References of "SALMON, Eric"
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See detailRéadaptation cognitive d'activités de vie quotidienne dans la maladie d'Alzheimer
Wojtasik, Vinciane ULg; Lekeu, Françoise ULg; Quittre, Anne ULg et al

in Gérontologie et Société : Cahiers de la Fondation Nationale de Gérontologie (2009), 130

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See detailSignes de conflit d’intentions dans un syndrome de déconnexion calleuse : cas J.B.
VINCENT, Eric ULg; DELRUE, Gaël ULg; SALMON, Eric ULg et al

Poster (2008, December)

Presentation of a patient showing multiple symptoms of a callosal disconnection.

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See detailExploration du réseau cérébral impliqué dans des jugements sur soi chez les personnes jeunes et âgées
Feyers, Dorothée ULg; Collette, Fabienne ULg; D'Argembeau, Arnaud ULg et al

Poster (2008, September 04)

Nous avons récemment observé que le cortex préfrontal ventro-médial (CPFVM) est activé à la fois chez des sujets jeunes et âgés dans une tâche de jugement d’adjectifs nécessitant d’évaluer sa propre ... [more ▼]

Nous avons récemment observé que le cortex préfrontal ventro-médial (CPFVM) est activé à la fois chez des sujets jeunes et âgés dans une tâche de jugement d’adjectifs nécessitant d’évaluer sa propre personnalité par rapport à celle d’un autre dans le contexte d’un prise de perspective à la première (1PP) et à la troisième (3PP) personne (Ruby et al., submitted). Nous avons poursuivi l’analyse de ces données par des analyses de connectivité fonctionnelle afin de déterminer le réseau des régions cérébrales associées à la performance des sujets jeunes et âgés. Les résultats montrent qu’en 1PP, l’activité du CPFVM est associée à celle du gyrus frontal inférieur et du gyrus parahippocampique chez les sujet âgés, mais uniquement à celle du cortex occipital chez les sujets jeunes. En 3PP, une connectivité fonctionnelle existe entre le CPFVM et le gyrus frontal médial, le gyrus frontal inférieur et les régions temporales supérieures chez les sujets âgées ; mais uniquement avec les régions occipitale et pariétale chez les sujets jeunes. Les régions cérébrales associées à l’activité du CPFVM chez les sujets jeunes ont été décrites comme impliquées dans la récupération en mémoire autobiographique ainsi que dans les processus de « mentalizing ». En ce qui concerne les personne âgées, le réseau cérébral découvert est relié à la récupération de souvenirs sémantique et épisodique (gyrus parahippocampique et temporal supérieur) mais aussi à l’attribution d’une valence émotionnelle à l’adjectif (gyrus frontal inférieur) et à la prise de perspective (gyrus frontal médial). Ces résultats indiquent (1) que le CPFVM est connecté à un réseau cérébral plus important chez les personnes âgées que chez les jeunes lors de jugement sur soi ; (2) que les sujets jeunes réalisent la tâche sur base d’informations autobiographiques seulement alors que les personnes âgées recrutent en plus des processus cognitifs de nature plus réflexive. [less ▲]

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See detailNeural network involved in self-judgment in young and elderly adults
Feyers, Dorothée ULg; Collette, Fabienne ULg; D'Argembeau, Arnaud ULg et al

Poster (2008, May 29)

In agreement with the literature, we have recently observed that the ventro-medial prefrontal cortex (VMPFC) is activated both in young and elderly subjects during a adjective judgment task requiring ... [more ▼]

In agreement with the literature, we have recently observed that the ventro-medial prefrontal cortex (VMPFC) is activated both in young and elderly subjects during a adjective judgment task requiring judgment about self vs. other in the context of a first (1PP) or third (3PP) perspective-taking (Ruby et al., submitted). Here, we have performed functional connectivity analyses to determine the network of cerebral areas associated to the performance of young and elderly subjects. <br />Results indicate that, in the 1PP condition, activity of the VMPFC is related to the inferior frontal gyrus, parahippocampal gyrus in elderly but to the occipital cortex only in young subjects. In the 3PP condition, functional connectivity exist between the VMPFC and medial frontal gyrus, inferior frontal gyrus and superior temporal areas in elderly, but with occipital and parietal areas only in young subjects. <br />The cerebral areas associated to VMPFC activity in young subjects were previously described as involved both in autobiographical memory retrieval and mentalizing processes. With regard to elderly, the cerebral network evidenced is related to retrieval of semantic and episodic memories (parahippocampal and superior temporal) but also to the attribution of emotional valence to the adjectives (inferior frontal) and perspective taking (medial frontal gyrus). <br />These results indicate (1) that the VMPFC is connected to a larger cerebral network in elderly than in young subjects during self judgements; (2) that young subjects perform the task on the basis of autobiographical information retrieval only, while elderly subjects use supplementary, more reflexive, cognitive processes. [less ▲]

