References of "Albouy, Geneviève"
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See detailSleep stabilizes visuomotor adaptation memory: a functional magnetic resonance imaging study
Albouy, Geneviève ULg; Vandewalle, Gilles ULg; Sterpenich, Virginie et al

in Journal of Sleep Research (2013), 22(2), 144-54

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See detailThe impact of visual perceptual learning on sleep and local slow wave initiation
Mascetti, Laura ULg; Muto, Vincenzo ULg; Matarazzo, Luca et al

in Journal of Neuroscience (2013)

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See detailImpact of early versus late acquired blindness on the fuctional organization and connectivity of the occipital cortex
Collignon, O; Phillips, C; Dormal, G et al

Poster (2012, May)

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See detailNeural Correlates of Performance Variabilty during Motor Sequence Acquisition
Albouy, Geneviève ULg; Sterpenich, V.; Vandewalle, Gilles ULg et al

in NeuroImage (2012), 60(1), 324-331

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See detailThe fate of incoming stimuli during NREM sleep is determined by spindles and the phase of the slow oscillation
Schabus, M.; Dang Vu, Thien Thanh ULg; Heib, D. P. J. et al

in Frontiers in Neurology (2012), 3(40), 1-11

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See detailFunctional specialization for auditory-spatial processing in the occipital cortex of congenitally blind humans
Collignon, Olivier; Vandewalle, Gilles ULg; Voss, Patrice et al

in Proceedings of the National Academy of Sciences of the United States of America (2011), 108(11), 4435-40

The study of the congenitally blind (CB) represents a unique opportunity to explore experience-dependant plasticity in a sensory region deprived of its natural inputs since birth. Although several studies ... [more ▼]

The study of the congenitally blind (CB) represents a unique opportunity to explore experience-dependant plasticity in a sensory region deprived of its natural inputs since birth. Although several studies have shown occipital regions of CB to be involved in nonvisual processing, whether the functional organization of the visual cortex observed in sighted individuals (SI) is maintained in the rewired occipital regions of the blind has only been recently investigated. In the present functional MRI study, we compared the brain activity of CB and SI processing either the spatial or the pitch properties of sounds carrying information in both domains (i.e., the same sounds were used in both tasks), using an adaptive procedure specifically designed to adjust for performance level. In addition to showing a substantial recruitment of the occipital cortex for sound processing in CB, we also demonstrate that auditory-spatial processing mainly recruits the right cuneus and the right middle occipital gyrus, two regions of the dorsal occipital stream known to be involved in visuospatial/motion processing in SI. Moreover, functional connectivity analyses revealed that these reorganized occipital regions are part of an extensive brain network including regions known to underlie audiovisual spatial abilities (i.e., intraparietal sulcus, superior frontal gyrus). We conclude that some regions of the right dorsal occipital stream do not require visual experience to develop a specialization for the processing of spatial information and to be functionally integrated in a preexisting brain network dedicated to this ability. [less ▲]

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See detailNeural precursors of delayed insight
Darsaud, Annabelle ULg; Wagner, Ullrich; Balteau, Evelyne ULg et al

in Journal of Cognitive Neuroscience (2011), 23(8), 1900-1910

The solution of a problem left unresolved in the evening can sometimes pop into mind as a sudden insight after a night of sleep in the following morning. Although favorable effects of sleep on insightful ... [more ▼]

