References of "Verwilghen, Denis"
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See detailSedation and locoregional Anesthesias of the head in the horse
Verwilghen, Denis ULg

Conference (2010, September 25)

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See detailOrthodontic corrections (Overjet/overbite) foals and osteodistraction adult horse
Verwilghen, Denis ULg

Conference (2010, September 24)

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See detailComputed Tomographic Features of Choanal Atresia in a Friesian Foal
Van Galen, Gaby ULg; Bolen, Géraldine ULg; Verwilghen, Denis ULg et al

in Journal of Equine Veterinary Science (2010), 30(8), 436-440

A 3 week old Friesian foal colt was presented with a history of respiratory distress since birth. Endoscopy showed obstruction of the right nasal passage to the nasopharynx. Computed tomography (CT) was ... [more ▼]

A 3 week old Friesian foal colt was presented with a history of respiratory distress since birth. Endoscopy showed obstruction of the right nasal passage to the nasopharynx. Computed tomography (CT) was performed to further characterize this unilateral blockage: images showed demonstrated a complete membranous obstruction of the ventral meatus, together with a deviation of the vomer bone to the left. The diagnosis of unilateral choanal atresia was confirmed. This is the first report describing CT features of choanal atresia in a foal. [less ▲]

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See detailRetrospective evaluation of 9 horses with surgical treatment of keratoma
Salciccia, Alexandra ULg; Bouhmala, Nabil; Serteyn, Didier ULg et al

Poster (2010, July 02)

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See detailEvaluation of a hydro-alcoholic solution as pre-surgical hand antisepsis in a veterinary setting.
Verwilghen, Denis ULg; Mastrocicco, Emilie; Mainil, Jacques ULg et al

Conference (2010, July 02)

Introduction: Despite the fact that presurgical antiseptic hand treatment of surgical staff has since become a worldwide accepted procedure, surgical site infection is still one of the most frequent types ... [more ▼]

Introduction: Despite the fact that presurgical antiseptic hand treatment of surgical staff has since become a worldwide accepted procedure, surgical site infection is still one of the most frequent types of nosocomial infections. Many products have been used for hand antisepsis, but the popularity of alcoholic rubs amongst human surgeons is increasing as they have shown to provide a rapid and immediate action, are considerably faster than disinfecting soap scrubs and cause less skin damage after repeated use. The purpose of this study was 1) to identify surgical hand antisepsis habits amongst veterinary surgery specialists in Europe (ECVS) and the United States (ACVS), 2) to compare povidone iodine and chlorhexidine gluconate scrubs with a hydro-alcoholic rub hand antisepsis protocol and 3) to evaluate the usefulness of a hydro-alcoholic rub solution in a veterinary surgical setting. Materials and Methods: Emails were sent to 1300 Diplomates to invite them to participate to an online survey in order to obtain an idea about pre-surgical hand disinfection techniques. In a preliminary trial the efficiency of 4% chlorhexidine gluconate, 7.5 % PVP-iodine and an alcoholic solution containing 45% 2-propanol, 30% 1-propanol, 0.2% mecetronium ethylsulphate (Sterillium®) in bacterial reduction on hands was compared. In a clinical trial, the suitability of Sterillium® was assessed in an equine and small animal set up during surgery procedures. Fingertips were pressed on blood agar plates and Gassner plates prior to hand antisepsis (PHA), after handantisepsis (AHA) and three hours after wearing sterile gloves (AG) in the preliminary trial or at the end of surgery (AS) in the clinical trial. Bacterial counts (colony forming units : CFU’s) were obtained after 24 h of incubation of the plates. The obtained values of CFU from PHA, AHA, AG and AS were expressed as log10 values. For each sample, a reduction factor (RF) was obtained from the difference of log10 pre-value and log10 post-value. An ANOVA comparison between the effects of the different antisepsis protocols on the mean log10 CFU values and RF’s in function of the different steps was established. Results: A 42.6% response rate was obtained for the survey. Most surgeons’ still use a disinfecting soap only (79.9%) for hand antisepsis prior to surgery, the majority based on chlorhexidine gluconate (81.4%). Significant differences were found between immediate and sustained activities of the different products tested. Sterillium® was shown to have significantly lower LSM log10 CFU at AG compared to both other products. At AHA, povidone iodine revealed to have significantly higher LSM log10 CFU than Sterillium® and chlorhexidine gluconate, with the last two products having comparable activities. Reduction factors for the Sterillium® were significantly greater than for the other products. Only RF1 was comparable between Sterillium® and chlorhexidine gluconate. In the clinical trial, no significant differences were found between surgeons regarding LSM log10 CFU after hand antisepsis, neither between RF from samples taken at the small animal versus the equine surgery theatre. Discussion: This study confirms that Sterillium® is more effective in reducing bacterial counts on hands prior to surgery in a veterinary setting as are chlorhexidine gluconate (CHX) and povidone iodine soap. Moreover, they provide better tolerance and compliance to surgical hygiene protocols. Despite this, veterinary surgeons from all over the world still prefer the use of CHX soap, which has far more disadvantages than commonly accepted. Apart from the better skin tolerance and the absence of known resitance to the product, the use of Sterillium® offers the advantage of a fast (1.5 minute) surgical handantisepsis. This study shows that, as previously reported for human medicine, Sterillium® can safely be used in a veterinary surgical setting. [less ▲]