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See detailFunctional imaging of cognition in Alzheimer's disease using positron emission tomography
Salmon, Eric ULg; Lekeu, Françoise ULg; Garraux, Gaëtan ULg et al

in Neuropsychologia (2008), 46(6), 1613-1623

Positron emission tomography in Alzheimer's disease (AD) demonstrates a metabolic decrease, predominantly in associative posterior cortices (comprising the posterior cingulate cortex), and also involving ... [more ▼]

Positron emission tomography in Alzheimer's disease (AD) demonstrates a metabolic decrease, predominantly in associative posterior cortices (comprising the posterior cingulate cortex), and also involving medial temporal structures and frontal regions at a lesser degree. The level of activity in this wide network is roughly correlated with dementia severity, but several confounds (such as age, education or subcortical ischemic lesions) may influence the brain-behaviour relationship. Univariate analyses allow one to segregate brain regions that are particularly closely related to specific neuropsychological performances. For example, a relationship was established between the activity in lateral associative cortices and semantic performance in AD. The role of semantic capacities (subserved by temporal or parietal regions) in episodic memory tasks was also emphasized. The residual activity in medial temporal structures was related to episodic memory abilities, as measured by free recall performance, cued recall ability and recognition accuracy. More generally, AD patients' performance on episodic memory tasks was correlated with the metabolism in several structures of Papez's circuit (including the medial temporal and posterior cingulate regions). Multivariate analyses should provide complementary information on impaired metabolic covariance in functional networks of brain regions and the consequences for AD patients' cognitive performance. More longitudinal studies are being conducted that should tell us more about the prognostic value of initial metabolic impairment and the neural correlates of progressive deterioration of cognitive performance in AD. [less ▲]

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See detailNeural network involved in young and elderly adults
Feyers, Dorothée ULg; Collette, Fabienne ULg; D'Argembeau, Arnaud ULg et al

in Proceedings of the Cognitive Aging Conference (2008, April 11)

In agreement with the literature, we have recently observed that the ventro-medial prefrontal cortex (VMPFC) is activated both in young and elderly subjects during a adjective judgment task requiring ... [more ▼]

In agreement with the literature, we have recently observed that the ventro-medial prefrontal cortex (VMPFC) is activated both in young and elderly subjects during a adjective judgment task requiring judgment about self vs. other in the context of a first (1PP) or third (3PP) perspective-taking (Ruby et al., submitted). Here, we have performed functional connectivity analyses to determine the network of cerebral areas associated to the performance of young and elderly subjects. Results indicate that, in the 1PP condition, activity of the VMPFC is related to the medial orbito-frontal, posterior and inferior temporal and parietal areas in elderly, but to the occipital cortex only in young subjects. In the 3PP condition, functional connectivity exist between the VMPFC and posterior temporal and lateral orbito-frontal areas in elderly, but with occipital and parietal areas only in young subjects. The cerebral areas associated to VMPFC activity in young subjects were previously described as involved both in autobiographic memory retrieval and mentalizing processes. With regard to elderly, the cerebral network evidenced is related to autobiographic memory retrieval (parietal and temporal areas) but also to the attribution of emotional valence to the adjectives (medial orbito-frontal) and perspective taking both in 1PP and 3PP conditions (lateral orbito-frontal). These results indicate (1) that the VMPFC is connected to a larger cerebral network in elderly than in young subjects during self judgements; (2) that young subjects perform the task on the basis of autobiographical information retrieval only, while elderly subjects use supplementary, more reflexive, cognitive processes. [less ▲]

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See detailOwl or lark? Stroop-related cerebral activity is modulated by time of day and chronotype
Schmidt, Christina ULg; Collette, Fabienne ULg; Sterpenich, Virginie et al

in Journal of Sleep Research (2008), 17(Suppl. 1),

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See detailChronotype-dependent performance modulation according to time of day : a functional neuroimaging approach
Schmidt, Christina ULg; Collette, Fabienne ULg; Sterpenich, Virginie et al

in NeuroImage (2008), 41(Suppl. 1),

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See detailImagerie cérébrale de la réflexion sur soi
Salmon, Eric ULg; D'Argembeau, Arnaud ULg; Bastin, Christine ULg et al

in Revue Médicale de Liège (2008), 63

Precise brain regions are activated when a subject gives a judgment on himself. Those are the medial parietal cortex, essentially related to episodic memory processing, and the ventromedial prefrontal ... [more ▼]

