References of "VALDES SOCIN, Hernan Gonzalo"
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See detailAssociation Acromégalie - Hyperparathyroïdie primaire : Néoplasie endocrinienne multiple de type 1 (NEM1) ou une nouvelle entité? Une étude du groupe de tumeurs neuroendocriniennes (GTE)
Valdes Socin, Hernan Gonzalo ULg; Delemer, B.; Burlacu, M. et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailMacroprolactinemia in a patient with prolactinoma : A condition that may occur
Burlacu, M. C.; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailEvolution d'une narcolepsie chez une patiente acromégale ayant subi une radiothérapie
Burlacu, M. C.; Valdes Socin, Hernan Gonzalo ULg; Poirrier, R. et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailComment j'explore... Une valeur élevée de calcitonine?
Rikir, Estelle ULg; Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg et al

in Revue Médicale de Liège (2006), 61(3), 195-200

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a ... [more ▼]

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a neuroendocrine neoplasm with ectopic calcitonin secretion. The article first reviews the physiology of calcitonin, then outlines the diagnostic tests that are required to investigate hypercalcitoninemia and finally discusses the interpretation of test results. [less ▲]

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See detailMale Hypogonadism caused by isolated luteinizing hormone deficiency
Daly, Adrian ULg; Salvi, R.; Petrossians, Patrick ULg et al

in 37th International symposium - GH and Growth Factors in Endocrinology and Metabolism (Athènes Symposium) (2005)

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See detailGross total resection or debulking of pituitary adenomas improves hormonal control of acromegaly by somatostatin analogs
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in European Journal of Endocrinology (2005), 152(1), 61-66

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60 ... [more ▼]

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60% of cases. The impact of tumor debulking on subsequent control of acromegaly with SSAs has not been studied previously. Methods: We studied retrospectively the response to SSA therapy in acromegalic patients before and after incomplete surgical tumor excision. A case review identified 24 acromegalic patients who had received SSA therapy for 1 month before and after gross total resection or debulking of adenomas. No patient received radiotherapy or combination treatment with SSAs and dopamine agonists during the study. GH and IGF-I responses to SSAs were recorded pre- and postoperatively. Postoperative SSA therapy was begun after a washout period of 1–3 months to assess the hormonal effects of the surgery alone. Results: Before preoperative SSA treatment, 24/24 (100%) patients had elevated GH levels and IGF-I levels were elevated in 19/21 (90.5%) patients with recorded values. During preoperative SSA treatment, GH and IGF-I levels were normalized in 7/24 (29.2%) and 11/24 (45.8%) patients respectively. Following postoperative washout, GH was controlled in only 3/24 (12.5%) patients, while IGF-I was controlled in 8/19 (42.1%) patients with available data. During the second SSA treatment period, normal GH levels were seen in 13/24 (54.2%) patients, while IGF-I control was noted in 18/23 (78.3%). Conclusion: Gross total tumor resection or debulking increases the likelihood of achieving biochemical disease control with SSAs in acromegalic patients with adenomas that were not amenable to complete surgical resection and in whom primary SSA therapy was unable to achieve good biochemical control. [less ▲]

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See detailHypogonadism in a Patient with a Mutation in the Luteinizing Hormone Beta-Subunit Gene
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Daly, Adrian ULg et al

in New England Journal of Medicine [=NEJM] (2004), 351(25), 2619-2625

A 30-year-old man who presented with delayed puberty and infertility was found to have hypogonadism associated with an absence of circulating luteinizing hormone. The patient had a homozygous missense ... [more ▼]

A 30-year-old man who presented with delayed puberty and infertility was found to have hypogonadism associated with an absence of circulating luteinizing hormone. The patient had a homozygous missense mutation in the gene that encodes the beta subunit of luteinizing hormone (Gly36Asp), a mutation that disrupted a vital cystine knot motif and abrogated the heterodimerization and secretion of luteinizing hormone. Treatment with human chorionic gonadotropin increased circulating testosterone, promoted virilization, and was associated with the appearance of normal spermatozoa in low concentrations. This case illustrates the important physiological role that luteinizing hormone plays in male sexual maturation and fertility. [less ▲]

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See detailLong-term outcome of patients with acromegaly and congestive heart failure
Bihan, Hélène; Espinosa, Consuelo; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Clinical Endocrinology and Metabolism (2004), 89(11), 5308-5313

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac ... [more ▼]

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac abnormalities. However, the long-term cardiac effects of treatment for acromegaly have not been studied in patients who have already developed chronic congestive heart failure (CHF). We reviewed the charts of 330 consecutive patients with acromegaly treated in two French and Belgian centers since 1985. Ten patients with both acromegaly and CHF (eight men, two women, mean age 49.7 yr) were studied retrospectively. One of them was excluded because CHF was due to severe aortic stenosis. CHF ( New York Heart Association stages III-IV and echocardiography showing dilated hypokinetic cardiomyopathy with left ventricular systolic dysfunction and a left ventricular ejection fraction less than 45%) was diagnosed before, concomitantly, or after acromegaly in, respectively, two, five, and two patients. Three patients were referred with terminal heart failure requiring transplantation. One patient had transient CHF associated with a hypertensive crisis. The other eight patients had symptomatic chronic CHF. Control of GH hypersecretion failed, totally or partially, in three patients: one had a long-term survival, and the two others died at 1 and 5 yr. Good GH control was achieved in five patients: four of these are still alive 2-16 yr after diagnosis of CHF, their clinical status is stable or improved, and their quality of life is good. Overall, the 1- and 5-yr mortality ( or transplantation) rates for patients with chronic symptomatic CHF were 25% ( 2 of 8 patients) and 37.5% ( 3 of 8 patients), respectively. In conclusion, less than 3% of acromegalic patients developed CHF in this study. Although effective treatment of acromegaly improved short-term cardiovascular status, its impact on long-term survival is questionable. [less ▲]

