References of "Schoenen, Jean"
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See detailThe role of the sympathetic nervous system in migraine and cluster headache
Schoenen, Jean ULg; MAERTENS DE NOORDHOUT, Alain ULg

in Olesen, J.; Edvinsson, L. (Eds.) Basic Mechanisms of Headache (1988)

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See detailNeuroanatomie chimique de la moelle épinière humaine.
Schoenen, Jean ULg

in Revue Neurologique (1988), 144(11), 630-42

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on ... [more ▼]

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on the literature and largely on personal results, is devoted to the chemical neuroanatomy of the normal human spinal cord. It provides a comprehensive overview of the differential distribution of various chemical messengers, their metabolizing enzymes and their receptors (acetylcholine, amino acids, monoamines, neuropeptides) in the neuronal laminae of the spinal gray matter. At the level of the dorsal horn, lamina II, i.e. Rolando's substantia gelatinosa, is characterized by a heavy concentration of several transmitters and receptors. Within the intermediate gray matter the autonomic nuclei receive a dense peptidergic input, e.g. substance P, enkephalin and VIP afferents. In the ventral horn close contacts are numerous between serotonergic or peptidergic (SP, TRH, enkephalins...) fibers and motoneuronal perikarya or dendrites. The present knowledge on the putative role of certain neurotransmitters in spinal functions is summarized. [less ▲]

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See detailNeuroanatomie chimique de la moelle épinière humaine: application à des cas pathologiques dans la sclérose latérale amyotrophique
Schoenen, Jean ULg

in Revue Neurologique (1988), 144(11), 630-42

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on ... [more ▼]

Modern neuroanatomical methods, specifically immunocytochemistry and receptor autoradiography, have greatly increased our knowledge on the organization of the human nervous system. This review, based on the literature and largely on personal results, is devoted to the chemical neuroanatomy of the normal human spinal cord. It provides a comprehensive overview of the differential distribution of various chemical messengers, their metabolizing enzymes and their receptors (acetylcholine, amino acids, monoamines, neuropeptides) in the neuronal laminae of the spinal gray matter. At the level of the dorsal horn, lamina II, i.e. Rolando's substantia gelatinosa, is characterized by a heavy concentration of several transmitters and receptors. Within the intermediate gray matter the autonomic nuclei receive a dense peptidergic input, e.g. substance P, enkephalin and VIP afferents. In the ventral horn close contacts are numerous between serotonergic or peptidergic (SP, TRH, enkephalins...) fibers and motoneuronal perikarya or dendrites. The present knowledge on the putative role of certain neurotransmitters in spinal functions is summarized. [less ▲]

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See detailExteroceptive suppression of temporalis muscle activity in chronic headache.
Schoenen, Jean ULg; Jamart, B.; Gerard, P. et al

in Neurology (1987), 37(12), 1834-6

Early (ES1) and late (ES2) exteroceptive suppression periods elicited by electrical stimulation of the labial commissure during teeth-clenching were recorded over the temporalis muscle in 45 headache ... [more ▼]

Early (ES1) and late (ES2) exteroceptive suppression periods elicited by electrical stimulation of the labial commissure during teeth-clenching were recorded over the temporalis muscle in 45 headache patients (25 tension headaches and 20 migraines) and 22 controls. Mean duration of ES2 for single shocks was significantly reduced in tension headache when compared with migraine or controls. At a stimulation rate of 2 Hz, ES2 was abolished in 40% of tension headache sufferers, but in none of the migraineurs. EMG analysis of temporalis late exteroceptive suppression might be a helpful diagnostic tool in functional headaches. Reduction of ES2 suggests that there is deficient activation or excessive inhibition of pontobulbar inhibitory interneurons which receive a strong input from limbic structures. ES2 might thus represent an interface between psychogenic and myogenic factors putatively involved in the pathogenesis of tension headache. [less ▲]

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See detailIntérêt de l'étude de la VCN dans les migraines et les céphalées de tension.
Timsit, M.; Timsit-Berthier, M.; Schoenen, Jean ULg et al

in Revue d'Eléctroencephalographie et de Neurophysiologie Clinique (1987), 17(3), 259-70

The aim of this study was to display the result obtained by the contingent negative variation (CNV) recording in patients suffering from headache. Eighty-five patients were taken into account: 59 with ... [more ▼]

The aim of this study was to display the result obtained by the contingent negative variation (CNV) recording in patients suffering from headache. Eighty-five patients were taken into account: 59 with migraines (M) and 26 with tension headache (TH). A typical CNV pattern (high CNV amplitude with no habituation) differentiated M from TH. Moreover, psychological data were collected through Rorschach ink blot test among 42 headache sufferers (31 M and 11 TH). The typical Rorschach repressive pattern of alexithymia was found as well in M as in TH while CNV amplitude was significantly higher in the 31 M (-25 microV) than in the 11 TH (-19 microV FP less than 0.04). Biochemical data collected among 28 patients (17 M and 11 TH) revealed a positive correlation between CNV amplitude and plasma level of noradrenaline, regardless of the type of headache (r = 0.58; P less than 0.01). Thus, besides psychological factors, catecholaminergic mechanisms seem implicated in the determination of the CNV pattern in migraine. CNV may help the clinician both to specify diagnosis and to decide between the many therapeutic strategies available. [less ▲]

