Showing results 1 to 20 of 38
 Purification and analysis by mass spectometry of low M.W. soluble factors released into conditioned culture media by B16 melanoma cellsGillet, Marie-Claire  ; ; et alPoster (1995, July) Detailed reference viewed: 17 (0 ULg) Metalloproteinases and serine proteases activities in mixed spheroids of mouse B16 melanoma cells and fibroblasts; ; Leprince, Pierre et alin International Journal of Oncology (1994), 5 Detailed reference viewed: 5 (0 ULg) 2,7-dihydroxyapogeissoschizine from root bark of Strychnos gossweileri; Dive, Georges ; et alin Phytochemistry (1994), 35(2), 533-536 In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based ... [more ▼] In this paper, we describe the isolation and structural determination of 2,7-dihydroxyapogeissoschizine, a new alkaloid from the root bark of Strychnos gossweileri. Elucidation of its structure is based mainly on 1D and 2D NMR studies; its conformation was optimized by energy minimization. This type of skeleton is related to geissoschizine but with the notable diffrence that the 1 and 17 positions are joined giving an additional fused ring. Such a seven-membered ring has ,to our knowledge, only been observed in apogeissoschizine, obtained after chemical tratment of two alkaloids ( geissospermine and geissoschizine). 2,7-dihydroxyapogeissoschizine is therefore, the first natural product possessing this skeleton. According to a preliminary test, this new alkaloid shows low toxicity to B16 melanoma cells, but not for non-cancer 3T3 fibroblasts cultured in vitro.THese results have to be confirmed by further tests. [less ▲] Detailed reference viewed: 24 (3 ULg)Effect of selenium compounds on murine B16 melanoma cells and pigmented cloned pB16 cells; ; et al in Archives of Toxicology (1994), 68(4), 246-254 Seleno-DL-cysteine and sodium selenate are toxic in B16 cells and this toxicity seems to involve glutathione metabolites. Detailed reference viewed: 8 (3 ULg)Effects of trace metals on mouse B16 melanoma cells in culture; ; Gillet, Marie-Claire et alin Biological Trace Element Research (1993), 36(2), 191-201 The effects of fourteen metal ions on B16 cell proliferation, differentiation and melanogenesis have been analysed. Detailed reference viewed: 3 (0 ULg)Anticancer activities of Strychnopentamine; ; Gillet, Marie-Claire et alPoster (1992) Detailed reference viewed: 2 (0 ULg)Revision of the structure of strychnofluorine, an alkaloid of Strychnos gossweileri; ; et al in Phytochemistry (1992), 31(12), 4347-4349 The structure of strychnofluorine, an indole alkaloid isolated in 1980 from the root bark of Strychnos gossweileri, has been revised. Strychnofluorine proved to be identical with 18 ... [more ▼] The structure of strychnofluorine, an indole alkaloid isolated in 1980 from the root bark of Strychnos gossweileri, has been revised. Strychnofluorine proved to be identical with 18-hydroxynorfluorocurarine that has been isolated as a minor (contaminated) alkaloid from Strychnos ngouniensis in 1983. [less ▲] Detailed reference viewed: 10 (1 ULg)Cytological effects of culture media conditioned B16 melanoma cells and 3T3 fibroblasts; ; Gillet, Marie-Claire et alin Anticancer Research (1991), 11(2), 801-804 Cytotoxic soluble fractions (M.W.<1,000) were prepared from media conditioned by mixed cultures of 3T3 fibroblasts and B16 cells. The ultrastructural analyses of cells (B16 or 3T3) treated with these ... [more ▼] Cytotoxic soluble fractions (M.W.<1,000) were prepared from media conditioned by mixed cultures of 3T3 fibroblasts and B16 cells. The ultrastructural analyses of cells (B16 or 3T3) treated with these fractions revealed in them mitochondria swelling, blebs, broken membranes and dead cells. [less ▲] Detailed reference viewed: 8 (2 ULg)Cytotoxic and mitogenic activities in culture media conditioned by mouse B16 melanoma cells and 3T3 fibroblasts; Wauthy, Jacques ; et alin Anticancer Research (1991), 11(2), 755-759 Cytotoxic (M.W.< 1000) and mitogenic (M.W.>10000) soluble factors are released into media conditioned by pure or mixed populations of mouse 3T3 fibroblasts and B16 melanoma cells cutivated in vitro. They ... [more ▼] Cytotoxic (M.W.