References of "Ballerini, P"
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See detailThe EChO science case
Tinetti, Giovanna; Drossart, Pierre; Eccleston, Paul et al

in ArXiv e-prints (2015), 1502

The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general ... [more ▼]

The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general population of planets in our Milky Way. The key science questions that urgently need addressing are therefore: What are exoplanets made of? Why are planets as they are? What causes the exceptional diversity observed as compared to the Solar System? EChO (Exoplanet Characterisation Observatory) has been designed as a dedicated survey mission for transit and eclipse spectroscopy capable of observing a large and diverse planet sample within its four-year mission lifetime. EChO can target the atmospheres of super-Earths, Neptune-like, and Jupiter-like planets, in the very hot to temperate zones (planet temperatures of 300K-3000K) of F to M-type host stars. Over the next ten years, several new ground- and space-based transit surveys will come on-line (e.g. NGTS, CHEOPS, TESS, PLATO), which will specifically focus on finding bright, nearby systems. The current rapid rate of discovery would allow the target list to be further optimised in the years prior to EChO's launch and enable the atmospheric characterisation of hundreds of planets. Placing the satellite at L2 provides a cold and stable thermal environment, as well as a large field of regard to allow efficient time-critical observation of targets randomly distributed over the sky. A 1m class telescope is sufficiently large to achieve the necessary spectro-photometric precision. The spectral coverage (0.5-11 micron, goal 16 micron) and SNR to be achieved by EChO, thanks to its high stability and dedicated design, would enable a very accurate measurement of the atmospheric composition and structure of hundreds of exoplanets. [less ▲]

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See detailt(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Francais de Cytogenetique Hematologique (GFCH)
Berger, R.; Dastugue, N.; Busson, M. et al

in Leukemia (2003), 17(9), 1851-1857

To accurately estimate the incidence of HOX11L2 expression, and determine the associated cytogenetic features, in T-cell acute lymphoblastic leukemia (T-ALL), the Groupe Francais de Cytogenetique ... [more ▼]

To accurately estimate the incidence of HOX11L2 expression, and determine the associated cytogenetic features, in T-cell acute lymphoblastic leukemia (T-ALL), the Groupe Francais de Cytogenetique Hematologique (GFCH) carried out a retrospective study of both childhood and adult patients. In total, 364 patients were included ( 211 children less than or equal to15 years and 153 adults), and 67 ( 18.5%) [ 47 children ( 22.4%) and 20 adults (13.1%)] were shown to either harbor the t(5; 14) q35; q32) translocation or express the HOX11L2 gene or both. Most of the common hematological parameters did not show significant differences within positive and negative populations, whereas the incidence of CD1a+/CD10+ and cytoplasmic CD3+ patients was significantly higher in positive than in negative children. Out of the 63 positive patients investigated by conventional cytogenetics, 32 exhibited normal karyotype, whereas the others 31 showed clonal chromosome abnormalities, which did not include classical T-ALL specific translocations. Involvement of the RANBP17/HOX11L2 locus was ascertained by fluorescence in situ hybridization in six variant or alternative (three-way translocation or cytogenetic partner other than 14q32) translocations out of the 223 patients. Our results also show that HOX11L2 expression essentially occurs as a result of a 5q35 rearrangement, but is not associated with another identified T-ALL specific recurrent genetic abnormality, such as SIL-TAL fusion or HOX11 expression. [less ▲]

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