References of "Balligand, Marc"
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See detailSubject-specific finite element modelling of canine long bones up to fracture
Laurent, Cédric; Bohme, Béatrice; d'Otreppe de Bouvette, Vinciane et al

in Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization (2013), 16

Long bone fracture constitutes a common reason for medical consultation within veterinary orthopaedic services. Owing to the specificities of the veterinary field, post-operative complications after a ... [more ▼]

Long bone fracture constitutes a common reason for medical consultation within veterinary orthopaedic services. Owing to the specificities of the veterinary field, post-operative complications after a fracture osteosynthesis are usually more numerous than those in human medicine, and therefore, there is a need to better understand which orthopaedic device(s) should be preferred for a given fracture. The interest of subjectspecific finite element (FE) simulations in the understanding of long bone mechanics has been largely emphasised (Helgason et al. 2008; Schileo et al. 2008). However, available studies are often limited by the many assumptions made throughout the procedure of creating a validated subject-specific FE model of a long bone, including geometry acquisition and modelling, assignment of realistic material properties and accurate validation of FE results based on ex vivo experiments. Particularly, fracture prediction has often been limited to the fracture onset prediction based on arbitrary criteria. Based on these previous studies, the objective of the present contribution is to propose and compare different subject-specific FE models of long bones that could accurately predict long bone response and failure. [less ▲]

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See detailTheoretical discrepancy between cage size and efficient tibial tuberosity advancement in dogs treated for cranial cruciate ligament rupture
Etchepareborde, Sébastien ULg; Mills; Busoni, Valeria ULg et al

in Veterinary and Comparative Orthopaedics and Traumatology (2011), 24

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See detailFinite element simulation of canine humeral condylar fractures
D'Otreppe, Vinciane ULg; Böhme, Béatrice; Balligand, Marc ULg et al

Conference (2011, July 04)

Humeral condylar fractures are common in dogs. Different types of fractures (lateral, medial, bicondylar) may occur, depending on the age of the dog and the position of its elbow during the impact. The ... [more ▼]

Humeral condylar fractures are common in dogs. Different types of fractures (lateral, medial, bicondylar) may occur, depending on the age of the dog and the position of its elbow during the impact. The goal of this work is to understand the effects of bone posture and skeletal development on canine humeral fractures by means of the finite element method. Four distinct finite element simulations were performed, corresponding to an immature and a mature dog elbow, respectively in extension and flexion. To create the finite element models, subject-specific finite element meshes were extracted from the CT-data. Appropriate material properties were used for cortical bone, trabecular bone and cartilage. The modified Mohr-Coulomb failure criterion was implemented to take account for strength asymmetry. Lateral humeral fractures are obtained for both the young and adult dog elbow, in extension and flexion. This is in agreement with clinical observations, in which lateral condylar fractures are most common. [less ▲]

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See detailContribution of CT scan for lesions affecting the spine
Deudon, Pauline ULg; Peeters, Dominique ULg; Balligand, Marc ULg et al

Poster (2011, January 22)

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See detailPreliminary experience of a modified Maquet technique for repair of cranial cruciate ligament rupture in dogs
Etchepareborde, Sébastien; Brunel, Laurencie ULg; Bolen, Géraldine ULg et al

in Veterinary and Comparative Orthopaedics and Traumatology (2011)

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See detailRelationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO(2), and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint.
Verwilghen, Denis ULg; Enzerink, E.; Martens, A. et al

in Osteoarthritis and Cartilage (2011), 19(11), 1323-9

OBJECTIVE: To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these ... [more ▼]

OBJECTIVE: To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these levels relate to arthroscopic findings of inflammation and degeneration. MATERIALS AND METHODS: Venous blood and synovial fluid samples were collected from 63 horses presented for arthroscopic removal of osteochondral fragments in the tarsocrural joint. Prior to removal of the osteochondral fragment, an exploration of the joint was performed and an inflammatory and degenerative score was determined. The blood and synovial levels of Coll2-1, Coll2-1NO(2) and MPO were also measured. The effects of the arthroscopic evaluation (inflammatory and degenerative classes) on the blood and synovial markers were evaluated using a linear model (GLM procedure), and correlations between biochemical markers in the blood and synovial fluid and the arthroscopic evaluation (inflammatory and degenerative classes) were established (Pearson's correlations). RESULTS: Significantly higher levels of Coll2-1 were detected in synovial fluid of higher degenerative classes. There was a significant correlation between the degenerative score and the synovial levels of Coll2-1 (r=0.27). According to the logistic regression model, there was a significant effect of the degenerative class on synovial levels of Coll2-1. CONCLUSIONS: Coll2-1 correlates well with the degenerative state of tarsocrural joints as evaluated by arthroscopy. This marker can therefore be classified as a burden-of-disease marker in the assessment of joint disease in horses. [less ▲]

