References of "Ansseau, Marc"
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See detailEfficacy of heroin-assisted treatment in Belgium: a randomised controlled trial
Demaret, Isabelle ULg; Quertemont, Etienne ULg; Litran, Géraldine et al

in European Addiction Research (in press)

Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT ... [more ▼]

Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT to existing methadone maintenance treatment. Methods: In this randomised controlled trial, HAT was limited to 12 months. Participants were assessed every 3 months. They were responders if they showed improvement on the level of street heroin use, health or criminal involvement. Results: 74 participants were randomised in the trial. The experimental group (n=36) counted 30% of responders more than the control group (n=38) at each assessment point (p<0.05), except at 12 months where the difference (11%) was no longer significant (p=0.35). Still, after 12 months, participants in the experimental group reported significantly greater improvements (p<0.05) than the control group on the level of street heroin use and on the level of physical and mental health. Both groups reported significantly less criminal facts after 12 months (p<0.001), but with no significant difference between the groups. Conclusions: This trial confirms the short-term efficacy of HAT for severe heroin addicts, who already failed methadone treatment. [less ▲]

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See detailDépression et diabète de type 2. Analyse étiopathogènique d'une comorbidité fréquente
LUPPENS, David ULg; PIETTE, Catherine ULg; RADERMECKER, R.P et al

in Revue Médicale de Liège (2014), 69(11), 611-617

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See detailAdditional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: An open trial.
Scantamburlo, Gabrielle ULg; Hansenne, Michel ULg; Geenen, Vincent ULg et al

in European psychiatry : the journal of the Association of European Psychiatrists (2014)

The aim of this open trial was to assess the antidepressant/anxiolytic effects of oxytocin used as an adjunct to antidepressant in treatment-resistant depression. Fourteen patients, who have not responded ... [more ▼]

The aim of this open trial was to assess the antidepressant/anxiolytic effects of oxytocin used as an adjunct to antidepressant in treatment-resistant depression. Fourteen patients, who have not responded to 40mg of escitalopram, received intranasal synthetic oxytocin during 4 weeks, in association with antidepressant. This is the first open trial study suggesting OT in association with escitalopram significantly reduced scores on Hamilton Depression Rating Scale. [less ▲]

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See detailHeroin-assisted treatment showed better efficacy than methadone
ANSSEAU, Marc ULg; Demaret, Isabelle ULg

Poster (2014, May 04)

Background: A fraction of patients receiving methadone treatment pursues their use of street heroin. In Switzerland, a new treatment with prescribed diacetylmorphine (pharmaceutical heroin) was developed ... [more ▼]

Background: A fraction of patients receiving methadone treatment pursues their use of street heroin. In Switzerland, a new treatment with prescribed diacetylmorphine (pharmaceutical heroin) was developed to help these heroin addicts resistant to methadone treatment to decrease their street heroin use. In this heroin-assisted treatment (HAT), diacetylmorphine is prescribed to severe heroin user and diacetylmorphine is administered by patients under the supervision of nurses in a specific centre. Six randomised controlled trials compared HAT to methadone treatment: in Switzerland, The Netherlands, Spain, Germany, Canada and United- Kingdom. HAT showed better efficacy than methadone. Patients used less street heroin, their health improved and their criminal behaviour decreased. A new trial assessed in Belgium the feasibility and efficacy of this treatment compared to methadone treatment. Methods: The TADAM (Treatment Assisted by Diacetylmorphine) was an open label randomised controlled trial developed on the Swiss model of HAT developed in 1994. Main inclusion criteria were 5 years of heroin addiction, (almost) daily use of street heroin and a previous attempt of methadone treatment. As in the Dutch experiment, patients could choose to inhale or to inject diacetylmorphine in the new HAT centre. HAT was stopped after 12 months and the best available treatment was offered to the patient. The research team assessed subjects every three months with standardised questionnaires (EuropASI, MAP-HSS, SCL-90-R) and questions on involvement in a criminal milieu. We completed our reported data with toxicological analysis and criminal proceedings. Results: 74 subjects were randomised in the trial: 36 in the experimental group and 38 in the control group. According to the primary efficacy criterion, the experimental group counted at least 30% more responders than the control group after 3 months (p<0.05), 6 months (p<0.05) and 9 months (p<0.01). At the 12 month assessment, the number of responders was still higher in the experimental group but the difference (11%) was no more significant (p=0.35). At the 12 month assessment, the condition of patients in the experimental group worsened compared to the 9 month assessment. This effect was not seen in the control group were patients could continue their methadone treatment after the 12 months. Conclusion: As in other countries, HAT is an effective treatment for severe heroin addicts resistant to methadone treatment. However, a predetermined duration of 12 month counteracts the efficacy of this treatment. [less ▲]

