References of "VALDES SOCIN, Hernan Gonzalo"
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See detailTwo novel mutations of the calcium sensing receptor gene
Livaradiu, E.; Rydlewski, C.; Hamoir, Etienne ULg et al

in 18th Meeting of the Belgian Endocrine and Metabolic societies : Bruxelles, 25 octobre 2008 (2008, October)

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See detailHypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene
VALDES SOCIN, Hernan Gonzalo ULg

Master of advanced studies dissertation (2008)

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See detailTwo Novel Mutations of the Calcium Sensing Receptor gene
Livadariu, E.; Rydlewski, C.; Hamoir, Etienne ULg et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailCharacterization of a family harboring a novel LHBéta subunit mutation associated with hypogonadism
Burlacu, M. C.; Daly, Adrian ULg; Salvi, R. et al

in 17th Meeting of the Belgian Endocrine Society : Bruxelles, 25 novembre 2007 (2007, November)

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See detailPseudomalabsorption of thyroid hormones: case report and review of the literature.
Livadariu, E.; Valdes Socin, Hernan Gonzalo ULg; Burlacu, M. C. et al

in Annales d'Endocrinologie (2007), 68(6), 460-463

Many causes of thyroxine malabsorption are described in the literature, but the most common cause of failure of thyroxine therapy is poor patient compliance, or pseudomalabsorption. We describe the case ... [more ▼]

Many causes of thyroxine malabsorption are described in the literature, but the most common cause of failure of thyroxine therapy is poor patient compliance, or pseudomalabsorption. We describe the case of a female patient who underwent total thyroidectomy for Basedow-Graves disease. Post-operatively, several treatment regimens were employed to achieve euthyroidism, but only injectable thyroxine was found to be effective. To exclude levothyroxine malabsorption, the patient was hospitalized in a hypothyroid state while a single oral test dose of levothyroxine (1000 microg) was administered. Within 4 hours a decrease of TSH level (from 59.7 to 55.6 microUI/ml) and a significant increase in free T4 levels (from 0.8 to 15.5 pg/ml) was observed, eliminating a malabsorption problem. The cause of resistance to thyroid hormone therapy was poor patient compliance, leading to the designation of this as a case of pseudomalabsorption. [less ▲]

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See detailAdénomes hypophysaires thyréotropes
Valdes Socin, Hernan Gonzalo ULg; Daly, Adrian ULg; Beckers, Albert ULg

in Chanson, Philippe; Young, Jacques (Eds.) Traité d'Endocrinologie (2007)

C’est le traité de référence dans la discipline : livre unique, sans concurrent de cette envergure. Il couvre toute l’endocrinologie moderne, qui s’appuie sur l’apport de la biologie moléculaire, de la ... [more ▼]

C’est le traité de référence dans la discipline : livre unique, sans concurrent de cette envergure. Il couvre toute l’endocrinologie moderne, qui s’appuie sur l’apport de la biologie moléculaire, de la biochimie, de l’immunocytochimie, de l’imagerie moderne avec, en particulier la T.E.P. La physiopathologie, les symptômes, les éléments du diagnostic, les orientations pronostiques, les choix thérapeutiques sont exposés de façon exhaustive pour les affections touchant toutes les glandes endocrines : thyroïde, parathyroïde, surrénales, testicules, ovaires, hypophyse. Au total, il s’agit d’un ouvrage complet, moderne et pratique ; la richesse des illustrations, des arbres décisionnels, l’abondante bibliographie contribuent à en faire un outil indispensable au quotidien. Ce Traité d'endocrinologie conçu par et maintenant publié sous la direction de Philippe Chanson et Jacques Young est remarquable, par son contenu, d'abord, ensuite, par le fait qu'il est écrit en français, ce qui en fait un ouvrage unique. En effet, les grands traités d'endocrinologie de ces dernières années sont en anglais. La liste des 154 chapitres couvre la totalité de l'endocrinologie d'aujourd'hui dans tous ses aspects, depuis la biologie moléculaire à la pratique du clinicien, interniste ou chirurgien. Et le texte, les textes, sont d'enseignement fondamental pour l'étudiant autant que de présentations et discussions diagnostiques pour le clinicien averti comme pour celui qui cherche à s'instruire. Comme la nostalgie, pour reprendre le cliché bien connu, l'endocrinologie n'est plus ce qu'elle était. Le concept de glandes endocrines, s'il reste vrai dans son ensemble, est cependant dépassé par ces nouvelles découvertes qui montrent sécrétion et utilisation in loto de ces mêmes substances (hormones ?) par des organes aussi variés que le cerveau ou le tissu adipeux. Et le Traité d'endocrinologie présente et discute, nombreuses références à l'appui, les nouveaux concepts des mécanismes d'action des différentes classes d'hormones tant au niveau du soma que du psyché. Les implications pour la thérapeutique sont considérables et ce sera le malade qui finalement, bénéficiera de toutes ces connaissances présentées ici à son médecin. L'endocrinologie et son ouverture sur la neuro-endocrinologie constituent plus que jamais la science de nous-mêmes, dans la santé comme dans la maladie. Ce Traité d'endocrinologie est une magnifique présentation de l'état des choses. [less ▲]

