References of "ARRESE ESTRADA, Jorge"
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See detailEpidemiological aspects and genotypic characterization of strains of Microsporum audouinii isolated in the context of a Belgian National survey on anthropophilic tinea
SACHELI, Rosalie ULg; Dekkers, Charlotte; DARFOUF, Rajae ULg et al

Poster (2015, May)

Objectives The last two years, clinical cases of tinea capitis caused by Microsporum audouinii (M. audouinii), have increased in Belgium. To better understand the emergence of this species in the ... [more ▼]

Objectives The last two years, clinical cases of tinea capitis caused by Microsporum audouinii (M. audouinii), have increased in Belgium. To better understand the emergence of this species in the population, the Belgian National Reference Center (NRC) for dermatophytes launched a national survey in 2013. Epidemiological aspects and genotypic characterization of the strains were included. Methods The study was conducted from March 2013 up to February 2014. All Belgian laboratories were asked to send M. audouinii strains isolated from hair to the NRC with a form to fill in including epidemiological informations. The fungal strains were identified by microscopy or ITS sequencing in case of doubt. The genotypic analysis was performed by the DiversiLab® system (bioMérieux) for DNA fingerprinting and analysis. Epidemiological informations were analyzed with the help of a biostatistician. Results Among the collected isolates, 117 strains have been currently confirmed as M. audouinii. Analysis of the epidemiological characteristics of the infected population shows that the main age category concerns 5-9 year-old children (64%, p< 0,0001) with a sex-ratio M/F of 1.97. Data concerning the geographic origin of the family have been obtained in only 33,6% of the cases. It reveals that strains have been mainly isolated from patients with a Belgian nationality (43,6%) suggesting bias in the data collection. The geographic origin of the remaining group includes several African countries such as Congo (20,61%), Guinea (12,8%) and Burundi (5,12%). The genotypic analysis led to the distinction of 6 genotypic variants of M. audouinii. One of these variants was exclusively recovered from South Belgium (11 strains). The major group was composed of 96 strains, well distributed in different Belgium locations. Two other groups of three strains each were close to the major group but the analysis of the spectral superposition showed some differences between these groups. The two last groups were clearly different from the major group but species identification was confirmed by ITS sequencing. Conclusion The results of the genomic analysis by Diversilab, show that several groups of M. audouinii isolates co-exist in Belgium providing evidence of genetic heterogeneity. However, no clear correlation could be established between the appartenance to a group and epidemiological factors, such as the age or ethnical origin. ________________________________________ [less ▲]

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See detailRecurrent In Situ Melanoma Successfully Treated with Ingenol Mebubate
MANSUY, Marion ULg; TASSOUDJI, Nazli ULg; ARRESE ESTRADA, Jorge ULg et al

in Dermatologic Therapy (2014)

Background:Treatment options for melanoma in situ (MIS) include imiquimod, radiation therapy, cryotherapy, excisional and Mohs surgery. Ingenol mebutate is a new topical treatment option recognized for ... [more ▼]

Background:Treatment options for melanoma in situ (MIS) include imiquimod, radiation therapy, cryotherapy, excisional and Mohs surgery. Ingenol mebutate is a new topical treatment option recognized for actinic keratosis. Although in vitro effectiveness has been demonstrated on melanoma cell lines, its therapeutic potential for in vivo melanomas is unknown. Case Report: In 2011, a 91-year-old woman presented a thick melanoma of her cheek. The lateral sections revealed persisting in situ melanoma, which were again excised. She presented for follow-up and a recurrent MIS was evidenced centered on the previous scar. She refused further surgery and ingenol mebutate (0.015% gel) was administered on three consecutive days. One month later, a complete clinical resolution was observed. Histology and immunohistology revealed no residual MIS. Conclusion: In this patient, ingenol mebutate was successful and well-tolerated as a topical, alternative therapy for MIS after failure of other treatment options. [less ▲]

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See detailEstablished and emerging oral antifungals in dermatology
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; Vroome, Valérie et al

in Dermatologic, Cosmeceutic, and Cosmetic Development (2013)