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See detailProjet TADAM: Conclusions scientifiques et recommandations
Lemaître, André ULg; ANSSEAU, Marc ULg; Demaret, Isabelle ULg

in Lettre du RESPADD (2014), (18), 2-4

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See detailWhy do heroin users refuse to participate in a heroin-assisted treatment trial?
Demaret, Isabelle ULg; Litran, Géraldine; Magoga, Cécile et al

in Heroin Addiction and Related Clinical Problems (2014), Epub ahead of print, March 22, 2014

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts who are resistant to other treatments. However, in a new HAT trial in Belgium, fewer subjects than expected were ... [more ▼]

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts who are resistant to other treatments. However, in a new HAT trial in Belgium, fewer subjects than expected were included. Aim: Our research team explored the reasons given by heroin users in explaining why they did not want to participate. Methods: In 2011, during the trial recruitment, we interviewed heroin users (n=52) who never took the opportunity to meet the research team during the recruitment process preceding the trial. Results: Of those 52 heroin users, 25 were afraid of the limited length of the HAT and 11 feared becoming more dependent as a result of HAT. Conclusion: A trial that was planned to last for a limited length of time may have demotivated heroin users who could otherwise have benefited from this new programme. [less ▲]

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See detailFolinic acid treatment for schizophrenia associated with folate receptor autoantibodies.
Ramaekers, V. T.; Thony, B.; Sequeira, J. M. et al

in Molecular genetics and metabolism (2014), 113(4), 307-14

BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia ... [more ▼]

BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. Acoustic hallucinations disappeared following folinic acid treatment. Folate transport to the CNS prevents homocysteine accumulation and delivers one-carbon units for methyl-transfer reactions and synthesis of purines. The guanosine derivative tetrahydrobiopterin acts as common co-factor for the enzymes producing dopamine, serotonin and nitric oxide. METHODS: Our study selected patients with schizophrenia unresponsive to conventional treatment. Serum from these patients with normal plasma homocysteine, folate and vitamin B12 was tested for FR autoantibodies of the blocking type on serial samples each week. Spinal fluid was analyzed for MTHF and the metabolites of pterins, dopamine and serotonin. The clinical response to folinic acid treatment was evaluated. RESULTS: Fifteen of 18 patients (83.3%) had positive serum FR auto-antibodies compared to only 1 in 30 controls (3.3%) (chi(2)=21.6; p<0.0001). FRalpha antibody titers in patients fluctuated over time varying between negative and high titers, modulating folate flux to the CNS, which explained low CSF folate values in 6 and normal values in 7 patients. The mean+/-SD for CSF MTHF was diminished compared to previously established controls (t-test: 3.90; p=0.0002). A positive linear correlation existed between CSF MTHF and biopterin levels. CSF dopamine and serotonin metabolites were low or in the lower normal range. Administration of folinic acid (0.3-1mg/kg/day) to 7 participating patients during at least six months resulted in clinical improvement. CONCLUSION: Assessment of FR auto-antibodies in serum is recommended for schizophrenic patients. Clinical negative or positive symptoms are speculated to be influenced by the level and evolution of FRalpha antibody titers which determine folate flux to the brain with up- or down-regulation of brain folate intermediates linked to metabolic processes affecting homocysteine levels, synthesis of tetrahydrobiopterin and neurotransmitters. Folinic acid intervention appears to stabilize the disease process. [less ▲]