The solution of a problem left unresolved in the evening can sometimes pop into mind as a sudden insight after a night of sleep in the following morning. Although favorable effects of sleep on insightful behavior have been experimentally confirmed, the neural mechanisms determining this delayed insight remain unknown. Here, using functional magnetic resonance imaging (fMRI), we characterize the neural precursors of delayed insight in the number reduction task (NRT), in which a hidden task structure can be learned implicitly, but can also be recognized explicitly in an insightful process, allowing immediate qualitative improvement in task performance. Normal volunteers practiced the NRT during two fMRI sessions (training and retest), taking place 12 hours apart after a night of sleep. After this delay, half of the subjects gained insight into the hidden task structure ("solvers," S), whereas the other half did not ("nonsolvers," NS). Already at training, solvers and nonsolvers differed in their cerebral responses associated with implicit learning. In future solvers, responses were observed in the superior frontal sulcus, posterior parietal cortex, and the insula, three areas mediating controlled processes and supporting early learning and novice performance. In contrast, implicit learning was related to significant responses in the hippocampus in nonsolvers. Moreover, the hippocampus was functionally coupled with the basal ganglia in nonsolvers and with the superior frontal sulcus in solvers, thus potentially biasing participants' strategy towards implicit or controlled processes of memory encoding, respectively. Furthermore, in solvers but not in nonsolvers, response patterns were further transformed overnight, with enhanced responses in ventral medial prefrontal cortex, an area previously implicated in the consolidation of declarative memory. During retest in solvers, before they gain insight into the hidden rule, significant responses were observed in the same medial prefrontal area. After insight, a distributed set of parietal and frontal areas is recruited among which information concerning the hidden rule can be shared in a so-called global workspace. [less ▲]

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See detailNeurobiological bases of suicidality in major depression
Desseilles, Martin ULg; Scwartz, Sophie; Dang Vu, Thanh et al

in World Journal of Biological Psychiatry (2009), 9(Suppl. 1),

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See detailAbnormal neural filtering of irrelevant visual information in depression
Desseilles, Martin ULg; Balteau, Evelyne ULg; Sterpenich, Virginie et al

in NeuroImage (2009), 45(Suppl. 1),

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See detailSleep modulates the neural substrates of both spatial and contextual memory consolidation
Rauchs, G; Orban, P; Schmidt, Christina ULg et al

in PLoS ONE (2008), 3(8), 2949

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See detailThe role of sleep in motor adaptation consolidation assessed by fMRI
Albouy, Geneviève ULg; Vandewalle, Gilles ULg; Gais, Steffen et al

in Journal of Sleep Research (2008), 17(Suppl. 1),

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See detailBoth the hippocampus and striatum are involved in consolidation of motor sequence memory.
Albouy, Geneviève ULg; Sterpenich, Virginie ULg; Balteau, Evelyne ULg et al

in Neuron (2008), 58(2), 261-72

Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor ... [more ▼]

Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior. [less ▲]

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See detailSpontaneous neural activity during human slow wave sleep.
Dang Vu, Thien Thanh ULg; Schabus, Manuel ULg; Desseilles, Martin ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2008), 105(39), 15160-5

Slow wave sleep (SWS) is associated with spontaneous brain oscillations that are thought to participate in sleep homeostasis and to support the processing of information related to the experiences of the ... [more ▼]

Slow wave sleep (SWS) is associated with spontaneous brain oscillations that are thought to participate in sleep homeostasis and to support the processing of information related to the experiences of the previous awake period. At the cellular level, during SWS, a slow oscillation (<1 Hz) synchronizes firing patterns in large neuronal populations and is reflected on electroencephalography (EEG) recordings as large-amplitude, low-frequency waves. By using simultaneous EEG and event-related functional magnetic resonance imaging (fMRI), we characterized the transient changes in brain activity consistently associated with slow waves (>140 microV) and delta waves (75-140 microV) during SWS in 14 non-sleep-deprived normal human volunteers. Significant increases in activity were associated with these waves in several cortical areas, including the inferior frontal, medial prefrontal, precuneus, and posterior cingulate areas. Compared with baseline activity, slow waves are associated with significant activity in the parahippocampal gyrus, cerebellum, and brainstem, whereas delta waves are related to frontal responses. No decrease in activity was observed. This study demonstrates that SWS is not a state of brain quiescence, but rather is an active state during which brain activity is consistently synchronized to the slow oscillation in specific cerebral regions. The partial overlap between the response pattern related to SWS waves and the waking default mode network is consistent with the fascinating hypothesis that brain responses synchronized by the slow oscillation restore microwake-like activity patterns that facilitate neuronal interactions. [less ▲]

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See detailWavelength-dependent modulation of brain responses to a working memory task by daytime light exposure
Vandewalle, Gilles ULg; Gais, S.; Schabus, Manuel ULg et al

in Cerebral Cortex (2007), 17(12), 2788-2795

In addition to classical visual effects, light elicits nonvisual brain responses, which profoundly influence physiology and behavior. These effects are mediated in part by melanopsin-expressing light ... [more ▼]