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See detailEffects of beta blockade on contingent negative variation in migraine.
MAERTENS DE NOORDHOUT, Alain ULg; Timsit-Berthier, M.; Timsit, M. et al

in Annals of Neurology (1987), 21(1), 111-112

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See detailCartographie électroencéphalographique dans les migraines en périodes critique et intercritique.
Schoenen, Jean ULg; Jamart, B.; Delwaide, P.

in Revue d'Eléctroencephalographie et de Neurophysiologie Clinique (1987), 17(3), 289-99

Twenty-nine migraineurs underwent spectral analysis and topographic EEG mapping. In a case of an induced attack of classic migraine with a complex aura, posterior-anterior spreading of slow activities and ... [more ▼]

Twenty-nine migraineurs underwent spectral analysis and topographic EEG mapping. In a case of an induced attack of classic migraine with a complex aura, posterior-anterior spreading of slow activities and depression of alpha activity contralateral to the neurological signs were the prominent findings. Another patient who developed a spontaneous attack of classic migraine with a visual aura had unilateral reduction of alpha and theta activity. In 19 out of 22 patients recorded during an attack of common migraine the only abnormality was markedly reduced alpha activity over one occipital region, usually on the side of the headache. Sixteen of these had concomitantly reduction of theta activity in the same location. In all patients, except one, restudied at least 7 days after an attack, EEG asymmetries had disappeared. Unilateral EEG changes can thus be detected during attacks of both classic and common migraine. The posterior-anterior spreading of slow activities during an induced attack of classic migraine has temporal and spatial similarities with the "spreading oligemia" (Olesen et al., 1981). Findings in classic migraine with a strictly visual aura, however, are identical to those observed during common migraine, i.e. unilateral reduction of alpha and theta activity. This suggests that common, as classic, migraine is associated with unilateral disturbances of cortical electrogenesis, which might reflect an underlying metabolic abnormality. [less ▲]

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See detailTopographic EEG mapping in common and classic migraine during and between attacks
Schoenen, Jean ULg; Jamart, B.; Delwaide, P. J.

in Clifford Rose, F. (Ed.) Advances in headache research (1987)

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See detailL'organisation anatomo-fonctionnelle de la sensibilité douloureuse
Delwaide, P. J.; Schoenen, Jean ULg

in La Douleur en Rhumatologie (1987)

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See detailSympathetic hyperarousal in migraine? Evaluation by contingent negative variation and psychomotor testing. Effects of beta-blockers
Schoenen, Jean ULg

in Clifford Rose, F. (Ed.) Advances in headache research (1987)

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See detailSpinal cord electrophysiological activities after small doses of TRH in control subjects and ALS patients
Delwaide, P. J.; Schoenen, Jean ULg

in Cosi, V.; Kato, A. C.; Parlette, W. (Eds.) et al Amyotrophic Lateral Sclerosis. Therapeutic, psychological and research aspects (1987)

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See detailSynenkephalin in bovine and human spinal cord.
Schoenen, Jean ULg; Lotstra, F.; Liston, D. et al

in Cell & Tissue Research (1986), 246(3), 641-5

Synenkephalin, which comprises 70 residues at the aminoterminal of proenkephalin, was studied with immunocytochemical methods in the human and bovine spinal cord. Immunoreactive fibers had the same ... [more ▼]

Synenkephalin, which comprises 70 residues at the aminoterminal of proenkephalin, was studied with immunocytochemical methods in the human and bovine spinal cord. Immunoreactive fibers had the same general distribution as methionine-enkephalin, but not as leucine-enkephalin fibers. They were found in all spinal layers and were most numerous in lamina II (outer zone) and V-VI (lateral portion). Synenkephalin immunoreactivity was overall less dense than that of the enkephalins. These results suggest that proenkephalin is the precursor protein also in enkephalinergic neurons of the human spinal cord. [less ▲]

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See detailContingent negative variation and efficacy of beta-blocking agents in migraine
Schoenen, Jean ULg; MAERTENS DE NOORDHOUT, Alain ULg; Timsit-Berthier, Martine et al

in Cephalalgia : An International Journal of Headache (1986), 6(4), 229-33

Thirty-three patients with common migraine underwent contingent negative variation (CNV) recordings before receiving prophylactic beta-blocker treatment with either metoprolol (27 patients) or propranolol ... [more ▼]