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See detailHERPES SIMPLEX VIRUS TYPE_i AND PYOGENIC GRANULOMA : A VASCULAR ENDOTHELIAL GROWTH FACTOR-MEDIATED ASSOCIATION?
EL HAYDERI, Lara ULg; PAUROBALLY, Dilshad ULg; FASSOTTE, Marie-France ULg et al

in Case Reports in Dermatology (2013), 5

Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not ... [more ▼]

Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not been reported up to date. A 52-year-old woman with hairly-cell leukemia presented because of a3-month history of a giant pseudotumoral lesion on her left cheek. All prior antibacterial, antifungal and anti-inflammatory treatments had failed. Histology revealed PG with sparse and isolated epithelial cell aggregates. Immunohistochemistry (IHC) identified herpes simplex virus type-I (HSV-I) antigens in the nuclei and cytoplasm of normal-appearing as well as cytopathic epithelial cells, suggesting a chronic, low-productive HSV infection. No HSV-I signal was evidenced in the endothelial cells of the PG. Furthermore, IHC revealed VEGF in the HSV-I infected epithelial cells as well as within the PG endothelial cells. These results incited oral treatment with valaciclovir, and the PG promptly resolved after 2 weeks. These findings suggest that a chronic HSV-I infection might play and indirect, partial role in neoangiogenesis, presumably via HSV-I infection-related stimulation of keratinocytic VEGF production. [less ▲]

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See detailPaclitaxel-Related Lymphedema and Scleroderma-Like Skin Changes
COLSON, Fany ULg; SIGHA, Berline; ARRESE ESTRADA, Jorge ULg et al

in Journal of Clinical Case Reports (2013), 3(11),

Paclitaxel is an antimucrotubule agent used for the treatment of metastatic breast cancer. The development of scleroderma-like skin changes is an exceptional adverse effect. We report two patients with ... [more ▼]

Paclitaxel is an antimucrotubule agent used for the treatment of metastatic breast cancer. The development of scleroderma-like skin changes is an exceptional adverse effect. We report two patients with metastatic breast cancer treated by paclitaxel who presented an enexplained unilateral lymphedema of the upper limb. Medical work-up did not demonstrate any mechanical or tumor obstruction of the lymphatic vessels. Dermatologic examination revealed cutaneous and bucutaneous indurations and hardening of certain areas of the involved arm. The clinical suspicion of scleroderma was confirmed by histology and immunohistology. Treatment was initiated with methotrexate and methylprednisolone, resulting in a clear reduction of the lymphedema and a regression of the scleroderma. These two cases suggest a pathogenic role of paclitaxel-induced scleroderma in the subsequent development of severe localized lymphedema. [less ▲]

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See detailMyxofibrosarcoma
CASTRONOVO, Charlotte ULg; ARRESE ESTRADA, Jorge ULg; QUATRESOOZ, Pascale ULg et al

in Rare Tumors (2013), 5(15), 60-61

Myxofibrosarcoma (MFS) is a variant of the group of malignant fibrous histiocytomas. It is one of the most aggressive types of soft tissue neoplasms. The clinical presentation is not pathognomonic and the ... [more ▼]

Myxofibrosarcoma (MFS) is a variant of the group of malignant fibrous histiocytomas. It is one of the most aggressive types of soft tissue neoplasms. The clinical presentation is not pathognomonic and the histological aspects are highly heterogenous, frequently delaying the diagnosis or leading to misdiagnosis. Complementary histochemical and immunohistochemical stainings are mandatory to achieve the diagnosis of MFS. A 78-year-old male patient is presented illustrating this diagnostic pitfall. Extensive surgery followed by radiotherapy is the first choice treatment. [less ▲]

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See detailChronic annular lesions of the cheeks
LOTHER, Anne Sophia; ARRESE ESTRADA, Jorge ULg; NIKKELS, Arjen ULg

in International Journal of Dermatology (2013), (52), 649-650

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See detailChronic annular lesions of the cheeks
LOTHER, Anne-Sophia; ARRESE ESTRADA, Jorge ULg; NIKKELS, Arjen ULg

in International Journal of Dermatology (2012)

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See detailIpilimumab induces simultaneous regression of melanocytic naevi and melanoma metastases
LIBON, Florence ULg; ARRESE ESTRADA, Jorge ULg; RORIVET, A. et al

in Clinical & Experimental Dermatology (2012), (4452), 1-4

Background : Ipilimumab blocks cytotoxic T-lymphocyte-associated antigen (CTLA)-4, potentiating the antimelanoma T-cell host reponse. Ipilimumab has been shown to improve overall survival in patients with ... [more ▼]

