References of "SALMON, Eric"
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See detailEffet de l’âge sur l’encodage en mémoire épisodique en fonction de l’expérience recollective à la reconnaissance: étude en IRMf
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Conference (2014)

Introduction. Il est désormais communément admis que l'avancée en âge s'accompagne d'un déclin en mémoire épisodique. Plus précisément, il semblerait que, contrairement aux processus de familiarité, les ... [more ▼]

Introduction. Il est désormais communément admis que l'avancée en âge s'accompagne d'un déclin en mémoire épisodique. Plus précisément, il semblerait que, contrairement aux processus de familiarité, les processus de recollection soient particulièrement touchés (a). Chez les sujets âgés, l'encodage semble requérir une activation préfrontale bilatérale lorsqu'il est réussi, tandis que chez les sujets jeunes cette activation est latéralisée à gauche (b). Dans cette étude, nous nous sommes intéressés aux différences d'activité cérébrale entre participants jeunes et âgés lors de l'encodage en fonction du statut attribué à l'item au moment de la reconnaissance (Recollection ou Familiarité). Méthodologie. Vingt sujets jeunes (entre 19 et 29 ans) et 19 sujets âgés (entre 60 et 78 ans) ont été confrontés, lors d'un examen en IRMf, à des stimuli visuels représentant des objets à propos desquels ils devaient effectuer des jugements de taille. Lors d'une seconde phase, on présentait à nouveau aux volontaires les stimuli de la phase d'encodage ainsi que des items distracteurs. Il leur était demandé de déterminer lesquels étaient nouveaux et lesquels avaient été présentés précédemment. Parmi ces derniers, les participants effectuaient également un jugement de type Recollection- Familiarité. Les analyses statistiques ont été réalisées au moyen du logiciel SPM8, avec un plan évènementiel comparant les modifications d’activité cérébrale entre nos deux groupes de sujets lors de l’encodage (1) pour les items ayant donné lieu à un processus de recollection lors de la phase de reconnaissance par rapport à ceux associés à de la familiarité (processus de Recollection), (2) pour les items associés à de la familiarité lors de la reconnaissance par rapport à ceux non-reconnus (processus de Familiarité). Résultats. La mise en jeu de processus de recollection lors de la récupération est spécifiquement associée lors de l'encodage, chez les sujets âgés à des augmentations d'activité au niveau du gyrus frontal moyen droit, des gyri cingulaire et paracingulaire médians gauches, ainsi qu'au niveau du précuneus de manière bilatérale. Par contre, aucune activité cérébrale plus importante lors de l’encodage n’était observée dans le groupe de sujets âgés pour les items ayant induit un processus de familiarité lors de la récupération Discussion. Parmi ces régions, le précuneus semble intervenir pour favoriser des processus compensatoires permettant aux seniors d’améliorer la richesse de l’encodage, ainsi qu’il a été précédemment suggéré pour les processus de recollection lors de la récupération(c). Au contraire, les processus de familiarité, moins exigeants en ressources attentionnelles, ne semblent pas recruter de tels processus de compensation. Références (a) Bugaiska, A., Clarys, D., Jarry, C., Taconnat, L., Tapia, G., Vanneste, S., & Isingrini, M. (2007). The effect of aging in recollective experience: the processing speed and executive functioning hypothesis. Consciousness and Cognition, 16(4), 797-808. doi: 10.1016/j.concog.2006.11.007 (b) Duverne, S., Motamedinia, S., & Rugg, M. D. (2009). The relationship between aging, performance, and the neural correlates of successful memory encoding. Cerebral Cortex, 19(3), 733-744. doi: 10.1093/cercor/bhn122 (c) Angel, L., Bastin, C., Genon, S., Balteau, E., Phillips, C., Luxen, A., . . . Collette, F. (2013). Differential effects of aging on the neural correlates of recollection and familiarity. Cortex, 49(6), 1585-1597. doi: 10.1016/j.cortex.2012.10.002 [less ▲]

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See detailEarly neuropsychological detection of Alzheimer's disease
Bastin, Christine ULg; Salmon, Eric ULg

in European Journal of Clinical Nutrition (2014), 68

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See detailBetter neuronal efficiency after emotional competences training: an fMRI study
Hansenne, Michel ULg; Nelis, Delphine; Feyers, Dorothée ULg et al

in Psychologica Belgica (2014), 54

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See detailThe neural bases of proactive and reactive control processes in normal aging
Manard, Marine ULg; François, Sarah ULg; Salmon, Eric ULg et al

in Frontiers in Human Neuroscience (2014)

