References of "Stevenaert, Achille"
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See detailGonadotropin secreting tumors
Beckers, Albert ULg; Ciccarelli, A.; Valdes Socin, Hernan Gonzalo ULg et al

in The Encyclopedia of Endocrinology and Endocrine Diseases (2004)

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See detailApproaching the true prevalence of pituitary tumors
Beckers, Albert ULg; Ciccarelli, A.; Daly, Adrian ULg et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailCushing's disease : very long-term results of transsphenoidal, clinical and genetic studies
Stevenaert, Achille ULg; Perrin, G.; Martin, Didier ULg et al

in 12th International Congress of Endocrinology - Abstract book (2004)

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See detailUne approche de la vraie prévalence des tumeurs hypophysaires
Beckers, Albert ULg; Ciccarelli, A.; Daly, Adrian ULg et al

in XXIème Congrès de la Société Française d'Endocrinologie - Abstract book (2004)

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See detailLa réduction chirurgicale de la masse tumorale des adénomes hypophysaires améliore le contrôle médical de l'acromégalie par les analogues de la Somatostatine
Petrossians, Patrick ULg; Borges-Martins, L.; Espinoza, C. et al

in XXIème Congrès de la Société Française d'Endocrinologie - Abstract book (2004)

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See detailResults of transsphenoidal microsurgery in Cushing's disease
Stevenaert, Achille ULg; Perrin, G.; Martin, Didier ULg et al

Conference (2003, March 29)

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See detailThe extraforaminal juxtafacet cyst as a rare cause of L5 radiculopathy: a case report.
Salmon, Bernard L; Deprez, Manuel ULg; Stevenaert, Achille ULg et al

in Spine (2003), 28(19), 405-7

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal ... [more ▼]

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal juxtafacet cysts develop most frequently at the dorsal aspect of the zygapophysial joint, sometimes in the posterolateral area of the canal. In one case, they have been described in the foraminal and extraforaminal region. METHODS: Description of the case report. RESULT: The authors report one case of a strictly extraforaminal juxtafacet cyst responsible for L5 sciatica. CONCLUSIONS: Juxtafacet cysts of the spine represent an infrequent cause of sciatica, usually when they grow in the canal, or more exceptionally when they occupy the foraminal or extraforaminal areas. [less ▲]

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See detailThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
Valdes Socin, Hernan Gonzalo ULg; Chanson, Philippe; Delemer, B. et al

in European Journal of Endocrinology (2003), 148(4), 433-442

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 ... [more ▼]

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 male and 20 female) among 4400 pituitary adenomas followed between 1976 and 2001 in six Belgian and French centers. RESULTS: TSH was elevated in 18/43 and alpha subunit in 13/32 patients. In patients with intact thyroid (n=30), mean free tri-iodothyronine was 13.1 pmol/l (range 3.5-23) and mean free thyroxine was 38.4 pmol/l (range 10.2-62.7). Hyperprolactinemia and acromegaly were associated in 9/43 and 8/43 cases. The number of associated hypersecretions was higher in macroadenomas than in microadenomas (Chi square = 11.2, P<0.01). Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome. The proportion of microadenomas versus macroadenomas was 1/11 (period 1974-1986) and 8/32 (period 1987-2001). Bilateral petrosal sinus sampling, (111)In-pentreotide scintigraphy and ((11)C)-l-methionine positron emission tomography scan confirmed diagnosis in four questionable microadenomas. Macroadenomas with extrasellar extension (31 cases) had a tendency to be medially located. Medical treatment with somatostatin analogs was initiated as first-line treatment in 26 patients. TSH levels were reduced by more than 50% in 23/26 cases. A tumoral shrinkage of more than 20% was observed in 5/13 cases. Surgery was performed in 36 patients. After 1 year, 21 of them (58.3%) met the criteria of surgical favorable outcome. Pituitary radiotherapy (n=8) and somatostatin analogs allowed normalization in cases not cured by surgery. CONCLUSION: Ultrasensitive methods for TSH measurement led to an earlier recognition of TSH-secreting pituitary tumors. In this series, we observed that TSH-secreting pituitary tumors are today more frequently found at the stage of microadenomas, medially located, without associated hypersecretions and needing new exploration methods as compared with older series. This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease. [less ▲]