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See detailHeroin-assisted Tx superior to methadone for heroin addiction
Ansseau, Marc ULg

in Medscape medical news (2014)

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See detailProjet TADAM: RAPPORT FINAL 2007-2013
Demaret, Isabelle ULg; Litran, Géraldine; Magoga, Cécile et al

Report (2013)

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in ... [more ▼]

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in order to assess its feasibility and efficacy in Belgium. Methods: TADAM (Treatment Assisted by Diacetylmorphine) was an open label randomised controlled trial. The experimental treatment was based upon the Swiss model of HAT developed in 1994. The primary efficacy criterion was determined by an improvement in street heroin use or in (physical or mental) health or a decrease in criminal involvement. Participants were assessed every 3 months. Self-reported data were complemented with toxicological analyses and criminal proceedings. Findings: 74 participants were randomised in the trial: 36 in the experimental group and 38 in the control group. The experimental group counted 30% of responders more than the control group at 3 months (p<0.05), 6 months (p<0.05), and 9 months (p<0.01). At 12 months, the number of responders was still higher in the experimental group (11%) but the difference was no longer significant (p=0.35). Street heroin use increased in the experimental group at the 12-month assessment just before the end of HAT. Conclusion: HAT is feasible and effective. However, HAT should not have a predetermined duration for heroin users for which heroin addiction became a chronic relapsing disease. Other data: In addition to the outcomes of the randomised controlled trial, the report contains other exploratory data and analysis: satisfaction of in treatment, criminological data, opinion of heroin users not included in the trial, opinion of caregivers and field workers (in the HAT centre, in the partner centres, and in other centres in the addiction field), impact of the HAT centre on its neighbourhood and a socio-economic evaluation. Funding: The TADAM trial was funded at 80% by the Federal Minister of Social Affairs and Public Health. It was also funded the City and the University of Liège. [less ▲]

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See detailL'héroïne
Demaret, Isabelle ULg; Lemaître, André ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (2013), 68(5-6), 287

Summary : Heroin (or diacetylmorphine), a depressant of the nervous central system, is a semi-synthetic opiate. Its main adverse effect, respiratory depression, can lead to death, especially after an ... [more ▼]

Summary : Heroin (or diacetylmorphine), a depressant of the nervous central system, is a semi-synthetic opiate. Its main adverse effect, respiratory depression, can lead to death, especially after an intravenous injection. By loss of tolerance, an overdose can be lethal following heroin use after a period of abstinence (voluntary or not). Mortality rate among heroin users is between 1 and 3%. Addiction, following a regular and continuous use, occurs in less than a quarter of persons who ever tried heroine. Heroin addicts often present with different problems (for instance, a criminal behaviour), without any obvious link with addiction. For a fraction of the addicts, addiction becomes a chronic relapsing disease, requiring a long term maintenance substitution therapy. However, relapses and sometimes continuous heroin use are frequent. For treatment resistant and severe heroin addicts, heroinassisted treatment can be a solution. Despite the numerous available therapies, heroin is considered to be the drug with the most negative effects on the user. [less ▲]

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See detailAssortative mating and personality in human couples : A study using Cloninger's Temperament and Character Inventory
LE BON, O; Hansenne, Michel ULg; AMARU, D et al

in Psychology (2013), 4(1), 11-18

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See detailComment je traite ...la prise en charge de l'agitation en urgence.
BAKAY, Sara ULg; IWEINS, Ariane ULg; Scantamburlo, Gabrielle ULg et al

in Revue Médicale de Liège (2013), 68(11), 553-6

Agitation in psychiatry is defined as "a request to which an answer cannot be deferred". If some types of controllable agitation can be solved by human means or psychotropic drugs, others may require the ... [more ▼]

