References of "Van der Linden, Martial"
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See detailThe neural substrates of the central executive: Exploration of the updating and shifting processes
Collette, Fabienne ULg; Van der Linden, Martial ULg; Delchambre, Marie et al

Conference (2002, December)

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See detailExploring the effect of action familiarity on SPTs recall performance in Alzheimer's disease
Lekeu, Françoise ULg; Van der Linden, Martial ULg; Moonen, Gustave ULg et al

in Journal of Clinical & Experimental Neuropsychology (2002), 24(8), 1057-1069

This study examined the performance of normal controls (NC) and Alzheimer's disease (AD) patients on free recall, semantic cued recall and object cued recall of both subject-performed tasks (SPTs) and ... [more ▼]

This study examined the performance of normal controls (NC) and Alzheimer's disease (AD) patients on free recall, semantic cued recall and object cued recall of both subject-performed tasks (SPTs) and verbal descriptions of actions, by controlling familiarity of actions associated to objects. The results showed that both groups performed better after SPT encoding than after verbal encoding. in all three types of recall. In addition, this SPT advantage was greater for AD patients than for NC in the object cued recall test, emphasizing AD patients' sensibility to the congruence of cues between encoding and retrieval conditions. Following verbal encoding. NC showed a better recall for less familiar actions than for highly familiar actions, whereas AD patients exhibited the opposite pattern. These results reflect that AD patients did not benefit from a distinctiveness effect at encoding for improving subsequent retrieval of verbal information, probably due to a reduced level of elaboration during encoding. However, there was no effect of action familiarity on recall performance by both groups following SPT encoding. These results suggest that memory for verbal actions and SPTs is governed by different principles. In addition. they demonstrate the robustness of the SPT effect in AD patients, who were able to improve memory performance in the SPT condition not only with highly familiar actions but also with less familiar actions. [less ▲]

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See detailThe neural substrates of the central executive: Exploration of the updating and shifting processes
Collette, Fabienne ULg; Van der Linden, Martial ULg; Delchambre, Marie et al

Conference (2002, September)

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See detailTraining early Alzheimer patients to use a mobile phone
Lekeu, Françoise ULg; Wojtasik, Vinciane ULg; Van der Linden, Martial ULg et al

in Acta Neurologica Belgica (2002), 102(3), 114-121

The mobile phone may be useful to keep in contact with spatially disoriented and memory impaired patients. In keeping with this idea, this study describes the training program developed to teach two ... [more ▼]

The mobile phone may be useful to keep in contact with spatially disoriented and memory impaired patients. In keeping with this idea, this study describes the training program developed to teach two patients with mild Alzheimer's disease (CI and ML) how to use their own mobile phone. Each training session was divided into two parts. In the first part, the spaced-retrieval technique was used to promote the consultation of a card pasted on the back of the phone. The card detailed each stage of phone utilization and which keys had to be pressed to call somebody. In the second part, the patients received repetitive exercises of calling based upon the errorless learning principle. At the end of three-months rehabilitation, the results showed different learning patterns for the patients. ML needed more spaced-retrieval sessions to spontaneously consult the card and to correctly use the phone, compared to CI However, by the repetition of calling exercises, both patients showed a decrease of instruction card consultation, whereas they were still able to correctly call somebody. This learning ability is hypothesized to be a consequence of a relatively preserved procedural memory in both patients. In conclusion, this study highlights the effectiveness of combined specific learning techniques for improving AD patient's autonomy in daily life activities. [less ▲]

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See detailA PET investigation of lexicality and phonotactic frequency in oral language processing
Majerus, Steve ULg; Collette, Fabienne ULg; Van der Linden, Martial ULg et al

in Cognitive Neuropsychology (2002), 19(4), 343-360

Lexicality and phonotactic frequency effects are observed in many cognitive studies on language processing, but little is known about their underlying neural substrates, especially with regard to ... [more ▼]

