References of "SADZOT, Bernard"
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See detailImaging serotonin-S2 receptors in humans with PET and the selective S2 antagonist [18F]altanserin. Preliminary results.
Sadzot, Bernard ULg; Lemaire, Christian ULg; Cantineau, R. et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1990, June 19), 31

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See detailCerebral Glucose Utilization During Sleep-Wake Cycle in Man Determined by Positron Emission Tomography and [18f]2-Fluoro-2-Deoxy-D-Glucose Method
Maquet, Pierre ULg; Dive, Dominique ULg; Salmon, Eric ULg et al

in Brain Research (1990), 513(1), 136-43

Using the [18F]fluorodeoxyglucose method and positron emission tomography, we studied cerebral glucose utilization during sleep and wakefulness in 11 young normal subjects. Each of them was studied at ... [more ▼]

Using the [18F]fluorodeoxyglucose method and positron emission tomography, we studied cerebral glucose utilization during sleep and wakefulness in 11 young normal subjects. Each of them was studied at least thrice: during wakefulness, slow wave sleep (SWS) and rapid eye movement sleep (REMS), at 1 week intervals. Four stage 3-4 SWS and 4 REMS fulfilled the steady state conditions of the model. The control population consisted of 9 normal age-matched subjects studied twice during wakefulness at, at least, 1 week intervals. Under these conditions, the average difference between the first and the second cerebral glucose metabolic rates (CMRGlu was: -7.91 +/- 15.46%, which does not differ significantly from zero (P = 0.13). During SWS, a significant decrease in CMRGlu was observed as compared to wakefulness (mean difference: -43.80 +/- 14.10%, P less than 0.01). All brain regions were equally affected but thalamic nuclei had significantly lower glucose utilization than the average cortex. During REMS, the CMRGlu were as high as during wakefulness (mean difference: 4.30 +/- 7.40%, P = 0.35). The metabolic pattern during REMS appeared more heterogeneous than at wake. An activation of left temporal and occipital areas is suggested. It is hypothetized that energy requirements for maintaining membrane polarity are reduced during SWS because of a decreased rate of synaptic events. During REMS, cerebral glucose utilization is similar to that of wakefulness, presumably because of reactivated neurotransmission and increased need for ion gradients maintenance. [less ▲]

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See detailEpilepsy: The Use of Oxygen-15-Labeled Gases
Franck, Georges ULg; Salmon, Eric ULg; Sadzot, Bernard ULg et al

in Seminars in Neurology (1989), 9(4), 307-16

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See detailSlowly Progressive Aphasia Syndrome. A Positron Emission Tomographic Study
Salmon, Eric ULg; Sadzot, Bernard ULg; Maquet, Pierre ULg et al

in Acta Neurologica Belgica (1989), 89(3-4, May-Oct), 242-245

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See detailDevelopment of a new in vivo tracer of the cerebral pH.
Plenevaux, Alain ULg; Demonceau, G.; Cantineau, R. et al

in Journal of Cerebral Blood Flow & Metabolism (1989), 9S1

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See detailEvaluation of [73Se]PROMOSE as a tracer of the human cerebral pH.
Demonceau, G.; Cantineau, R.; Plenevaux, Alain ULg et al

Poster (1988, October 10)

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See detailAngiotropic lymphoma of proliferating systematized angioendotheliomatosis type
Pierard, Gérald ULg; Soyeur-Broux, Monique ULg; FRIDMAN, Viviana ULg et al

in Annales de Dermatologie et de Vénéréologie (1988), 115(3), 333-336

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See detailEncéphalopathie limbique paranéoplasique, secrétion inappropriée d'ADH et crises épileptiques subintrantes infracliniques: Corrélations cliniques, anatomo-pathologiques et métaboliques par tomographie à émission de positons
Franck, Georges ULg; Sadzot, Bernard ULg; Salmon, Eric ULg et al

in Revue Neurologique (1987), 143(10), 657-669

We report a case of limbic encephalopathy clinically characterized by a progressive amnestic syndrome and many EEG seizures mainly localized on the left temporal area. Biological investigations revealed ... [more ▼]

We report a case of limbic encephalopathy clinically characterized by a progressive amnestic syndrome and many EEG seizures mainly localized on the left temporal area. Biological investigations revealed diabetes mellitus and a syndrome of inappropriate antidiuretic hormone secretion (IADH). Haemodynamic and metabolic studies by positron-emission tomography showed an important increase in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen on the left anterior temporal region precisely where the electrical seizures were recorded. Nine months later, severe disorders of memory and a dramatic decrease in CBF and CMRO2 on the same area region were present. At autopsy, a small size oat cell bronchial carcinoma was found with metastases in two small adjacent lymph nodes. Neuropathological examination showed atrophy (neuronal loss, protoplasmic gliosis) in the amygdala; where there was in addition an area of nodular gliosis. The hippocampus and parahippocampal gyrus lesions were severe on the left and moderate on the right side. The authors discuss the nosology of their case in the paraneoplastic syndromes and, with a review of the literature, the role of ADH and cellular hyperactivity in the pathogenesis of specifically localized neuronal alterations. [less ▲]

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See detailEtude hémodynamique et métabolique par tomographie à émission de positons d'un cas d'atteinte ischémique thalamo-capsulaire droite
Franck, Georges ULg; Salmon, Eric ULg; Sadzot, Bernard ULg et al

in Revue Neurologique (1986), 142

The authors report the results of a Positron Emission Tomographic (PET) study of local cerebral blood flow and oxygen consumption in one patient with a right capsulo-thalamic ischemic lesion. That lesion ... [more ▼]

The authors report the results of a Positron Emission Tomographic (PET) study of local cerebral blood flow and oxygen consumption in one patient with a right capsulo-thalamic ischemic lesion. That lesion is well demonstrated using X-ray CT Scan. PET study demonstrates a decreased perfusion and metabolism at three levels: first in right thalamus region, second in whole right hemisphere, more marked at orbitofrontal area and third at the level of the left cerebellar hemisphere. The authors point out the usefulness of PET studies which allow a better understanding of clinical signs by demonstrating functional consequences of damage in deeply located structures such as thalamus and internal capsule on cerebral and cerebellar cortices. [less ▲]

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