References of "BECKERS, Albert"
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See detailVIEUX PHENOTYPE ET NOUVEAUX GENOTYPES Actualités dans le domaine des adénomes hypophysaires
GERARD, Caroline ULg; JEDIDI, Haroun ULg; PETROSSIANS, Patrick ULg et al

in Revue Médicale de Liège (in press)

Gigantism and acromegaly, usually caused by a pituitary adenoma linked innapropriate secretion of growth hormon (GH) are generally considered as very rare diseases, even if, regarding some authors, their ... [more ▼]

Gigantism and acromegaly, usually caused by a pituitary adenoma linked innapropriate secretion of growth hormon (GH) are generally considered as very rare diseases, even if, regarding some authors, their cumulative prevalence is about 1/5000. Starting from the historical case of a giant from Liège we will describe the different types of GH pituitary adenomas and their physiopathology. We will overall discuss rare forms of inherited GH secreting pituitary adenomas like the FIPA (familial inherited isolated pituitary adenomas) and the X-LAG (X linked acrogigantism), both described in Liège, respectively in 2000 and 2014. [less ▲]

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See detailLe phénotype d’Akhenaton ; revue critique entre canons artistiques et expression pathologique.
JEDIDI, Zayd ULg; JEDIDI, Haroun ULg; LAVEAUX, Elisabeth et al

in Revue Médicale de Liège (in press)

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 ... [more ▼]

Of all the royal families of ancient or modern fame, few are as iconic as the eighteenth dynasty of pharaohs of the New Kingdom of Egypt, whose opulence and deeds we are still familiar to nearly 3,500 years after their time. Tenth pharaoh of this dynasty and father of Tutankhamun, Akhenaten (Amenhotep/Amenhotep IV) still fascinates Egyptologists and history lovers through the many questions surrounding his atypical rule. One of the most striking aspects of the so-called Amarna period concerns the representations of the pharaoh himself, very confusing compared to the traditional iconography of the New Kingdom. These intriguing portraits of Pharaoh raised a whole lot of medical assumptions, more or less substantiated. We review here the main theories developed throughout history. [less ▲]

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See detailLa pollution lumineuse, entre écologie et santé
JEDIDI, Haroun ULg; DEPIERREUX, Frédérique ULg; JEDIDI, Zayd ULg et al

in Revue Médicale de Liège (in press)

Light pollution is defined as the abnormal and disturbing presence of light and its adverse consequences on flora, faunae, ecosystems and its suspected or proven effects on human health. Light pollution ... [more ▼]

Light pollution is defined as the abnormal and disturbing presence of light and its adverse consequences on flora, faunae, ecosystems and its suspected or proven effects on human health. Light pollution is a quite recent and increasing phenomenon within our society and it leads to a major environmental damage, obviously near wildlife, but also on human health (cancers, obesity, fatigue, depression...). The solutions to this problem are however simple, efficient and de facto inexpensive and involving a substantial energy saving. [less ▲]

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See detailCongenital gigantism in a girl with anterior pituitary hyperplasia : a new genes for a new disease
Lysy, PA; Daly, Adrian ULg; Brunelle, C et al

in Abstract book - 43ème Congrès Annuel de la Société Belge de Pédiatrie (2015, March)

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See detailX-Linked acro-gigantism (X-LAG) syndrome : a new form of infant-onset pituitary gigantism
Stratakis, CA; Trivellin, G; Rostomyan, Liliya ULg et al

in Abstract book - 14th International Pituitary Congress (2015, March)

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See detailAIP mutations : who should we screen ?
Beckers, Albert ULg

in Abstract book - 14th International Pituitary Congress (2015, March)

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See detailAn orphan GPCR may be mutated in patients with Cushing Disease
Correa, RR; Trivellin, G; Li, Y et al

in Abstract book - ENDO 2015 (2015, March)

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See detailDisease characteristics of patients with X-linked acrogigantism (X-LAG) syndrome
Daly, Adrian ULg; Lodish, MB; Trivellin, G et al

in Abstract book - ENDO 2015 (2015, March)

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See detailX-Linked acro-gigantism (X-LAG) due to microduplications of chromosome Xq26 : A new disorder and implications for acromegaly
Trivellin, G; Daly, AF; Faucz, FR et al

in Abstract book - ENDO 2015 (2015, March)

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See detailCharacteriation of GPR101 expression across different species
Trivellin, G; Bjelobaba, I; Daly, Adrian ULg et al

in Abstract book - ENDO 2015 (2015, March)

