References of "Sandersen, Charlotte"
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See detailSerum vitamin E concentrations in a group of horses, with a high incidence of equine motor neurone disease
Delguste, Catherine ULg; de Moffarts, Brieuc; Sandersen, Charlotte ULg et al

in Pflügers Archiv : European Journal of Physiology (2002), 444(1-2), 3

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See detailMyopathies atypiques chez les chevaux au pré: une série de cas en Belgique
Delguste, Catherine ULg; Cassart, Dominique ULg; Baise, Etienne ULg et al

in Annales de Médecine Vétérinaire (2002), 146(4, AUG-SEP), 235-247

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liege between November 2000 and April 2001 ... [more ▼]

Atypical myoglobinuria in grazing horses was described in United Kingdom and Germany between 1984 and 1996. Fourteen horses were presented at the University of Liege between November 2000 and April 2001, with a clinical history suggesting atypical myoglobinuria. Lesions were similar to those previously described. All horses were at rest and grazing when they developed clinical signs. Three times, the syndrome killed several horses grazing together. Horses were generally found recumbent, nearly or totally unable to stand up. They were presenting tachycardia, polypnoea, myoglobinuria and died rapidly. When performed, blood analysis revealed severe muscular enzymatic activity rises. Histopathology revealed pulmonary congestion and oedema, and squeletal muscular fibers degeneration, mostly in respiratory and postural muscles. These observations are in accordance with cases of atypical myoglobinuria previously described in UK and Germany. The aetiology of this pathology is still unknown, despite of research attempts. [less ▲]

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See detailEchocardiographic evaluation of cardiac performance during stimulation with dobutamine in conscious horses: a preliminary study.
Sandersen, Charlotte ULg; Delguste, Catherine ULg; Becker, Martine et al

in Pflügers Archiv : European Journal of Physiology (2002), 444(1-2), 4

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See detailMyopathies atypiques chez les chevaux au pré : une série de cas en Belgique
Delguste, Catherine ULg; Sandersen, Charlotte ULg; Amory, Hélène ULg et al

Poster (2001, October)

Des séries de cas de myopathies atypiques ont été décrites entre 1986 et 1995 chez des chevaux au pré en Grande-Bretagne et en Allemagne. En automne 2000, l’examen nécropsique de 5 poneys et de 7 chevaux ... [more ▼]

Des séries de cas de myopathies atypiques ont été décrites entre 1986 et 1995 chez des chevaux au pré en Grande-Bretagne et en Allemagne. En automne 2000, l’examen nécropsique de 5 poneys et de 7 chevaux présentés à notre Faculté avec une anamnèse soit de signes cliniques suggestifs de cette pathologie, soit de mort subite, a mis en évidence des lésions similaires à celles précédemment décrites. De même, en avril 2001, deux poneys morts au pré après avoir présenté des symptômes évocateurs de myopathie atypique nous ont été référés pour autopsie, et des lésions de même nature ont été mises en évidence. Au total, entre les mois de novembre 2000 et avril 2001, outre ces 14 animaux présentés à notre Faculté, nous avons recensé, suite aux contacts téléphoniques avec les vétérinaires praticiens, 29 cas suspects de myopathie atypique en Belgique. Tous les chevaux et poneys atteints étaient au pré au moment du début des signes cliniques et aucun d’entre eux n’avait été récemment soumis à un exercice. Dans différents cas, la pathologie atteignait, simultanément ou à quelques jours d’intervalle, plusieurs chevaux pâturant sur un même pré. Ils étaient d’âge, de race et de sexe variables. A notre connaissance, la Belgique n’a été touchée que dans sa partie Sud et la pathologie semble associée à des conditions météorologiques particulières. Les animaux étaient le plus souvent retrouvés couchés et présentaient des difficultés importantes voire une incapacité à se relever. La conscience semblait toujours intacte, l’appétit était en général conservé et les chevaux présentaient de la tachycardie, de la polypnée et une myoglobinurie importante. Certains chevaux présentaient de la dysphagie et/ou un souffle ou une arythmie cardiaque. Lorsqu’une analyse de sang a été réalisée, elle a démontré une augmentation très sévère des enzymes musculaires. De la congestion et de l’œdème pulmonaires, une dégénérescence des fibres musculaires squelettiques atteignant surtout les muscles respiratoires et posturaux, et une dégénérescence plus modérée des fibres cardiaques ont été mis en évidence à l’examen histopathologique . Tous les examens virologiques, bactériologiques et toxicologiques réalisés post-mortem se sont jusqu’à présent révélés négatifs. Ces observations concordent avec les cas de myopathie myoglobinurique atypique décrits jusqu’ici en Grande-Bretagne et en Allemagne, dont l’étiologie demeure à ce jour inconnue. [less ▲]

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See detailP65 Homodimer Activity in Distal Airway Cells Determines Lung Dysfunction in Equine Heaves
Sandersen, Charlotte ULg; Bureau, Fabrice ULg; Turlej, R. et al

in Veterinary Immunology and Immunopathology (2001), 80(3-4), 315-26

Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity ... [more ▼]

