References of "Schoenen, Jean"
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See detailInduction of long-lasting changes of visual cortex excitability by five daily sessions of repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers and migraine patients
Fumal, Arnaud ULg; Coppola, G.; Bohotin, V. et al

in Cephalalgia : An International Journal of Headache (2006), 26(2), 143-149

We have shown that in healthy volunteers (HV) one session of 1 Hz repetitive transcranial magnetic stimulation (rTMS) over the visual cortex induces dishabituation of visual evoked potentials (VEPs) on ... [more ▼]

We have shown that in healthy volunteers (HV) one session of 1 Hz repetitive transcranial magnetic stimulation (rTMS) over the visual cortex induces dishabituation of visual evoked potentials (VEPs) on average for 30 min, while in migraineurs one session of 10 Hz rTMS replaces the abnormal VEP potentiation by a normal habituation for 9 min. In the present study, we investigated whether repeated rTMS sessions (1 Hz in eight HV; 10 Hz in eight migraineurs) on 5 consecutive days can modify VEPs for longer periods. In all eight HV, the 1 Hz rTMS-induced dishabituation increased in duration over consecutive sessions and persisted between several hours (n = 4) and several weeks (n = 4) after the fifth session. In six out eight migraineurs, the normalization of VEP habituation by 10 Hz rTMS lasted longer after each daily stimulation but did not exceed several hours after the last session, except in two patients, where it persisted for 2 days and 1 week. Daily rTMS can thus induce long-lasting changes in cortical excitability and VEP habituation pattern. Whether this effect may be useful in preventative migraine therapy remains to be determined. [less ▲]

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See detailHerbal medicines and vitamins
Schoenen, Jean ULg; Magis, Delphine ULg

in Lipton, R. B.; Bigal, M. E. (Eds.) Migraines and Other headache disorders (2006)

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See detailFuture preventive therapy: are there promising drug targets
Schoenen, Jean ULg

in Headache Currents (2006), 3

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See detailElectrophysiological response patterns of primary sensory cortices in migraine.
Ambrosini, Anna; Schoenen, Jean ULg

in Journal of Headache & Pain (2006), 7(6), 377-88

Migraine is an ictal disorder characterised by a particular vulnerability of patients to sensory overload, both during and outside of the attack. Central nervous system dysfunctions are supposed to play a ... [more ▼]

Migraine is an ictal disorder characterised by a particular vulnerability of patients to sensory overload, both during and outside of the attack. Central nervous system dysfunctions are supposed to play a pivotal role in migraine. Electroneurophysiological methods, which aim to investigate sensory processing, seem thus particularly appropriate to study the pathophysiology of migraine. We have thus reviewed evoked potential studies performed in migraine patients. Although results are in part contradictory, these studies nonetheless demonstrate an interictal dysfunction of sensory cortices, and possibly of subcortical structures, in migraine with and without aura. The predominant abnormality is a deficient habituation of evoked responses to repeated stimuli, probably due to cortical, and possibly widespread neural, "dysexcitability". [less ▲]

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See detailForamen ovale perméable et migraines: association fortuite ou relation causale?
Schoenen, Jean ULg; Burette, P.; Materne, P.

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 362-8

Epidemiologic studies have shown a clear comorbidity between migraine with aura and a patent foramen ovale (PFO). Under the age of 55, migraine with aura is a risk factor for ischemic stroke and a ... [more ▼]

Epidemiologic studies have shown a clear comorbidity between migraine with aura and a patent foramen ovale (PFO). Under the age of 55, migraine with aura is a risk factor for ischemic stroke and a proportion of the latter is due to a PFO. It remains to be determined whether PFO is causally related to migraine attacks, or is a fortuitous association due to common genetic factors. Cortical spreading depression which is the underlying mechanism of the migrainous aura, could be favoured by a PFO. Several retrospective and uncontrolled studies suggest that percutaneous closure of a PFO for stroke or decompression illness in divers reduces frequency of migraine attacks with, but also without aura. Multicentric, prospective and controlled trials of this intervention in migraineurs are underway or in preparation. As long as their results are not known, there is no rationale for proposing PFO closure for migraine. [less ▲]

