References of "Tirelli, Ezio"
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See detailAdult-like neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice
Tirelli, Ezio ULg; Jodogne, C.; Perikel, J.

in Developmental Brain Research (1991), 61(2), 207-215

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old ... [more ▼]

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old) outbred male mice. In Exp 1, relatively high doses of muscimol (0.05-0.40 mg/kg in developing and 0.50-3 mg/kg in adult Ss) were found to dose-dependently induce solid catalepsy and ataxia. In Exp 2, the GABA agonist was injected in dose ranges that included relatively small concentrations to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. Levels of rearing and especially locomotion were enhanced at low doses (0.025-0.050 mg/kg in developing and 1.3-2.9 mg/kg in adult mice) and inhibited at higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailModulation of tolerance to the GABA-sub(A) agonist THIP by environmental cues
Jodogne, C.; Tirelli, Ezio ULg

in Behavioural Brain Research (1990), 36(1-2), 33-40

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See detailStereoselective effects of cocaine
Katz, John L; Tirelli, Ezio ULg; Witkin, Jeffrey M

in Behavioural Pharmacology (1990), 1

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See detailDopamine-GABAergic mechanisms of rearing and locomotion in infant and weanling mice
Tirelli, Ezio ULg; Jodogne, C.

in Psychobiology (1990), 18(4), 443-450

Examined tue modulatory effects of the gamma-aminobutyric acid(GABA)-A agonist muscimol on supported rearing and locomotion induced by the indirect dopamine agonist D-amphetamine (DAM). A total of 288 ... [more ▼]

Examined tue modulatory effects of the gamma-aminobutyric acid(GABA)-A agonist muscimol on supported rearing and locomotion induced by the indirect dopamine agonist D-amphetamine (DAM). A total of 288 infant, weanling, and adult outbred mice were tested in 2 experiments. In adult mice, muscimol at 1,3 mg/kg DAM-induced locomotion but not rearing, whereas 1,9 mg/kg muscimol blocked both behaviors. While 0,025 mg/kg muscimol reduced 2mg/kg DAM-induced rearing without altering locomotion in infants, it affected neither rearing nor locomotion in weanlings. In infant mice, 0,075 mg/kg muscimol engendered gnawing and self-biting, a typical effect of dopamine^GABAergic pharmacological activation. Maturation of dopamine^GABAergic behavioral functions may follow a near-monotonic continuity starting a few days after birth. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailThe GABA-A agonist muscimol facilitates muscular twitches and locomotor movements in the neonatal mouse
Tirelli, Ezio ULg

in Pharmacology, Biochemistry & Behavior (1989), 33(2), 497-500

The effects of nonsedative doses of muscimol, a postsynaptic GABA-A agonist, on neurobehavioral activities in 5- and 11-day-old newborn mice were assessed using an observational point sampling procedure ... [more ▼]

The effects of nonsedative doses of muscimol, a postsynaptic GABA-A agonist, on neurobehavioral activities in 5- and 11-day-old newborn mice were assessed using an observational point sampling procedure. Muscimol activated the emission of muscular twitches after injections of 0.025 or 0.050 mg/kg in 5-day-old pups, and 0.075 mg/kg in 11-day-old pups. At 0.075 mg/kg, the GABA agonist also produced an increase of locomotor movement levels in the younger age group. Given that muscimol at low dosages typically produces an increase of locomotion in mature mice, it is suggested that the GABAergic activity involved in locomotor behaviors is functional very early in life. Furthermore, since twitching behavior exhibited while lying presumably indicates paradoxical sleep early in life, it is speculated that muscimol may have activated this form of sleep in our newborn mice. [less ▲]

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See detailFunctional Maturation of the Gabaergic Inhibition on Dopamine-Mediated Behaviours During the Neonatal Period in the Mouse
Tirelli, Ezio ULg

in Behavioural Brain Research (1989), 33(1), 83-95

Previous works have indicated that systemic injection of GABA-agonists depress motoric behaviours in neonatal murids, suggesting an early maturation of GABAergic inhibitory processes. In this paper, the ... [more ▼]

