Safety and Performance of Stochastic Targeted (STAR) TGC of Insulin and Nutrition

in Proceedings of SQAO 2011 (2011)

Enteral nutrition-associated incretin effect in the critically ill

in Proceedings of the 33rd Congress of Clinical Nutrition and Metabolism (ESPEN 2011) (2011)

Validation of subject-specific cardiovascular system models from porcine measurements.

in Computer Methods & Programs in Biomedicine (2011)

A previously validated mathematical model of the cardiovascular system (CVS) is made subject-specific using an iterative, proportional gain-based identification method. Prior works utilised a complete set ... [more ▼]

A previously validated mathematical model of the cardiovascular system (CVS) is made subject-specific using an iterative, proportional gain-based identification method. Prior works utilised a complete set of experimentally measured data that is not clinically typical or applicable. In this paper, parameters are identified using proportional gain-based control and a minimal, clinically available set of measurements. The new method makes use of several intermediary steps through identification of smaller compartmental models of CVS to reduce the number of parameters identified simultaneously and increase the convergence stability of the method. This new, clinically relevant, minimal measurement approach is validated using a porcine model of acute pulmonary embolism (APE). Trials were performed on five pigs, each inserted with three autologous blood clots of decreasing size over a period of four to five hours. All experiments were reviewed and approved by the Ethics Committee of the Medical Faculty at the University of Liege, Belgium. Continuous aortic and pulmonary artery pressures (P(ao), P(pa)) were measured along with left and right ventricle pressure and volume waveforms. Subject-specific CVS models were identified from global end diastolic volume (GEDV), stroke volume (SV), P(ao), and P(pa) measurements, with the mean volumes and maximum pressures of the left and right ventricles used to verify the accuracy of the fitted models. The inputs (GEDV, SV, P(ao), P(pa)) used in the identification process were matched by the CVS model to errors <0.5%. Prediction of the mean ventricular volumes and maximum ventricular pressures not used to fit the model compared experimental measurements to median absolute errors of 4.3% and 4.4%, which are equivalent to the measurement errors of currently used monitoring devices in the ICU ( approximately 5-10%). These results validate the potential for implementing this approach in the intensive care unit. [less ▲]

Model-based cardiac disease diagnosis in critical care

in Proceedings of the Health Research Society of Canterbury (HRSC) Clinical Meeting 2010 (2010)

A Model-based Approach to Cardiovascular Monitoring of Pulmonary Embolism

in Proceedings of CONTROL 2010 (2010)

Patient-specific modelling of cardiovascular dysfunction: Identifying models of pulmonary embolism in pigs

in Proceedings of the 19th International Conference of the Cardiovascular System Dynamics Society (2010)

Validation of a virtual trial method for tight glycemic control in intensive care

in Proceedings of the Health Research Society of Canterbury (HRSC) Clinical Meeting 2010 (2010)

Tight Glycaemic control and nutrition: A comparison of two protocols

in Proceedings of the Centre for Bio-Engineering One Day Conference 2010 (2010)

Why Protocolised care works in my unit?

in Proceedings of the Australia-New Zealand Intensive Care Society Scientific Meeting (ANZICS 2010) (2010)

Patient-specific modelling of the cardiovascular system – application to septic shock with a minimal data set,

in World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany (2010)