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See detailWhats your diagnosis: fragmentation of the proximal tubercle of the talus
Verwilghen, Denis ULg; Bolen, Géraldine ULg; Paindavaine, Pierre et al

in Journal of the American Veterinary Medical Association [=JAVMA] (2010), 1(237),

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See detailMeckel's diverticulum as a cause of colic: 2 cases with different morphological features
Verwilghen, Denis ULg; Van Galen, Gaby ULg; Busoni, Valeria ULg et al

in Tijdschrift voor Diergeneeskunde (2010), 135(11), 452-455

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See detailSTEM CELL IN THE TREATMENT OF TENDONITIS IN EQUINE PATIENTS
Verwilghen, Denis ULg; Briquet, Alexandra ULg; Gothot, André ULg et al

Poster (2010, May 07)

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See detailGene expression profiling from leukocytes of horses affected by osteochondrosis.
Serteyn, Didier ULg; Piquemal, D.; Vander Heyden, Laurent ULg et al

in Journal of Orthopaedic Research (2010)

Osteochondrosis (OC) is a developmental disease that affects growing horses and that severely affects their ability to perform. The genetic basis of its pathogenesis is poorly understood. The aim of the ... [more ▼]

Osteochondrosis (OC) is a developmental disease that affects growing horses and that severely affects their ability to perform. The genetic basis of its pathogenesis is poorly understood. The aim of the study was to analyze the transcript profile of leukocytes from horses affected with OC. Two transcriptome libraries were constructed from leukocytes of OC-affected and non-OC-affected horses using digital gene expression analysis (DGE) and real-time PCR. Statistical analysis allowed selection of 1,008 tags upregulated in the non-OC-affected group and 1,545 tags upregulated in the OC-affected group. Among these genes, 16 regulated genes and 5 housekeeping genes were selected. Metabolic pathways analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation or cartilage repair, including Wnt, Indian hedgehog, and TGF-beta signaling. Other genes, including ISG, ApoB, MGAT4, and TBC1D9, showed a significantly different expression between groups. These genes may play a role in high carbohydrate diet, abnormal insulin metabolism, or inflammation, mechanisms suspected to be involved in OC. This DGE analysis of the transcript profile of leukocytes from OC-affected horses demonstrated significant differences in comparison to the control library. These results open new perspectives for the understanding of equine OC. (c) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res. [less ▲]

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See detailLes tendinopathies et desmopathies des régions métacarpienne et –tarsienne: revue des thérapies actuelles. Seconde partie : les traitements
Verwilghen, Denis ULg; Caudron, Isabelle; Van Galen, Gaby ULg et al

in Annales de Médecine Vétérinaire (2010), 154(1), 1-15

Lesions to the horse’s tendon are very frequent and are a non negligible reason for early retirement of sport and leisure horses. For decades man has been searching for “the” treatment but unfortunately ... [more ▼]

