References of "Salmon, Eric"
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See detailItem familiarity and controlled associative retrieval in Alzheimer’s disease: An fMRI study.
Genon, Sarah ULg; Collette, Fabienne ULg; Feyers, Dorothée ULg et al

in Frontiers in Human Neuroscience (2012)

Alzheimer’s disease (AD) is characterised by altered recollection function, with impaired controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be ... [more ▼]

Alzheimer’s disease (AD) is characterised by altered recollection function, with impaired controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be preserved in the early stages of the disease. This is the first study that directly examines whole brain regional activity during one core aspect of the recollection function: associative controlled episodic retrieval (CER), contrasted to item familiarity in AD patients. Cerebral activity related to associative CER and item familiarity in AD patients and healthy controls (HC) was measured with functional magnetic resonance imaging during a word-pair recognition task to which the process dissociation procedure was applied. Some patients had null CER estimates (AD–), whereas others did show some CER abilities (AD+), although significantly less than HC. In contrast, familiarity estimates were equivalent in the three groups. In AD+, as in controls, associative CER activated the inferior precuneus/posterior cingulate cortex (PCC). However, during associative CER, functional connection between this region and the hippocampus, the inferior parietal and dorsolateral prefrontal cortex (DLPFC) was significantly higher in HC than in AD+. In all three groups, item familiarity was related to activation along the intraparietal sulcus (IPS). In conclusion, whereas the preserved automatic detection of an old item (without retrieval of accurate word association) is related to parietal activation centred on the IPS, the inferior precuneus/PCC supports associative CER ability in AD patients, as in HC. However, AD patients have deficient functional connectivity during associative CER, suggesting that the residual recollection function in these patients might be impoverished by the lack of some recollection-related aspects such as autonoetic quality, episodic details and verification. [less ▲]

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See detailThe neural correlates of recollection and familiarity during aging
Angel, Lucie; Bastin, Christine ULg; Genon, Sarah ULg et al

in Frontiers in Human Neuroscience (2012)

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See detailThe Neural Substrates of Memory Suppression: A fMRI Exploration of Directed Forgetting
Bastin, Christine ULg; Feyers, Dorothée ULg; Majerus, Steve ULg et al

in PLoS ONE (2012), 7(1), 29905

The directed forgetting paradigm is frequently used to determine the ability to voluntarily suppress information. However, little is known about brain areas associated with information to forget. The ... [more ▼]

The directed forgetting paradigm is frequently used to determine the ability to voluntarily suppress information. However, little is known about brain areas associated with information to forget. The present study used functional magnetic resonance imaging to determine brain activity during the encoding and retrieval phases of an item-method directed forgetting recognition task with neutral verbal material in order to apprehend all processing stages that information to forget and to remember undergoes. We hypothesized that regions supporting few selective processes, namely recollection and familiarity memory processes, working memory, inhibitory and selection processes should be differentially activated during the processing of to-be-remembered and to-be-forgotten items. Successful encoding and retrieval of items to remember engaged the entorhinal cortex, the hippocampus, the anterior medial prefrontal cortex, the left inferior parietal cortex, the posterior cingulate cortex and the precuneus; this set of regions is well known to support deep and associative encoding and retrieval processes in episodic memory. For items to forget, encoding was associated with higher activation in the right middle frontal and posterior parietal cortex, regions known to intervene in attentional control. Items to forget but nevertheless correctly recognized at retrieval yielded activation in the dorsomedial thalamus, associated with familiarity-based memory processes and in the posterior intraparietal sulcus and the anterior cingulate cortex, involved in attentional processes. [less ▲]

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See detailSelf-appraisal and medial prefrontal activation in early stage Alzheimer’s disease.
Genon, Sarah ULg; Collette, Fabienne ULg; Angel, Lucie et al

Conference (2012)

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See detailDissociation entre recollection et familiarité dans la maladie d’Alzheimer: Etude des bases cérébrales en imagerie par résonance magnétique fonctionnelle
Bastin, Christine ULg; Genon, Sarah ULg; Collette, Fabienne ULg et al

Conference (2012)

1. Matériels et méthodes. Les difficultés mnésiques des patients à un stade léger d’une maladie d’Alzheimer sont marquées par une atteinte sévère de la récupération consciente des informations dans leur ... [more ▼]

