   Tomographie sténopéïque au 99mTc-MIBI dans l’hyperparathyroïdie primaire; ; et al in Médecine Nucléaire (2007), 31(10), 553-561 Purpose: This prospective study was conducted to determine the interest of 99mTc-MIBI pinhole SPECT (pSPECT) compared with conventional SPECT (cSPECT), planar scintigraphy and ultrasonography, for the ... [more ▼] Purpose: This prospective study was conducted to determine the interest of 99mTc-MIBI pinhole SPECT (pSPECT) compared with conventional SPECT (cSPECT), planar scintigraphy and ultrasonography, for the preoperative localization of parathyroid lesions in primary hyperparathyroidism. Methods: Fifty one patients cured after surgery were studied. pSPECT was reconstructed with a dedicated OSEM algorithm. A diagnostic confidence score (CS) was assigned to each procedure considering intensity and extra-thyroidal location of suspected lesions and was defined as follows: 0 = negative, 1 = doubtful, 2 = moderately positive, 3 = positive. Results: Surgery revealed 55 lesions. Sensitivity of ultrasonography, planar imaging, cSPECT and pSPECT were respectively 51%, 76%, 82% and 87%. Five glands were only detected by pSPECT. Combination of ultrasonography, planar and pSPECT showed the highest sensitivity (94.5%). The mean CS of the 55 pathologic glands was significantly higher with pSPECT compared with planar imaging and cSPECT (p<0.0001). Compared with planar imaging and cSPECT, pSPECT increased CS for 42% and 53% of parathyroid lesions respectively, and contributed to markedly reduce the number of uncertain results. Nevertheless, planar imaging and ultrasonography were useful to analyze thyroid morphology and to detect some ectopic glands. Conclusion: The use of pSPECT increases sensitivity and CS of scintigraphy. Combination of ultrasonography, planar and pSPECT appears to be complementary and the optimal preoperative imaging procedure in primary hyperparathyroidism. [less ▲] Detailed reference viewed: 126 (6 ULg)Improvement of parathyroid lesion visualization in primary hyperparathyroidism with 99mTc-MIBI pinhole SPECT: comparison with conventional SPECT and planar scintigraphy.; ; et al in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(S2), 100 Detailed reference viewed: 12 (2 ULg)Amélioration de la visualisation des lésions parathyroïdiennes dans l’hyperparathyroïdie primaire par la tomographie pinhole au MIBI-Tc99m.; ; et al in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2006), 30(09), 518 Detailed reference viewed: 26 (2 ULg) |
||
