References of "Salmon, Eric"
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See detailIs posterior cerebral hypometabolism always predicitve of dementia in Parkinson's disease?
Deville, Benjamin ULg; Lemaire, Christian ULg; Degueldre, Christian ULg et al

Poster (2010, June 08)

In Parkinson's disease, altered activity in posterior associative cortices has often been associated with dementia. It remains to be determined if this pattern is a reliable marker of a progression toward ... [more ▼]

In Parkinson's disease, altered activity in posterior associative cortices has often been associated with dementia. It remains to be determined if this pattern is a reliable marker of a progression toward dementia in patients without demonstratable dementia. In this retrospective analysis, we used positron emission tomography to study resting-state cerebral fluodeoxyglucose uptake in 8 healthy controls and 8 Parkinson's disease patients who did not have evidence of dementia at the time of assessment. For those patients, clinical follow up was available and we know that they did not meet dementia criteria on average 10,37 years after assessment. The results show that patients had reduced fluodeoxyglucose uptake mostly localised in the right hemisphere and including precuneus, superior temporal, middle temporal and inferior parietal cortices. It also includes right insula. These cerebral activity predominating in posterior cortices is present in non-demened patients but is not always predictive of dementia within the 10,34 years. [less ▲]

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See detailControlled Memory Processes in Questionable Alzheimer's Disease: A View from Neuroimaging Research
Bastin, Christine ULg; Kerrouche N; Lekeu, Françoise ULg et al

in Journal of Alzheimer's Disease [=JAD] (2010), 20(2), 547-560

Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates ... [more ▼]

Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes, and neuroimaging studies at early stages of AD provide an opportunity to tease out the neural correlates of controlled processes. Accordingly, controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer's disease (QAD). The patients' brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study. Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure. The results demonstrated the central role of a medial frontal-posterior cingulate network for controlled processing of episodic memory in the early stages of AD. [less ▲]

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See detailIs Anosognosia in Alzheimer disease also observed for behavioural and personality changes?
Feyers, Dorothée ULg; Bastin, Christine ULg; Jaspar, Mathieu ULg et al

Poster (2010, May 28)

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously ... [more ▼]

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously explored anosognosia for personality and behaviour changes. We have tackled this question with 20 AD patients and 20 matched elderly subjects (ES). Participants (AD and ES) assessed their personality and their reactions in social situation both in current (S1) and past (S1_bef) time period. Assessment of these characteristics was also performed by relatives of the participants (R2 and R2_bef). Mann-Whitney test (p<0.05) were performed between discrepancy scores (calculated by comparing answers of subjects and relatives) obtained for AD and ES. A specific measure of anosognosia was also calculated by comparing S1 and R2. Statistical analyses demonstrated (1) that relatives of AD patients report more personality and behavioural changes across time (S1-S1_bef) than relatives of ES (R2–R2_bef); (2) that self-reported changes were not significantly different between AD patients and ES; (3) that anosognosia (S1-R2) was observed in AD patients for personality changes only. Results obtained support the hypothesis that anosognosia does not affect all domain in AD. Indeed, even if AD patients are no more able to assess their current personality, they perceive adequately their current reactions in social situations. [less ▲]

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See detailConsciousness of memory functioning in Alzheimer’s disease
Jaspar, Mathieu ULg; Feyers, Dorothée ULg; Bastin, Christine ULg et al

Poster (2010, May 28)

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to ... [more ▼]

Metamemory is a multi-faceted concept which deals with the individual’s knowledge and control of memory functioning. Previous studies that have examined the ability of Alzheimer’s disease (AD) patients to monitor efficiently their memory processes provided contradictory results. These discrepancies between studies could be the result of two factors: the kind of memory task used (episodic, semantic) and the kind of memory process on which memory monitoring is assessed (encoding, maintenance, retrieval). In the present study, different aspects of memory monitoring in 21 AD patients and 21 healthy elderly participants were explored with two tasks : a semantic memory task assessing the feeling-of-knowing (FOK) accuracy for general knowledge and an episodic memory task assessing judgment-of-learning (JOL) and FOK accuracy for information associated to a specific spatiotemporal encoding context By comparison to healthy participants, AD patients exhibit impaired performance on episodic FOK accuracy but not on semantic FOK accuracy. Moreover, no difference was observed between the two groups on the JOL post-encoding accuracy. These results confirm that not all aspects of memory monitoring are impaired in AD. Indeed, although there exists an impairment of episodic FOK performance, semantic FOK and JOL post-encoding appear preserved. The dissociation between the two FOK performance could be due to recruitment of more automatic processes for metacognitive judgment on general knowledge (semantic FOK) than for metacognitive judgment based on specific recent experience (episodic FOK). Similarly, a global prediction during maintenance (JOL) could be based on more automatic processes than an item-by-item judgment during retrieval. [less ▲]

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See detailNeural correlates of cognitive control at the item specific level in the Stroop task
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Fias, Wim et al

Poster (2010, May 04)

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See detailLa vignette thérapeutique de l'étudiant: la maladie d'Alzheimer
Jedidi, Haroun ULg; Jedidi, Zayd ULg; Salmon, Eric ULg

in Revue Médicale de Liège (2010), (65(3)), 163-168

Alzheimer's disease is the most common neurodegenerative disease encountered in patients over 60 years. By its prevalence and the consequent individual and social loss of function Alzheimer's disease is a ... [more ▼]

