References of "ANSSEAU, Marc"
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See detailAssortative mating and personality in human couples : A study using Cloninger's Temperament and Character Inventory
LE BON, O; Hansenne, Michel ULg; AMARU, D et al

in Psychology (in press)

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See detailProjet TADAM: RAPPORT FINAL 2007-2013
Demaret, Isabelle ULg; Litran, Géraldine; Magoga, Cécile et al

Report (2013)

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in ... [more ▼]

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in order to assess its feasibility and efficacy in Belgium. Methods: TADAM (Treatment Assisted by Diacetylmorphine) was an open label randomised controlled trial. The experimental treatment was based upon the Swiss model of HAT developed in 1994. The primary efficacy criterion was determined by an improvement in street heroin use or in (physical or mental) health or a decrease in criminal involvement. Participants were assessed every 3 months. Self-reported data were complemented with toxicological analyses and criminal proceedings. Findings: 74 participants were randomised in the trial: 36 in the experimental group and 38 in the control group. The experimental group counted 30% of responders more than the control group at 3 months (p<0.05), 6 months (p<0.05), and 9 months (p<0.01). At 12 months, the number of responders was still higher in the experimental group (11%) but the difference was no longer significant (p=0.35). Street heroin use increased in the experimental group at the 12-month assessment just before the end of HAT. Conclusion: HAT is feasible and effective. However, HAT should not have a predetermined duration for heroin users for which heroin addiction became a chronic relapsing disease. Other data: In addition to the outcomes of the randomised controlled trial, the report contains other exploratory data and analysis: satisfaction of in treatment, criminological data, opinion of heroin users not included in the trial, opinion of caregivers and field workers (in the HAT centre, in the partner centres, and in other centres in the addiction field), impact of the HAT centre on its neighbourhood and a socio-economic evaluation. Funding: The TADAM trial was funded at 80% by the Federal Minister of Social Affairs and Public Health. It was also funded the City and the University of Liège. [less ▲]

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See detailL'héroïne
Demaret, Isabelle ULg; Lemaître, André ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (2013), 68(5-6), 287

Summary : Heroin (or diacetylmorphine), a depressant of the nervous central system, is a semi-synthetic opiate. Its main adverse effect, respiratory depression, can lead to death, especially after an ... [more ▼]

Summary : Heroin (or diacetylmorphine), a depressant of the nervous central system, is a semi-synthetic opiate. Its main adverse effect, respiratory depression, can lead to death, especially after an intravenous injection. By loss of tolerance, an overdose can be lethal following heroin use after a period of abstinence (voluntary or not). Mortality rate among heroin users is between 1 and 3%. Addiction, following a regular and continuous use, occurs in less than a quarter of persons who ever tried heroine. Heroin addicts often present with different problems (for instance, a criminal behaviour), without any obvious link with addiction. For a fraction of the addicts, addiction becomes a chronic relapsing disease, requiring a long term maintenance substitution therapy. However, relapses and sometimes continuous heroin use are frequent. For treatment resistant and severe heroin addicts, heroinassisted treatment can be a solution. Despite the numerous available therapies, heroin is considered to be the drug with the most negative effects on the user. [less ▲]

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See detailComment je traite ...la prise en charge de l'agitation en urgence.
BAKAY, Sara ULg; IWEINS, Ariane ULg; Scantamburlo, Gabrielle ULg et al

in Revue Médicale de Liège (2013), 68(11), 553-6

Agitation in psychiatry is defined as "a request to which an answer cannot be deferred". If some types of controllable agitation can be solved by human means or psychotropic drugs, others may require the ... [more ▼]

Agitation in psychiatry is defined as "a request to which an answer cannot be deferred". If some types of controllable agitation can be solved by human means or psychotropic drugs, others may require the intervention of intensivists who will contribute to the onset of crisis resolution. In addition, an organic aetiology must be carefully excluded a before considering a psychiatric origin of agitation, especially in patients with no psychiatric history and in the elderly. Indeed, acute agitation can hide serious somatic traps and be life threatening. [less ▲]

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See detailANALYSIS AND OPTIMIZATION OF SUBSTITUTION. TREATMENT IN BELGIUM (SUBANOP)
VANDER LAENEN, FREYA; VANDERPLASSCHEN, WOUTER; SMET, VALERIE et al

