Thyrotropin-Secreting Pituitary Adenomas: Report of Seven Cases
Beckers, Albert ; ; et al
in Journal of Clinical Endocrinology and Metabolism (1991), 72(2), 477-83
Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied ... [more ▼]
Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied between 1.1-36.3 mU/L. The serum alpha-subunit level was low in 1 case, while in 4 other cases the concentration was elevated and varied between 3.7-7.8 micrograms/L. Serum TSH beta levels were normal in the 4 cases in which it was determined. Serum GH or PRL levels were elevated in 5 cases. In 1 patient the cosecretion of TSH, GH, and PRL was confirmed by immunocytochemical examination. Serum TSH and alpha-subunit responses to TRH, GnRH, CRF, GRF, dexamethasone, methimazole, T3, and bromocriptine administration were variable when studied. Serum TSH and alpha-subunit circadian rhythms were absent in 1 case and inverted in another. A serum alpha-subunit pulsatility without TSH pulses was observed in 1 patient. Five patients underwent transsphenoidal adenomectomy. Three of 4 patients operated on in our center were cured, but a recurrence of the adenoma was found in 1 of them after 5 yr. The fifth patient was not cured. Treatment with octreotide in 3 patients resulted in normalization of serum TSH, GH, and thyroid hormones levels. Cosecretion of PRL in 1 case and alpha-subunit in 2 cases was also inhibited. Partial tachyphylaxis occurred in 1 patient. In summary, heterogeneity in clinical presentation, hormonal expression, and therapeutic response appears to characterize these TSH-secreting adenomas. [less ▲]Detailed reference viewed: 59 (0 ULg)
CV 205-502 : Een niewe lang-werkende dopamine-agonist voor de behandeling van hyperprolactinemie.
; ; Beckers, Albert et al
in Tijdschrift voor Geneeskunde (1991)Detailed reference viewed: 8 (0 ULg)
Adenohypophysis hormone gene products in 14 pituitary adenomas: analysis by immunohistochemistry and northern blotting.
Scippo, Marie-Louise ; Beckers, Albert ; Frankenne, Francis et al
in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1991), 99(2), 135-40
We investigated 14 pituitary adenomas (10 silent adenomas; 3 prolactinomas and one GH-secreting tumor) for the presence of hormone gene transcripts (Northern blot) as well as for translation products ... [more ▼]
We investigated 14 pituitary adenomas (10 silent adenomas; 3 prolactinomas and one GH-secreting tumor) for the presence of hormone gene transcripts (Northern blot) as well as for translation products (immunohistochemistry). The GH-secreting tumor was shown to express the genes coding for GH and PRL and to synthesize the corresponding hormones. In the cases of prolactinomas, immunohistochemical data demonstrated the synthesis of prolactin only. In addition to the PRL gene, Northern blot analysis revealed the transcription of the alpha-subunit gene in one case. Hormone genes were found to be expressed in 7 out of the 10 silent tumors, whereas no hormone synthesis was detected in any of these tissues. LH-beta mRNA was found in 3 cases, FSH-beta mRNA in 5 cases and alpha-subunit gene was shown to be expressed in one case. Surprisingly, the level of expression of the FSH-beta gene was higher than in normal tissue. This study confirms that some so called "silent" adenomas are expressing alpha- and/or beta-subunit glycoprotein hormone genes, even if no hormone is synthesized. The therapeutic action of bromocriptine described in some "silent" adenomas cases could be related to that hormone gene expression potentiality. [less ▲]Detailed reference viewed: 43 (8 ULg)
Transplants of syngenic adult dorsal root ganglion neurons to the spinal cord of rats with acute traumatic paraplegia: morphological analyses.
