References of "SEGHAYE, Marie-Christine"
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See detailRecommandations Europeennes pour la prise en charge des cardiopathies congenitales de l'adulte.
Miltner, B.; Seghaye, Marie-Christine ULg; Lancellotti, Patrizio ULg

in Revue medicale de Liege (2013), 68(9), 450-7

Improved survival of patients with congenital heart disease has increased the number of these patients at adulthood. In 2010, the European Society of Cardiology has published new guidelines for the ... [more ▼]

Improved survival of patients with congenital heart disease has increased the number of these patients at adulthood. In 2010, the European Society of Cardiology has published new guidelines for the management of grown-up congenital heart disease. They provide more detailed information on specific defects in adults. This article summarizes the guidelines for the management of the most common adult congenital heart diseases. [less ▲]

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See detailInterleukin-6 as a marker of inflammatory related post-operative myocardial dysfunction
von der Stück, H.; SCHUMACHER, Katharina ULg; Buding, B. et al

Conference (2013, May)

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See detailSalmonella infections in young children due to turtle contamination
MATHY, F.; CHIARADIA, F.; MASTOURI, M. et al

Conference (2013, March)

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See detailDelayed diagnosis of cardiomyopathy in a girl treated for asthma bronchiale
MASTOURI, M.; FUDVOYE, Julie ULg; ANTOLE, N. et al

Conference (2013, March)

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See detailCardiac malformations in neonates born from mothers with gestational diabetes
ANTOLE, N.; JACQUEMART, C.; GKIOUGKI, Evangelia ULg et al

Conference (2013, March)

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See detailNeonates show transient and incomplete anti-inflammatory response to cardiac surgery
Wiecker, Carola; Buding, Brigitte; Vazquez-Jimenez, Jaime et al

Conference (2013, January)

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See detailInterleukin-6 as a marker of inflammatory related post-operative myocardial dysfunction
von der Stück, Hannah; Buding, Brigitte; Vazquez-Jimenez, Jaime et al

Conference (2013, January)

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See detailReply to the Editor
SEGHAYE, Marie-Christine ULg

in Annals of Thoracic Surgery (2012), 94(5), 1787

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See detailQuel suivi pour les adultes presentant une cardiopathie congenitale?
Miltner, B.; Pierard, Luc ULg; SEGHAYE, Marie-Christine ULg

in Revue Médicale de Liège (2012), 67(7-8), 407-12

During the last decades, the care of children with congenital heart disease has markedly improved. In consequence, the number of those who reach adulthood is continuously growing. In 2010, the European ... [more ▼]

During the last decades, the care of children with congenital heart disease has markedly improved. In consequence, the number of those who reach adulthood is continuously growing. In 2010, the European Society of Cardiology published guidelines for the management of grown-up congenital heart disease (GUCH) and recommended that each GUCH patient should be examined at least once in a specialized center. Due to their specific needs, this population requires specific and organized care. Indeed, GUCH patients do not only have significant extra-cardiac problems, but also present specific cardiac complications such as right ventricular failure, incisionnal arrhythmias. They may require repeated surgical and/ or percutaneous interventions. Since this emerging population is ageing, they also may suffer from arterial hypertension, diabetes and coronary artery disease. Last but not least, young women with congenital heart disease need specialized advice and care for contraception, follow-up during pregnancy and peripartal management. In order to optimize the follow-up of this growing population, a shared care model where cardiologists, specialized GUCH centers and other specialized centers for the treatment of extra-cardiac problems work in tight collaboration is recommended. [less ▲]

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See detailDexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.
Heying, Ruth; Wehage, Edith; SCHUMACHER, Katharina ULg et al

in Annals of Thoracic Surgery (2012), 93(3), 869-76

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the ... [more ▼]

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the systemic inflammatory reaction upon cardiac operation, and provide organ protection in neonates. METHODS: Twenty neonates (age, 8 to 21 days) with transposition of the great arteries scheduled for arterial switch operation were included. Nine received dexamethasone (1 mg/kg body weight) 4 hours before cardiopulmonary bypass, and 11 received natrium chloride. We studied intramyocardial messenger RNA expression of interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), as well as IL-10 and expression of TNF-alpha on protein level in right atrial tissue taken before institution of CPB. We measured plasma levels of IL-6, IL-10, lipopolysaccharide binding protein, and cardiac troponin T. Cytokine expression was related to postoperative outcome. RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha. Plasma concentrations of IL-6 were significantly lower and those of IL-10 significantly higher in pretreated patients. This was associated with lower cardiac troponin T values and lower dobutamine requirement. Levels of lipopolysaccharide binding protein were significantly higher postoperatively in pretreated neonates. CONCLUSIONS: Dexamethasone administration before arterial switch operation leads to a shift in the myocardial and systemic cytokine expression profile in neonates with transposition of the great arteries, with downregulation of proinflammatory and upregulation of antiinflammatory cytokines. Lower myocardial cell damage and lower catecholamine requirement suggest myocardial protection in treated patients. [less ▲]

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