References of "Tirelli, Ezio"
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See detailBehavioral and pharmacological differentiation of direct and indirect dopamine agonists and among dopamine uptake inhibitors
Witkin, J. M.; Tirelli, Ezio ULiege; Geter-Douglass, B.

in National Institute on Drug Abuse Research Monograph Series (1995), 131

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See detailDifferential effects of drawing and indirect dopamine agonists on the induction of gnawing in C57BI/6J mice
Tirelli, Ezio ULiege; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1995), 273(1), 7-15

Compared the ability of indirect dopamine (DA) agonists to induce gnawing behavior (GB) in male C57BL/6J mice with that of direct DA agonists acting at DA D-sub-1 or D-sub-2 receptor subtypes. Eight Ss ... [more ▼]

Compared the ability of indirect dopamine (DA) agonists to induce gnawing behavior (GB) in male C57BL/6J mice with that of direct DA agonists acting at DA D-sub-1 or D-sub-2 receptor subtypes. Eight Ss were used per dose. Holes left by Ss on corrugations of packing cardboard were used as an objective index of GB. Indirect DA agonists, including DA releasers such as fencamfamine and amfonelic acid and DA uptake inhibitors such as cocaine and nomifensine, produced dose-dependent increases in GB. None of the direct agonists (e.g., apomorphine, quinpirole) increased GB. The dopaminergic nature of GB was confirmed in studies in which a host of compounds (e.g., nicotine, caffeine, dizocilpine) with primary actions at nondopaminergic sites did not induce GB. Given the general contrast between the effects of direct and indirect DA agonists, this procedure could serve as a rapid in vivo method of distinguishing direct- from indirect-acting DA agonists. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailGnawing induced by dopaminergic mobilzation : differential effects of direct and indirect dopamine agonists in mice
Tirelli, Ezio ULiege; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1995), 273

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See detailEarly ontogenesis od sensitization to the behavioral effects of cocaine in rats.
Tirelli, Ezio ULiege; Adam, Eric; Ferrara, Maurizio

in Behavioural Pharmacology (1994), 5

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See detailVerticalization of behavior elicited by dopaminergic mobilization is qualitatively different between C57BL/6J and DBA/2J mice
Tirelli, Ezio ULiege; Witkin, J. M.

in Psychopharmacology (1994), 116(2), 191-200

Behavioral effects of dopaminergic stimulation were compared for C57BL/6J mice and DBA/2J mice. Effects of apomorphine (APO) alone and in combination with cocaine (COC) were assessed using a time-sampling ... [more ▼]

Behavioral effects of dopaminergic stimulation were compared for C57BL/6J mice and DBA/2J mice. Effects of apomorphine (APO) alone and in combination with cocaine (COC) were assessed using a time-sampling technique that classified climbing and leaning in separate categories. Climbing occurred in DBA/2J mice only at doses of APO that were 16 times higher than the smallest effective dose in C57BL/6J mice, but relative to baseline values, effects were comparable. Whereas DBA/2J mice showed dose-dependent leaning under APO, C57BL/6J mice exhibited significantly increased leaning only after the highest APO dose. When given alone, COC produced significant climbing, but not leaning or gnawing, in either strain. COC potentiated APO-induced climbing and gnawing in both strains but did not consistently change APO-induced leaning in either strain. APO alone reduced locomotor activity and attenuated COC-induced hyperkinesia. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailTransient hypersensitivity to apomorphine-induced gnawing after termination of acute effects high dose of cocaine
Tirelli, Ezio ULiege; Witkin, J. M.

in Behavioural Pharmacology (1994), 5(3), 289-298

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from ... [more ▼]

Male mice were tested for behavioral effects (BEs) of the dopamine (DA) agonist apomorphine (AP) at various times after acute administration of cocaine (COC). When most of the COC had disappeared from brain and the BEs of COC had dissipated (2 hrs and 4 hrs after administration), effects of AP on gnawing were increased 4-fold. This dopaminergic hypersensitivity (DA-H) was induced by acute treatment with doses of 15 mg/kg COC and higher. Effects of AP were not enhanced 6-24 hrs after COC, indicating a rapid waning of the DA-H. Hypersensitivity to AP (AP-H) was not further augmented by 8 days of daily COC injections. COC did not influence climbing and hypomotility induced by AP 4 hrs after its injection, demonstrating selectivity in the BEs of the DA-H. Further, COC did not induce sensitization to its own effects, indicating that the AP-H was not due to a typical sensitization phenomenon. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailBehavioral sensitization and tolerance to the D-sub-2 agonist RU 24213 : dissociation between several patterns in mice
Tirelli, Ezio ULiege; Jodogne, C.