Alzheimer's disease is the most common neurodegenerative disease encountered in patients over 60 years. By its prevalence and the consequent individual and social loss of function Alzheimer's disease is a major public health problem. With the presentation of a clinical story of Alzheimer's disease in an elderly patient, we propose a diagnostic and therapeutic discussion on this clinical problem. We must adjust the treatment for each patient and overall not omit the non pharmacological therapeutic approaches. [less ▲]

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See detailGait analysis in elderly adult patients with mild cognitive impairment and patients with mild Alzheimer’s disease: simple versus dual task: A preliminary report
Maquet, Didier ULg; Lekeu, Françoise ULg; Warzee, Emmanuelle ULg et al

in Clinical Physiology & Functional Imaging (2010), 30(1), 51-56

Background ⁄ Aims: The aim of this study was to assess gait characteristics during simple and dual task in patients with mild cognitive impairment (MCI) and compare them with those of healthy elderly ... [more ▼]

Background ⁄ Aims: The aim of this study was to assess gait characteristics during simple and dual task in patients with mild cognitive impairment (MCI) and compare them with those of healthy elderly subjects and mild Alzheimer s disease (AD) patients. Methods: We proposed a gait analysis to appreciate walking (simple task and dual task) in 14 MCI, 14 controls and six AD subjects who walked at their preferred speed. A 20-second period of stabilized walking was used to calculated stride frequency, stride length, symmetry and regularity. Speed walking was measured by electrical photocells. Results: Variables measured during simple and dual tasks showed an alteration of motor function as well in mild AD patients as in MCI patients. Conclusion: At the end of this preliminary study, we defined a specific gait pattern for each cognitive profile. Further researches appear necessary to enlarge the study cohort. [less ▲]

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See detailA grid for a precise analysis of daily activities
Wojtasik, Vinciane ULg; Olivier, Catherine ULg; Lekeu, Françoise ULg et al

in Neuropsychological Rehabilitation (2010), 20

Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual ... [more ▼]

Assessment of daily living activities is essential in patients with Alzheimer's disease. Most current tools quantitatively assess overall ability but provide little qualitative information on individual difficulties. Only a few tools allow therapists to evaluate stereotyped activities and record different types of errors. We capitalised on the Kitchen Activity Assessment to design a widely applicable analysis grid that provides both qualitative and quantitative data on activity performance. A cooking activity was videotaped in 15 patients with dementia and assessed according to the different steps in the execution of the task. The evaluations obtained with our grid showed good correlations between raters, between versions of the grid and between sessions. Moreover, the degree of independence obtained with our analysis of the task correlated with the Kitchen Activity Assessment score and with a global score of cognitive functioning. We conclude that assessment of a daily living activity with this analysis grid is reproducible and relatively independent of the therapist, and thus provides quantitative and qualitative information useful for both evaluating and caring for demented patients. [less ▲]

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See detailWorking memory load affects chronotype- and time-of-day dependent cerebral activity modulations
Schmidt, Christina ULg; Peigneux, Philippe ULg; Leclercq, Yves ULg et al

in Journal of Sleep Research (2010), 19(Suppl. 2),

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See detailThe California Verbal Learning Test and other standard clinical neuropsychological tests to predict conversion from mild memory impairment to dementia.
Lekeu, Françoise ULg; Magis, Delphine ULg; Marique, Patricia et al

in Journal of Clinical & Experimental Neuropsychology (2010), 20

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See detailThe commonality of neural networks for verbal and visual short-term memory.
Majerus, Steve ULg; D'Argembeau, Arnaud ULg; Martinez Perez, Trecy ULg et al

in Journal of Cognitive Neuroscience (2010), 22(11), 2570-2593

Although many neuroimaging studies have considered verbal and visual short-term memory (STM) as relying on neurally segregated short-term buffer systems, the present study explored the existence of shared ... [more ▼]

Although many neuroimaging studies have considered verbal and visual short-term memory (STM) as relying on neurally segregated short-term buffer systems, the present study explored the existence of shared neural correlates supporting verbal and visual STM. We hypothesized that networks involved in attentional and executive processes, as well as networks involved in serial order processing, underlie STM for both verbal and visual list information, with neural specificity restricted to sensory areas involved in processing the specific items to be retained. Participants were presented sequences of nonwords or unfamiliar faces, and were instructed to maintain and recognize order or item information. For encoding and retrieval phases, null conjunction analysis revealed an identical fronto-parieto-cerebellar network comprising the left intraparietal sulcus, bilateral dorsolateral prefrontal cortex, and the bilateral cerebellum, irrespective of information type and modality. A network centered around the right intraparietal sulcus supported STM for order information, in both verbal and visual modalities. Modality-specific effects were observed in left superior temporal and mid-fusiform areas associated with phonological and orthographic processing during the verbal STM tasks, and in right hippocampal and fusiform face processing areas during the visual STM tasks, wherein these modality effects were most pronounced when storing item information. The present results suggest that STM emerges from the deployment of modality-independent attentional and serial ordering processes toward sensory networks underlying the processing and storage of modality-specific item information. [less ▲]

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See detailNeural substrates of recollection and familiarity in Alzheimer’s disease
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

in Proceedings of the 16th annual meeting of the Organization for Human Brain Mapping (2010)

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See detailLes corrélats cérébraux de le recollection et de la familiarité dans la maladie d’Alzheimer
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

in Proceedings du XIeme colloque international sur le vieillissement cognitif (2010)

Detailed reference viewed: 25 (4 ULg)