Nuclear factor-kappaB (NF-kappaB) activity, which is a key regulator of inflammatory gene expression, is increased in bronchial epithelial cells from horses suffering from heaves (a hypersensitivity-associated inflammatory condition of the lung). To determine whether this increased activity extends to distal airways and to other pulmonary cells, cells recovered by broncho-alveolar lavage (BAL) in healthy and heaves-affected horses were assessed for NF-kappaB activity. NF-kappaB activity was much higher in BAL cells from heaves-affected horses, especially during crisis (disease exacerbation), than in cells from healthy horses. Moreover, the level of NF-kappaB activity found in BAL cells was positively correlated to total lung resistance and to the proportion of neutrophils present in BAL fluid. Finally, prototypical p65-p50 NF-kappaB heterodimers were absent from BAL cells, which mostly contained p65 homodimers. These results (1) show that increased NF-kappaB activity is a general feature of heaves lung; (2) demonstrate the importance of p65 homodimers in neutrophilic inflammation; and (3) suggest that the use of specific NF-kappaB inhibitors could improve lung function in heaves-affected horses. [less ▲]

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See detailEchocardiographie Doppler chez l’âne
Amory, Hélène ULg; Delvaux, Véronique ULg; Boquet, B et al

in Proceedings of the Annual meeting of the French Equine Veterinary Association (AVEF) (2001)

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See detailGrass sickness en Belgique : une étude rétrospective sur 11 cas cliniques
Sandersen, Charlotte ULg; Delguste, Catherine ULg; Cassart, Dominique ULg et al

in Proceedings of the Annual meeting of the French Equine Veterinary Association (AVEF) (2001)

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See detailEnhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway
Turlej, Renata K; Fievez, Laurence ULg; Sandersen, Charlotte ULg et al

in Thorax (2001), 56(9), 696-702

As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we ... [more ▼]

As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we sought to determine whether asthma is also associated with a GM-CSF dependent increase in lung granulocyte survival. Moreover, because GM-CSF mediates its effects through activation of signal transducer and activator of transcription 5 (STAT5), we also investigated the potential role of STAT5 in allergic inflammation. METHODS: Blood granulocytes were recovered from six healthy and six heaves affected horses, a model of asthma. Lung granulocytes were obtained by bronchoalveolar lavage (BAL) from the same horses. Granulocytes were cultured in the presence or absence of anti-GM-CSF receptor antibodies for different times and apoptosis was determined using the Annexin-V/propidium iodide detection method. Nuclear protein extracts from cultured granulocytes were analysed for STAT5 binding activity by electrophoretic mobility shift assay. RESULTS: BAL fluid granulocytes from heaves affected horses demonstrated a significant delay in apoptosis compared with blood granulocytes from the same horses and blood and BAL fluid granulocytes from healthy horses. Conversely, the rate of apoptosis in blood granulocytes from healthy and heaves affected horses was comparable. The enhanced survival of BAL fluid granulocytes from affected horses was suppressed in the presence of antibodies directed against GM-CSF receptors. Increased levels of active STAT5 were found in BAL fluid granulocytes from heaves affected horses and were markedly reduced after treatment with anti-GM-CSF receptor antibodies. CONCLUSIONS: These data indicate that granulocyte survival is enhanced in the lung of heaves affected horses and suggest a role for a GM-CSF activated STAT5 pathway in delaying apoptosis of lung granulocytes in this model of asthma. [less ▲]

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See detailMécanismes de la persistance de l’inflammation chez les chevaux poussifs en rémission
Bureau, Fabrice ULg; Fievez, Laurence ULg; Kirschvink, Nathalie et al

in Proceedings: 27ème Journée de la Recherche Equine (2001)

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See detailEnhanced survival of lung granulocytes in an animal model of asthma : evidence for a role of GM-CSF-activated STAT5 signaling pathway
Turlej, R.; Sandersen, Charlotte ULg; Fievez, Laurence ULg et al

in Proceedings: International Conference of the American Thoracic Society (2001)

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See detailIncreased NF-kB activity in broncho-alveolar lavage cells from an animal model of asthma
Sandersen, Charlotte ULg; Bureau, Fabrice ULg; Turlej, R. et al

in Proceedings: International Conference of the American Thoracic Society (2001)

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See detailp65 homodimer activity in BAL cells is correlated to lung dysfunction in equine heaves
Sandersen, Charlotte ULg; Bureau, Fabrice ULg; Turlej, R. et al

in Proceedings: 2001 World Equine Airways Symposium (2001)

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See detailAutochtonus cases of piroplasmosis in Belgium and Northern France
Christmann, U; Sandersen, Charlotte ULg; Lhonneux, JF et al

in Proceedings of the 39th Annual Congress of the British Equine Veterinary Association (BEVA) (2000)

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See detailDoppler echocardiographic measurement of cardiac output in the calf: a preliminary study
Amory, Hélène ULg; Sandersen, Charlotte ULg; Brihoum, M et al

in Proceedings of the World Assoc. Buiatrics Congress (2000)

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See detailGranulocyte macrophage-colony stimulating factor delay granulocytic apoptosis in heaves-affected horses
Turlej, R. K.; Sandersen, Charlotte ULg; Fievez, Laurence ULg et al

in Pflügers Archiv : European Journal of Physiology (2000)

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See detailNuclear factor kappaB activity and characterization in lung cells from heaves affected horses
Sandersen, Charlotte ULg; Turlej, R. K.; Fievez, Laurence ULg et al

in Pflügers Archiv : European Journal of Physiology (2000), 440(R217),

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