References of "Antoine, M.-H"
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See detailKATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1 -dioxides
Lebrun, P.; Becker, B.; Morel, N. et al

in Biochemical Pharmacology (2008), 75

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See detailEffect on KATP channel activation properties and tissue selctivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine
Boverie, S.; Antoine, M.-H.; Somers, F. et al

in Journal of Medicinal Chemistry (2005), 48

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See detailNew insights into the development pf ATP-sensitive potassium channel openers
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Antoine, M.-H. et al

in Expert Opinion on Therapeutic Patents (2005), 15

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See detailRecent developments in the chemistry of potassium channel activators : the cromakalim analogues
Sebille, S.; De Tullio, Pascal ULg; Boverie, S. et al

in Current Medicinal Chemistry (2004), 11

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See detailEffects on rat pancreatic B-cells and rat aorta rings of 4,6-disubstituted 2,2-dimethylchromans structurally related to the potassium channel opener cromakalim
Sebille, S.; Becker, B.; Antoine, M.-H. et al

in Fundamental & Clinical Pharmacology (2002), 16

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See detailBPDZ 154 Activates Adenosine 5’-Triphosphate-Sensitive Potassium Channels; In Vitro Studies Using Rodent Insulin-Secreting Cells and Islets Isolated from Patients with Hyperinsulinism
Cosgrove, K. E.; Antoine, M.-H.; Lee, A. T. et al

in Journal of Clinical Endocrinology and Metabolism (2002), 87

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See detail2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?
Ouedraogo, R.; Becker, B.; Boverie, S. et al

in Biological Chemistry (2002), 383

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See detailSynthesis and characterisation of a quinolinonic compound activating ATP-sensitive K+ channels in endocrine and smooth muscle tissues
Becker, B.; Antoine, M.-H.; Nguyen, Q.-A. et al

in British Journal of Pharmacology (2001), 134

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See detailOriginal 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP channel activity
Somers, F.; Ouedraogo, R.; Antoine, M.-H. et al

in Journal of Medicinal Chemistry (2001), 44

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See detailA potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release
Lebrun, P.; Arkhammar, P.; Antoine, M.-H. et al

in Diabetologia (2000), 43

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See detailEffect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide
Boverie, S.; Antoine, M.-H.; Becker, B. et al

in Pflügers Archiv : European Journal of Physiology (2000), 439

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See detail7-Substituted alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as new analogues of diazoxide: effects on the insulin releasing process in vitro
Boverie, S.; Somers, F.; Ouedraogo, R. et al

in Fundamental & Clinical Pharmacology (2000), 14

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See detailEffects of 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides on smooth muscle contractile activity
Ouedraogo, R.; Fontaine, J.; Antoine, M.-H. et al

in Pharmacy and Pharmacology Communications (2000), 6

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See detailSynthesis and biological effects of new 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides on insulin-secreting cells
Somers, F.; De Tullio, Pascal ULg; Boverie, S. et al

in Pharmacy and Pharmacology Communications (2000), 6

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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