Lesions to the horse’s tendon are very frequent and are a non negligible reason for early retirement of sport and leisure horses. For decades man has been searching for “the” treatment but unfortunately most of the known treatments have empiric bases and very few have actually proven their real efficiency. Diagnostic techniques like ultrasound allows to better evaluate the improvements made in tendonitis therapies. Stem cells and gene therapy are probably the most innovating of them, but their long-term effectiveness still has to stand the test of times. This article gives an overview of the possible treatments of tendonitis today. [less ▲]

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See detailDe behandeling van overbeet bij het paard
Verwilghen, Denis ULg; Vlaminck, Lieven

in Vlaams Diergeneeskundig Tijdschrift (2010), 79

Overbeet is de meest voorkomende congenitale tandafwijking bij het veulen. Minimale overbeten behoeven waarschijnlijk geen specifieke behandeling echter in erg aangetaste dieren kunnen zich secundaire ... [more ▼]

Overbeet is de meest voorkomende congenitale tandafwijking bij het veulen. Minimale overbeten behoeven waarschijnlijk geen specifieke behandeling echter in erg aangetaste dieren kunnen zich secundaire tandproblemen ontwikkelen. Erge overbeet kan gemakkelijk bij het onvolwassen dier door middel van een orthodontische behandeling worden aangepakt. Hiertoe wordt een beugel geplaatst die de groei van de maxilla remt. Bij volwassen dieren echter zal een erge overbeet enkel middels een dure en invasieve chirurgische ingreep gecorrigeerd kunnen worden. Dit artikel geeft een overzicht van de courante terminologie ter beschrijving van overbeet bij het paard en bespreekt achtereenvolgens de verschillende mogelijkheden tot correctie van deze afwijking bij onvolwassen en volwassen dieren. [less ▲]

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See detailEuropean outbreak of atypical myopathy in the autumn 2009.
Van Galen, Gaby ULg; Amory, Hélène ULg; Busschers, Evita et al

in Journal of Veterinary Emergency & Critical Care (2010)

Background: Atypical myopathy (AM) is an acute, severe rhabdomyolysis occurring in grazing horses. Since In the beginning of October 2009, a new outbreak affects started in several European countries ... [more ▼]

Background: Atypical myopathy (AM) is an acute, severe rhabdomyolysis occurring in grazing horses. Since In the beginning of October 2009, a new outbreak affects started in several European countries. Geographic, demographic and clinical data of the reported cases in the month October 2009 are described. Key Findings: The survival rate over the month October 2009 was 25%. The most frequently observed clinical signs were congestedive mucous membranes, dyspnea, tachycardia, depression, weakness, stiffness, recumbency, trembling, transpirationsweating, and myoglobinuria. Non-survivors were significantly more often likely to be recumbent than survivors. Prognostic factors, symptomatic treatment and preventive measures are discussed. Significance: Slight differences were encountered during the described outbreak of AM in October 2009 compared to previous studies. Equine practitioners should be alert aware that previous epidemiological studies have shown that after a high prevalence this autumn, for new cases are likely to occur in the upcoming spring 2010. [less ▲]

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See detailPrevalence of radiographic findings in candidate sires (2001-2008)
Verwilghen, Denis ULg; Serteyn, Didier ULg; Pille, Frederik et al

in Vlaams Diergeneeskundig Tijdschrift (2009), 78

Radiographic screening of horses prior to purchase or admission to studbooks has become an important tool for evaluating the osteo-articular status of the animals. Developmental orthopedic disorders (DOD ... [more ▼]

Radiographic screening of horses prior to purchase or admission to studbooks has become an important tool for evaluating the osteo-articular status of the animals. Developmental orthopedic disorders (DOD) are the main cause of potential lameness in youngsters. The genetic factor associated with DOD has been established, and specific selection schemes have been developed to diminish the prevalence of lesions. Increasing knowledge of prevalence in different breeds may help in developing specific breeding strategies. This article presents the results of the radiographic screening of 676 stallions presented for sire admission to the Royal Belgian Sports Horse Society (Studbook sBs). On average, two radiographic findings were noted per horse. The prevalence of DOD in this population was 38.9%. A high percentage of horses showed radiographic signs of effusion of the distal interphalangeal joint. An uncommon fragment location at the proximal tubercle of the talus was found in 7 horses. The present paper presents a review and discussion of all the radiographic findings. [less ▲]

