References of "Scuvée-Moreau, Jacqueline"
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See detailHydrogen Peroxide Hyperpolarizes Rat Ca1 Pyramidal Neurons by Inducing an Increase in Potassium Conductance
Seutin, Vincent ULg; Scuvée-Moreau, Jacqueline ULg; Massotte, Laurent ULg et al

in Brain Research (1995), 683(2), 275-8

It has been suggested that hydrogen peroxide is involved in cascades of pathological events affecting neural cells. The aim of this study was therefore to examine whether this molecule is able by itself ... [more ▼]

It has been suggested that hydrogen peroxide is involved in cascades of pathological events affecting neural cells. The aim of this study was therefore to examine whether this molecule is able by itself to modify membrane properties of pyramidal neurons in the CA1 region of the rat hippocampus. Intracellular recordings in the slice preparation showed that 3.3 mM hydrogen peroxide hyperpolarized all neurons tested (n = 41) by 11 +/- 3 mV. This effect persisted in the presence of tetrodotoxin. It developed slowly, was reversible and reproducible. In the presence of tetrodotoxin, the extrapolated reversal potential of this effect was -95 +/- 5 mV in 2.5 mM external potassium. This value was not significantly different from the one obtained with the GABAB agonist baclofen (10 microM) (-98 +/- 5 mV). It shifted when the concentration of external potassium was increased to 10.5 mM (from -96 +/- 5 to -62 +/- 4 mV), in close agreement with the Nernst equation potassium ions. The hyperpolarization was significantly reduced (by 65 +/- 22%) by the potassium channel blocker barium (100 microM). We suggest that hydrogen peroxide is able to induce an increase in potassium conductance in rat CA1 pyramidal neurons. The exact mechanism by which it produces this effect (direct action on channels or indirect effect) remains to be determined. [less ▲]

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See detailElectrophysiological effects of ethanol on monoaminergic neurons: an in vivo and in vitro study.
Verbanck, P.; Seutin, Vincent ULg; Dresse, Albert ULg et al

in Alcoholism, Clinical & Experimental Research (1990), 14(5), 728-35

Monoaminergic neurons have been shown to play a role in both the intoxicating and chronic effects of ethanol. We present here the results of a study about the acute effects of ethanol on serotonergic ... [more ▼]

Monoaminergic neurons have been shown to play a role in both the intoxicating and chronic effects of ethanol. We present here the results of a study about the acute effects of ethanol on serotonergic raphe nucleus, noradrenergic locus coeruleus, and dopaminergic ventral tegmental area. These nuclei were investigated electrophysiologically by recording the spontaneous firing rate of single neurons using glass microelectrodes, both in vivo in chloral hydrate anesthetized rats and in vitro in brain slices. Ethanol was perfused intravenously at a rate ranging from 0.2 mg/kg/min to 0.2 g/kg/min in vivo, and at concentrations between 10(-8) M and 1 M in vitro. We observed that each monoaminergic nucleus had its own pattern of responses to acute ethanol perfusion, and that high and low concentrations have different actions, suggesting a biphasic effect. For example, in slices, ethanol concentrations higher than 10 mM induce an excitation in most raphe and ventral tegmental area neurons, and an inhibition of firing in locus coeruleus neurons. The results were comparable in the in vivo model, but much more heterogenous. We conclude that the effect of ethanol on the monoaminergic neurons is specific of the type of neuron, and that a biphasic effect is commonly found. [less ▲]

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See detailEffect of BHT-920 on monoaminergic neurons of the rat brain : an electrophysiological in vivo and in vitro study
Seutin, Vincent ULg; Scuvée-Moreau, Jacqueline ULg; Giesbers, Irène ULg et al

in Mededelingen van de Faculteit Landbouwwetenschappen (Rijksuniversiteit te Gent) (1990), 342

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See detailAction of Rilmenidine on Locus Ceruleus and Dorsal Raphe Cells in Vivo and in Vitro
Dresse, Albert ULg; Scuvée-Moreau, Jacqueline ULg; Seutin, Vincent ULg

in American Journal of Cardiology (1988), 61(7), 32-34

The effect of rilmenidine (S 3341) and clonidine on the firing rate of locus ceruleus (LC) and dorsal raphe (DR) cells was studied in vivo after systemic and microiontophoretic administration. The effect ... [more ▼]

The effect of rilmenidine (S 3341) and clonidine on the firing rate of locus ceruleus (LC) and dorsal raphe (DR) cells was studied in vivo after systemic and microiontophoretic administration. The effect of the 2 drugs was also studied in vitro on brain slices containing LC cells. Rilmenidine and clonidine inhibited the firing of LC and DR neurons. Complementary experiments performed with yohimbine and prazosin demonstrated that the effect of LC is related to an agonistic action on alpha 2 somatodendritic receptors, whereas the effect observed on DR cells is indirect. On LC cells, clonidine is 30 to 60 times as potent as rilmenidine. These observations may be related to less sedative effects of rilmenidine than of clonidine. [less ▲]

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See detailInfluence of the alpha2 agonist oxaminozoline (S3341) on the firing rate of central noradrenergic and serotonergic neurons in the rat
Dresse, Albert ULg; Scuvée-Moreau, Jacqueline ULg

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1986), 94

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See detailSensitivity in vivo of central alpha2 and opiate receptors after chronic treatment with various antidepressents
Scuvée-Moreau, Jacqueline ULg; Svensson, T. H.

in Journal of Neural Transmission (1982), 54

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See detailEffect of amineptine on the firing rate of central monoaminergic neurons in the rat
Scuvée-Moreau, Jacqueline ULg; Dresse, Albert ULg

in Archives Internationales de Physiologie et de Biochimie (1982), 90

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See detailEffect of trazodone on the firing rate of central monoaminergic neurons
Scuvée-Moreau, Jacqueline ULg; Dresse, Albert ULg

in Archives Internationales de Pharmacodynamie et de Thérapie (1982), 260

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See detailInhibitory effect of tricyclic antidepressant drugs on spontaneous activity of noradrenergic neurons - relation with blood and brain concentrations
Scuvée-Moreau, Jacqueline ULg; Fischer, Paul; Dresse, Albert ULg

in Archives Internationales de Physiologie et de Biochimie (1979), 87(1), 134-141

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See detailRelation between the effects of antidepressant drugs on the uptake of monoamines and on the spontaneous activity of central neurons
Scuvée-Moreau, Jacqueline ULg; Quinaux, Nicole; Dresse, Albert ULg

in Archives Internationales de Pharmacodynamie et de Thérapie (1979), 242(2), 318-320

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