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See detailFunctional connectivity and recognition of familiar faces in Alzheimer’s disease
Kurth, Sophie ULg; Bahri, Mohamed Ali ULg; Moyse, Evelyne ULg et al

in Frontiers in Human Neuroscience (2014)

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See detailExploration of unitization processes in episodic memory in Alzheimer's disease
Delhaye, Emma ULg; Salmon, Eric ULg; Bastin, Christine ULg

in Frontiers in Human Neuroscience (2014)

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See detailMetabolic cerebral correlates of conjunctive and relational memory in Alzheimer's disease
Bastin, Christine ULg; Bahri, Mohamed Ali ULg; Collette, Fabienne ULg et al

Poster (2014)

Introduction. Memory deficits are the clinical hallmark of typical Alzheimer’s disease. The precise nature of these deficits however remains to be fully characterized. In this study, we investigated ... [more ▼]

Introduction. Memory deficits are the clinical hallmark of typical Alzheimer’s disease. The precise nature of these deficits however remains to be fully characterized. In this study, we investigated binding in long-term episodic memory. Relational binding processes in memory create an associative link between independent items or between items and context into episodic memories (Cohen et al., 1999). An alternative process, conjunctive binding, allows associations to be encoded as a united representation of features into a single entity (O'Reilly and Rudy, 2001; Mayes et al., 2007). The current study (1) assessed whether Alzheimer’s disease disrupt both conjunctive and relational memory, and (2) related patients’ memory performance to cerebral metabolism. Methods. Thirty patients with mild Alzheimer’s disease and 24 healthy older adults performed a source memory task where items were associated to a background color (Diana et al., 2008, 2010). In one condition, relational binding was promoted by the instruction to associate the item with another object of the same color as the background. In the other condition, color had to be integrated as an item feature (conjunctive binding). Patients’ brain metabolic activity at rest (FDG-PET) was analysed with spatio-temporal Partial Least Squares (McIntosh et al., 1996) in order to assess the relation of behavioral performance and activity in functional cerebral networks. Results. Alzheimer’s disease patients had an impaired capacity to remember item-color associations, with deficits in both relational and conjunctive memory. However, performance in the two kinds of associative memory varied independently across patients. Partial least square analyses revealed a significant pattern of metabolic activity that correlated specifically with each condition (accounting for 76.48 % of the covariance in the data; p< .05). More specifically, poor conjunctive memory was related to hypometabolism in an anterior temporal-posterior fusiform brain network, whereas relational memory correlated with metabolism in regions of the default mode network. Conclusions. These findings support the hypothesis of distinct neural systems specialized in different types of associative memory and point to heterogeneous profiles of memory alteration in Alzheimer’s disease as a function of damage to the respective neural networks. [less ▲]

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See detailBrains creating stories of selves: the neural basis of autobiographical reasoning.
D'Argembeau, Arnaud ULg; Cassol, Helena; Phillips, Christophe ULg et al

in Social Cognitive and Affective Neuroscience (2014), 9

Personal identity critically depends on the creation of stories about the self and one's life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the ... [more ▼]

Personal identity critically depends on the creation of stories about the self and one's life. The present study investigates the neural substrates of autobiographical reasoning, a process central to the construction of such narratives. During fMRI scanning, participants approached a set of personally significant memories in two different ways: on some trials, they remembered the concrete content of the events (autobiographical remembering), whereas on other trials they reflected on the broader meaning and implications of their memories (autobiographical reasoning). Relative to remembering, autobiographical reasoning recruited a left-lateralized network involved in conceptual processing (including the dorsal medial prefrontal cortex (MPFC), inferior frontal gyrus, middle temporal gyrus, and angular gyrus). The ventral MPFC-an area that may function to generate personal/affective meaning-was not consistently engaged during autobiographical reasoning across participants but, interestingly, the activity of this region was modulated by individual differences in interest and willingness to engage in self-reflection. These findings support the notion that autobiographical reasoning and the construction of personal narratives go beyond mere remembering in that they require deriving meaning and value from past experiences. [less ▲]

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