Lexicality and phonotactic frequency effects are observed in many cognitive studies on language processing, but little is known about their underlying neural substrates, especially with regard to phonotactic frequency effects. Here, we conducted a positron emission tomography (PET) study in which 11 right-handed volunteers had either to repeat or to listen to lists of words, high phonotactic frequency nonwords, and low phonotactic frequency nonwords. The comparison of word versus nonword processing consistently confirmed previous findings of left temporal and prefrontal activations classically ascribed to lexicosemantic processing. Higher activation was found in the right posterior superior temporal gyrus when comparing high phonotactic frequency nonwords to words, but not when comparing low phonotactic frequency nonwords to words. We propose that this region is implicated in the formation of temporary phonological representations for high-probability phonological events, which may support processing of high phonotactic frequency nonwords [less ▲]

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See detailPréservation de la reconnaissance basée sur la familiarité chez un patient amnésique
Bastin, Christine ULg; Van der Linden, Martial ULg; Charnallet, Annick et al

Poster (2002, May 24)

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See detailBrain imaging of the central executive component of working memory
Collette, Fabienne ULg; Van der Linden, Martial ULg

in Neuroscience & Biobehavioral Reviews (2002), 26(2), 105-125

This review presents neuroimaging studies which have explored the cerebral substrates of the central executive component of the working memory model proposed by Baddeley and Hitch [working memory (1986 ... [more ▼]

This review presents neuroimaging studies which have explored the cerebral substrates of the central executive component of the working memory model proposed by Baddeley and Hitch [working memory (1986); Recent advances in learning and motivation (1974)]. These studies have demonstrated that different executive functions (manipulating and updating of information, dual-task coordination, inhibition and shifting processes) not only recruit various frontal areas, but also depend upon posterior (mainly parietal) regions. Such results are in agreement with the hypothesis that executive functions rely on a distributed cerebral network not restricted to anterior cerebral areas. Moreover, the intervention of similar prefrontal regions in a large number of executive tasks suggests that the central executive functioning must be understood in terms of different interactions between a network of regions rather than in terms of a specific association between one region and one higher-level cognitive process [less ▲]

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See detailNormal mere exposure effect with impaired recognition in Alzheimer's disease
Willems, Sylvie ULg; Adam, Stéphane ULg; Van der Linden, Martial ULg

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2002), 38(1), 77-86

We investigated the mere exposure effect and the explicit memory in Alzheimer's disease (AD) patients and elderly control subjects, using unfamiliar faces. During the exposure phase, the subjects ... [more ▼]

We investigated the mere exposure effect and the explicit memory in Alzheimer's disease (AD) patients and elderly control subjects, using unfamiliar faces. During the exposure phase, the subjects estimated the age of briefly flashed faces. The mere exposure effect was examined by presenting pairs of faces (old and new) and asking participants to select the face they liked. The participants were then presented with a forced-choice explicit recognition task. Controls subjects exhibited above-chance preference and recognition scores for old faces. The AD patients also showed the mere exposure effect but no explicit recognition. These results suggest that the processes involved in the mere exposure effect are preserved in AD patients despite their impaired explicit recognition. The results are discussed in terms of Seamon et al.'s (1995) proposal that processes involved in the mere exposure effect are equivalent to those subserving perceptual priming. These processes would depend on extrastriate areas which are relatively preserved in AD patients. [less ▲]

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See detailProcessus attentionnels et vieillissement normal
Adam, Stéphane ULg; Van der Linden, Martial ULg; Collette, Fabienne ULg

in Couillet, Josettte; Leclerq, Michel; Moroni, Christine (Eds.) et al Neuropsychologie de l'attention (2002)

De très nombreuses études ont mis en évidence une diminution de performance des sujets âgés dans une grande variété de tâches cognitives, à la fois en condition de laboratoire et dans la vie réelle ... [more ▼]