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See detailA novel mutation of the luteinizing hormone/choionic gonadotrophin receptor gene leading to Leydig cell hypoplasia type I
Potorac, Iulia ULg; Rivero-Müller, A; Pintiaux, Axelle ULg et al

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

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See detailIntérêt du signal T2 des adénomes hypophysaires à GH traités par analogues de la somatostatine - premiers résultats de l'étude IRMA#2
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

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See detailNouvelle classification des acro-gigantismes
Rostomyan, Liliya ULg; Beckers, Albert ULg

in Symposium "Perspectives in Endocrinology" - 5ème édition (2015, February 07)

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See detailGigantism and acromegaly due to Xq26 microduplications and GPR101 mutation
Beckers, Albert ULg

Scientific conference (2015, January 27)

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See detailTHERAPY OF ENDOCRINE DISEASE: Outcomes in patients with Cushing's disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recurrence.
Petersenn, Stephan; Beckers, Albert ULg; Ferone, Diego et al

in European journal of endocrinology / European Federation of Endocrine Societies (2015)

Objective: A number of factors can influence the reported outcomes of transsphenoidal surgery (TSS) for Cushing's disease - including different remission and recurrence criteria, for which there is no ... [more ▼]

Objective: A number of factors can influence the reported outcomes of transsphenoidal surgery (TSS) for Cushing's disease - including different remission and recurrence criteria, for which there is no consensus. Therefore, a comparative analysis of the best treatment options and patient management strategies is difficult. In this review, we investigated the clinical outcomes of initial TSS in patients with Cushing's disease based on definitions of and assessments for remission and recurrence. Methods: We systematically searched PubMed and identified 44 studies with clear definitions of remission and recurrence. When data were available, additional analyses by time of remission, tumour size, duration of follow-up, surgical experience, year of study publication, and adverse events related to surgery were performed. Results: Of the 44 articles selected, only one reported endoscopic TSS. Data from a total of 6,400 patients who received microscopic TSS were extracted and analysed. A variety of definitions of remission and recurrence of Cushing's disease after initial microscopic TSS was used, giving broad ranges of remission (42.0-96.6%; median, 77.9%) and recurrence (3.1-47.4%; median, 11.5%). Better remission and recurrence outcomes were achieved for micro- versus macroadenomas; however, no correlations were found with other parameters, other than improved safety with longer surgical experience. Conclusions: The variety of methodologies used in clinical evaluation of TSS for Cushing's disease strongly support the call for standardization and optimization of studies to inform clinical practice and maximize patient outcomes. Clinically significant rates of failure of initial TSS highlight the need for effective second-line treatments. [less ▲]

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See detailPituitary MRI characteristics in 297 acromegaly patients based on T2-weighted sequences.
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Endocrine-related cancer (2015)

Context: Responses of GH-secreting adenomas to multimodal management of acromegaly varies widely between patients. Understanding the behavioral patterns of GH-secreting adenomas by identifying predictive ... [more ▼]

Context: Responses of GH-secreting adenomas to multimodal management of acromegaly varies widely between patients. Understanding the behavioral patterns of GH-secreting adenomas by identifying predictive factors of their evolution is a research priority. Objective: To clarify the relationship between adenoma T2-weighted signal on diagnostic MRI in acromegaly and clinical and biological features at diagnosis. Design: International, multicenter, retrospective analysis. Setting: 10 endocrine tertiary referral centers. Patients: 297 acromegalic recently diagnosed patients with available diagnostic MRI evaluations were included in the study. Main outcome measure: Clinical, biochemical characteristics and MRI signal findings. Results: T2-hypointense adenomas represented 52.9% of the series, were smaller than their T2-hyper- and isointense counterparts (p<0.0001), were associated with higher IGF1 levels (p=0.0001), invaded the cavernous sinus less frequently (p=0.0002) and rarely caused optic chiasm compression (p<0.0001). Acromegalic men tended to be younger at diagnosis than women (p=0.067) and presented higher IGF1 values (p=0.01). Although in total, adenomas had a predominantly inferior extension in 45.8% of cases, in men this was more frequent (p<0.0001), whereas in women optic chiasm compression of macroadenomas occurred more often (p=0.0067). Most adenomas (45.1%) measured between 11-20mm in maximal diameter and bigger adenomas were diagnosed at younger ages (p=0.0001). Conclusions: T2-weighted signal differentiates GH-secreting adenomas into subgroups with particular behaviors. This raises the question of whether T2-weighted signal could represent a factor in the classification of acromegalic patients in future studies. [less ▲]

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See detailFamilial Isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene
Daly, Adrian ULg; Beckers, Albert ULg

in Endocrinology & Metabolism Clinics of North America (2015), 44

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