The Major Homology Region Of Bovine Leukaemia Virus P24(Gag) Is Required For Virus Infectivity In Vivo

in Journal of General Virology (1997), 78

Bovine Herpesvirus 1-Induced Apoptosis Occurs At The G0/G1 Phase Of The Cell Cycle

in Virology (1997), 232(2), 351-358

We have previously shown that bovine herpesvirus 1 (BHV-1), even when inactivated, induces apoptotic cell death in mitogen-stimulated bovine peripheral blood mononuclear cells (PBMCs) (Hanon et al., 1996 ... [more ▼]

We have previously shown that bovine herpesvirus 1 (BHV-1), even when inactivated, induces apoptotic cell death in mitogen-stimulated bovine peripheral blood mononuclear cells (PBMCs) (Hanon et al., 1996, J. Virol. 70, 4116-4120). In order to gain insight into this process, we have investigated the cell cycle phase at which BHV-1 induces apoptosis in PBMCs. Our results show that the percentage of cells that progress through the S phase was always lower in BHV-1-infected PBMCs than in control cells. This effect was not due to a defective activation of mitogen-stimulated PBMCs since BHV-1 only slightly affected the percentage of cells expressing BoCD25, a well-known lymphocyte activation marker. Furthermore, mimosine and cyclosporine A, two chemicals that inhibit entry into the S phase of the cell cycle by different pathways, did not affect the ability of BHV-1 to induce apoptosis. BHV-1-induced apoptosis also occurred in unstimulated PBMCs and interestingly, this was associated with the expression of c-myc and BoCD25 proteins both of which are related to cell cycle progression. All together, these data provide evidence demonstrating that BHV-1-induced apoptosis occurs at the G0/G1 phase of the cell cycle. [less ▲]

Oncogenic potential of Tax requires phosphorylation on serines 106 et 293.

in Virus Research (1997), 47(2 -Special Issue), 121-122

Modulation Of Cd3-Gamma Gene Expression After Hiv Type 1 Infection Of The We17/10 T Cell Line Is Progressive And Occurs In Concert With Decreased Production Of Viral P24 Antigen

in Aids Research and Human Retroviruses (1996), 12(8),

The Creb, Atf-1, And Atf-2 Transcription Factors From Bovine Leukemia Virus-Infected B Lymphocytes Activate Viral Expression

in Journal of Virology (1996), 70(3),

Rat embryo fibroblasts immortalization by bovine leukemia virus Tax protein

in Methods in Cell Science : An Official Journal of the Society for in Vitro Biology (1995)

Mutations in the p53 tumor-suppressor gene are frequently associated with bovine leukemia virus-induced leukemogenesis in cattle but not in sheep.

in Virology (1995), 209(2),

Nucleotide sequence of the bovine P53 tumor-suppressor cDNA.

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1995), 5(4),

Involvement Of The Cyclic Amp-Responsive Element-Binding Protein In Bovine Leukemia-Virus Expression In-Vivo

in Journal of Virology (1994), 68(9),

Expression Of Interleukin-6 Receptors And Interleukin-6 Messenger-Rna By Bovine Leukemia Virus-Induced Tumor-Cells

in Cytokine (1994), 6(6),