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See detailMale hypogonadism caused by isolated LH deficiency : From pathology to gene, from gene to physiology
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Pralong, F. et al

in ENEA congress : Napoli, April 2004 (2004, April)

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See detailSurgical debulking of GH secreting pituitary adenomas improves GH control of acromegaly by somatostatin analogs
Beckers, Albert ULg; Petrossians, Patrick ULg; Borges Martins, L. et al

in ENEA congress : Napoli, April 2004 (2004, April)

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See detailThyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies
Ciccarelli, A.; Valdes Socin, Hernan Gonzalo ULg; Parma, J. et al

in European Journal of Endocrinology (2004), 150(4), 431-437

OBJECTIVE: Atypical forms of hyperthyroidism represent a diagnostic challenge for clinicians. Struma ovarii is an ovarian teratoma and constitutes a rare cause of ectopic thyroidal hormonal production. We ... [more ▼]

OBJECTIVE: Atypical forms of hyperthyroidism represent a diagnostic challenge for clinicians. Struma ovarii is an ovarian teratoma and constitutes a rare cause of ectopic thyroidal hormonal production. We describe a case of struma ovarii that combined two different sources of hyperthyroidism in the same patient and report genetic studies in order to contribute a better understanding of the autonomy and tumorigenesis of the struma ovarii. CASE REPORT: A 73-year-old nulliparous woman presented a thyroid toxic adenoma that was successfully treated with 10 mCi radioiodine. Unexpectedly, a new onset of hyperthyroidism prompted us to look for a second etiology. A whole-body scan with (123)I detected a pelvic hyperfixation suggesting struma ovarii, and a thyroid differentiated left ovarian teratoma 3 cm in size was surgically removed. We screened for mutations of thyroid-stimulating hormone receptor and Gs-alpha protein genes, as these mutations are common in thyroid adenomas. We did not identify any mutations. Androgen receptor study demonstrated a monoclonal status. Comparative genomic hybridization did not reveal any chromosomal abnormality. However, loss of heterozygosity analysis showed several structural abnormalities, compared with the majority of benign ovarian teratomas, which show a normal karyotype. CONCLUSIONS: This is the first well-documented report of thyrotoxic struma ovarii revealed after treatment of a single thyroid toxic adenoma. We have shown in this case that struma ovarii originates from a single germ cell, and, albeit benign, this tumor presents several chromosomal abnormalities. Struma ovarii-induced hyperthyroidism is likely to be mediated by mechanisms different from those of the classical thyroid toxic adenoma. [less ▲]

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See detailGonadotropin secreting tumors
Beckers, Albert ULg; Ciccarelli, A.; Valdes Socin, Hernan Gonzalo ULg et al

in The Encyclopedia of Endocrinology and Endocrine Diseases (2004)

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See detailMale hypogonadism caused by insolated LH deficiency : From pathology to gene, from gene to physiology
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Pralong, F. et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailLa réduction chirurgicale de la masse tumorale des adénomes hypophysaires améliore le contrôle médical de l'acromégalie par les analogues de la Somatostatine
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in XXIème Congrès de la Société Française d'Endocrinologie - Abstract book (2004)

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See detailFamilial isolated pituitary adenomas : epidemiological, clinical and genetic studies
Ciccarelli, A.; Valdes Socin, Hernan Gonzalo ULg; Jaffrain-Rea, M. L. et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailMale hypogonadism caused by isolated LH deficiency : From pathology to gene, from gene to physiology
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Pralong, F. et al

in Meeting of the Belgian Endocrine Society : December 2003 (2003, December)

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See detailFamilial isolated pituitary adenomas (FIPA) : not only acromegaly
Jaffrain-Réa, M. L.; Tamburrano, G.; Ciccarelli, A. et al

in 30 Congresso Nazionale della Socièta Italiana di Endocrinologia : Milano, 24-27 settembre 2003 (2003, September)

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See detailAssociation of acute leukemia and autoimmune polyendocrine syndrome in two kindreds.
Willems, Evelyne ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2003), 17(9), 1912-1914

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See detailChapitre 6: Le syndrome tumoral hypophysaire de l'acromégalie
Brue, Thierry; Dufour, Henry; VALDES SOCIN, Hernan Gonzalo ULg et al

in Chanson, Philippe (Ed.) Visages de l'acromégalie (2003)

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See detailMale hypogonadism caused by insolated LH deficiency : From pathology to gene, from gene to physiology
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Pralong, F. et al

in 8th International Pituitary Congress - Abstract book (2003)

Detailed reference viewed: 4 (2 ULg)