in Pharmacology, Biochemistry & Behavior (1993), 44(3), 627-632

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See detailBiphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice
Tirelli, Ezio ULiege; Terry, P.

in Psychopharmacology (1993), 110(1-2), 69-75

Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously ... [more ▼]

Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously) locomotor stimulation. The time-course effect was biphasic at very high doses (100-300 mg/kg), with dose-related locomotor depression followed by dose-related long-term hyperlocomotion. For all doses, locomotor effects were detectable throughout the 4-hr test period. To determine whether these effects were mediated by D-sub-1 receptor stimulation, effects of SKF 38393 were assessed in combination with behaviorally inactive and active doses (0.1 and 0.2 mg/kg, respectively) of the selective D-sub-1 receptor antagonist SCH 39166. Both doses of SCH 39166 attenuated the hyperlocomotion induced by 30 mg/kg of the agonist to a similar degree. However, neither dose was able to reverse either the depressant or the stimulatory effects of 300 mg/kg SKF 38393. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailOxytocin blocks the environmentally conditioned compensatory response present after tolerance to ethanol-induced hypothermia in mice
Tirelli, Ezio ULiege; Jodogne, C.; Legros, Jean-Jacques ULiege

in Pharmacology, Biochemistry & Behavior (1992), 43(4), 1263-1267

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment ... [more ▼]

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment-specific tolerance. According to the conditioning model of tolerance, such tolerance occurs because an opposite compensatory response conditioned to ethanol-paired cues attenuates ethanol's effects. Tolerance to ethanol-induced hypothermia was established to a particular environment over 4 days by injecting mice (daily) with oxytocin 2 h before ethanol, outside the colony room. As controls, other mice were injected similarly but following testing in the animal room. We found that oxytocin suppressed the conditioned compensatory response, revealed by injecting saline to every group in the tolerance-associated environment. These results suggest that oxytocin acted, at least partly, via an inhibition of the associative learning processes that facilitate tolerance development. [less ▲]

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See detailConditioned amphetamine effects and habituation in mice
Tirelli, Ezio ULiege; Terry, P.

in National Institute on Drug Abuse Research Monograph Series (1992), 119

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See detailOxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Jodogne, C.; Tirelli, Ezio ULiege; Klingbiel, P. et al

in Pharmacology, Biochemistry & Behavior (1991), 40(2), 261-265

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the ... [more ▼]

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol. [less ▲]

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See detailAdult-like biphasic neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice
Tirelli, Ezio ULiege; Jodogne, C.; Perikel, J. J.

in Brain Research. Developmental Brain Research (1991), 61(2), 207-215

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old ... [more ▼]

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old) outbred male mice. In the first experiment, relatively high doses of muscimol (ranging from 0.05 to 0.40 mg/kg in developing and from 0.50 to 3 mg/kg in adult animals) were found to dose-dependently induced solid catalepsy and ataxia, evaluated 5 times at 20-min intervals. In the second experiment, the GABA agonist was injected in dose ranges which include relatively small concentrations in order to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. It appeared that levels of rearing and especially locomotion were enhanced at the low doses (0.025 and 0.050 mg/kg in developing, and 1.3 and 1.9 mg/kg in adult mice) and inhibited at the higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). This adult-like biphasic action of muscimol in developing mice--excitation at low and depression/sedation at high doses--strongly suggests a full maturation of the GABA-A-related behavioral functions at a period of ontogeny where adult-like locomotion emerges. Given that previous studies have shown that muscimol can biphasically affect behavioral activity in newborn murines as well, it is suggested that GABA-related behavioral functions mature near-monotonically during ontogeny, unlike those related to other major neurotransmitter systems. [less ▲]

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See detailAdult-like neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice
Tirelli, Ezio ULiege; Jodogne, C.; Perikel, J.

in Developmental Brain Research (1991), 61(2), 207-215

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old ... [more ▼]

Neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old), and young adult (53-day-old) outbred male mice. In Exp 1, relatively high doses of muscimol (0.05-0.40 mg/kg in developing and 0.50-3 mg/kg in adult Ss) were found to dose-dependently induce solid catalepsy and ataxia. In Exp 2, the GABA agonist was injected in dose ranges that included relatively small concentrations to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. Levels of rearing and especially locomotion were enhanced at low doses (0.025-0.050 mg/kg in developing and 1.3-2.9 mg/kg in adult mice) and inhibited at higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailModulation of tolerance to the GABA-sub(A) agonist THIP by environmental cues
Jodogne, C.; Tirelli, Ezio ULiege

in Behavioural Brain Research (1990), 36(1-2), 33-40

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See detailStereoselective effects of cocaine
Katz, John L; Tirelli, Ezio ULiege; Witkin, Jeffrey M

in Behavioural Pharmacology (1990), 1

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See detailDopamine-GABAergic mechanisms of rearing and locomotion in infant and weanling mice
Tirelli, Ezio ULiege; Jodogne, C.