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See detailClinical characterization of familial isolated pituitary adenomas.
Daly, Adrian ULg; Jaffrain-Rea, M.-L.; Ciccarelli, A. et al

in Journal of Clinical Endocrinology and Metabolism (2006), 91(9), 3316-23

CONTEXT: Familial pituitary adenomas occur rarely in the absence of multiple endocrine neoplasia type 1 (MEN1) and Carney complex (CNC). OBJECTIVE: Our objective was to characterize the clinical and ... [more ▼]

CONTEXT: Familial pituitary adenomas occur rarely in the absence of multiple endocrine neoplasia type 1 (MEN1) and Carney complex (CNC). OBJECTIVE: Our objective was to characterize the clinical and genealogical features of non-MEN1/CNC familial isolated pituitary adenomas (FIPA). DESIGN AND SETTING: We conducted a retrospective study of clinical and genealogical characteristics of FIPA cases and performed a comparison with a sporadic population at 22 university hospitals in Belgium, Italy, France, and The Netherlands. RESULTS: Sixty-four FIPA families including 138 affected individuals were identified [55 prolactinomas, 47 somatotropinomas, 28 nonsecreting adenomas (NS), and eight ACTH-secreting tumors]. Cases were MEN1/PRKAR1A-mutation negative. First-degree relationships predominated (75.6%) among affected individuals. A single tumor phenotype occurred in 30 families (homogeneous), and heterogeneous phenotypes occurred in 34 families. FIPA cases were younger at diagnosis than sporadic cases (P = 0.015); tumors were diagnosed earlier in the first vs. the second generation of multigenerational families. Macroadenomas were more frequent in heterogeneous vs. homogeneous FIPA families (P = 0.036). Prolactinomas from heterogeneous families were larger and had more frequent suprasellar extension (P = 0.004) than sporadic cases. Somatotropinomas occurred as isolated familial somatotropinoma cases and within heterogeneous FIPA families; isolated familial somatotropinoma cases represented 18% of FIPA cases and were younger at diagnosis than patients with sporadic somatotropinomas. Familial NS cases were younger at diagnosis (P = 0.03) and had more frequently invasive tumors (P = 0.024) than sporadic cases. CONCLUSIONS: Homogeneous and heterogeneous expression of prolactinomas, somatotropinomas, NS, and Cushing's disease can occur within families in the absence of MEN1/CNC. FIPA and sporadic cases have differing clinical characteristics. FIPA may represent a novel endocrine neoplasia classification that requires further genetic characterization. [less ▲]

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See detailPathologie de la parathyroïde : aspects cliniques et biologiques
Cavalier, Etienne ULg; Valdes Socin, Hernan Gonzalo ULg

Conference given outside the academic context (2006)

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See detailManifestations cutanées des pathologies endocriniennes
Quatresooz, Pascale ULg; Thirion, Laurence; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(2), 104-8

Some cutaneous lesions accompany or reveal endocrine disorders. Identifying the endocrinopathy is very important because it sometimes allows corrective rather than symptomatic treatment. The most ... [more ▼]

Some cutaneous lesions accompany or reveal endocrine disorders. Identifying the endocrinopathy is very important because it sometimes allows corrective rather than symptomatic treatment. The most frequenly involved diseases include thyrotoxicosis, hypothyroidism, the auto-immune disorders of thyroid, Cushing syndrome, Addison disease, acromegaly, androgen-dependent disorders, hypopituitarism, hypoparathyroidism, pseudohypoparathyroidism and diabetes mellitus. [less ▲]