Background : Ipilimumab blocks cytotoxic T-lymphocyte-associated antigen (CTLA)-4, potentiating the antimelanoma T-cell host reponse. Ipilimumab has been shown to improve overall survival in patients with previously treated metastatic melanoma. CTLA-4 antibodies generate immune responses to the melanoma-associated antigens Melan-A, NY-ESO-1 and glycoprotein (gp) 100 in metastatic melanoma. Digital epiluminescence microscopy (DELM) is a noninvasive method permitting the monitoring of the morphology of melanocytic lesions over time. Observation : A 50-year-old man with metastatic melanoma received four ipilimumab injections after failure of dacarbazine chemotherapy. Positron emission tomography revealed regression of pulmonary metastases, and simultaneously, DELM showed regression of several melanocytic naevi. On histological examination of the regressing naevi, prominent CD8+, CD4+ and CD45R0 lichenoid lymphohistiocytic infiltrates were seen, whereas nonregressing naevi were almost free of inflammatory infiltrate. Conclusion : Expression of melanoma-associated antigens in benign melanocytic naevi may explain the induction of naevus regression by ipilimumab. DELM could represent a valuable noninvasive method to monitor ipilimumab efficacy. [less ▲]

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See detailTumores cutaneos malignos
ARRESE ESTRADA, Jorge ULg; NIKKELS, Arjen ULg

in TINCOPA-WONG, OSCAR (Ed.) DERMATOLOGIA (2011)

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See detailCyanoacrylate skin surface strippings
PIERARD-FRANCHIMONT, Claudine ULg; ARRESE ESTRADA, Jorge ULg; QUATRESOOZ, Pascale ULg et al

in Textbook of aging skin (2010)

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See detailL'image du mois. Melanome a croissance rapide.
Bourguignon, Raphaël; Giet-Lesuisse, Marianne; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2009), 64(9), 429-31

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See detailMini-mélanome papulo-achromique de croissance rapide.
Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Dermatologie Actualité (2009), 114

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See detailVoir l'iceberg au ras des flots en scotomisant la métrologie cutanée.
Pierard, Gérald ULg; Quatresooz, Pascale ULg; Neuberg, S. et al

in Dermatologie Actualité (2009), 117

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See detailPorokératoses verruqueuses multipes.
ARRESE ESTRADA, Jorge ULg; QUATRESOOZ, Pascale ULg; AL RUSTOM, K. et al

in Dermatologie Actualité (2008), 106

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See detailEstablished and emerging oral antifungals in dermatology
PIERARD, Gérald ULg; PIERARD-FRANCHIMONT, Claudine ULg; vroome, v et al

in Dermatologic, cosmeceutic and cosmetic development (2008)

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See detailClinicopathologic presentations of dermatomycoses in cancer patients.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Journal of the European Academy of Dermatology & Venereology (2008)

Many of the skin fungal infections in cancer patients may look similar to those infections in non-cancer patients. However, in some cases, they become more extensive and even life threatening. Prolonged ... [more ▼]

Many of the skin fungal infections in cancer patients may look similar to those infections in non-cancer patients. However, in some cases, they become more extensive and even life threatening. Prolonged and severe neutropenia is the main risk factor for the dramatic issue of fungal infections. The dermatomycoses in cancer patients can be classified in four broad groups: primary superficial dermatophytoses, primary superficial yeast infections, opportunistic mold infections with distinct potential for dissemination and secondary cutaneous manifestations of fungaemia. Occasionally, more than one fungus are found inside a given skin lesion. A special condition is represented by the mycotic colonization of mucosal squamous cell carcinomas. Angio-invasion by fungi accounts for the frequency of disseminated infections prevailing in immunocompromised cancer patients. In case of skin involvement, the dermatologist may assist by recognizing subtle semiological signs and performing biopsies for swift histological examination, molecular biology and/or culture. [less ▲]

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See detailPorokératoses verruqueuses multiples
Arrese Estrada, Jorge ULg; Al Rustom, Kamil; Letot, Bernard ULg et al

in Dermatologie Actualité (2008), 106

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