Previous works have indicated that systemic injection of GABA-agonists depress motoric behaviours in neonatal murids, suggesting an early maturation of GABAergic inhibitory processes. In this paper, the inhibitory effects of muscimol, a postsynaptic GABAA-agonist, on D-amphetamine-induced enhancement of locomotion, wall-climbing and head-raising were examined in neonatal 5-, 8- and 11-day-old mouse pups, using a direct observational procedure. The results show that muscimol can selectively attenuate high levels of locomotion, wall-climbing and head-raising produced by the indirect dopamine agonist in 8- as well as 11-day-old pups. However, while muscimol is able to moderate amphetamine-induced wall-climbing and head-rising in 5-day-old pups, no GABAergic inhibition was seen for locomotion at this age. Licking episodes elicited by amphetamine in 11-day-old pups can be magnified by muscimol if the dosage of the former is relatively too potent. It is suggested that the GABAergic inhibitory processes on dopaminergic functioning have reached good levels of functional maturation in the neonatal murid. [less ▲]

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See detailLes modèles animaux dans l'étude du comportement de pharmacodépendance
Tirelli, Ezio ULg

in Psychotropes (1988), 4

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See detailL'animal toxicomane: les modèles de comportement animal dans l'étude de la tolérance et de la toxicomanie
Tirelli, Ezio ULg

in Nouvelles de la Science et des Technologies (1987), 5

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See detailOntogeny of GABA-ergic and dopaminergic mediation of gnawing behavior in the mouse
Tirelli, Ezio ULg

in Psychopharmacology (1987), 92(1), 89-95

Examined the ontogenetic course of dopaminergically mediated gnawing and the potentiation of this behavior by muscimol (a gamma-aminobutyric acid receptor agonist) in developing and young adult mice using ... [more ▼]

Examined the ontogenetic course of dopaminergically mediated gnawing and the potentiation of this behavior by muscimol (a gamma-aminobutyric acid receptor agonist) in developing and young adult mice using a time-sampling or a corrugated paper procedure. In Exp I, the older group (14-53 days), displayed a dose-dependent gnawing behavior after intraperitoneal injections of methylphenidate ([MTPD], 20, 30, 50 mg/kg). In 5-, 8-, 11-, and 14-day-old pups, MTPD (10, 20, 50 mg/kg) evoked stereotyped gnawing. Muscimol pretreatment (0.025-2.3 mg/kg) induced a clear-cut potentiation of gnawing elicited by MTPD (10 or 20 mg/kg) as early as 8 days of age. It is argued that the effectiveness of MTPD in inducing gnawing-licking among 5-day-old pups confirms the early maturation of central dopamine receptors reported in the literature. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailShort-, medium-, and long-term effects of prenatal oxazepam on neurobehavioural development of mice
Alleva, E.; Laviola, G.; Tirelli, Ezio ULg et al

in Psychopharmacology (1985), 87(4), 434-441

Oxazepam was given to nulliparous CD-1 mice on Days 12-26 of pregnancy, and the development and young adult behavior of the offspring were studied. Exp I, using 5, 15, and 50 mg/kg oral doses given twice ... [more ▼]

Oxazepam was given to nulliparous CD-1 mice on Days 12-26 of pregnancy, and the development and young adult behavior of the offspring were studied. Exp I, using 5, 15, and 50 mg/kg oral doses given twice daily, showed a dose-dependent retardation of postnatal development of several responses such as righting, barholding, limb placing, and auditory startle. These changes were maximal in the 1st 2 postnatal weeks and then were markedly attenuated, or disappeared, being apparently related to a temporary retardation of body growth. A reduction of locomotor activity at 60 days was found only in the 50 mg/kg group. In Exps II and III, prenatal oxazepam reduced open-field activity at 14-26 days and attenuated the hyperactivity induced by dl-amphetamine (d,l-amphetamine) sulfate (2 mg/kg, intraperitoneally). Exp III, using a cross-fostering procedure, showed that postnatal maternal effects were not responsible for the aforementioned changes. Exp II also investigated the acquisition of several go/no go avoidance discriminations. The main effect of prenatal oxazepam was an impairment of active avoidance responding, while the treatment effects on overall discrimination performance were less marked and limited to the later stages of training. (29 ref) ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailLa perception des nombres chez les animaux
Tirelli, Ezio ULg

in Cahiers d'Ethologie (1983), 3(2), 231-265

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