References of "Stevenaert, Achille"
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See detailLe cathétérisme bilatérale des sinus pétreux avec dosages multihormonaux dans la maladie de Cushing
Valdes Socin, Hernan Gonzalo ULg; Bataille, Yoann ULg; Meurisse, Nicolas ULg et al

in Annales d'Endocrinologie (2002), 63(1), 23-30

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI ... [more ▼]

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI, surgical findings and multihormonal BPSS. Seven patients (6F/1M) with Cushing's disease, mean age at diagnosis of 35 years (range 24-55) were prospectively studied to compare radiological and multihormonal BPSS data with surgical and pathological findings. In untreated patients, simultaneous measures of ACTH, TSH and prolactine (PRL) were done at time 0, 7, 15, 22 minutes after CRH (500 mg) and TRH (200 mg) stimulation. An intersinus gradient of 1.4 was considered as a lateralisation. All microadenomas were identified during surgery, diameters ranged from 2 to 7 mm. All patients were in long-term surgical remission. Pathological studies confirmed a tumoral tissue with ACTH immunostaining in 6/7 cases and PRL in 3/7 cases. Pituitary MRI correctly identified tumors in 4 cases, the remaining tumors were not seen. Basal and stimulated intersinus gradients of ACTH, TSH and PRL were homolateral in 6/7 cases and were coincident with surgical findings in 4/7 cases. The other three cases were contralateral to MRI and surgical data. In conclusion, simultaneous gradient of ACTH, PRL and TSH did not improve lateralisation prediction in this series. Hormonal hypersecretion was homolateral in six cases whereas pathological studies demonstrated a mixed secretion in only three cases. A preferential pituitary draining could explain these discordances. Data from our series and from others (done with CRH stimulation and ACTH-PRL measures) strongly suggest a paracrine interaction between tumoral and normal pituitary tissue. [less ▲]

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See detailAcute traumatic central cord syndrome: magnetic resonance imaging and clinical observations
Collignon, F. D.; Martin, Didier ULg; Lenelle, Jacques ULg et al

in Journal of Neurosurgery (2002), 96(1 Suppl), 29-33

Object. Acute traumatic central cord syndrome has been classically thought to be caused by a hemorrhage that primarily affects the central part of the spinal cord and that destroys the axons of the inner ... [more ▼]

Object. Acute traumatic central cord syndrome has been classically thought to be caused by a hemorrhage that primarily affects the central part of the spinal cord and that destroys the axons of the inner part of the corticospinal tract devoted to the motor control of the hands. Some authors, however, have proposed that its pathogenesis is based on the destruction of the motor neurons supplying the muscles of the hand. To test the validity of these two theories, the authors retrospectively studied the magnetic resonance (MR) images obtained in 18 cases of acute traumatic central cord syndrome (ATCCS) to assess the presence of intramedullary blood and to define the distribution of the abnormal signal intensities in the cervical spinal cord. Methods. The authors used the American Spinal Injury Association (ASIA) motor scale to assess upper- and lower-limb deficits and to evaluate its metameric distribution. The abnormal intramedullary signal was then compared with the distribution of the motor deficit. All MR imaging sessions performed in the acute stage revealed a hyperintense signal on T-2-weighted sequences without any signal change suggesting the presence of intramedullary blood. The localization of this signal was distributed predominantly from the C3-4 to the C5-6 disc levels. The mean ASIA motor score was 74.3 of 100, with an unequal representation between the upper and lower limbs (32 of 50 compared with 42.3 of 50, respectively). The metameric distribution of the deficit was also unequal, with a major deficit in hand function (C8-T1) compared with the more proximal cord segments (5.2 of 10 compared with 7.8 of 10, respectively). This demonstrates the absence of any correlation between the hyperintense signal and the motor deficit distribution. Conclusions. Acute traumatic central cord syndrome cannot be explained by the injury to the gray matter at the level of motor neurons supplying the hand muscles. In agreement with recently published data, the results of this series confirm the absence of intramedullary hemorrhage and corroborate the hypothesis that ATCCS may be explained by the impairment of the corticospinal tract, which can be affected globally. [less ▲]

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See detailAcromégalie : Diabète, intolérance au glucose et sensibilité à l'insuline
Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg; Betea, Daniela ULg et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailSevere Growth hormone deficiency in non diabetic patients with corticotroph microadenomas : effects of pituitary surgery and implications for GH replacement
Valdes Socin, Hernan Gonzalo ULg; Laret, V.; de Fays, C. et al

in 10th Meeting of the European Neuroendocrine Association - Abstract book (2002)