Precise brain regions are activated when a subject gives a judgment on himself. Those are the medial parietal cortex, essentially related to episodic memory processing, and the ventromedial prefrontal cortex, recruited for evaluating the personal valence of an information. These regions are not activated in Alzheimer's disease. The decrease of awareness for own deficits in a patient with Alzheimer's disease would depend on a reduction of episodic memory capacities and a worsening of judgment for self significance. [less ▲]

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See detailMetabolic correlates of clinical heterogeneity in questionable Alzheimer’s disease
Salmon, Eric ULg; Lekeu, Françoise ULg; Garraux, Gaëtan ULg et al

in Neurobiology of Aging (2008), 29

Thirty-four subjects with questionable Alzheimer's disease (QAD) were included in a 3-year prospective study and underwent neuropsychological testing and measurement of brain metabolism using FDG-PET at ... [more ▼]

Thirty-four subjects with questionable Alzheimer's disease (QAD) were included in a 3-year prospective study and underwent neuropsychological testing and measurement of brain metabolism using FDG-PET at entry. Seventeen patients (50%) did not convert to AD during the follow-up period. Compared to elderly controls of similar age, the cerebral activity of non-converters was reduced in the dorsolateral prefrontal cortex. Moreover, the variability of metabolism in the posterior cingulate cortex was related to their visuospatial memory performance, while disparity in parietal activity was related to their verbal memory performance. These results demonstrate the cerebral metabolic heterogeneity of patients with QAD. Initial functional images of converters showed that activity was already impaired in the posterior cingulate, lateral temporal cortex, anterior cingulate and orbitofrontal cortex. This metabolic pattern is consistent with a pre-dementia stage of AD, and highlights the fact that significant frontal metabolic involvement may be associated with impaired activity in posterior associative cortices in very early AD. [less ▲]

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See detailDifférentes facettes de la maladie de type Alzheimer
Salmon, Eric ULg

in Revue Médicale de Liège (2008), 63

Les maladies de type Alzheimer sont fréquentes. Les efforts réalisés en recherche clinique pour en améliorer le diagnostic précoce sont justifiés par les espoirs de traitements étiologiques. Dès à présent ... [more ▼]

Les maladies de type Alzheimer sont fréquentes. Les efforts réalisés en recherche clinique pour en améliorer le diagnostic précoce sont justifiés par les espoirs de traitements étiologiques. Dès à présent cependant, un diagnostic précoce est justifié par la possibilité de ralentir les conséquences symptomatiques de la maladie. Bien que l’évolution extrêmement variable soit fort préoccupante pour le patient et son entourage, l’objectif thérapeutique est d’adapter les conditions de vie aux capacités du patient (et de ses proches) et de maintenir une qualité de vie optimale. [less ▲]

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See detailA Comparison of Unawareness in Frontotemporal Dementia and Alzheimer's Disease
Salmon, Eric ULg; Perani, Daniela; Collette, Fabienne ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2008), 79(2), 176-9

BACKGROUND: Loss of insight is a core diagnostic feature of frontotemporal dementia (FTD) and anosognosia is frequently reported in Alzheimer's disease (AD). AIM: To compare unawareness (anosognosia) for ... [more ▼]

BACKGROUND: Loss of insight is a core diagnostic feature of frontotemporal dementia (FTD) and anosognosia is frequently reported in Alzheimer's disease (AD). AIM: To compare unawareness (anosognosia) for different symptoms, measured with a discrepancy score between patient's and caregiver's assessment, in AD and FTD. METHOD: In a prospective, multi-centre study, 123 patients with probable AD, selected according to the NINCDS-ADRDA procedure, were matched for age, sex, education, disease duration and dementia severity to patients with FTD (n = 41), selected according to international consensus criteria. A research complaint questionnaire was used to obtained patient's and caregiver's assessment concerning neuropsychological and behavioural symptoms. Data were compared in each group and between groups. Unawareness (measured by discrepancy scores) was compared between patients with AD and FTD. RESULTS: The caregivers generally assessed symptoms more severely than did patients, but both patient groups reported changes in affect (depressive mood or irritability) as their caregivers did. Unawareness was greater in patients with FTD than in patients with AD for language and executive difficulties, and for changes in behaviour and daily activities. CONCLUSION: The main finding is that unawareness was observed in both patients with FTD and patients with AD for most clinical domains. However, qualitative and quantitative differences showed that lack of awareness was greater in patients with FTD. [less ▲]

