References of "Waltregny, David"
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See detailLoss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas
Dehan, Pierre ULg; Waltregny, David ULg; Beschin, Alain et al

in American Journal of Pathology (1997), 151(4), 1097-104

Type IV collagen, a major component of basement membranes, is organized in a network responsible for the mechanical resistance of the basement membranes. It also plays a key role in epithelial cell ... [more ▼]

Type IV collagen, a major component of basement membranes, is organized in a network responsible for the mechanical resistance of the basement membranes. It also plays a key role in epithelial cell adhesion to basement membranes. This study was designed to investigate the distribution of type IV collagen alpha-chains in normal, preneoplastic, and malignant prostate basement membranes. For this purpose, immunohistochemistry using specific antibodies raised against the different alpha-chains of type IV collagen was performed in eight normal samples, six prostatic intraepithelial neoplasia, and 20 malignant lesions of the prostate. Our results demonstrate the presence of the "novel" alpha 5 (IV) and alpha 6 (IV) chains along with the "classical" alpha 1 (IV)/alpha 2 (IV) chains in the basement membrane of the normal prostate gland. The alpha 3 (IV) chain was never detected in any prostate specimen. Prostatic intraepithelial neoplasia showed a similar immunostaining pattern to that found in normal glands. In cancer gland basement membranes, we demonstrate for the first time a specific loss of the alpha 5 (IV) and alpha 6 (IV) chains, whereas the classical alpha 1 (IV) and alpha 2 (IV) chains were consistently exhibited. Additionally, type VII collagen colocalized with alpha 5 (IV) collagen chain, and these two proteins, which were always observed in normal and prostatic intraepithelial neoplasia gland basement membranes, were lost in invasive carcinoma basement membranes. This observation raises questions about the possible association or cooperation between alpha 5 (IV)/alpha 6 (IV) chains and anchoring fibrils in prostate glands basement membrane. [less ▲]

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See detailOverexpression of the 67-kD laminin receptor correlates with tumor progression in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Ménard, Sylvie et al

in Proceedings of the American Association for Cancer Research (1997), 38

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See detailIndependent prognostic value of the 67-kD laminin receptor in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Ménard, Sylvie et al

in British Journal of Urology (1997), 80(Suppl. 2), 231

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See detailIndependent value of the 67-kilodalton laminin receptor in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Ménard, Sylvie et al

in Acta Clinica Belgica (1997), 52(2), 93

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See detailIndependent prognostic value of the 67-kd laminin receptor in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Menard, Sylvie et al

in Journal of the National Cancer Institute (1997), 89(16), 1224-7

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See detailOverexpression of the 67-kDa laminin receptor correlates with tumor progression in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Ménard, Sylvie et al

in Clinical & Experimental Metastasis (1996, March), 14(Suppl. 1), 1996

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See detailRecent advances in prostate cancer metastasis
Waltregny, David ULg; Castronovo, Vincenzo ULg

in Tumori (1996), 82(3, May-Jun), 193-204

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy ... [more ▼]

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy that exists between the prevalence of 'latent' cancer, recognizable only histologically, and that of the clinical disease. Histologically detected localized prostate cancers are heterogeneous, with only a small subset having undergone all of the malignant changes required to produce clinically aggressive tumors. Most of these 'latent' carcinoma never become fully malignant and do not threaten the life or well-being of the host. At present, it is not possible to predict which localized cancers will progress to clinically overt disease. Likewise, many patients have underevaluated and unpredictable extent of their prostate carcinoma, thus resulting in inadequate therapeutic strategies. It is clear that we need to identify molecular and/or cellular markers that are able to define the invasive and metastatic potential of prostate cancer on an individual patient basis. Acquisition of metastatic ability is a definitive criterion by which substage localized prostate cancers. Under the light of recent studies designed to identify some of the features associated with the metastatic phenotype of prostate cancer, the authors review recent advances aimed at gaining insight into those factors that may be involved in prostate cancer metastasis. [less ▲]