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See detailMechanical testing of a modified stabilisation method for tibial tuberosity advancement
Etchepareborde, Sébastien; Barthelemy, Nicolas; Mills, J. et al

in Veterinary and Comparative Orthopaedics and Traumatology (2010)

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See detailMandibular osteodistraction for correction of deep bite class II malocclusion in a horse
Verwilghen, Denis ULg; Van Galen, Gaby ULg; Vander Heyden, Laurent ULg et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (2008), 37(6), 571-579

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See detailTraumatic partial elbow luxation in a dog
Bongartz, A.; Carofiglio, F.; Piaia, T. et al

in Journal of Small Animal Practice (2008)

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See detailMechanical evaluation of a thermoplastic casting material.
Claeys, Stéphanie ULg; Meuron, M.; Boeraeve, P. et al

in Veterinary Record : Journal of the British Veterinary Association (2007), 161(7), 238-40

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See detailMG-63 Osteoblast culture on P culture on PLA– based copolymers for bone tissue engineering applications
Moniotte, Nicolas; Shim, Yong-Ho; Borget, Pascal et al

Poster (2007)

Physical injury or pathological changes such as removal of a tumor can result in large bone defects, preventing the recovery of its original function. Autogenous bone grafting, which is the most common ... [more ▼]

Physical injury or pathological changes such as removal of a tumor can result in large bone defects, preventing the recovery of its original function. Autogenous bone grafting, which is the most common technique for bone defect repairing, is associated with serious limitations, e.g. limited supply and donor site morbidity. Since a few years bone tissue engineering by degradable biomaterials has been shown as a very promising avenue for providing bone substitutes. Among these materials, bioresorbable synthetic polymers such as poly(ethylene oxide) (PEO), poly(vinyl alcohol) (PVA), poly(acrylic acid) (PAA) and poly(lactic acid) (PLA) are very appealing because their chemistry and properties are controllable and reproducible. Cellular activity and proliferation of osteosarcoma cell lines (MG-63) on films were determined by the tetrazolium salt MTT assay and by phase contrast/fluorescence microscope observations. The cytotoxicity of the materials was found to be low or negligible. Cells viability variations were observed on the surface of the films. Long-term cell culture and degradability of PLA-PEOpolymer film was investigated by optical microscopy (Giemsa staining) and environmental scanning electron microscopy (ESEM). Hydrolysis of the PLLA ester linkages led to slow film degradation. After 113 days, optical microscope observations revealed the presence of large cracks on the surface, and even breaks of small polymer fragments, while MG-63 proliferation was still very important, showing a tissue-like aspect, with extracellular matrix (ECM) deposition. These results show that PLA-PEO copolymers are very interesting bioresorbable materials for long-term bone tissue engineering applications. [less ▲]

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See detailNon-destructive characterization of deer (Cervus Elaphus) antlers by X-ray microtomography coupled with image analysis
Léonard, A.; Guiot, L. P.; Pirard, J. P. et al

in Journal of Microscopy (2007), 225(3), 258-263

X-ray microtomography coupled with image analysis was tested as a non-destructive alternative method for the textural characterization of the trabecular part of deer antlers (Cervus Elaphus). As gas ... [more ▼]

X-ray microtomography coupled with image analysis was tested as a non-destructive alternative method for the textural characterization of the trabecular part of deer antlers (Cervus Elaphus). As gas adsorption and mercury intrusion cannot be applied on this soft and spongy material, its pore texture was, up to now, determined from histological sections that give only two-dimensional information. In this work, X-ray microtomography is used to scan entire or half pieces of antlers and three-dimensional image analysis is performed in order to assess the differences between samples collected at various antler locations. Results clearly show a porosity profile along the sample diameter. The pore size distribution is showed to be dependent on the sample original site. [less ▲]

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See detailHealth status of dogs referred to the consultation of clinical nutrition at the faculty of Liège
Lhoest, Estelle; Claeys, Stéphanie ULg; Saulnier-Troff, François et al

in Coenen, M.; Vervuert, I. (Eds.) Proceedings of the 11th ESVCN Congress (2007)

