References of "Tassoudji, Nazli"
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See detailL1-protein in incipient lymphocyte-depleted graft-versus-host disease. Expression in keratinocytes and coexpression with Factor XIIIa in dermal cells
Pierard, Gérald ULiege; Tassoudji, Nazli ULiege; Arrese Estrada, Jorge ULiege et al

in Turkish Journal of Dermatology = Dermatopatoloji Dergisi (1998), 7

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated ... [more ▼]

With the introduction of effective immunosuppressive regimens some cutaneous rashes following bone marrow transplant may appear histologically unremarkable. We report three cases of cyclosporin-abated cutaneous graft-versus-host reaction (GVHR) where the most straightful histologic clue was the epidermal L1-protein (calprotectin) expression revealed by a positive immunolabelling using the Mac 387 antibody. The epidermis looked otherwise normal and inflammatory cells were scant in the dermis. The expression of calprotectin by keratinocytes occurred early in cutaneous GVHR. In addition, CD45RO-positive T memory lymphocytes were exceedingly rare in the dermis while a few Mac 387-positive monocytes coexpressed Factor XIIIa immunoreactivity. Hyperplasia of the Factor XIIIa-positive dendrocytic population was obvious. Calprotectin and Factor XIIIa immunolagellings should be regarded as a diagnostic adjunct in lymphocyte-depleted cutaneous GVHR. Calprotectin positivity of the epidermis is indicative although not specific for such condition. However, its combination with a low lymphocytes/monocytes ratio in the dermis which is enriched in plup dendrocytes is almost diagnostic. [less ▲]

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See detailNaevocyte Triggering by Recombinant Human Growth Hormone
Pierard, Gérald ULiege; Pierard-Franchimont, Claudine ULiege; Nikkels, Arjen ULiege et al

in Journal of Pathology (The) (1996), 180(1), 74-79

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is ... [more ▼]

The influence of growth hormone and insulin-like growth factor I on human melanocytes is being increasingly recognized. Clinical evidence has shown that when recombinant human growth hormone (hGH) is administered to children of short stature, the growth of melanocytic naevi is boosted. This study was conducted on 56 hGH-triggered naevi and nine similar lesions excised before or after hGH therapy for hypopituitarism and Turner's syndrome. A series of 40 naevi excised from age-matched healthy children served as controls. Atypicality of naevocytes was investigated using image analysis, AgNOR counts, immunohistochemistry (HMB-45, NKI-C3, Ki-67, anti-bcl-2-oncoprotein), and DNA flow cytometry. The data associate hGH treatment with anisokaryosis and increased AgNOR and Ki-67 counts in naevocytes. The same cells also show abnormal patterns of HMB-45 immunolabelling. These indications of naevocyte activation were not suggestive of malignant transformation. hGH-triggered melanocytomas should be added to the list of atypical melanocytic naevi. The long-term evolution of these lesions remains unknown and the potential risk of malignant transformation awaits careful evaluation. [less ▲]

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See detailImprovement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion
Pierard, Gérald ULiege; Pierard-Franchimont, Claudine ULiege; Tassoudji, Nazli ULiege et al

in Journal of Dermatological Treatment (1996), 7

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This ... [more ▼]

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This study was conducted in 20 men who used a lotion containing the antimicrobials, piroctone olamine and triclosan, regularly for 18 months. At entry, mild pruritus and abnormal hair loss were reported by the volunteers. During treatments, pruritus resolved rapidly. Comparison of clinical photographs and trichograms taken at 3-month intervals suggested signs of hair regrowth with moderate increase in density of transitional hairs. Biopsies taken at 6-month intervals were processed for immunohistochemistry. There was a decrease in the density of activated T cells in the region of the follicular infrainfundibulum and isthmus over time. UgG deposits found within the epithelial sheaths at entry to the study were absent in the subsequent biopsies. The volume of the sebaceous glands, as assessed by computerized morphometry, was not modified by the treatment. It was concluded that inflammation associated with AGA transitional hairs may be driven by the presence of microorganisms harboured in the infrainfundibulum. They may modulate the severity of AGA and may potentially be controllable. This offers a new possibility of prevention and partial reversal of hair loss in AGA. [less ▲]

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See detailNeuropeptides cutanés
Tassoudji, Nazli ULiege; Nikkels, Arjen ULiege; Pierard, Gérald ULiege

in Les Nouvelles Dermatologiques (1994), 13

The neuropeptides act as mediators in the transmission of nervous influx and as messengers between the nervous system and other cell populations. The skin contains numerous neuropeptides which are ... [more ▼]

The neuropeptides act as mediators in the transmission of nervous influx and as messengers between the nervous system and other cell populations. The skin contains numerous neuropeptides which are involved in the regulation of inflammation, immunomodulation, and thermoregulation. Cutaneous trophicity, pigmentation, and to a lesser extent sebaccous secretions are also influenced by neuropeptides. This review describes the functions of the most important neuropeptides encountered at the level of the skin. [less ▲]

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See detailDiagnostic des infections cutanées par les herpes virus de types simplex et varicelle-zona
Nikkels, Arjen ULiege; Hermanns-Lê, Trinh ULiege; Tassoudji, Nazli ULiege et al

in Revue Médicale de Liège (1993), 48(7), 401-405

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See detailThe HLA dermatosis connection
Nikkels, Arjen ULiege; Tassoudji, Nazli ULiege; Pierard, Gérald ULiege

in Journal of the European Academy of Dermatology & Venereology (1992), 1

A number of dermatological diseases are associated with distinct HLA types. These associations vary in different populations and ethnic groups. HLA determination can be related to different diseases ... [more ▼]

A number of dermatological diseases are associated with distinct HLA types. These associations vary in different populations and ethnic groups. HLA determination can be related to different diseases courses, various anatomical predilection sites and can be used as a diagnostic tool. However, the pathogenic role of HLA in susceptibility to specific dermatological diseases often remains unclear. [less ▲]

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See detailLes auto-anticorps et le profil immunopathologique des lupus érythémateux
Nikkels, Arjen ULiege; Tassoudji, Nazli ULiege; Arrese Estrada, Jorge ULiege et al

in Revue Médicale de Liège (1991), 46(5), 279-285

Nous présentons une synthèse de la signification diagnostique, clinique et pronostique d'une série d'auto-anticorps apparaissant dans les diverses formes de lupus érythémateux.

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See detailLe système immunitaire cutané et le photovieillissement
Nikkels, Arjen ULiege; Tassoudji, Nazli ULiege; Arrese Estrada, Jorge ULiege et al

in Revue Médicale de Liège (1991), 46(3), 158-163

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe ... [more ▼]

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe immunocompétent. Le vieillissement cutané et l'exposition à la lumière ultraviolette ont une influence importante sur le système immunitaire cutané. Après une brève actualisation et description des cellules immunocompétentes de l'épiderme et du derme, nous considérerons la modulation du système immunitaire cutané liée au photovieillissement. [less ▲]

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