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See detailDéficience sévère en hormone de croissance chez les patients non diabétiques avec un microadénome corticotrope : Effets de la chirurgie hypophysaire et implications thérapeutiques
Valdes Socin, Hernan Gonzalo ULg; Laret, V.; de Fays, C. et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailFamilial isolated pituitary tumors : clinical and molecular studies in 80 patients
Valdes Socin, Hernan Gonzalo ULg; Jaffrain-Réa, M. L.; Tamburrano, G. et al

in The Endocrine Society's 84th Annual Meeting - Abstract book (2002)

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See detailFamilial Pituitary tumors
Valdes Socin, Hernan Gonzalo ULg; Poncin, J.; Vanbellinghen, Jean-François ULg et al

in Neuroendocrinologica : Dalla Riserca di base alla Clinica (2002)

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See detailExtensive inflammatory pseudotumor of the pituitary.
Hansen, Isabelle ULg; Petrossians, Patrick ULg; Thiry, Albert ULg et al

in Journal of Clinical Endocrinology and Metabolism (2001), 86(10), 4603-4610

A 40-yr-old female presented with an extensive lesion of the sellar area and the sphenoid sinus, spreading to the optic nerves and associated with pachymeningitis. Histological findings were consistent ... [more ▼]

A 40-yr-old female presented with an extensive lesion of the sellar area and the sphenoid sinus, spreading to the optic nerves and associated with pachymeningitis. Histological findings were consistent with an inflammatory pseudotumor, and steroid treatment allowed the disappearance of all the lesions. Inflammatory pseudotumors of the pituitary are very rare. This case appears unique with regard to the extension of the lesions and the dramatic response to medical treatment. The differential diagnosis of inflammatory lesions of the pituitary is difficult. It relies mainly on histological analysis and includes sarcoidosis, Wegener's granulomatosis, histiocytosis (Langerhans, Rosai-Dorfman, and Erdheim-Chester diseases) and lymphocytic hypophysitis. [less ▲]

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See detailMétamorphose d'une acromégalie en un adénome hypophysaire non-fonctionnel : Etudes clinique et génétiques
Valdes Socin, Hernan Gonzalo ULg; Stevenaert, Achille ULg; Legros, Jean-Jacques ULg et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailMetamorphosis of acromegaly to a non-functioning pituitary adenoma
Valdes Socin, Hernan Gonzalo ULg; Stevenaert, Achille ULg; Legros, Jean-Jacques ULg et al

in 5th European Congress of Endocrinology - Abstract book (2001)

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See detailSurgical outcome inagromecalics treated with somatostatin analogues before surgery
Stevenaert, Achille ULg; Valdes Socin, Hernan Gonzalo ULg; Flandroy, P. et al

in 5th European Congress of Endocrinology - Abstract book (2001)

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See detailApport du cathétérisme des sinus pétreux inférieux (CSPI) dans la prédiction de la localisation d'un adénome hypophysaire
Valdes Socin, Hernan Gonzalo ULg; Bataille, Yoann ULg; Meurisse, Nicolas ULg et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailLes adénomes hypophysaires familiaux isolés non liés aux syndromes MEN1 et carney Complex : Etude multicentrique
Valdes Socin, Hernan Gonzalo ULg; Poncin, J.; Vanbellinghen, Jean-François ULg et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailThytropin producing pituitary adenomas : a large belgo-french experience of 41 cases
Valdes Socin, Hernan Gonzalo ULg; Chanson, P.; Delemer, B. et al

in 5th European Congress of Endocrinology - Abstract book (2001)

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See detailFractionated stereotactic radiotherapy : treatment of 24 pituitary adenoma
Valdes Socin, Hernan Gonzalo ULg; Kaschten, Bruno ULg; Rutten, I. et al

in 5th European Congress of Endocrinology - Abstract book (2001)

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See detailFamilial Isolated pituitary adenomas not related to the MEN1 syndrome
Valdes Socin, Hernan Gonzalo ULg; Poncin, J.; Vanbelinghen, J. F. et al

in 5th European Congress of Endocrinology - Abstract book (2001)

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See detailRésultats de la chirurgie trans-sphénoïdale chez les acromégales traités par analogues de la somatostatine avant chirurgie
Stevenaert, Achille ULg; Valdes Socin, Hernan Gonzalo ULg; Flandroy, P. et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailJuxtafacet Cyst of the Lumbar Spine. Clinical, Radiological and Therapeutic Aspects in 28 Cases
Salmon, B.; Martin, Didier ULg; Lenelle, Jacques ULg et al

in Acta Neurochirurgica (2001), 143(2), 129-34

OBJECT: A consecutive series of 28 "operated" juxtafacet cysts is reported. We emphasize the clinical and radiological aspects leading to diagnosis. We also discuss the results of the surgical treatment ... [more ▼]