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See detailConsistency of Neuropsychiatric Syndromes across Dementias: Results from the European Alzheimer Disease Consortium
Aalten, Pauline; Verhey, Frans R. J.; Boziki, Marina et al

in Dementia & Geriatric Cognitive Disorders (2008), 25(1), 1-8

Background/Aims: The aim of this study was to determine the consistency of neuropsychiatric subsyndromes of the Neuropsychiatric Inventory across several clinical and demographic subgroups ( e. g ... [more ▼]

Background/Aims: The aim of this study was to determine the consistency of neuropsychiatric subsyndromes of the Neuropsychiatric Inventory across several clinical and demographic subgroups ( e. g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia. Methods: Cross-sectional data of 2,808 patients with dementia from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Subanalyses were performed for dementia subtypes, dementia severity, medication use, age and gender. Results: The results showed the relatively consistent presence of the 4 neuropsychiatric subsyndromes `hyperactivity', `psychosis', `affective symptoms' and `apathy' across the subanalyses. The factor structure was not dependent on dementia subtypes, age and gender but was dependent on dementia severity and cholinesterase use. The factors hyperactivity and affective symptoms were present in all subanalyses, but the presence of the factors apathy and psychosis was dependent on use of cholinesterase inhibitors and dementia severity, respectively. Conclusion: The present study provided evidence of the relative consistency of neuropsychiatric subsyndromes across dementia subtypes, age and gender, thereby stressing the importance of thinking about neuropsychiatric subsyndromes instead of separate symptoms. However, the subsyndromes apathy and psychosis were dependent on use of cholinesterase inhibitors and dementia severity. Copyright (c) 2007 S. Karger AG, Basel. [less ▲]

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See detailImplicit/explicit memory dissociation in Alzheimer's disease: the consequence of inappropriate processing?
Willems, Sylvie ULg; Salmon, Eric ULg; Van der Linden, Martial ULg

in Neuropsychology (2008), 22(6), 710-7

Dual-process theories of recognition posit that perceptual fluency contributes to both familiarity-based explicit recognition and perceptual priming. However, the priming-without-recognition dissociation ... [more ▼]

Dual-process theories of recognition posit that perceptual fluency contributes to both familiarity-based explicit recognition and perceptual priming. However, the priming-without-recognition dissociation, as observed through the intact mere exposure effect and impaired recognition in patients with Alzheimer's disease (AD), might indicate that familiarity and perceptual priming are functionally distinct. This study investigated whether the AD patients' processing strategies at testing may explain this priming-without-recognition dissociation. First, we replicated the priming-without-recognition effect in 16 patients who exhibited intact exposure effects despite null recognition. Second, we showed that, under identical conditions, inducing a holistic processing strategy during recognition testing increased AD patients' recognition--performance was similar for AD patients and healthy control participants. Furthermore, prompting analytic processing during both priming and recognition tasks decreased AD patients' performance in both tasks. These findings suggest that the extent to which AD patients use perceptual fluency in priming and recognition tasks is contingent on their processing approach. The choice of processing strategy may depend on how difficult patients perceive the task to be. [less ▲]

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See detailMesurer la douleur chez le patient non communicant.
Chatelle, Camille ULg; Vanhaudenhuyse, Audrey ULg; Mergam, Anne-Nora ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 429-37

Pain is a subjective experience. Its assessment is based on the subject's direct verbal report. This method of assessment is, however, impossible in patients who cannot communicate their feelings. In this ... [more ▼]

Pain is a subjective experience. Its assessment is based on the subject's direct verbal report. This method of assessment is, however, impossible in patients who cannot communicate their feelings. In this context, indirect measurements such as behavioral observations or physiological measurements are needed. To facilitate the assessment of pain in non-communicative patients, numerous standardized behavioral scales have been developed. The aim of this review is to discuss the main validated pain scales employed in end-stage dementia, newborn and preverbal children, and severely brain damaged patients with a disorder of consciousness such as coma, the vegetative state or the minimally conscious state. [less ▲]

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