Martin, Didier ; ; Schoenen, Jean et al
in Restorative Neurology & Neuroscience (1991), 2Detailed reference viewed: 43 (13 ULg)
Experimental acute spinal cord injury in rats : behavioural and histopathological analyses. Morphological studies on autologous transplants of cultured, adult DRG-derived Schwann cells to the injured spinal cord in adult rats
Martin, Didier ; ; Schoenen, Jean et al
Conference (1990, September)Detailed reference viewed: 10 (5 ULg)
Acromegaly, multinodular goiter, and silent polyostotic fibrous dysplasia : a variant of the Mc Cune Albright syndrome.
; Beckers, Albert ; Stevenaert, Achille et al
in Journal of Endocrinological Investigation (1990), 13(8), 671-675
A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident ... [more ▼]
A 36-year-old woman is reported with a possible variant of the McCune-Albright syndrome. The triad was incomplete because of the absence of skin pigmentation and since the sexual precocity was not evident. The presence of a pituitary mass and the secretory dynamics of growth hormone and prolactin were suggestive of a mammosomatotroph cell adenoma. A toxic multinodular goiter was also associated, but unique was the spontaneous normalization of the thyroid function. Unusual was the silent evolution of the polyostotic fibrous dysplasia, which was only fortuitously discovered during magnetic resonance imaging of the pituitary region. Treatment of the acromegaly with the long-acting somatostatin analogue octreotide resulted in an important inhibition of the GH secretion and in a reduction of the volume of the pituitary adenoma. [less ▲]Detailed reference viewed: 35 (0 ULg)
Pituitary microadenomas: diagnosis with two-and three-dimensional MR imaging at 1.5 T before and after injection of gadolinium.
; Stevenaert, Achille ; Beckers, Albert et al
in Radiology (1990), 176(2), 419-428
The usefulness of different magnetic resonance (MR) imaging sequences (coronal and sagittal spin-echo [SE] and three-dimensional fast low-angle shot [3D FLASH]) in the detection of pituitary microadenomas ... [more ▼]
The usefulness of different magnetic resonance (MR) imaging sequences (coronal and sagittal spin-echo [SE] and three-dimensional fast low-angle shot [3D FLASH]) in the detection of pituitary microadenomas before and after gadolinium injection was prospectively evaluated in 28 patients with surgical confirmation. When evaluated separately, the most useful sequences in the detection of these microadenomas were coronal pregadolinium T1-weighted SE, coronal pregadolinium 3D FLASH, coronal postgadolinium T1-weighted SE, and coronal postgadolinium 3D FLASH. The combination of pre- and postgadolinium T1-weighted sequences with pre-and postgadolinium 3D FLASH sequences produced the highest number of true-positive findings (90%) and the lowest number of false-positive findings (5%). When a 1.5-T imaging unit with a high signal-to-noise ratio allowing useful three-dimensional acquisition is used, the authors advocate a coronal T1-weighted SE sequence, followed (if necessary) by a coronal 3D FLASH sequence, both without injection of gadolinium, in the diagnosis of pituitary microadenomas. When no confident diagnosis is reached, the same sequences should be performed after the injection of gadolinium. The sagittal pre- and postgadolinium T1-weighted SE and long-TR SE sequences are useful only in specific cases. [less ▲]Detailed reference viewed: 25 (1 ULg)
La neurostimulation épidurale pour artérite sévère des membres inférieurs
Van Damme, Hendrik ; Martin, Didier ; Devoghel, Jean-Claude et al
in Revue Médicale de Liège (1990), 45(5), 219-27Detailed reference viewed: 68 (2 ULg)
Experimental acute spinal cord injury using subdural inflatable balloon
Martin, Didier ; ; et al
Conference (1990, May)Detailed reference viewed: 3 (0 ULg)
Placental and Pituitary Growth Hormone Secretion During Pregnancy in Acromegalic Women
Beckers, Albert ; Stevenaert, Achille ; Foidart, Jean-Michel et al
in Journal of Clinical Endocrinology and Metabolism (1990), 71(3), 725-31
It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period ... [more ▼]