De très nombreuses études ont mis en évidence une diminution de performance des sujets âgés dans une grande variété de tâches cognitives, à la fois en condition de laboratoire et dans la vie réelle. Cependant, ce déclin lié à l'âge n'est pas observé dans toutes les situations et les personnes âgées peuvent même présenter dans certaines tâches des performances supérieures à celles des sujets jeunes. [less ▲]

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See detailEffet de Simple exposition et reconnaissance pour des objets tridimensionnels chez des enfants âgés de 5 à 12 ans et des jeunes adultes
Catale, Corinne ULg; Willems, Sylvie ULg; Van der Linden, Martial ULg

Poster (2002)

Introduction Chez l’adulte, il est classiquement observé que l’exposition répétée à des stimuli conduit à un accroissement de la préférence pour ces derniers en comparaison à de nouveaux stimuli (Effet de ... [more ▼]

Introduction Chez l’adulte, il est classiquement observé que l’exposition répétée à des stimuli conduit à un accroissement de la préférence pour ces derniers en comparaison à de nouveaux stimuli (Effet de simple exposition, ESE; [1]). En revanche, un grand nombre d’études [2] montrent chez l’enfant un effet inverse suggérant une préférence pour la nouveauté. Le but de cette étude est d’utiliser le paradigme de simple exposition chez des enfants de différentes tranches d’âge afin de déterminer la période durant laquelle la préférence pour la nouveauté s’inverse et est remplacée par la préférence pour la familiarité. Participant 16 enfants (de 5 à 6 ans et de 7 à 8 ans), 22 enfants (de 9 à 10 ans), et 17 enfants (de 11 à 12 ans) et 16 jeunes adultes (de 18 à 30 ans). Matériel Dans la phase d’encodage, les sujets évaluent l’orientation (droite/gauche) de 12 figures tridimensionnelles présentées 5 fois durant 2,5 secondes. Lors de la phase test, le sujet est soumis à deux tâches de jugement à choix forcés (préférence et reconnaissance) sur 12 paires d’objets tridimensionnels nouveaux-familiers. Les deux jugements se portent sur les mêmes items et leur ordre de passation est contrebalancés entre les sujets. Résultats et Discussion Un effet de préférence différent du hasard est observé chez les adultes (P<.05) dans le sens d’une préférence pour les stimuli préalablement exposés (ESE), mais non chez les enfants (Ps>.1). Pourtant, lorsque l’on examine les relations entre préférence et reconnaissance, on constate que les enfants de 5/6 ans ont tendance à préférer les nouvelles figures et non les figures préalablement exposées et reconnues (Chi-carré= -.15, p=.05). En revanche, cette tendance s’inverse au cours du développement, et ce, dès 11/12 ans où les enfants tendent à préférer les stimuli préalablement exposés et reconnus (Chi-carré=.17, p=.02). Ce choix de préférence pour les stimuli familiers persistent chez les jeunes adultes (p<.05). Notre étude montre que les plus jeunes enfants ont tendance à préférer les nouveaux stimuli alors que les jeunes adultes préfèrent les stimuli familiers quand on compare leurs choix de préférence à leur performance en reconnaissance. A partir de 11-12 ans, les enfants montrent le pattern inverse indiquant un « shifting » de la préférence pour la nouveauté vers la préférence pour la familiarité. Ces données montrent que les scores en reconnaissance influencent différemment la préférence en fonction de l’âge. [less ▲]

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See detailImplicit learning abilities of amnesic patients
Meulemans, Thierry ULg; Van der Linden, Martial ULg

in French, R. (Ed.) Implicit learning (2002)

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See detailEffects of incidental and intentional feature binding on recognition: a behavioural and PET activation study
Lekeu, Françoise ULg; Van der Linden, Martial ULg; Collette, Fabienne ULg et al

in Neuropsychologia (2002), 40(2), 131-144

Using Positron Emission Tomography (PET), we investigated cerebral regions associated with the episodic recognition of words alone and words bound to contextual colours. Two modes of colour encoding were ... [more ▼]