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See detailLe cas clinique du mois. Masse médiastinale antérieure chez une patiente acromégale.
Laret, Vinciane ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Revue Médicale de Liège (2003), 58(12), 724-728

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the ... [more ▼]

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the first diagnostic step consists of finding the etiology of the disease in order to use adequate treatment. This can be complicated by the fact that acromegaly can be associated with other tumors (for instance in MEN-1 disease and Carney Complex) and because chronic GH hypersecretion can stimulate tumor overgrowth and perhaps tumor formation. We describe the case of a 44-year-old acromegalic woman with an anterior mediastinal mass. We present the different diagnoses and a review of the literature. [less ▲]

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See detailThe treatment of sporadic versus MEN1-related pituitary adenomas.
Beckers, Albert ULg; Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Internal Medicine (2003), 253(6), 599-605

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single ... [more ▼]

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single or a combination of three different methods: surgery, medication and radiotherapy. The rationale for deciding the treatment are many but include the aggressiveness of the tumour. The aetiologies of sporadic pituitary adenomas are not fully understood. However, several causes have been identified resulting in specific familial phenotypes like multiple endocrine neoplasia type I (MEN1). MEN1 is related to mutations in the MEN1 gene, a tumour suppressor gene localized on chromosome 11q13 and which encodes menin, a 610 amino acid protein. During the last years, an evidence progressively emerged that MEN1-related adenomas were more aggressive and less responsive to therapy than their sporadic counterparts. In this article, we review the differences between sporadic and MEN1-related adenomas and suggest specific ways of treatment and follow-up for MEN1-related tumours. [less ▲]

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See detailAcromégalie et grossesse
Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg; Hansen, Isabelle ULg et al

in Annales d'Endocrinologie (2002), 63(5), 457-63

Acromegaly usually results from GH hypersecretion by a somatotroph adenoma. The fertility of acromegalic patients is often impaired. Several factors may impact the course of pregnancy in acromegaly ... [more ▼]

Acromegaly usually results from GH hypersecretion by a somatotroph adenoma. The fertility of acromegalic patients is often impaired. Several factors may impact the course of pregnancy in acromegaly. Disturbed pituitary function might lead to infertility or spontaneous abortion. GH is a powerful insulin antagonist, and pregnant acromegalic patients are prone to added glucose intolerance and diabetes. Pregnancy itself might also impact the course of the pituitary tumor. During pregnancy, the normal pituitary increases in size due to estrogens-mediated hyperplasia. Therefore, tumors are at risk for hemorrhage due to enhanced vascularity, and might compress the optic chiasm. In this article we summarize the data on the literature on the reciprocal influences between acromegaly and pregnancy, we discuss therapeutic options and advance diagnostic and surveillance schedules of acromegaly during pregnancy. [less ▲]

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See detailSevere growth hormone deficiency in non diabetic patients with corticotroph microadenomas: effects of pituitary surgery and implications for GH replacement.
Valdes, S.; Laret, V.; Dufays, C. et al

Conference (2002, September 12)

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See detailMaladie de Cushing et adénome corticotrope: fonctions antéhypophysaires avant et après microchirurgie transsphénoidale
Martin, Didier ULg; Valdes Socin, Hernan Gonzalo ULg; Beckers, Albert ULg et al

in Neuro-Chirurgie (2002), 48(2-3, Pt 2), 226-233

Background and purpose. - Cushing's disease is characterized by an overproduction of ACTH inducing an hypersecretion of corticosteroids. We assessed the non-corticotrophic pituitary functions before and ... [more ▼]