It is now well established that during the second half of normal pregnancy, the human placenta secretes its specific GH variant (placental GH) in increasing amounts up to delivery. During the same period, pituitary GH secretion is progressively suppressed. The present study was aimed at clarifying the physiology of GH secretion in pregnant acromegalic women. Two young women remained acromegalic despite transphenoidal removal of their pituitary adenoma. Increased basal levels of GH and insulin-like growth factor-I (IGF-I) as well as paradoxical GH release after TRH injection were noted. Both women became pregnant and delivered term babies without any complication. In both patients, pituitary GH remained elevated during the entire pregnancy, contrary to the situation in normal women. Paradoxical GH release after TRH treatment was also present, whereas no response was observed in five normal control subjects. GH pulsatility studies revealed a highly pulsatile secretory pattern of pituitary GH, in contrast to that in normal woman, whose placental GH is secreted tonically. Tissue placental GH concentrations were within the range of levels in normal placentas. An increase in serum IGF-I in late pregnancy was also similar to that observed in normal pregnancy. These findings confirm that increased IGF-I levels are not pituitary GH dependent in late pregnancy. They add new evidence that adenomatous somatotrophs lack an IGF-I-dependent feedback regulation present in normal somatotrophs. [less ▲]Detailed reference viewed: 56 (9 ULg)
The comparison of two dimensional and three dimensional sequences before and after Gadolinium injection in the diagnosis of microadenomas at 1.5 Tesla.
; Stevenaert, Achille ; Beckers, Albert et al
in Radiology (1990), 176Detailed reference viewed: 2 (0 ULg)
Cyclical Cushing's disease and its successful control under sodium valproate.
Beckers, Albert ; Stevenaert, Achille ; et al
in Journal of Endocrinological Investigation (1990), 13(11), 923-9
Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical ... [more ▼]
Several subgroups of Cushing's disease were recently described (anterior or intermediate lobe origin, hyper-or hypo-pulsatility of cortisol, presence or absence of response after GRH or TRH, cyclical Cushing's disease). We present here a detailed case report on a patient suffering from Cushing's disease whose endocrine functions were extensively investigated. Treatment with bromocriptine, as well as subsequent transsphenoidal surgery, were followed by rapid but transient reversal of symptoms. When clinical manifestations reoccurred, daily measurements of free urinary cortisol revealed a cyclic pattern of cortisol hyperexcretion. A study of ultradian rhythm revealed hyperpulsatility of cortisol secretion. More interestingly, a treatment with sodium valproate, a drug known to inhibit CRH production, was followed by a rapid and longstanding normalization of clinical and biological data for 2 years. Based on these data, and on information from the literature, the present case of Cushing's disease exhibits characteristics suggesting a possible hypothalamic origin. [less ▲]Detailed reference viewed: 42 (0 ULg)
The treatment of macroprolactinomas with long acting repeatable bromocriptine.
Beckers, Albert ; ; Petrossians, Patrick et al
in Journal of Endocrinological Investigation (1990)
Thyrotropin-secreting pituitary adenomas : report of 7 cases.
Beckers, Albert ; ; et al
in Journal of Endocrinological Investigation (1990)Detailed reference viewed: 1 (0 ULg)
The physiology of pituitary and placental GH function during pregnancy in acromegalic as compared on normal women
Beckers, Albert ; ; Stevenaert, Achille et al
in Endocrinology under 35, sienna italy - Abstract book (1990)Detailed reference viewed: 7 (7 ULg)
Sarcome d'Ewing du rachis : à propos de trois observations
Lenelle, Jacques ; ; et al
Conference (1989, December)Detailed reference viewed: 29 (2 ULg)
Tratamiento farmacologico de la hiperprolactinemia
Petrossians, Patrick ; Stevenaert, Achille ; Beckers, Albert
in Hiperprolactinemias : Avances en el Diagnostico y tratamiento de las hiperprolactinemias (1989)Detailed reference viewed: 14 (0 ULg)