1. Matériels et méthodes. Les difficultés mnésiques des patients à un stade léger d’une maladie d’Alzheimer sont marquées par une atteinte sévère de la récupération consciente des informations dans leur contexte d’apprentissage (recollection). Par contre, la reconnaissance des informations sur base d’un sentiment de familiarité (savoir qu’une information a été rencontrée auparavant sans récupérer son contexte d’apprentissage) est relativement préservée (Dalla Barba, 1997; Rauchs et al., 2007). L’objectif de cette étude était de révéler les substrats cérébraux des processus de recollection et familiarité dans la maladie d’Alzheimer au moyen d’une tâche de mémoire associative analysée selon les principes de la Procédure de Dissociation des Processus (Jacoby, 1991). Pendant une acquisition en IRM fonctionnelle, 26 patients avec une maladie d’Alzheimer probable à un stade léger et 17 témoins âgés ont étudié des paires de mots, puis ont dû les reconnaître parmi des paires recombinées (deux mots vus mais pas ensemble) et des paires nouvelles. 2. Résultats. Les analyses comportementales ont indiqué que 10 patients Alzheimer avaient des indices de recollection nuls (AD-), tandis que 16 autres patients présentaient des processus de recollection résiduels (AD+) bien que significativement moins importants que les témoins. Par contre, le score estimant la contribution des processus de familiarité était équivalent dans les trois groupes. L’analyse de l’activité cérébrale a montré que, chez les patients AD+ comme chez les témoins, la recollection activait le cortex cingulaire postérieur. Cependant, cette région était fonctionnellement connectée à l’hippocampe, au cortex pariétal inférieur et au cortex préfrontal dorsolatéral uniquement chez les témoins. Par ailleurs, dans les trois groupes, la familiarité activait le sillon intrapariétal. 3. Conclusion. Cette étude montre un déficit sévère de recollection et une relative préservation de la familiarité chez des patients Alzheimer. Lorsque les patients possèdent des capacités résiduelles de recollection, celles-ci sont soutenues par le cortex cingulaire postérieur comme chez les personnes âgées saines. Cependant, une perturbation de la connectivité fonctionnelle entre le cortex cingulaire postérieur et des régions impliquées dans la mémoire relationnelle, les aspects subjectifs de la recollection et les processus de monitoring post-récupération suggère que la qualité de la recollection résiduelle des patients Alzheimer est dégradée. 4. Références. Dalla Barba, G. (1997). Recognition memory and recollective experience in Alzheimer's disease. Memory, 5, 657-672. Jacoby, L.L. (1991). A process dissociation framework: Separating automatic from intentional uses of memory. Journal of Memory and Language, 30, 513-541. Rauchs, G., Piolino, P., Mézenge, F., Landeau, B., Lalevée, C., Pélerin, A. et al. (2007). Autonoetic consciousness in Alzheimer's disease: Neuropsychological and PET findings using an episodic learning and recognition task. Neurobiology of Aging, 28, 1410-1420. [less ▲]

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See detailThe influence of cognitive reserve on inter-individual variability in resting-state cerebral metabolism in normal aging
Bastin, Christine ULg; Yakushev, Igor; Bahri, Mohamed Ali ULg et al

in Frontiers in Human Neuroscience (2012)

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See detailCognitive reserve impacts on inter-individual variability in resting-state cerebral metabolism in normal aging
Bastin, Christine ULg; Yakushev, Igor; Bahri, Mohamed Ali ULg et al

in NeuroImage (2012), 63

There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning. One potential factor contributing to individual differences among the elders is the cognitive reserve ... [more ▼]

There is a great deal of heterogeneity in the impact of aging on cognition and cerebral functioning. One potential factor contributing to individual differences among the elders is the cognitive reserve, which designates the partial protection from the deleterious effects of aging that lifetime experience provides. Neuroimaging studies examining task-related activation in elderly people suggested that cognitive reserve takes the form of more efficient use of brain networks and/or greater ability to recruit alternative networks to compensate for age-related cerebral changes. In this multi-centre study, we examined the relationships between cognitive reserve, as measured by education and verbal intelligence, and cerebral metabolism at rest (FDG-PET) in a sample of 74 healthy older participants. Higher degree of education and verbal intelligence was associated with less metabolic activity in the right posterior temporoparietal cortex and the left anterior intraparietal sulcus. Functional connectivity analyses of resting-state fMRI images in a subset of 41 participants indicated that these regions belong to the default mode network and the dorsal attention network respectively. Lower metabolism in the temporoparietal cortex was also associated with better memory abilities. The findings provide evidence for an inverse relationship between cognitive reserve and resting-state activity in key regions of two functional networks respectively involved in internal mentation and goal-directed attention. [less ▲]

