References of "Rozet, Eric"
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See detailReliable low cost capillary electrophoresis device for drug quality control and counterfeit medicines
Marini Djang'Eing'A, Roland ULg; Rozet, Eric ULg; Montes De Lourdes Aja, Maria et al

in Journal of Pharmaceutical & Biomedical Analysis (2010), 53(5), 1278-1287

The proportion of counterfeit medicines is dramatically increasing these last few years. According to numerous official sources, in some pharmaceutical wholesalers in African countries, the proportion has ... [more ▼]

The proportion of counterfeit medicines is dramatically increasing these last few years. According to numerous official sources, in some pharmaceutical wholesalers in African countries, the proportion has reached 80%. Unfortunately, this situation is far to be improved due to lack of suitable analytical equipment allowing rapid actions of the Regulatory Agencies based on scientific consideration, at affordable cost and all over the drug supply chain. For that purpose, a network group considered that mater by building a low-cost original capillary electrophoresis (CE) equipment equipped with a new deep UV detector based on LED technology. The generic conditions for analysis were investigated: capillary zone electrophoresis (CZE) performed at acidic pH for basic drug molecules (i.e., quinine, highly used as the last antimalarial rampart), basic pH for compounds such as furosemide (a common diuretic drug) and at neutral pH for a well known antibiotic combination, trimethoprim/sulfamethoxazol. To evaluate the ability of the CE equipment for quantification, a full validation and a method comparison study were carried out for the CZE method dedicated to quinine determination. The validation involved the use of accuracy profile and total error concept to monitor the adequacy of the results obtained by the new prototype. The method comparison was based on the Bland and Altman approach by comparing results obtained by the low-cost CE and a conventional set-up. Subsequent validation studies were realized with neutral and acidic drug molecules, each focusing on a single concentration level calibration curve in order to maintain as low as possible the expenses due to reagents and thus the cost of analysis, as important advantages of CE for drug quality control. [less ▲]

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See detailRISK MANAGMENT IN THE VALIDATION OF ANALYTICAL METHODS
Hubert, Philippe ULg; Ziemons, Eric ULg; Mantanus, Jérôme ULg et al

Conference (2010, October)

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See detailTOLERANCE INTERVALS AS CONTROL CHART: COMPARISON TO CLASSIC SHEWHART X̅-R CONTROL CHART
Marini Djang'Eing'A, Roland ULg; Lambert, Véronique; Denooz, Raphael ULg et al

Poster (2010, September)

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See detailDoes placebo based validation standards mimic well real batch products behaviour? A case study
Bouabidi, Abderrahim ULg; Talbi, M.; Bouklouze, A. et al

Poster (2010, September)

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See detailTotal error as natural decision criteria for analytical methods validation and transfer
Rozet, Eric ULg; Boulanger, Bruno ULg; Dewe et al

Conference (2010, September)

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See detailEvaluation analytique de la cystatine C: résultats de l'étude multicentrique SN/SFBC
Cavalier, Etienne ULg; Barguil, Y.; Bourgeois, A. M. et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 314

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See detailQuels paramètres cliniques et biologiques peuvent être considérés comme prédictifs des calcifications vasculaires chez le patient hémodialysé?
Delanaye, Pierre ULg; Warling, X.; Moonen, M. et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 296

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See detailLe dosage urinaire et plasmatique du NGAL: étude analytique et implications pratiques pour le clinicien
Cavalier, Etienne ULg; Rozet, Eric ULg; Bekaert, Anne-Catherine ULg et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 350

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See detailComparaison d'une méthode "acide" et enzymatique pour le dosage de l'inuline
Thibaudin, L.; Delanaye, Pierre ULg; Maillard, N. et al

in Néphrologie & Thérapeutique (2010, September), 6(5), 316

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See detailLa contrefaçon des médicaments : outils pour lutter contre ce fléau
Marini Djang'Eing'A, Roland ULg; Mbinze Kindende, Jérémie; Lecomte, Frédéric et al

Scientific conference (2010, July 31)

The increase of counterfeit drug medicines is very remarkable all over the world and particulary in developing countries where many dramatic consequences on public health and economics have been reported ... [more ▼]

The increase of counterfeit drug medicines is very remarkable all over the world and particulary in developing countries where many dramatic consequences on public health and economics have been reported. Therefore, several tools to fight against counterfeit are presented including the simple ones such as organoleptic tools that can be applied by any one and the complex ones namely the analytical tools that belongs to the competence of laboratory. [less ▲]

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See detailGuidelines and Validation Issues in Pharmaceutical Analysis
Rozet, Eric ULg; Rudaz, S.

Conference (2010, June 16)

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