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See detailExploration du testicule cryptorchide non palpe
Waltregny, David ULg; de Leval, Jean ULg

in Acta Urologica Belgica (1995), 63(2), 69-76

Cryptorchidism affects approximately 1 in 150 boys. Non-palpable testes represent nearly 20% of all cases. If present, they are situated between the inferior renal pole and the external inguinal ring ... [more ▼]

Cryptorchidism affects approximately 1 in 150 boys. Non-palpable testes represent nearly 20% of all cases. If present, they are situated between the inferior renal pole and the external inguinal ring. Often at surgical exploration, however, a "nubbin" of testicular tissue is found at the end of blind ending spermatic vessels without demonstration of a recognizable testis; this finding is referred to as an absent testis. In other patients, no vascular or ductular (epididymis-vas deferens) or even testicular structure can be observed. This situation defines true testicular agenesis. Non-palpable testes have an increased risk of malignant transformation, infertility, associated inguinal hernia and congenital ductular abnormalities. Surgical treatment is often more complex and unsuccessful. Many imaging diagnostic methods to investigate patients with non-palpable testes (pneumoperitoneography, angiography, ultrasonography, CT scan and RMN) have been used so far but none of these has been uniformly accepted as the ideal investigative technique because they are unreliable and/or they involve a fair risk. Since Cortesi and associates first described in 1976 a case of abdominal testes identified by laparoscopy, this technique has gained increased acceptance by pediatric urologists and surgeons. Today, celioscopy plays a central role in the exploration of non-palpable cryptorchid testes. The authors try to establish an algorithm methodology for investigating non-palpable testes under the light of recently reported anatomical, pathological and surgical data. [less ▲]

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See detailFlow cytometry in prostate cancer: Histological and clinical correlation
de Leval, Laurence ULg; Waltregny, David ULg; Greimers, Roland ULg et al

in Acta Urologica Belgica (1994), 62(1), 37-43

DNA histograms were obtained by flow cytometry for 39 human prostate carcinomas (27 total prostatectomy specimens, 5 biopsies and 7 transuretral resections). The study was performed on formalin-fixed and ... [more ▼]

DNA histograms were obtained by flow cytometry for 39 human prostate carcinomas (27 total prostatectomy specimens, 5 biopsies and 7 transuretral resections). The study was performed on formalin-fixed and paraffin-embedded material. In this report, ploidy index did not seem to be a good marker of prognosis as no significant variation in ploidy was found neither among the different stages nor among the different Gleason categories. Proliferative index of the tumors seemed to be a more sensitive parameter; a significant relation was observed between proliferative index and stage of the tumor. The authors discuss these results under the light of previously reported observations. [less ▲]

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See detailCytofluorometric analysis of prostate cancer specimens: Histological and clinical correlations
de Leval, Laurence ULg; Waltregny, David ULg; Greimers, Roland ULg et al

in Acta Urologica Belgica (1994, January), 62

DNA histograms were oblained by flow cytometry for 39 human prostate carcinomas (27 total proslatectomy specimens, 5 biopsies and 7 transuretral resections). The study was performed on formalin-fixed and ... [more ▼]

DNA histograms were oblained by flow cytometry for 39 human prostate carcinomas (27 total proslatectomy specimens, 5 biopsies and 7 transuretral resections). The study was performed on formalin-fixed and paraffin-embedded. material. In this report, ploidy index did not seem to be a good marker of prognosis as no significant variation in ploidy was found neither among the different stages nor among the different Gleason categories. Proliferative index of the tumors seemed to be a more sensitive parameter; a significant relation was observed between proliferative index and stage of the tumor. The authors discuss these results under the light of previously reported observations. [less ▲]

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See detailAngiosarcome hépatique chez une patiente ayant présenté une hépatite autoimmune
Reginster, M. A.; Mazy, V.; Waltregny, David ULg et al

in Revue Médicale de Liège (1993), 48(4), 220-3

Detailed reference viewed: 134 (8 ULg)