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See detailCorrelation of postmortem 9.4 tesla magnetic resonance imaging and immunohistopathology of the human thoracic spinal cord 7 months after traumatic cervical spine injury.
Scholtes, Félix ULg; Adriaensens, Peter; Storme, Liesbet et al

in Neurosurgery (2006), 59(3), 671-8671-8

OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as ... [more ▼]

OBJECTIVE: To correlate high-resolution magnetic resonance imaging (MRI) with immunohistopathology in the injured human spinal cord. METHODS: Postmortem MRI scans at a field strength of 9.4 T, as well as standard histology and immunohistochemistry, were performed on an excised specimen of human high thoracic spinal cord, obtained 7 months after the initial trauma, several segments below a severe spinal cord lesion (C5). RESULTS: A precise correlation is described between MRI and immunohistochemistry of the long white matter tracts undergoing Wallerian degeneration and of an extension of the cervical lesion into the high thoracic cord. CONCLUSION: MRI, the only imaging technique that currently provides useful information on the spinal cord parenchyma after trauma, is rapidly evolving. High-field scanners of up to 9.4 T are being clinically tested. The present postmortem investigation of an isolated spinal cord specimen demonstrates the precise correlation that can be achieved between imaging and pathology. In future investigations, this type of technique can lead to a more precise description of spinal cord injuries and their consequences in remote tissue. Translation into the clinical setting will improve diagnosis and follow-up of spinal cord injured patients. [less ▲]

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See detailNew appendix criteria open for a broader concept of chronic migraine.
Olesen, J.; Bousser, M*-G; Diener, H*-C et al

in Cephalalgia : An International Journal of Headache (2006), 26(6), 742-6

After the introduction of chronic migraine and medication overuse headache as diagnostic entities in The International Classification of Headache Disorders, Second Edition, ICHD-2, it has been shown that ... [more ▼]

After the introduction of chronic migraine and medication overuse headache as diagnostic entities in The International Classification of Headache Disorders, Second Edition, ICHD-2, it has been shown that very few patients fit into the diagnostic criteria for chronic migraine (CM). The system of being able to use CM and the medication overuse headache (MOH) diagnosis only after discontinuation of overuse has proven highly unpractical and new data have suggested a much more liberal use of these diagnoses. The International Headache Classification Committee has, therefore, worked out the more inclusive criteria for CM and MOH presented in this paper. These criteria are included in the appendix of ICHD-2 and are meant primarily for further scientific evaluation but may be used already now for inclusion into drug trials, etc. It is now recommended that the MOH diagnosis should no longer request improvement after discontinuation of medication overuse but should be given to patients if they have a primary headache plus ongoing medication overuse. The latter is defined as previously, i.e. 10 days or more of intake of triptans, ergot alkaloids mixed analgesics or opioids and 15 days or more of analgesics/NSAIDs or the combined use of more than one substance. If these new criteria for CM and MOH prove useful in future testing, the plan is to include them in a future revised version of ICHD-2. [less ▲]

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See detailFamilial basilar migraine associated with a new mutation in the ATP1A2 gene
Ambrosini, A.; D'Onofrio, M.; Grieco, G. S. et al

in Neurology (2005), 65(11), 1826-1828

Basilar migraine (BM), familial hemiplegic migraine (FHM), and sporadic hemiplegic migraine (SHM) are phenotypically similar subtypes of migraine with aura, differentiated only by motor symptoms, which ... [more ▼]

Basilar migraine (BM), familial hemiplegic migraine (FHM), and sporadic hemiplegic migraine (SHM) are phenotypically similar subtypes of migraine with aura, differentiated only by motor symptoms, which are absent in BM. Mutations in CACNA1A and ATP1A2 have been found in FHM. The authors detected a novel mutation in the ATP1A2 gene (R548H) in members of a family with BM, suggesting that BM and FHM may be allelic disorders. [less ▲]