OBJECT: A consecutive series of 28 "operated" juxtafacet cysts is reported. We emphasize the clinical and radiological aspects leading to diagnosis. We also discuss the results of the surgical treatment. MATERIAL AND METHODS: Medical information and radiological studies involving 28 patients were analyzed. Each patient has been operated on by decompressive laminectomy and resection of the cyst. The diagnosis was always confirmed by a pathological examination. The cyst most frequently occurred at the L4-L5 level (n = 18), and seldom at the L5-S1 (n - 6) or L3-L4 (n - 4) levels. RESULTS: The differential diagnosis from other pathological causes responsible for a radicular compression could not be done by physical examination. Spine X-rays or myelogram were nonspecific. Computed Tomography or CT-myelography could help in the diagnosis but MR imaging was the most sensitive. In our series, the respective sensitivities of these techniques are 56, 42 and 77%. The preoperative diagnosis was correct in 18 patients (64%). The cyst was sometimes adherent to the underlying dura, then significantly increasing the risk of dural tear and spinal fluid leak, especially when located at L3-L4 level. Surgical ablation lead to a complete recovery or an important improvement in 26 patients. CONCLUSIONS: The diagnosis of the juxtafacet cyst of the lumbar spine is better achieved by MRI. Surgery is the gold standard treatment, safe and long-term effective. When a total cyst removal with an internal facetectomy are performed, recurrence is exceptional. [less ▲]

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See detailACTH silent adenoma shrinking under cabergoline.
Petrossians, Patrick ULg; Ronci, N.; Valdes Socin, Hernan Gonzalo ULg et al

in European Journal of Endocrinology (2001), 144(1), 51-57

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non ... [more ▼]

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non-functioning pituitary adenomas. DESIGN: Following the clinical and radiological improvement of a recurrent silent ACTH adenoma in a 77-year-old patient treated with cabergoline (0.5 mg every 2 days for 2 years), in vitro studies of the original tumor were performed. METHODS: The original tumor from the patient was studied by in situ hybridization and dopamine D2 receptor autoradiography. It was compared with four macroprolactinomas and two macroadenomas from patients with Cushing's disease. RESULTS: The D2 receptor mRNA signal of the reported case was intense and of the same order of magnitude as that observed in control prolactinomas. Dopamine D2 receptor autoradiography was twice that of control corticotroph adenomas and was close to that observed in prolactinomas. CONCLUSIONS: This is the first description of an in vivo shrinkage of an ACTH silent adenoma under cabergoline. We demonstrate in vitro, the presence of D2 receptors in the primitive tumor in concentrations similar to those found in control prolactinomas. These results suggest that therapeutic trials with cabergoline might be undertaken in recurring cases of ACTH silent tumors and more generally, non-functioning pituitary adenomas. [less ▲]

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See detailPharmacological Modulation of the Bystander Effect in the Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy System: Effects of Dibutyryl Adenosine 3',5'-Cyclic Monophosphate, Alpha-Glycyrrhetinic Acid, and Cytosine Arabinoside
Robe, Pierre ULg; Princen, Frédéric; Martin, Didier ULg et al

in Biochemical Pharmacology (2000), 60(2), 241-9

The herpes simplex virus type 1 thymidine kinase (HSV1-tk) suicide gene/ganciclovir system was first applied to the treatment of glioblastoma tumors, but was hampered by the low gene transfection yield ... [more ▼]

The herpes simplex virus type 1 thymidine kinase (HSV1-tk) suicide gene/ganciclovir system was first applied to the treatment of glioblastoma tumors, but was hampered by the low gene transfection yield. Fortunately, the gap junction-dependent diffusion of phosphorylated ganciclovir metabolites from transfected cells to their neighbors proved to enhance the overall benefit of this strategy. However, as tumor cells are often gap junction-deficient, we sought to restore this property pharmacologically and hence to improve the efficacy of the treatment. We demonstrated that this approach was feasible in glioblastoma cells using dibutyryl adenosine 3',5'-cyclic monophosphate (cAMP) (100 microM) as a pharmacological inducer of gap junctions. alpha-Glycyrrhetinic acid (25 microM), on the other hand, strongly inhibited both gap junction-mediated intercellular communication and the bystander effect, thus confirming the role of gap junctions in HSV-tk-mediated bystander killing. Using cytosine arabinoside as a growth inhibitor, we underlined the role of tumor cell proliferation in the sensitivity of HSV-tk-transfected cells to ganciclovir and demonstrated its correlation with the importance of the bystander effect. [less ▲]

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