Using Positron Emission Tomography (PET), we investigated cerebral regions associated with the episodic recognition of words alone and words bound to contextual colours. Two modes of colour encoding were tested: incidental and intentional word-to-colour binding. Word-only recognition was associated with brain activation in a lexico-semantic left middle temporal region and in the cerebellum following an incidental colour encoding, and with brain activation in the left posterior middle frontal gyrus, right anterior cingulate and right inferior frontal gyrus following an intentional encoding. Recognition of bound features was associated with activation in left prefrontal and superior parietal regions following an incidental colour encoding, and with preferential right prefrontal cortex activation following an intentional colour encoding. Our results are in line with the hypothesis of a parietal involvement in context processing, and prefrontal areas in monitoring retrieval processes. Our results also support the hypothesis of a 'cortical asymmetry for reflective activity' (CARA). [less ▲]

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See detailFrontal hypometabolism does not explain inhibitory dysfunction in Alzheimer disease
Collette, Fabienne ULg; Van der Linden, Martial ULg; Delrue, Gaël ULg et al

in Alzheimer Disease and Associated Disorders (2002), 16(4, Oct-Dec), 228-238

A series of tasks assessing inhibitory processes was administered to patients with Alzheimer disease and control subjects. Two groups of patients with Alzheimer disease were examined: patients with ... [more ▼]

A series of tasks assessing inhibitory processes was administered to patients with Alzheimer disease and control subjects. Two groups of patients with Alzheimer disease were examined: patients with hypometabolism restricted to the posterior (temporal and parietal) cerebral areas and patients with hypometabolism in both posterior and anterior (frontal) cerebral areas. The performances of the patients with Alzheimer disease were inferior to those of control subjects on all inhibitory tasks, but the two groups of patients obtained similar scores. These data indicate that frontal lobe hypometabolism is not necessary to produce inhibitory impairment in Alzheimer disease. Consequently, inhibitory dysfunction could be the consequence of a (partial) disconnection process between posterior and anterior cerebral areas. [less ▲]

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See detailAttention et mémoire de travail
Van der Linden, Martial ULg; Collette, Fabienne ULg

in Couillet, J.; Leclerq, M.; Moroni, C. (Eds.) et al La neuropsychologie de l'attention (2002)

Les concepts d'attention et de mémoire de travail ont très souvent été considérés de façon distincte, que ce soit dans le domaine de la recherche ou dans celui de la pratique clinique en neuropsychologie ... [more ▼]

Les concepts d'attention et de mémoire de travail ont très souvent été considérés de façon distincte, que ce soit dans le domaine de la recherche ou dans celui de la pratique clinique en neuropsychologie. Or, une analyse détaillée des modèles théoriques de l'attention et de la mémoire de travail indique au contraire qu'il existe un large recouvrement entre ces deux domaines. L'objectif de ce chapitre est de mettre en exergue ces relations et recouvrements. Plus spécifiquement, nous montrerons en quoi la mémoire de travail a une fonction essentielle de contrôle attentionnel de l'action, nous décrirons les études d'imagerie fonctionnelle ayant exploré les bases cérébrales de cette fonction de contrôle attentionnel et nous présenterons enfin quelques travaux ayant mis en évidence une relation spécifique entre mémoire de travail, attention sélective et vigilance. [less ▲]

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See detailInhibition et lobes frontaux
Le Gall, Didier; Van der Linden, Martial ULg; Andrès Bénito, Pilar et al

in Boujon, C. (Ed.) L'inhibition au carrefour des neurosciences et des sciences de la cognition : fonctionnements normal et pathologique (2002)

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See detailArtificial grammar learning and amnesia
Meulemans, Thierry ULg; Van der Linden, Martial ULg

in French, Robert; Cleeremans, Axel (Eds.) Implicit learning and consciousness : an empirical, philosophical, and computational consensus in the making (2002)

