressants were associated with a 42 %, 47 %, and 38 % risk increase in non-vertebral, hip, and spine fractures, respectively ([For non-vertebral fractures: RR01.42, 95%CI 1.34–1.51]; [For hip fractures: RR01.47, 95%CI 1.36–1.58]; [For spine fractures: RR01.38, 95%CI 1.19–1.61]). Studies examining SSRI use showed systematically a higher increase in the risk of fractures of all types, non-vertebral, and hip fractures than studies evaluating TCA use. Conclusions Results from this large meta-analysis show that both SSRIs and TCAs are associated with a moderate and clinically significant increase in the risk of fractures of all types. [less ▲]