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See detailProton MRS findings in migraine patients during visual stimulation
da Silva, H. M.; Magis, Delphine ULg; Balteau, Evelyne ULg et al

in Cephalalgia : An International Journal of Headache (2005, December), 25(12), 1196

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See detailOccipital nerve stimulation in refractory chronic cluster headache: a pilot study of efficacy and mechanisms in five patients
Magis, Delphine ULg; Allena, M.; Vandenheede, Michel et al

in Cephalalgia : An International Journal of Headache (2005, December), 25(12), 1197

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See detailSuboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: A double-blind placebo-controlled study
Ambrosini, A.; Vandenheede, Michel; Gathot, P. et al

in Pain (2005), 118(1-2), 92-96

Oral steroids can interrupt bouts of cluster headache (CH) attacks, but recurrence is frequent and may lead to steroid-dependency. Suboccipital steroid injection may be an effective 'single shot ... [more ▼]

Oral steroids can interrupt bouts of cluster headache (CH) attacks, but recurrence is frequent and may lead to steroid-dependency. Suboccipital steroid injection may be an effective 'single shot' alternative, but no placebo-controlled trial is available. The aim of our study was to assess in a double-blind placebo-controlled trial the preventative effect on CH attacks of an ipsilateral steroid injection in the region of the greater occipital nerve. Sixteen episodic (ECH) and seven chronic (CCH) CH outpatients were included. ECH patients were in a new bout since no more than I week. After a one-week run-in period, patients were allocated by randomization to the placebo or verurn arms and received on the side of attacks a suboccipital injection of a mixture of long- and rapid-acting betamethasone (n=13; Verum-group) or physiological saline (n=10; Plac-group). Acute treatment was allowed at any time, additional preventative therapy if attacks persisted after I week. Three investigators performed the injections, while four others, blinded to group allocation, followed the patients. Follow-up visits were after I and 4 weeks, whereafter patients were followed routinely. Eleven Verum-group patients (3 CCH) (85%) became attack-free in the first week after the injection compared to none in the Plac-group (P=0.0001). Among them eight remained attack-free for 4 weeks (P=0.0026). Remission lasted between 4 and 26 months in five patients. A single suboccipital steroid injection completely suppresses attacks in more than 80% of CH patients. This effect is maintained for at least 4 weeks in the majority of them. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailOccipital nerve stimulation in refractory chronic cluster headache: a pilot study of efficacy and mechanisms in five patients.
MAGIS, Delphine ULg; Allena, Marta; Vandenheede, Michel et al

in Cephalalgia : An International Journal of Headache (2005, October), 25

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See detailLack of habituation of visual evoked gamma band oscillations in migraine patients between attacks
Coppola, G.; Ambrosini, A.; Di Clemente, L. et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 885

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See detailThe vestibulo-collic reflex is smaller and lacks habituation in migraine patients between attacks
Allena, M.; Magis, Delphine ULg; da Silva, H. M. et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 874-875

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See detailTrigeminal nociceptive evoked potentials (TNEP) in migraine
Magis, Delphine ULg; Allena, Marta; De Pasqua, Victor ULg et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 875

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See detailSearch for a correlation between MTHFR C677T polymorphism and efficacy of riboflavin in migraine prophylaxis
Magis, Delphine ULg; Allena, Marta; da Silva, Hilton Mariano et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 864

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See detailEffects of nitroglycerin on the nociception specific blink reflex
Di Clemente, Laura; Magis, Delphine ULg; Coppola, Gianluca et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 888

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See detailMTHFR C677T polymorphism and susceptibility to migraine with aura
Magis, Delphine ULg; Coppola, Gianluca; Allena, Marta et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 863-864

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See detailThe syndrome of transient headache with neurological deficits and CSF lymphocytosis (HaNDL): electrophysiological findings suggesting a migrainous pathophysiology
Fumal, Arnaud ULg; Vandenheede, Michel; Coppola, Giunluca et al

in Cephalalgia : An International Journal of Headache (2005), 25(9), 754-758

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