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See detailModulation of brain activity during a Stroop inhibitory task by the kind of cognitive control required
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Phillips, Christophe ULg et al

in PLoS ONE (2012), 7(7), 41513

This study used a proportion congruency manipulation in the Stroop task in order to investigate, at the behavioral and brain substrate levels, the predictions derived from the Dual Mechanisms of Control ... [more ▼]

This study used a proportion congruency manipulation in the Stroop task in order to investigate, at the behavioral and brain substrate levels, the predictions derived from the Dual Mechanisms of Control (DMC) account of two distinct modes of cognitive control depending on the task context. Three experimental conditions were created that varied the proportion congruency: mostly incongruent (MI), mostly congruent (MC), and mostly neutral (MN) contexts. A reactive control strategy, which corresponds to transient interference resolution processes after conflict detection, was expected for the rare conflicting stimuli in the MC context, and a proactive strategy, characterized by a sustained task-relevant focus prior to the occurrence of conflict, was expected in the MI context. Results at the behavioral level supported the proactive/reactive distinction, with the replication of the classic proportion congruent effect (i.e., less interference and facilitation effects in the MI context). fMRI data only partially supported our predictions. Whereas reactive control for incongruent trials in the MC context engaged the expected fronto-parietal network including dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex, proactive control in the MI context was not associated with any sustained lateral prefrontal cortex activations, contrary to our hypothesis. Surprisingly, incongruent trials in the MI context elicited transient activation in common with incongruent trials in the MC context, especially in DLPFC, superior parietal lobe, and insula. This lack of sustained activity in MI is discussed in reference to the possible involvement of item-specific rather than list-wide mechanisms of control in the implementation of a high task-relevant focus. [less ▲]

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See detailAttention Supports Verbal Short-Term Memory via Competition between Dorsal and Ventral Attention Networks.
Majerus, Steve ULg; Attout, Lucie ULg; D'Argembeau, Arnaud ULg et al

in Cerebral Cortex (2012), 22

Interactions between the neural correlates of short-term memory (STM) and attention have been actively studied in the visual STM domain but much less in the verbal STM domain. Here we show that the same ... [more ▼]

Interactions between the neural correlates of short-term memory (STM) and attention have been actively studied in the visual STM domain but much less in the verbal STM domain. Here we show that the same attention mechanisms that have been shown to shape the neural networks of visual STM also shape those of verbal STM. Based on previous research in visual STM, we contrasted the involvement of a dorsal attention network centered on the intraparietal sulcus supporting task-related attention and a ventral attention network centered on the temporoparietal junction supporting stimulus-related attention. We observed that, with increasing STM load, the dorsal attention network was activated while the ventral attention network was deactivated, especially during early maintenance. Importantly, activation in the ventral attention network increased in response to task-irrelevant stimuli briefly presented during the maintenance phase of the STM trials but only during low-load STM conditions, which were associated with the lowest levels of activity in the dorsal attention network during encoding and early maintenance. By demonstrating a trade-off between task-related and stimulus-related attention networks during verbal STM, this study highlights the dynamics of attentional processes involved in verbal STM. [less ▲]

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See detailMémoire associative dans le vieillissement normal : Effet de l’unification des associations
Simon, Jessica ULg; Collette, Fabienne ULg; Genon, Sarah ULg et al

in Proceedings of the XIIème Colloque International sur le Vieillissement Cognitif (2012)

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See detailAssociative memory in normal aging: The effect of unitization
Simon, Jessica ULg; Collette, Fabienne ULg; Genon, Sarah ULg et al

in Proceedings of the first joint meeting of the Belgian Association for Psychological Sciences (BAPS) and the Sociedad Española de Psicología Experimental (SEPEX) (2012)

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See detailThe role of the salience of fluency in recognition memory in Alzheimer’s disease
Bastin, Christine ULg; Salmon, Eric ULg; Willems, Sylvie ULg

in Proceedings of the First joint meeting of the Belgian Association for Psychological Sciences (BAPS) and the Sociedad Española de Psicología Experimental (SEPEX) (2012)