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See detailEvaluation of the urodynamic and hemodynamic effects of orally administered phenylpropanolamine and ephedrine in female dogs.
Carofiglio, Francesca; Hamaide, Annick ULg; Farnir, Frédéric ULg et al

in American Journal of Veterinary Research (2006), 67(4), 723-730

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See detailUrodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs
Hamaide, Annick ULg; Grand, Jean-Guillaume; Farnir, Frédéric ULg et al

in American Journal of Veterinary Research (2006), 67(5), 901-908

OBJECTIVE: To compare the urodynamic and morphologic effects of the administration of estriol alone and in combination with phenylpropanolamine on the lower portion of the urogenital tract in female dogs ... [more ▼]

OBJECTIVE: To compare the urodynamic and morphologic effects of the administration of estriol alone and in combination with phenylpropanolamine on the lower portion of the urogenital tract in female dogs. ANIMALS: 3 sexually intact and 3 spayed female Beagles without urinary incontinence. PROCEDURE: Dogs received estriol (2 mg, PO) once daily for 7 days followed by estriol (2 mg, PO) and phenylpropanolamine (1.5 mg/kg, PO) once daily for 7 days. Urethral pressure profilometry, diuresis cystometry, and vaginourethrography were performed before treatment (day 0) and at days 7 and 14. The maximum urethral pressure (MUP) and closure pressure (MUCP), urethral functional and anatomic profile lengths, integrated pressure (IP), plateau, distance before MUP, maximum meatus pressure, threshold pressure, threshold volume, compliance, urethral length, and vaginal length and width were measured. RESULTS: Before treatment, no urodynamic differences were observed between the 2 groups; however, vaginal length and width were significantly shorter in spayed dogs. Compared with day 0 values, estriol treatment significantly increased MUP, MUCP, and IP values at day 7, but at day 14, this effect decreased despite phenylpropanolamine administration. No morphologic changes from baseline were detected after either treatment in any dog. CONCLUSIONS AND CLINICAL RELEVANCE: Data suggest that estriol mainly acts on the urethral sphincter mechanism by increasing urethral resistance in sexually intact and spayed female dogs without urinary incontinence. Administration of estriol and phenylpropanolamine did not increase the urethral resistance more than estriol alone. The urodynamic effects of estriol in female dogs with urinary incontinence remain to be elucidated [less ▲]

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See detailIs There a Difference Between Energy Balance of Cats Hospitalised for Surgical or for Medical Reasons?
Lhoest, Estelle; Claeys, Stéphanie ULg; Gabriel, Alexendra et al

in Journal of Veterinary Internal Medicine (2005, November), 19(6), 939

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See detailPharmaceutical and nutraceutical management of canine osteoarthritis: Present and future perspectives
Henrotin, Yves ULg; Sanchez, Christelle ULg; Balligand, Marc ULg

in Veterinary Journal (2005), 170(1), 113-123

Osteoarthritis (OA) is one of the most common chronic musculoskeletal diseases and causes of lameness in the dogs. The osteoarthritic disease process involves the entire synovial joint, encompassing the ... [more ▼]

Osteoarthritis (OA) is one of the most common chronic musculoskeletal diseases and causes of lameness in the dogs. The osteoarthritic disease process involves the entire synovial joint, encompassing the synovium, cartilage and underlying bone. Joint failure results from an abnormal mechanical strain causing damage to normal tissue or failure of pathologically impaired articular cartilage and bone under the influence of normal physiological strain or a combination of both. In both cases, the end point is cartilage loss and joint impairment. Osteoarthritic chondrocytes show an altered phenotype characterised by an excess production of catabolic factors, including metalloproteinases and reactive oxygen species. These factors constitute potential therapeutic targets and some new drugs and nutraceuticals have been proposed to promote the return to homeostasis. Until now, the therapeutic management of OA in dogs has been dominated by nonsteroidal anti-inflammatory drugs, but some new compounds, including diacerhein, with potential structure-modifying effects, are already used to treat OA in humans and could be helpful to manage OA in the dog. In addition, novel nutraceuticals, such as avocado/soybean unsaponifiable substances, have shown symptomatic effects in knee OA in humans, and could offer an alternative to prevent OA progression. This paper provides an overview of recent discoveries in the pathophysiology and in the therapeutic management of osteoarthritis in dogs. (c) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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