Fatal Massive Liver Steatosis--a Clinicopathological Case Report

in Acta Gastro-Enterologica Belgica (1997), 60(2, Apr-Jun), 180-3

Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman ... [more ▼]

Hepatic fatty change is a common lesion. Two forms are recognized: micro- and macrovesicular steatosis, the former being much less frequent and more serious than the latter. The case of an alcoholic woman under anticonvulsivant therapy and with medications for a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) who presented with rapidly progressive cholestasis and hepatocellular failure is reported. Massive macro- and micro-vesicular hepatic steatosis was diagnosed at autopsy. The authors review the clinico-pathological features associated with this condition, and causal factors possibly implicated in this case are discussed in regard with currently considered pathophysiological mechanisms. [less ▲]

Independent prognostic value of the 67-kD laminin receptor in human prostate cancer

in British Journal of Urology (1997), 80(Suppl. 2), 231

Independent prognostic value of the 67-kd laminin receptor in human prostate cancer

in Journal of the National Cancer Institute (1997), 89(16), 1224-7

Morphological Changes of Thymus in Retrovirus-Induced Murine Acquired Immunodeficiency Syndrome (Maids)

in Pathology - Research & Practice (1995), 191(6), 506-12

The possible contribution of the thymus in the setting of acquired immunodeficiencies is still questioned. Here we report some new findings regarding a potential involvement of the thymus in mice infected ... [more ▼]

The possible contribution of the thymus in the setting of acquired immunodeficiencies is still questioned. Here we report some new findings regarding a potential involvement of the thymus in mice infected with RadLV-Rs, a viral mixture inducing murine acquired immunodeficiency syndrome (MAIDS). Thymi were sequentially removed, weighted and morphologically analyzed at different time intervals post-infection. Infection with RadLV-Rs led to a decrease in thymus weight mostly apparent from the fourth week. The first changes were seen at the third week as perivascular clusters of B-cells at the cortico-medullary junction. The ensuing process of atrophy mainly involved the cortex, while a mixed population of large T- and B-cells filled the medulla. These observations are discussed with regard to the pathological changes occurring in other lymphoid and non-lymphoid organs, in the context of the lymphoproliferation and immunodeficiency characterizing the disease, and by comparison with other models of retrovirus-induced immunodeficiencies. [less ▲]

Cytofluorometric analysis of prostate cancer specimens: Histological and clinical correlations

in Acta Urologica Belgica (1994, January), 62

DNA histograms were oblained by flow cytometry for 39 human prostate carcinomas (27 total proslatectomy specimens, 5 biopsies and 7 transuretral resections). The study was performed on formalin-fixed and ... [more ▼]

DNA histograms were oblained by flow cytometry for 39 human prostate carcinomas (27 total proslatectomy specimens, 5 biopsies and 7 transuretral resections). The study was performed on formalin-fixed and paraffin-embedded. material. In this report, ploidy index did not seem to be a good marker of prognosis as no significant variation in ploidy was found neither among the different stages nor among the different Gleason categories. Proliferative index of the tumors seemed to be a more sensitive parameter; a significant relation was observed between proliferative index and stage of the tumor. The authors discuss these results under the light of previously reported observations. [less ▲]

Influence of laminin or fibroblasts upon colony formation in the mouse by B16 melanoma cell spheroids: a morphometric analysis.

in In Vivo (Athens, Greece) (1992), 6(2), 119-24

By microscopical observation and using an original morphometric method, we analyzed on histological sections the rate of lung colony formation after the intravenous injection into the mouse of B16 ... [more ▼]

By microscopical observation and using an original morphometric method, we analyzed on histological sections the rate of lung colony formation after the intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as aggregates. After the injection of B16 pure spheroids, superficial lung colonies were more numerous than internal lung colonies. After the injection of mixed spheroids (B16 + 3T3 fibroblasts), the size of colony sections was increased. Addition of laminin to pure or mixed spheroids decreased the size of colony sections but increased the number of internal lung colonies. [less ▲]