Book published by ACADEMIA PRESS (2013)

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See detailSevrage rapide aux opiaces sous anesthesie (RODA).
DUBOIS, Nathalie ULg; Hallet, C.; Luppens, D. et al

in Revue medicale de Liege (2013), 68(5-6), 298-302

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure ... [more ▼]

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and methadone during anesthesia and patient stay at the hospital in order to assess the amount of active substances at each protocol step. Plasma concentrations of antagonists were also quantified and compared to the recommended target values. Blood samples were drawn in 10 patients undergoing RODA at different times of the procedure (during anesthesia, in post-anesthesia care unit and in psychiatry unit). The plasma concentrations of heroin metabolites, methadone and antagonists were measured using a previously described method. Heroin active metabolites were no longer detected in the patient blood when helshe left the hospital; by contrast, methadone was still present at significant concentrations 3 days after the beginning of the detoxification procedure. Naltrexone analysis allowed us to adjust doses to insure opiate receptor blockade during acute withdrawal, which is a critical period. [less ▲]

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See detailTraitement du trouble bipolaire II
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg

in Aubry, Jean-Marie; FERRERO, F; SCHAAD, N (Eds.) Psychopharmacologie des Troubles Bipolaires, Médecine et Hygiène (2013)

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See detailLa dependance affective.
SCANTAMBURLO, Gabrielle ULg; PITCHOT, William ULg; Ansseau, Marc ULg

in Revue medicale de Liege (2013), 68(5-6), 340-7

Affective dependency is characterized by emotional distress (insecure attachment) and dependency to another person with a low self-esteem and reassurance need. The paper proposes a reflection on the ... [more ▼]

Affective dependency is characterized by emotional distress (insecure attachment) and dependency to another person with a low self-esteem and reassurance need. The paper proposes a reflection on the definition of emotional dependency and the confusion caused by various denominations. Overprotective and authoritarian parenting, cultural and socio-environmental factors may contribute to the development of dependent personality. Psychological epigenetic factors, such as early socio-emotional trauma could <imprint>> on neuronal circuits in prefronto-limbic regions that are essential for emotional behaviour.We also focus on the interrelations between dependent personality, domestic violence and addictions. The objective for the clinician is to propose a restoration of self-esteem and therapeutic strategies focused on autonomy. [less ▲]

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See detailComplications psychiatriques et addictions.
PITCHOT, William ULg; Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg

in Revue medicale de Liege (2013), 68(5-6), 218-20

Psychiatric complications are clearly associated with substance abuse. Psychopathological symptoms appear during intoxication or in patients suffering from substance-induced psychiatric disorders. However ... [more ▼]

Psychiatric complications are clearly associated with substance abuse. Psychopathological symptoms appear during intoxication or in patients suffering from substance-induced psychiatric disorders. However, the assessment of the psychiatric symptomatology is particularly challenging in patients who express clear difficulties to accept that the disorder is favoured by substance abuse. Psychotic reactions, major depression and anxiety disorders are the main psychiatric issues observed in addict patients. [less ▲]

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See detailTraitement du trouble bipolaire de type II
Scantamburlo, Gabrielle ULg; ANSSEAU, Marc ULg

in Thérapeutique des toubles de l'humeur (2013)

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See detailSevrage rapide aux opiacés sous anesthésie (RODA)
DUBOIS, Nathalie ULg; HALLET, Claude ULg; LUPPENS, David ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 298-302

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure ... [more ▼]

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measure the plasma concentrations of heroin metabolites and methadone during anesthesia and patient stay at the hospital in order to assess the amount of active substances at each protocol step. Plasma concentrations of antagonists were also quantified and compared to the recommended target values. Blood samples were drawn in 10 patients undergoing RODA at different times of the procedure (during anesthesia, in post-anesthesia care unit and in psychiatry unit). The plasma concentrations of heroin metabolites, methadone and antagonists were measured using a previously described method. Heroin active metabolites were no longer detected in the patient blood when he/she left the hospital; by contrast, methadone was still present at significant concentrations 3 days after the beginning of the detoxification procedure. Naltrexone analysis allowed us to adjust doses to insure opiate receptor blockade. [less ▲]