Background and purpose. - Cushing's disease is characterized by an overproduction of ACTH inducing an hypersecretion of corticosteroids. We assessed the non-corticotrophic pituitary functions before and after microsurgical resection of the corticotrophic adenoma. Methods. - We reviewed retrospectively a series of 98 patients (19 males, 79 females) undergoing transsphenoidal surgery between 1974 and 2001. Prolactin levels, somatrotrophic, gonadotrophic and thyroidotrophic functions were assessed and compared before and after resection of the adenoma. Results. - Before surgery, we observed an elevation of prolactin and a reduction of the GH, TSH, LH and FSH levels. These modifications were not linked to the volume of the adenoma but depended on the systemic effect of the hypercorticism or on local paracrine mechanisms. Selective adenomectomy usually restored altered corticotrophic and also, unlike (partial or total) hypophysectomy, the non-corticotrophic functions. Conclusions. - Non-corticotrophic functions are often altered in Cushing's disease but can be restored after selective adenomectomy. [less ▲]

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See detailMaladie de Cushing et adénome corticotrope: résultats de la microchirurgie hypophysaire
Stevenaert, Achille ULg; Perrin, G.; Martin, Didier ULg et al

in Neuro-Chirurgie (2002), 48(2-3, Pt 2), 234-265

Between November 1994 and June 2001, 194 patients with Cushing's disease underwent transsphenoidal surgery: 167 patients had adenomectomy, 14 had ante hypophysectomy, 5 had subtotal hypophysectomy, 4 had ... [more ▼]

Between November 1994 and June 2001, 194 patients with Cushing's disease underwent transsphenoidal surgery: 167 patients had adenomectomy, 14 had ante hypophysectomy, 5 had subtotal hypophysectomy, 4 had hemihypophysectomy 4 had central hypophysectomy. Complications occurred in 18 patients (9.3%), including 4 deaths (three were apparently not related to surgery). Remission of disease was achieved in 162 of 190 (85.3%) patients analyzed. Surgical failures were associated with lack of pituitary adenoma, size of the tumor and invasiveness. Among patients with confirmed adenomas, the rate of remission was significantly higher (p<0.01) in patients with microadenomas (92.6%) than in patients with macroadenomas (66.7%). Reoperation in 6 failures was followed by remission in 4 cases. The overall remission rate was 87.4%. In the 162 patients with immediate success, duration of follow-up was 10.0 +/- 5.9 years (m +/- DS; median=10.0). Recurrence of the disease occurred in 24 (14.8%) of 162 patients at a mean 4.8 years (range: 0.8-12.0 years). Our longest sustained remission is 25.6 years. Actuarial analysis indicates that the probability of a patient remaining well 12 years after surgery is 80.0%. It is 86.2% in microadenomas versus 52.5% in macroadenomas and 94.5% in the patients with postoperative hypocortisolism versus 59.2% in the others. [less ▲]

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See detailDiagnostic differentiel et traitement medical dans la maladie de Cushing.
Beckers, Albert ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Neuro-Chirurgie (2002), 48(2-3 Pt 2), 163-172

Cushing's disease remains a difficult diagnosis in spite of new technical procedures such as pituitary MRI, selective bilateral petrosal or cavernous sampling, (111)In pentreotide scan and 18 ... [more ▼]

Cushing's disease remains a difficult diagnosis in spite of new technical procedures such as pituitary MRI, selective bilateral petrosal or cavernous sampling, (111)In pentreotide scan and 18 Flurodeoxyglucose pituitary PET scan. In this article, we review biological diagnostic procedures of Cushing's disease and corticotroph adenomas. According to our experience and the literature, we summarize the approach in medical treatment of Cushing's disease. [less ▲]

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See detailLe syndrome centro-médullaire aigu traumatique. Corrélations cliniques et radiologiques
Martin, Didier ULg; Collignon, F.; Schils, F. et al

Conference (2002, April 25)

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See detailPrimary cerebral lymphoma. A retrospective study of 32 patients
Dubuisson, Annie ULg; Kaschten, Bruno ULg; Lenelle, Jacques ULg et al

Conference (2002, April 25)

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See detailUse of polylactide scaffolds in different models of spinal cord injury to promote axonal regeneration.
Schils, F.; Franzen, R.; Maquet, V. et al

Conference (2002, March 23)

Detailed reference viewed: 6 (0 ULg)