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See detailPreserved familiarity-based recognition memory in a case of global amnesia
Bastin, Christine ULg; Van der Linden, Martial ULg; Charnallet, Annik et al

in Journal of Cognitive Neuroscience (2002), 14(Supplemental), 32

Whether recognition memory can be preserved relative to recall in global amnesia is a matter of debate. Some studies suggest that amnesic patients with selective lesion to the hippocampal circuit show a ... [more ▼]

Whether recognition memory can be preserved relative to recall in global amnesia is a matter of debate. Some studies suggest that amnesic patients with selective lesion to the hippocampal circuit show a relatively normal recognition memory in the presence of impaired recall. However, other findings did not support this assumption. We investigated the recognition memory performance of a patient (ER) who became amnesic following a carbon monoxide poisoning. The MR scan revealed bilateral lesions to the pallidum. Based on the aetiology, a hippocampal lesion is suspected, but needs to be confirmed by a volumetric analysis. The recall and recognition performance of the patient was tested by means of the nonverbal subtests of the Doors and People Test Battery, which were matched on difficulty. On these subtests, ER’s recall performance was much more impaired than his recognition memory. ER’s recognition memory performance was further examined on a yes-no and a forced-choice recognition memory task, using faces as material. On the yes-no task, ER’s hit rate was normal, but he made a lot of false alarms compared to control subjects. By contrast, his forced-choice recognition memory was completely normal. This suggests that ER is able to use the familiarity process to make recognition decisions. Familiarity and recollection were finally investigated with a recognition task using the Process Dissociation Procedure (Jacoby, 1991). On this task, ER’s familiarity score was normal, whereas his recollection score was lower. These results support the assumption that familiarity-based recognition memory can be preserved in amnesia. [less ▲]

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See detailMemory for temporal context: Effects of aging and retrieval strategies
Bastin, Christine ULg; Van der Linden, Martial ULg

in Proceedings of the International Conference Binding in Human Memory: A neurocognitive approach (2002)

The purpose of the present study was to re-explore the effects of age on memory for temporal context, assessed by a list discrimination task. Contrary to previous studies, each list (with faces as stimuli ... [more ▼]

The purpose of the present study was to re-explore the effects of age on memory for temporal context, assessed by a list discrimination task. Contrary to previous studies, each list (with faces as stimuli) was associated with a different type of judgement (honesty versus intelligence rating). The results showed no age differences on this task when no particular retrieval strategy was induced. However, when participants were encouraged to retrieve the list of occurrence of the items by retrieving the type of judgement made at encoding, there was an age effect. Older adults’ performance was at chance, whereas younger adults had a good performance. Moreover, younger adults who reported using the strategy performed as well as younger adults who did not use it. These results will be discussed by reference to the distinction between automatic versus effortful encoding processes. [less ▲]

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See detailProcessus attentionnels et maladie d'Alzheimer
Collette, Fabienne ULg; Van der Linden, Martial ULg

in Couillet, J.; Leclerq, M.; Moroni, C. (Eds.) et al La neuropsychologie de l'attention (2002)

La maladie d'Alzheimer se caractérise par l'accumulation progressive de déficits affectant différents domaines cognitifs.(...)Il est maintenant largement reconnu que la maladie d'Alzheimer n'affecte pas ... [more ▼]

La maladie d'Alzheimer se caractérise par l'accumulation progressive de déficits affectant différents domaines cognitifs.(...)Il est maintenant largement reconnu que la maladie d'Alzheimer n'affecte pas tous les processus cognitifs de façon équivalente.(...)Les modèles cognitifs de l'attention suggèrent que l'attention n'est pas un système homogène et que différents types de processus attentionnels peuvent être distingués.(...)Le but de ce chapitre est de présenter les travaux les plus représentatifs ayant exploré ces différents types de processus dans la maladie d'Alzheimer. [less ▲]

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