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See detailDuration perception: A Developmental Semiology from 2:6 to 13 Years, General Population versus Atypical, Assessment by Parental Questionnaire
SCHOLL, Jean-Marc ULg; Philippe, Paule; Gérard, Paul ULg et al

Conference (2012, December 20)

Introduction Perception of duration has a major impact on the child’s ability to manage everyday life. Usually, the perception of time is considered in its sequential component. To our knowledge, possible ... [more ▼]

Introduction Perception of duration has a major impact on the child’s ability to manage everyday life. Usually, the perception of time is considered in its sequential component. To our knowledge, possible semiological markers for the capacity to apprehend temporal duration have not yet been explored. There are thus no existing tools either for its evaluation (in everyday life) or for the description of its development during childhood. We are thus largely in the dark about how the perception of duration develops during childhood. Hypothesis 1) It is possible to track perception of duration using semiological markers in everyday life; 2) Children with developmental disorders can be expected to develop difficulties in this domain. Method We designed a questionnaire for parents using a Likert scale. The questionnaire was administered to 2 samples from 2:6 to 13 years: 827 in a general population and 297 in a mixed-psychopathological population recruited from the Mental Health Services network. We carried out a multinomial logistic regression and used percentiles curves (P5,50,95). Results In the general population, perception of duration is gradually acquired and full competence is attained by 9 years. The apprehension of sequential time is achieved by 4 years. In the psychopathological sample, mean perception of temporal duration is delayed by 18 months and significant difficulties remain even at 13 years. The apprehension of sequential time is also delayed: even at 13 years it remains low (at percentile 95). We have found no sex-related differences. Discussion Perception of duration is an important developmental feature which has not been taken into account until now. Semiological markers can be used to differentiate typically developing children from clinical populations as to their respective capacities to perceive temporal duration. [less ▲]

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See detailSexual dysfunction induced by antidepressants and antipsychotics
LICITSYNA, Olga; Ansseau, Marc ULg; GERNAY, Delphine ULg et al

in Terapevticheskii arkhiv (2012), 84(10), 103-8

The interest in sexual dysfunction induced by psychotropic drugs has increased considerably in recent years because of the new-generation antidepressants (AD) and antipsychotics (AP) being put into ... [more ▼]

The interest in sexual dysfunction induced by psychotropic drugs has increased considerably in recent years because of the new-generation antidepressants (AD) and antipsychotics (AP) being put into medical practice. These drugs are widely used to treat not only depression and schizophrenia, but also anxiety and affective disorders. Other, additional indications for the use of antidepressants are appetite disorders, premenstrual syndrome, chronic pain, etc. Neuroleptics are administered to treat resistant depressions, aggressiveness, impulsivity, and alcoholism. Impaired sexual functioning due to AD and AP lowers quality of life in patients and increases the risk of their refusing treatment, the result of which is a phenomenon associated with the occurrence of recurrent mental illnesses. There are few scientific data on the nature and prevalence of sexual dysfunctions induced by these medications. This topic is universally underestimated as it is rarely touched upon by specialists during their consultations. The aim of the review is to show the side effects of AP and AD on the sexual sphere, to compare different classes of the drugs, and to propose possible management strategies to correct these undesirable effects. [less ▲]

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See detailLe trouble bipolaire: une affection bien complexe.
PITCHOT, William ULg; Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg et al

in Revue Médicale de Liège (2012), 67(5-6), 366-73

Bipolar disorder is a multifactorial disease with a strong genetic component. However, environmental factors also play a role in the onset of the disease and in manic and depressive recurrence. The onset ... [more ▼]

Bipolar disorder is a multifactorial disease with a strong genetic component. However, environmental factors also play a role in the onset of the disease and in manic and depressive recurrence. The onset of the disorder is the consequence of a complex interaction between genetic and environmental factors. This gene-environment interaction is well illustrated by the influence of childhood trauma on the clinical expression of the disease in terms of age of onset, comorbidity and suicide. The complexity and heterogeneity of bipolar disorder require the identification of homogenous sub-groups with the use of biomarkers that could help reduce the etiological heterogeneity and better target the therapeutical options. [less ▲]

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