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See detailAssociation Acromégalie - Hyperparathyroïdie primaire : Néoplasie endocrinienne multiple de type 1 (NEM1) ou une nouvelle entité? Une étude du groupe de tumeurs neuroendocriniennes (GTE)
Valdes Socin, Hernan Gonzalo ULg; Delemer, B.; Burlacu, M. et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailMacroprolactinemia in a patient with prolactinoma : A condition that may occur
Burlacu, M. C.; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailEvolution d'une narcolepsie chez une patiente acromégale ayant subi une radiothérapie
Burlacu, M. C.; Valdes Socin, Hernan Gonzalo ULg; Poirrier, R. et al

in 23ème Congrès de la Société Française d'Endocrinologie - Abstract book (2006)

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See detailComment j'explore... Une valeur élevée de calcitonine?
Rikir, Estelle ULg; Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg et al

in Revue Médicale de Liège (2006), 61(3), 195-200

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a ... [more ▼]

This article describes a case of lung cancer with associated hypercalcitoninemia in a man with a goitre. The case raises the problem of the differential diagnosis between medullary thyroid carcinoma and a neuroendocrine neoplasm with ectopic calcitonin secretion. The article first reviews the physiology of calcitonin, then outlines the diagnostic tests that are required to investigate hypercalcitoninemia and finally discusses the interpretation of test results. [less ▲]

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See detailMale Hypogonadism caused by isolated luteinizing hormone deficiency
Daly, Adrian ULg; Salvi, R.; Petrossians, Patrick ULg et al

in 37th International symposium - GH and Growth Factors in Endocrinology and Metabolism (Athènes Symposium) (2005)

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See detailGross total resection or debulking of pituitary adenomas improves hormonal control of acromegaly by somatostatin analogs
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in European Journal of Endocrinology (2005), 152(1), 61-66

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60 ... [more ▼]

Introduction: Invasive GH-secreting pituitary adenomas are rarely cured by surgery and although long-term therapy with somatostatin analogs (SSAs) may be employed, hormonal control is achieved in only 60% of cases. The impact of tumor debulking on subsequent control of acromegaly with SSAs has not been studied previously. Methods: We studied retrospectively the response to SSA therapy in acromegalic patients before and after incomplete surgical tumor excision. A case review identified 24 acromegalic patients who had received SSA therapy for 1 month before and after gross total resection or debulking of adenomas. No patient received radiotherapy or combination treatment with SSAs and dopamine agonists during the study. GH and IGF-I responses to SSAs were recorded pre- and postoperatively. Postoperative SSA therapy was begun after a washout period of 1–3 months to assess the hormonal effects of the surgery alone. Results: Before preoperative SSA treatment, 24/24 (100%) patients had elevated GH levels and IGF-I levels were elevated in 19/21 (90.5%) patients with recorded values. During preoperative SSA treatment, GH and IGF-I levels were normalized in 7/24 (29.2%) and 11/24 (45.8%) patients respectively. Following postoperative washout, GH was controlled in only 3/24 (12.5%) patients, while IGF-I was controlled in 8/19 (42.1%) patients with available data. During the second SSA treatment period, normal GH levels were seen in 13/24 (54.2%) patients, while IGF-I control was noted in 18/23 (78.3%). Conclusion: Gross total tumor resection or debulking increases the likelihood of achieving biochemical disease control with SSAs in acromegalic patients with adenomas that were not amenable to complete surgical resection and in whom primary SSA therapy was unable to achieve good biochemical control. [less ▲]

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See detailHypogonadism in a Patient with a Mutation in the Luteinizing Hormone Beta-Subunit Gene
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Daly, Adrian ULg et al

in New England Journal of Medicine [=NEJM] (2004), 351(25), 2619-2625

A 30-year-old man who presented with delayed puberty and infertility was found to have hypogonadism associated with an absence of circulating luteinizing hormone. The patient had a homozygous missense ... [more ▼]

A 30-year-old man who presented with delayed puberty and infertility was found to have hypogonadism associated with an absence of circulating luteinizing hormone. The patient had a homozygous missense mutation in the gene that encodes the beta subunit of luteinizing hormone (Gly36Asp), a mutation that disrupted a vital cystine knot motif and abrogated the heterodimerization and secretion of luteinizing hormone. Treatment with human chorionic gonadotropin increased circulating testosterone, promoted virilization, and was associated with the appearance of normal spermatozoa in low concentrations. This case illustrates the important physiological role that luteinizing hormone plays in male sexual maturation and fertility. [less ▲]