in Psychobiology (1990), 18(4), 443-450

Examined tue modulatory effects of the gamma-aminobutyric acid(GABA)-A agonist muscimol on supported rearing and locomotion induced by the indirect dopamine agonist D-amphetamine (DAM). A total of 288 ... [more ▼]

Examined tue modulatory effects of the gamma-aminobutyric acid(GABA)-A agonist muscimol on supported rearing and locomotion induced by the indirect dopamine agonist D-amphetamine (DAM). A total of 288 infant, weanling, and adult outbred mice were tested in 2 experiments. In adult mice, muscimol at 1,3 mg/kg DAM-induced locomotion but not rearing, whereas 1,9 mg/kg muscimol blocked both behaviors. While 0,025 mg/kg muscimol reduced 2mg/kg DAM-induced rearing without altering locomotion in infants, it affected neither rearing nor locomotion in weanlings. In infant mice, 0,075 mg/kg muscimol engendered gnawing and self-biting, a typical effect of dopamine^GABAergic pharmacological activation. Maturation of dopamine^GABAergic behavioral functions may follow a near-monotonic continuity starting a few days after birth. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailThe GABA-A agonist muscimol facilitates muscular twitches and locomotor movements in the neonatal mouse
Tirelli, Ezio ULiege

in Pharmacology, Biochemistry & Behavior (1989), 33(2), 497-500

The effects of nonsedative doses of muscimol, a postsynaptic GABA-A agonist, on neurobehavioral activities in 5- and 11-day-old newborn mice were assessed using an observational point sampling procedure ... [more ▼]

The effects of nonsedative doses of muscimol, a postsynaptic GABA-A agonist, on neurobehavioral activities in 5- and 11-day-old newborn mice were assessed using an observational point sampling procedure. Muscimol activated the emission of muscular twitches after injections of 0.025 or 0.050 mg/kg in 5-day-old pups, and 0.075 mg/kg in 11-day-old pups. At 0.075 mg/kg, the GABA agonist also produced an increase of locomotor movement levels in the younger age group. Given that muscimol at low dosages typically produces an increase of locomotion in mature mice, it is suggested that the GABAergic activity involved in locomotor behaviors is functional very early in life. Furthermore, since twitching behavior exhibited while lying presumably indicates paradoxical sleep early in life, it is speculated that muscimol may have activated this form of sleep in our newborn mice. [less ▲]

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See detailFunctional Maturation of the Gabaergic Inhibition on Dopamine-Mediated Behaviours During the Neonatal Period in the Mouse
Tirelli, Ezio ULiege

in Behavioural Brain Research (1989), 33(1), 83-95

Previous works have indicated that systemic injection of GABA-agonists depress motoric behaviours in neonatal murids, suggesting an early maturation of GABAergic inhibitory processes. In this paper, the ... [more ▼]

Previous works have indicated that systemic injection of GABA-agonists depress motoric behaviours in neonatal murids, suggesting an early maturation of GABAergic inhibitory processes. In this paper, the inhibitory effects of muscimol, a postsynaptic GABAA-agonist, on D-amphetamine-induced enhancement of locomotion, wall-climbing and head-raising were examined in neonatal 5-, 8- and 11-day-old mouse pups, using a direct observational procedure. The results show that muscimol can selectively attenuate high levels of locomotion, wall-climbing and head-raising produced by the indirect dopamine agonist in 8- as well as 11-day-old pups. However, while muscimol is able to moderate amphetamine-induced wall-climbing and head-rising in 5-day-old pups, no GABAergic inhibition was seen for locomotion at this age. Licking episodes elicited by amphetamine in 11-day-old pups can be magnified by muscimol if the dosage of the former is relatively too potent. It is suggested that the GABAergic inhibitory processes on dopaminergic functioning have reached good levels of functional maturation in the neonatal murid. [less ▲]

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See detailLes modèles animaux dans l'étude du comportement de pharmacodépendance
Tirelli, Ezio ULiege

in Psychotropes (1988), 4

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See detailL'animal toxicomane: les modèles de comportement animal dans l'étude de la tolérance et de la toxicomanie
Tirelli, Ezio ULiege

in Nouvelles de la Science et des Technologies (1987), 5

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