< 1000) and mitogenic (M.W.>10000) soluble factors are released into media conditioned by pure or mixed populations of mouse 3T3 fibroblasts and B16 melanoma cells cutivated in vitro. They are generally more active on B16 than on fibroblasts. [less ▲] Detailed reference viewed: 8 (1 ULg)Matadine, a cytotoxic alkaloid from Strychnos gossweileri; ; et al in Phytochemistry (1991), 30(5), 1697-1700 Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on ... [more ▼] Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on cancer cells and normal cells. Matadine is an anhydronium base as serpentine, that exerts also a selective inhibiting activity on B16 melanoma cells while it is less toxic in human 2002 non-cancer cells. This selective activity might be well due , as it seems to be the case for serpentine and alstonine, to a higher affinity of matadine for destabilized single-stranded DNA as mainly present in cancer cells. [less ▲] Detailed reference viewed: 31 (3 ULg)Cytotoxic activities exerted by low M.W. fractions present in culture media conditioned by mouse B16 melanoma cells and 3T3 fibroblasts; WAUTHY, Jacques ; et alPoster (1990, September) Detailed reference viewed: 3 (0 ULg)Characterization of tridimensional mixed cultures of mouse B16 melanoma cells and 3T3 fibroblasts; ; Munaut, Carine et alConference (1990, September) Detailed reference viewed: 1 (1 ULg)Effects of FeSO4 on B16 melanoma cells differentiation and proliferationGillet, Marie-Claire ; ; et alin Anticancer Research (1990), 10(4), 1029-1033 The paper shows that FeS04 can increase or reduce B16 cell proliferation and melanogenesis. Vitamin C toxicity for B16 cells was reduced in the presence of FeSO4. Detailed reference viewed: 17 (2 ULg)Control of B16 mealnoma cells differentiation and proliferation by CuSO4 and vitamin CGillet, Marie-Claire ; ; et alin Anticancer Research (1990), 10(2A), 391-405 The paper demonstrates that the toxicity of CuSO4 in B16 melanoma cells is increased in serum-free medium and in the presence of Vitamin C. Vitamin C toxicity for B16 cells was increased in the presence ... [more ▼] The paper demonstrates that the toxicity of CuSO4 in B16 melanoma cells is increased in serum-free medium and in the presence of Vitamin C. Vitamin C toxicity for B16 cells was increased in the presence of CUS04. [less ▲] Detailed reference viewed: 16 (3 ULg)Toxic and mitogenic activities of culture media conditioned by B16 melanoma cells; ; Gillet, Marie-Claire et alConference (1990) Detailed reference viewed: 3 (0 ULg)Identification of cytotoxic factors in media conditioned by mouse B16 melanoma cells; Gillet, Marie-Claire ; et alin Anticancer Research (1990), 10(5B), 1390 Detailed reference viewed: 4 (0 ULg)Influence of laminin and fibroblasts upon colony formation in the mouse by B16 melanoma cell spheroids; ; et al in Anticancer Research (1990), 10(5B), 1447 Detailed reference viewed: 7 (5 ULg)Synthesis and antimitotic effects of isoretulinal, a main alkaloid isolated from Strychnos variabilisTits, Monique ; ; Angenot, Luc in Journal de Pharmacie de Belgique (1990), 45(6), 393 Isoretulinal is a new alkaloid isolated from Strychnos variabilis rootbark. It can also be easily prepared by oxydation of isoretuline. This alkaloid shows an antimitotic effect at a dose of 10 micrograms ... [more ▼] Isoretulinal is a new alkaloid isolated from Strychnos variabilis rootbark. It can also be easily prepared by oxydation of isoretuline. This alkaloid shows an antimitotic effect at a dose of 10 micrograms/ml on different strains of cancer cells. Moreover isoretulinal possesses an analgesic activity. However this alkaloid is sixty-fold less toxic than strychnine (intravenous acute toxicity in mice). [less ▲] Detailed reference viewed: 13 (4 ULg)Cooperativity between fibroblasts and melanoma cells during invasion; Munaut, Carine ; De Pauw, Marie-Claire et alConference (1989) Detailed reference viewed: 2 (0 ULg)Control of B16 melanoma cells differentiation in culture by exogenous FeS04, CuS04 and Vitamin CDe Pauw, Marie-Claire ; ; in Cytotechnology (1988) Detailed reference viewed: 4 (1 ULg)
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