Agitation in psychiatry is defined as "a request to which an answer cannot be deferred". If some types of controllable agitation can be solved by human means or psychotropic drugs, others may require the intervention of intensivists who will contribute to the onset of crisis resolution. In addition, an organic aetiology must be carefully excluded a before considering a psychiatric origin of agitation, especially in patients with no psychiatric history and in the elderly. Indeed, acute agitation can hide serious somatic traps and be life threatening. [less ▲]

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See detailANALYSIS AND OPTIMIZATION OF SUBSTITUTION. TREATMENT IN BELGIUM (SUBANOP)
VANDER LAENEN, FREYA; VANDERPLASSCHEN, WOUTER; SMET, VALERIE et al

Book published by ACADEMIA PRESS (2013)

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See detailSevrage rapide aux opiaces sous anesthesie (RODA).
DUBOIS, Nathalie ULg; Hallet, C.; Luppens, D. et al

in Revue medicale de Liege (2013), 68(5-6), 298-302

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure ... [more ▼]

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and methadone during anesthesia and patient stay at the hospital in order to assess the amount of active substances at each protocol step. Plasma concentrations of antagonists were also quantified and compared to the recommended target values. Blood samples were drawn in 10 patients undergoing RODA at different times of the procedure (during anesthesia, in post-anesthesia care unit and in psychiatry unit). The plasma concentrations of heroin metabolites, methadone and antagonists were measured using a previously described method. Heroin active metabolites were no longer detected in the patient blood when helshe left the hospital; by contrast, methadone was still present at significant concentrations 3 days after the beginning of the detoxification procedure. Naltrexone analysis allowed us to adjust doses to insure opiate receptor blockade during acute withdrawal, which is a critical period. [less ▲]

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See detailTraitement du trouble bipolaire II
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg

in Aubry, Jean-Marie; FERRERO, F; SCHAAD, N (Eds.) Psychopharmacologie des Troubles Bipolaires, Médecine et Hygiène (2013)

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See detailLa dependance affective.
SCANTAMBURLO, Gabrielle ULg; PITCHOT, William ULg; Ansseau, Marc ULg

in Revue medicale de Liege (2013), 68(5-6), 340-7

Affective dependency is characterized by emotional distress (insecure attachment) and dependency to another person with a low self-esteem and reassurance need. The paper proposes a reflection on the ... [more ▼]

Affective dependency is characterized by emotional distress (insecure attachment) and dependency to another person with a low self-esteem and reassurance need. The paper proposes a reflection on the definition of emotional dependency and the confusion caused by various denominations. Overprotective and authoritarian parenting, cultural and socio-environmental factors may contribute to the development of dependent personality. Psychological epigenetic factors, such as early socio-emotional trauma could <imprint>> on neuronal circuits in prefronto-limbic regions that are essential for emotional behaviour.We also focus on the interrelations between dependent personality, domestic violence and addictions. The objective for the clinician is to propose a restoration of self-esteem and therapeutic strategies focused on autonomy. [less ▲]

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See detailComplications psychiatriques et addictions.
PITCHOT, William ULg; Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg

in Revue medicale de Liege (2013), 68(5-6), 218-20

Psychiatric complications are clearly associated with substance abuse. Psychopathological symptoms appear during intoxication or in patients suffering from substance-induced psychiatric disorders. However ... [more ▼]

Psychiatric complications are clearly associated with substance abuse. Psychopathological symptoms appear during intoxication or in patients suffering from substance-induced psychiatric disorders. However, the assessment of the psychiatric symptomatology is particularly challenging in patients who express clear difficulties to accept that the disorder is favoured by substance abuse. Psychotic reactions, major depression and anxiety disorders are the main psychiatric issues observed in addict patients. [less ▲]

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