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See detailLong-term outcome of patients with acromegaly and congestive heart failure
Bihan, Hélène; Espinosa, Consuelo; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Clinical Endocrinology and Metabolism (2004), 89(11), 5308-5313

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac ... [more ▼]

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac abnormalities. However, the long-term cardiac effects of treatment for acromegaly have not been studied in patients who have already developed chronic congestive heart failure (CHF). We reviewed the charts of 330 consecutive patients with acromegaly treated in two French and Belgian centers since 1985. Ten patients with both acromegaly and CHF (eight men, two women, mean age 49.7 yr) were studied retrospectively. One of them was excluded because CHF was due to severe aortic stenosis. CHF ( New York Heart Association stages III-IV and echocardiography showing dilated hypokinetic cardiomyopathy with left ventricular systolic dysfunction and a left ventricular ejection fraction less than 45%) was diagnosed before, concomitantly, or after acromegaly in, respectively, two, five, and two patients. Three patients were referred with terminal heart failure requiring transplantation. One patient had transient CHF associated with a hypertensive crisis. The other eight patients had symptomatic chronic CHF. Control of GH hypersecretion failed, totally or partially, in three patients: one had a long-term survival, and the two others died at 1 and 5 yr. Good GH control was achieved in five patients: four of these are still alive 2-16 yr after diagnosis of CHF, their clinical status is stable or improved, and their quality of life is good. Overall, the 1- and 5-yr mortality ( or transplantation) rates for patients with chronic symptomatic CHF were 25% ( 2 of 8 patients) and 37.5% ( 3 of 8 patients), respectively. In conclusion, less than 3% of acromegalic patients developed CHF in this study. Although effective treatment of acromegaly improved short-term cardiovascular status, its impact on long-term survival is questionable. [less ▲]

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See detailMale hypogonadism caused by isolated LH deficiency : From pathology to gene, from gene to physiology
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Pralong, F. et al

in ENEA congress : Napoli, April 2004 (2004, April)

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See detailSurgical debulking of GH secreting pituitary adenomas improves GH control of acromegaly by somatostatin analogs
Beckers, Albert ULg; Petrossians, Patrick ULg; Borges Martins, L. et al

in ENEA congress : Napoli, April 2004 (2004, April)

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See detailThyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies
Ciccarelli, A.; Valdes Socin, Hernan Gonzalo ULg; Parma, J. et al

in European Journal of Endocrinology (2004), 150(4), 431-437

OBJECTIVE: Atypical forms of hyperthyroidism represent a diagnostic challenge for clinicians. Struma ovarii is an ovarian teratoma and constitutes a rare cause of ectopic thyroidal hormonal production. We ... [more ▼]

OBJECTIVE: Atypical forms of hyperthyroidism represent a diagnostic challenge for clinicians. Struma ovarii is an ovarian teratoma and constitutes a rare cause of ectopic thyroidal hormonal production. We describe a case of struma ovarii that combined two different sources of hyperthyroidism in the same patient and report genetic studies in order to contribute a better understanding of the autonomy and tumorigenesis of the struma ovarii. CASE REPORT: A 73-year-old nulliparous woman presented a thyroid toxic adenoma that was successfully treated with 10 mCi radioiodine. Unexpectedly, a new onset of hyperthyroidism prompted us to look for a second etiology. A whole-body scan with (123)I detected a pelvic hyperfixation suggesting struma ovarii, and a thyroid differentiated left ovarian teratoma 3 cm in size was surgically removed. We screened for mutations of thyroid-stimulating hormone receptor and Gs-alpha protein genes, as these mutations are common in thyroid adenomas. We did not identify any mutations. Androgen receptor study demonstrated a monoclonal status. Comparative genomic hybridization did not reveal any chromosomal abnormality. However, loss of heterozygosity analysis showed several structural abnormalities, compared with the majority of benign ovarian teratomas, which show a normal karyotype. CONCLUSIONS: This is the first well-documented report of thyrotoxic struma ovarii revealed after treatment of a single thyroid toxic adenoma. We have shown in this case that struma ovarii originates from a single germ cell, and, albeit benign, this tumor presents several chromosomal abnormalities. Struma ovarii-induced hyperthyroidism is likely to be mediated by mechanisms different from those of the classical thyroid toxic adenoma. [less ▲]

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