References of "Van Oosterwyck, Hans"
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See detailMultiscale modelling of the influence of VEGF on sprouting angiogenesis.
Carlier, Aurélie ULg; Geris, Liesbet ULg; Van Oosterwyck, Hans

Poster (2012, July 06)

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See detailBridging the Gap: A Theoretical Model of Mechanotransduction Through ERK Signalling
Kerkhofs, Johan ULg; Geris, Liesbet ULg; Bosmans, Bart et al

Conference (2012, July 02)

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See detailTip cells at the top: a multiscale model of sprouting angiogenesis.
Carlier, Aurélie ULg; Geris, Liesbet ULg; Van Oosterwyck, Hans

Conference (2012, July 01)

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See detailRelating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype
Kerkhofs, Johan ULg; Roberts, Scott J; Luyten, Frank P et al

in PLoS ONE (2012)

During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a ... [more ▼]

During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated. [less ▲]

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See detailCoupling Cell Mechanics and Intracellular Signalling: Mechanotransduction through ERK
Kerkhofs, Johan ULg; Geris, Liesbet ULg; Bosmans, Bart et al

in Middleton, John (Ed.) The Proceedings of the 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. Hotel Berlin, Berlin, Germany, April 7th – 11th, 2012 pages:0-0 (2012, April 12)

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See detailTip cells at the top: multiscale modeling of angiogenesis during fracture healing
Carlier, Aurélie ULg; Geris, Liesbet ULg; Van Oosterwyck, Hans

in Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) - Proceedings (2012, April)

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See detailMOSAIC: a multiscale model of osteogenesis and sprouting angiogenesis with lateral inhibition of endothelial cells.
Carlier, Aurélie ULg; Geris, Liesbet ULg; Bentley, Katie et al

in PLoS Computational Biology (2012), 8(10), 1002724

The healing of a fracture depends largely on the development of a new blood vessel network (angiogenesis) in the callus. During angiogenesis tip cells lead the developing sprout in response to ... [more ▼]

The healing of a fracture depends largely on the development of a new blood vessel network (angiogenesis) in the callus. During angiogenesis tip cells lead the developing sprout in response to extracellular signals, amongst which vascular endothelial growth factor (VEGF) is critical. In order to ensure a correct development of the vasculature, the balance between stalk and tip cell phenotypes must be tightly controlled, which is primarily achieved by the Dll4-Notch1 signaling pathway. This study presents a novel multiscale model of osteogenesis and sprouting angiogenesis, incorporating lateral inhibition of endothelial cells (further denoted MOSAIC model) through Dll4-Notch1 signaling, and applies it to fracture healing. The MOSAIC model correctly predicted the bone regeneration process and recapitulated many experimentally observed aspects of tip cell selection: the salt and pepper pattern seen for cell fates, an increased tip cell density due to the loss of Dll4 and an excessive number of tip cells in high VEGF environments. When VEGF concentration was even further increased, the MOSAIC model predicted the absence of a vascular network and fracture healing, thereby leading to a non-union, which is a direct consequence of the mutual inhibition of neighboring cells through Dll4-Notch1 signaling. This result was not retrieved for a more phenomenological model that only considers extracellular signals for tip cell migration, which illustrates the importance of implementing the actual signaling pathway rather than phenomenological rules. Finally, the MOSAIC model demonstrated the importance of a proper criterion for tip cell selection and the need for experimental data to further explore this. In conclusion, this study demonstrates that the MOSAIC model creates enhanced capabilities for investigating the influence of molecular mechanisms on angiogenesis and its relation to bone formation in a more mechanistic way and across different time and spatial scales. [less ▲]

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See detailµCT-Based, Anatomical Finite Element Model of a Unilateral Fixator for Bone Reconstruction in Rabbit Tibia
Karunratanakul, Kavin; Kerckhofs, Greet ULg; Lammens, Johan et al

Conference (2012)

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See detailMultiscale modeling of sprouting angiogenesis
Carlier, Aurélie ULg; Geris, Liesbet ULg; Van Oosterwyck, Hans

Poster (2011, December 02)

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See detailCalcium phosphate scaffolds customizations for bone tissue engineering applications
Carlier, Aurélie ULg; Chai, Yoke Chin; Theys, Tina et al

Poster (2011, November 18)

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See detailA Boolean network approach to developmental engineering
Kerkhofs, Johan ULg; Roberst, Scott J; Luyten, Frank P et al

Conference (2011, June 13)

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See detailAn integrative model based approach to optimize calcium phosphate scaffold-stem cell combinations
Carlier, Aurélie ULg; Chai, Yoke Chin; Theys, Tina et al

Poster (2011, June 07)

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See detailOptimization of calcium phosphate scaffold-cell combinations using an integrative model based approach
Carlier, Aurélie ULg; Chai, Yoke Chin; Theys, Tina et al

in International Conference on Tissue Engineering (ECCOMAS) - proceedings (2011, June 03)

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See detailFluorescent microparticle incorporation in chondrogenic cell aggregates to monitor local oxygen tension
Lambrechts, Dennis; Kerckhofs, Greet ULg; Roberts, Scott et al

in Histology and Histopathology (2011)

Peer Reviewed
See detailCAD versus micro-CT based models of Ti6Al4V scaffolds for bone tissue engineering: a solid and fluid mechanical analysis
Truscello, Silvia; Kerckhofs, Greet ULg; Moesen, Maarten et al

in Proceedings of II International Conference on Tissue Engineering (2011)

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See detailA computational solid and fluid mechanical analysis of CAD-versus micro-CT-based models of regular Ti6Al4V scaffolds for bone tissue engineering
Truscello, Silvia; Kerckhofs, Greet ULg; Moesen, Maarten et al

in Histology and Histopathology (2011)

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See detailA Boolean network model of the growth plate
Kerkhofs, Johan ULg; Roberts, Scott J; Luyten, Frank P et al

Poster (2010, November 26)

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See detailComputational modelling of calcium mediated bone regeneration
Carlier, Aurélie ULg; Chai, Yoke Chin; Theys, Tina et al

Poster (2010, November 26)

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See detailA mathematical model of calcium ion influence on the activity of osteogenic cells
Carlier, Aurélie ULg; Chai, Yoke Chin; Theys, Tina et al

Poster (2010, November 19)

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See detailA Boolean network model of the growth plate
Kerkhofs, Johan ULg; Roberts, Scott J; Luyten, Frank P et al

Poster (2010, October 10)

Detailed reference viewed: 7 (0 ULg)