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See detailAn unusual cell type of the auditory organ during neonatal development: the inner pillar cells
Thelen, Nicolas ULg; Breuskin, I; Malgrange, B et al

Poster (2007)

Detailed reference viewed: 4 (0 ULg)
See detailSox 10 is not necessary for auditory neurons survival
Breuskin, I; Bodson, M; Thelen, Nicolas ULg et al

Poster (2007)

Detailed reference viewed: 5 (0 ULg)
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See detailSpatial dynamics of rRNAs within the cell nucleus
Thiry, Marc ULg; Lamaye, Françoise; Thelen, Nicolas ULg et al

Poster (2007)

Detailed reference viewed: 6 (2 ULg)
See detailRole of Sox 10 in the development of the inner ear
Bodson, M; Breuskin, I; Thelen, Nicolas ULg et al

Poster (2007)

Detailed reference viewed: 8 (0 ULg)
See detailPrenatal development study of rat corti organ at the morphological level
Thelen, Nicolas ULg; Malgrange, Brigitte ULg; Thiry, Marc ULg

Poster (2006, September)

Although the structural organization of the mature Corti organ is generally well defined, little is known about its prenatal development. Here, we have examined by photonic and electron transmission ... [more ▼]

Although the structural organization of the mature Corti organ is generally well defined, little is known about its prenatal development. Here, we have examined by photonic and electron transmission microscopies the morphological changes occurring in the cochlear epithelium from the embryonic day 16 to 19 in rat. Moreover, we have used the periodic acid-thiocarbohydrazide-silver proteinate method to detect the glycogen particles on semithin and ultrathin sections of the cochlear duct. <br />At the embryonic day 16 (E16), whatever the region of the cochlear studied (base, medium, apex), the organ of Corti is not present. The cochlear epithelium appears as a pseudostratified epithelium formed formed by two distinct regions according to the presence or the absence of microvilli at the apical surface of cells. The region with the microvilli is on the modiolar side and the presence of microvilli is a characteristic of cells in the greater epithelial ridge (GER). In basal part of the cochlear duct, glycogen particles are visible on ultrathin sections in only one cell. On both sides of this cell, apical part of the epithelium shows microvilli. At E17, on semithin sections of basal and medium parts of cochlear duct, one cell visible on the whole height of the epithelium shows rich content in glycogen . At E18, in the majority of sections realized at the base and medium of the cochlear canal, the organ of Corti is relatively well recognizable. We distinguish principally the inner hair cells but also to a lesser extent the outer hair cells as well as the supporting cells (pillar, phalengeal and Deiters cells).We show that only the pillar cells have a rich content in glycogen. At E19, the organ of Corti is clearly recognizable in all the basal and medium parts of the cochlear duct. By contrast, it is yet differenciated in the apex. <br />These data seem to indicate that the Corti organ in rat develops from base to apex in the greater epithelial ridge starting by the pillar cells. [less ▲]

Detailed reference viewed: 9 (5 ULg)
See detailRole of Sox 10 in the development of the inner ear
Bodson, M; Breuskin, I; Thelen, Nicolas ULg et al

Poster (2006)

Detailed reference viewed: 6 (2 ULg)
See detailSox 10 is not necessary for auditory neurons survival
Breuskin, I; Bodson; Thelen, Nicolas ULg et al

Poster (2006)

Detailed reference viewed: 2 (0 ULg)
See detailRole of Sox 10 in the development of the inner ear
Bodson, M; Breuskin, I; Thelen, Nicolas ULg et al

Poster (2006)

Detailed reference viewed: 6 (0 ULg)
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See detailÉtude morphologique et immunocytologique du développement prénatal de l’organe de Corti chez le rat.
Thelen, Nicolas ULg

Master of advanced studies dissertation (2006)

Detailed reference viewed: 27 (9 ULg)
See detailPrenatal development study of rat Corti organ at the morphological level
Thelen, Nicolas ULg; Malgrange, Brigitte; Thiry, Marc ULg

Poster (2005, September)

Although the structural organization of the mature Corti organ is generally well defined, little is known about its prenatal development. Here, we have examined by photonic and electron transmission ... [more ▼]

Although the structural organization of the mature Corti organ is generally well defined, little is known about its prenatal development. Here, we have examined by photonic and electron transmission microscopies the morphological changes occurring in the cochlear epithelium from the embryonic day 16 to 19 in rat. <br />At the embryonic day 16 (E16), whatever the region of the cochlear studied (base, medium, apex), the organ of Corti is not present. The cochlear epithelium appears as a pseudostratified epithelial tissue formed by two distinct regions according to the staining of the cells : a pale region on the striolar side of the cochlear canal and a darker region on the modiolar side. At E17, it appears in the basal and medium cells of the cochlear epithelium, at the transition between the pale and the dark one, a cell visible on the whole height of the epithelium. By electron microscopy, we also show that this cell has a rich content in glycogen, a characteristic reminiscent to pillar cells. These results suggest that the first differentiating cell in the cochlear epithelium could be a pillar cell. At E18, in the majority of sections realized at the base and medium of the cochlear canal, the organ of Corti is relatively well recognizable. We distinguish principally the inner hair cells but also to a lesser extent the outer hair cells as well as the supporting cells (pillar, phalengeal and Deiters cells). At E19, the organ of Corti is clearly recognizable in all the basal and medium cells. By contrast, it is yet differenciated at the apex. <br />These data seem to indicate that the Corti organ in rat develops from base to apex starting by the pillar cells. [less ▲]

Detailed reference viewed: 11 (6 ULg)