In addition to classical visual effects, light elicits nonvisual brain responses, which profoundly influence physiology and behavior. These effects are mediated in part by melanopsin-expressing light-sensitive ganglion cells that, in contrast to the classical photopic system that is maximally sensitive to green light (550 nm), is very sensitive to blue light (470-480 nm). At present, there is no evidence that blue light exposure is effective in modulating nonvisual brain activity related to complex cognitive tasks. Using functional magnetic resonance imaging, we show that, while participants perform an auditory working memory task, a short (18 min) daytime exposure to blue (470 nm) or green (550 nm) monochromatic light (3 x 10(13) photons/cm(2)/s) differentially modulates regional brain responses. Blue light typically enhanced brain responses or at least prevented the decline otherwise observed following green light exposure in frontal and parietal cortices implicated in working memory, and in the thalamus involved in the modulation of cognition by arousal. Our results imply that monochromatic light can affect cognitive functions almost instantaneously and suggest that these effects are mediated by a melanopsin-based photoreceptor system. [less ▲]

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See detailSleep deprivation on the post-encoding night modifies the neural correlates of retrieval of emotional memories 6 months later
Sterpenich, Virginie ULg; Albouy, Geneviève ULg; Darsaud, Annabelle et al

in Journal of Neuroscience (2007), 27(Suppl. 1),

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See detailThe Role of Sleep in Motor Memory Consolidation assessed by fMRI and MEG
Albouy, Geneviève ULg; Sterpenich, Virginie ULg; Darsaud, Annabelle et al

in Journal of Neuroscience (2007), 27(Suppl. 1),

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See detailSleep transforms the cerebral trace of declarative memories
Gais, Steffen; Albouy, Geneviève ULg; Boly, Mélanie ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2007), 104(47), 18778-18783

After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid ... [more ▼]

After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, the latter is presumed to rely on an interaction between different brain regions, in particular the hippocampus and the medial prefrontal cortex (mPFC). Specifically, sleep has been proposed to provide a setting that supports such systems consolidation processes, leading to a transfer and perhaps transformation of memories. Using functional MRI, we show that postlearning sleep enhances hippocampal responses during recall of word pairs 48 h after learning, indicating intrahippocampal memory processing during sleep. At the same time, sleep induces a memory-related functional connectivity between the hippocampus and the mPFC. Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level. [less ▲]

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See detailBrain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem
Vandewalle, Gilles ULg; Schmidt, Christina ULg; Albouy, Geneviève ULg et al

in PLoS ONE (2007), 2(11), 1247

BACKGROUND: Relatively long duration retinal light exposure elicits nonvisual responses in humans, including modulation of alertness and cognition. These responses are thought to be mediated in part by ... [more ▼]

BACKGROUND: Relatively long duration retinal light exposure elicits nonvisual responses in humans, including modulation of alertness and cognition. These responses are thought to be mediated in part by melanopsin-expressing retinal ganglion cells which are more sensitive to blue light than violet or green light. The contribution of the melanopsin system and the brain mechanisms involved in the establishment of such responses to light remain to be established. METHODOLOGY/PRINCIPAL FINDINGS: We exposed 15 participants to short duration (50 s) monochromatic violet (430 nm), blue (473 nm), and green (527 nm) light exposures of equal photon flux (10(13)ph/cm(2)/s) while they were performing a working memory task in fMRI. At light onset, blue light, as compared to green light, increased activity in the left hippocampus, left thalamus, and right amygdala. During the task, blue light, as compared to violet light, increased activity in the left middle frontal gyrus, left thalamus and a bilateral area of the brainstem consistent with activation of the locus coeruleus. CONCLUSION/SIGNIFICANCE: These results support a prominent contribution of melanopsin-expressing retinal ganglion cells to brain responses to light within the very first seconds of an exposure. The results also demonstrate the implication of the brainstem in mediating these responses in humans and speak for a broad involvement of light in the regulation of brain function. [less ▲]

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