Thirty-three patients with common migraine underwent contingent negative variation (CNV) recordings before receiving prophylactic beta-blocker treatment with either metoprolol (27 patients) or propranolol (6 patients) at mean daily dosages of 110 mg and 122 mg, respectively. After 3 months the therapeutic efficacy of the beta-blocker was assessed in each patient by means of a global severity score and compared with the initial CNV recordings. The mean clinical improvement was 62%. A significant positive correlation was found between CNV amplitude before prophylaxis and the clinical response to beta-blockers: patients with higher CNV tended to respond better to therapy. Eight of 10 patients with a CNV amplitude higher than -25 microV had a more than 50% reduction of the severity score--that is, a good or excellent response to the beta-blocking agent--whereas only 2 of 9 patients with an amplitude lower than -20 microV had a good response. [less ▲]

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See detailLes algies faciales.
MAERTENS DE NOORDHOUT, Alain ULg; Schoenen, Jean ULg

in Revue Médicale de Liège (1986), 41(9), 342-8

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See detailContingent Negative Variation in Headache
MAERTENS DE NOORDHOUT, Alain ULg; Timsit-Berthier, Martine; Timsit, M. et al

in Annals of Neurology (1986), 19(1), 78-80

Contingent negative variation (CNV), an event-related slow cerebral potential, was analyzed in 79 consecutive headache patients. Compared to normal controls (n = 33), CNV did not differ in tension ... [more ▼]

Contingent negative variation (CNV), an event-related slow cerebral potential, was analyzed in 79 consecutive headache patients. Compared to normal controls (n = 33), CNV did not differ in tension headache (n = 21) or in combined headaches with a predominant tension component (n = 13). The mean amplitude of CNV was significantly (p less than 0.001) increased in migraine (n = 29) as well as in combined headache with predominant migraine (n = 16). All migraineurs were studied between attacks and without prophylactic treatment. CNV may be a useful diagnostic test in headache. Its increased amplitude in migraine might reflect central catecholaminergic hyperactivity. [less ▲]

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See detailA psychophysiological approach to psychosomatic headache
Timsit, M.; Schoenen, Jean ULg; Timsit-Berthier, M.

in Mc Callum, W. C.; Zappoli, R.; Denoth, F. (Eds.) Cerebral Psychophysiology: Studies in Event-related Potentials (1986)

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See detailEffects of therapeutic measures taken during the aura
Schoenen, Jean ULg

in Amery, W. K.; Wauquier, A. (Eds.) The Prelude of the Migraine Attack (1986)

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See detailBeta blockers and the central nervous system.
Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1986), 6 Suppl 5

The exact mechanism of action of beta blockers in migraine remains undetermined. An effect on the central nervous system (CNS) might be a factor. The evidence from the literature indicates that the ... [more ▼]

The exact mechanism of action of beta blockers in migraine remains undetermined. An effect on the central nervous system (CNS) might be a factor. The evidence from the literature indicates that the anatomical and chemical targets for these drugs are present in the mammalian brain, that they readily penetrate the brain, and that they may modify CNS functions. The present study shows that psychomotor tests and contingent negative variation (CNV), an event related slow cerebral potential, both of which are abnormal in untreated migraineurs, tend to normalize after treatment with the beta blocker metoprolol. Moreover, a strong positive correlation was found between the amplitude of CNV and the clinical efficacy of beta blockers in migraineurs. One might hypothesize that a hyperactive central catecholaminergic state in migraine might be the common denominator between reduced performance on psychomotor testing and enhanced CNV. It remains to be determined whether this is due to hyperactivity of catecholaminergic neurons or to hypersensitivity of catecholamine receptors. [less ▲]

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See detailContingent negative variation (CNV) as a diagnostic and physiopathologic tool in headache patients
SCHOENEN, Jean ULg; Maertens De Noordhout, Alain ULg; Timsit-Berthier, M. et al

in Clifford Rose, F. (Ed.) Migraine Proc. (1985)

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See detailMetoprolol v. clonidine in the prophylactic treatment of migraine.
Louis, P.; Schoenen, Jean ULg; Hedman, C.

in Cephalalgia : An International Journal of Headache (1985), 5(3), 159-65

In a double-blind, cross-over trial, the migraine prophylactic effect of the beta 1-adrenoceptor antagonist metoprolol was compared with that of clonidine. The dosage of metoprolol was 50 mg b.i.d. and of ... [more ▼]

In a double-blind, cross-over trial, the migraine prophylactic effect of the beta 1-adrenoceptor antagonist metoprolol was compared with that of clonidine. The dosage of metoprolol was 50 mg b.i.d. and of clonidine 50 micrograms b.i.d. Thirty-one patients were included; twenty-three completed the entire study. Six patients withdrew during clonidine treatment, one during metoprolol treatment and one during the wash-out period (placebo). Metoprolol had a significantly better migraine prophylactic effect than clonidine regarding such parameters as the attack frequency, the number of migraine days and the sum of intensity score. Compared to baseline (placebo), metoprolol decreased these parameters, while clonidine did not. Metoprolol, but not clonidine, also reduced the acute consumption of analgesics. No differences were found as regards side effects. [less ▲]

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