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See detailDissociation entre recollection et familiarité dans la maladie d'Alzheimer : Etude des bases cérébrales en imagerie par résonance magnétique fonctionnelle.
Bastin, Christine ULg; Genon, Sarah ULg; Collette, Fabienne ULg et al

in Proceedings of the 11th Reunion Francophone sur la Maladie d’Alzheimer et les Syndromes Apparentés (2012)

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See detailFrontal and posterior cingulate metabolic impairment in the behavioural variant of frontotemporal dementia with impaired autonoetic consciousness
Bastin, Christine ULg; Feyers, Dorothée ULg; Souchay, Céline et al

in Human Brain Mapping (2012), 33

Although memory dysfunction is not a prominent feature of the behavioural variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They ... [more ▼]

Although memory dysfunction is not a prominent feature of the behavioural variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling-of-knowing (FOK) in bv-FTD. Analyses of the patients’ cerebral metabolism (FDG-PET) allowed an examination of whether impaired episodic memory in bv-FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory-specific regions pertaining to Papez’s circuit. Data were obtained from 8 bv-FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv-FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (7) patients, 4 bv-FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self-referential processes, suggesting that the bv-FTD patients’ problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self. [less ▲]

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See detailLes troubles cognitifs associés au vieillissement normal
Collette, Fabienne ULg; Salmon, Eric ULg; Audiffren, Michel

in Audiffren, Michel; François, Pierre-Henri (Eds.) Créativité, Motivation et Vieillissement. Les science cognitives en débat. (2012)

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See detailPerceptual and motor abilities in normal aging and Alzheimer’s disease: a preliminary study
Stawarczyk, David ULg; Grandjean, Julien ULg; Salmon, Eric ULg et al

in Archives of Gerontology & Geriatrics (2012), 54

Deficits in inhibitory abilities are frequently observed in normal aging and Alzheimer disease (AD). However, few studies have explored the generality of these deficits in a single group of participants ... [more ▼]

Deficits in inhibitory abilities are frequently observed in normal aging and Alzheimer disease (AD). However, few studies have explored the generality of these deficits in a single group of participants. A battery of tasks assessing perceptual and motor inhibitory functioning was administered to young and older healthy participants (Study 1), as well as to mild Alzheimer patients (Study 2). Results did not agree with a selective impairment of motor or perceptual inhibition in either AD or normal aging but rather suggest that a decrease in cognitive resources available in working memory could explain inhibitory performance both in normal aging and AD. [less ▲]

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See detailValuing One's Self: Medial Prefrontal Involvement in Epistemic and Emotive Investments in Self-views.
D'Argembeau, Arnaud ULg; Jedidi, Haroun ULg; Balteau, Evelyne ULg et al

in Cerebral Cortex (2012), 22

Recent neuroimaging research has revealed that the medial prefrontal cortex (MPFC) is consistently engaged when people form mental representations of themselves. However, the precise function of this ... [more ▼]

Recent neuroimaging research has revealed that the medial prefrontal cortex (MPFC) is consistently engaged when people form mental representations of themselves. However, the precise function of this region in self-representation is not yet fully understood. Here, we investigate whether the MPFC contributes to epistemic and emotive investments in self-views, which are essential components of the self-concept that stabilize self-views and shape how one feels about oneself. Using functional magnetic resonance imaging, we show that the level of activity in the MPFC when people think about their personal traits (by judging trait adjectives for self-descriptiveness) depends on their investments in the particular self-view under consideration, as assessed by postscan rating scales. Furthermore, different forms of investments are associated with partly distinct medial prefrontal areas: a region of the dorsal MPFC is uniquely related to the degree of certainty with which a particular self-view is held (one's epistemic investment), whereas a region of the ventral MPFC responds specifically to the importance attached to this self-view (one's emotive investment). These findings provide new insight into the role of the MPFC in self-representation and suggest that the ventral MPFC confers degrees of value upon the particular conception of the self that people construct at a given moment. [less ▲]

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See detailThe neural basis of semantic and episodic forms of self-knowledge: insights from functional neuroimaging
D'Argembeau, Arnaud ULg; Salmon, Eric ULg

in Lopez-Larrea, Carlos (Ed.) Sensing in nature (2012)

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