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See detailLes tendinopathies et desmopathies de la région métacarpienne et –tarsienne: une revue des thérapies actuelles. Première partie : la structure, les lésions du tendon et le diagnostic.
Verwilghen, Denis ULg; Gabriel, Annick ULg; Busoni, Valeria ULg et al

in Annales de Médecine Vétérinaire (2009), 3(153), 145-155

Lesions to the horse’s tendon are very frequent and are a non negligible reason for early retirement of sport and leisure horses. For decades man has been searching for “the” treatment but unfortunately ... [more ▼]

Lesions to the horse’s tendon are very frequent and are a non negligible reason for early retirement of sport and leisure horses. For decades man has been searching for “the” treatment but unfortunately most of the known treatments have empiric bases and very few have actually proven their real efficiency. Better knowledge of tendon anatomy and pathophysiology of tendonitis together with evolutions in diagnostic techniques like ultrasonography allows us to better evaluate the improvements made in tendonitis therapies today. The first part of this article gives a review on tendon structure, tendon healing and ultrasonographic evaluation of the tendon. In the second part an overview of therapeutic options for tendonitis will be discussed. [less ▲]

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See detailEvaluation of low-molecular-weight heparin for the prevention of equine laminitis after colic surgery
de la Rebière de Pouyade, Geoffroy ULg; Grulke, Sigrid ULg; Detilleux, Johann ULg et al

in Journal of Veterinary Emergency and Critical Care (2009), 19(1), 113-119

Objectives – The aim of this study is to describe the prevalence of postoperative laminitis in colic cases and to determine if low-molecular-weight heparin (LMWH) is effective in preventing this ... [more ▼]

Objectives – The aim of this study is to describe the prevalence of postoperative laminitis in colic cases and to determine if low-molecular-weight heparin (LMWH) is effective in preventing this complication. Design – Retrospective clinical study. Animals – Client-owned horses. Interventions – SC administration of enoxaparin during the postoperative period. Measurements and Main Results – Medical records of 360 horses undergoing surgery for colic and surviving at least 3 days were evaluated. Fifty-six horses admitted before 1995 did not receive LMWH (control group) and 304 admitted after 1995 received LMWH as a prophylaxis for laminitis (treatment group). Three grades of severity were defined for laminitis. Prevalence and severity of laminitis were compared between the 2 groups. Several parameters recorded on admission (sex, age, breed, site and nature of the disease, heart rate, PCV, gravity score, and shock score) and the administration of LMWH were tested as risk factors in the development of laminitis in a logistic regression procedure. Prevalence and grade of laminitis were significantly lower in the treatment group. Only the absence of LMWH was recognized as a significant risk factor in the logistic regression model. Conclusions – The administration of LMWH appears to be effective in the prophylaxis of laminitis following colic surgery and may be useful in the postoperative management of these horses. [less ▲]

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See detailRelationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions
Verwilghen, Denis ULg; Busoni, Valeria ULg; Gangl, Monika et al

in Research in Veterinary Science (2009), 87(2), 319-28

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could reveal to be an interesting alternative to this ... [more ▼]

Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could reveal to be an interesting alternative to this procedure which is time consuming and sometimes technically difficult. The aim of this study was to investigate the relationship between the radiological status of the horses and the levels of biochemical markers of cartilage degradation and synovial inflammation. A specific radiological scoring and classification system was therefore developed and applied on 63 stallions presented for studbook admission. Additionally, groups of horses were established according to the occurrence of osteochondrosis, degenerative joint disease and distal interphalangeal joint effusion. Insulin growth factor-I, myeloperoxidases, Coll2-1 and Coll2-1NO(2) were used as blood markers. The combination of the blood parameters did not seem to correlate with the used scoring system. Coll2-1NO(2) levels however tended to increase with poorer radiological class and this could therefore potentially be a useful predictor of the osteoarticular status in the horse. Coll2-1 levels were significantly higher in the degenerative joint disease group. A high percentage of horses with distal interphalangeal joint effusion was present in this study and was associated with decreased IGF-I and increased Coll2-1 levels. [less ▲]

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