Dental extractions in patients treated with intravenous bisphosphonates and risk of osteonecrosis of jaws.
GAUDIN, Elise ; HERION, Francine ; ROMPEN, Eric et al
Poster (2012, June)
Aim : Dental extraction remains contra-indicated in patients treated with intravenous (IV) bisphosphonates for oncology reasons because of the high risk of bisphosphonate-related osteonecrosis of the jaw ... [more ▼]
Aim : Dental extraction remains contra-indicated in patients treated with intravenous (IV) bisphosphonates for oncology reasons because of the high risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The objective of the present abstract was to present a preventive tooth extraction protocol in patients treated with IV bisphosphonates based on the surgical removal of the alveolar process. The second objective was to identify potential risk factors to develop BRONJ. Material and Methods : 17 patients treated with IV bisphosphonate and needing at least a tooth extraction, were included. A standardized extraction protocol was followed, including alveolectomy of at least 50% of the alveolar process, pre and post-operative antibiotherapy was administrated. The patients were followed for a mean period of 29 months (min:3 -max:62). Results : In all, 17 patients and 22 extraction sites mandible (15), maxilla (7) were involved in the study. No signs of inflamed tissue or necrotic exposed bone in any patient were observed during the follow-up period and the level of comfort for the patient was improved in all cases. Nevertheless, when a careful screening of the healing area was made using a probe, in 4 out of 22 (18,2%) sites, a remaining bone contact was found and appeared to be related location (mandible), duration of biphosphonate treatment and to concomitant. Conclusion : The present cases series suggests that the described extraction protocol in IV biphosphonate patients allowed 100% bone healing and complete soft tissues healing in 81.8% of the extraction sites.The sites that have not fully recovered seemed to be related to different factors. [less ▲]Detailed reference viewed: 60 (3 ULg)
Patient morbidity after 2 different surgical protocols to treat miller class I recession in the anterior maxilla: A Comparaitive Ramdomized Control Trial.
SALHI, Leila ; ROMPEN, Eric ; LECLOUX, Geoffrey et al
Conference (2012, June)
Aim: The objective of this study was to compare two different periodontal plastic surgery procedures to treat Miller’s class I recession: a coronally advanced flap (control group) versus the pouch ... [more ▼]
Aim: The objective of this study was to compare two different periodontal plastic surgery procedures to treat Miller’s class I recession: a coronally advanced flap (control group) versus the pouch technique (test group), both of which were associated with connective tissue graft. Methods: Forty consecutive patients were included, with 20 patients being allocated for each group. The level of recession coverage, the keratinised tissue quantity, gingival aesthetics (PES), and postoperative outcomes were assessed for a follow-up period of 6 months. Results: After 6 months, both techniques allowed for the excellent mean root coverage of 96.3 ± 12.1% in the control group and of 91.3 ± 17.6% in the test group. Complete root coverage was achieved in 89.5% (17/19) and 79% (15/19) of the recession cases in the control and the test groups, respectively. A significant increase in keratinised tissue height (p=0.0011) was observed in the test group. A significant improvement in the pink aesthetic score was found in the 2 groups, but gingival texture displayed significantly better results in the test group (p<0.0001). No significant difference between the 2 groups was found in terms of the morbidity outcomes. Pain killer consumption was similar in the 2 groups and significantly decreased over time. [less ▲]Detailed reference viewed: 62 (4 ULg)
Description of the bone-remodeling pattern after socket preservation procedures in human: a methodological study
LAMBERT, France ; VINCENT, Kim ; VANHOUTTE, Vanessa et al
Background: The bone remodeling after tooth extraction can result in the loss of as much as 50% of the buccal wall and a global crestal reduction in width of 3.87mm according to a recent systematic review ... [more ▼]
Background: The bone remodeling after tooth extraction can result in the loss of as much as 50% of the buccal wall and a global crestal reduction in width of 3.87mm according to a recent systematic review. Multiple surgical protocols using biomaterials are proposed in order to limit the typical postextraction bone resorption. However, because of the heterogeneity of the studies and, more specifically, of the assessment methods, it is difficult to assert the superiority of one technique over another. Aim: The objective of this study was to develop a new radiographic method to assess alveolar bone remodeling after socket preservation procedures. Methods: Sixteen extraction sites (in 14 patients) localized in the upper anterior maxilla were treated with bovine hydroxyapatite (0.25–1mm particles) and a saddled connective tissue graft. A radiographic 3-dimensional assessment of the hard tissues was performed at baseline and at 3 months after the procedure. Standardized horizontal measurements were taken at three corono apical levels ( 2, 5, and 9mm) and at three mesio-diatal level (Mesial, Center, and Distal) in the buccal and palatal aspects. Vertical measurements were also recorded in nine regions over the top of the alveolar crest. Results: Extraction socket-preservation technique assessed in the present study significantly reduced horizontal bone remodeling. The horizontal dimension of the crest decreased by 1.6mm (20%) in the cervical regions ( 2mm level), experienced a moderate decrease of 1mm (12%) at the 5mm level, and experienced a very low decrease of 0.5mm(6%) in the apical ( 8mm) level. The losses were always significantly higher in the buccal than in the palatal aspect. Buccally, the maximal bone remodeling at the cervical level remained below 1mm. Vertical bone resorption was homogeneous and was < 1mm in the nine measured regions. Conclusions and clinical implications: The radiographic measuring methodology proved to be accurate and reproducible. It can be applied in other clinical settings. Moreover, the surgical procedure evaluated in the present study, significantly limits the postextraction buccal bone remodeling compared with the data found in the literature for untreated extraction socket in the aesthetic area. However, a complete inhibition of the bone remodeling was not reached and the authors suggest a surgical technique using a ‘‘saddled’’ connective tissue graft to thicken buccal soft tissue biotype and consequently compensate for cervical bone loss. [less ▲]Detailed reference viewed: 45 (3 ULg)
Bone regeneration using porous titanium particles vs. bovine hydroxyapatite: a sinus lift study in rabbits
LAMBERT, France ; LECLOUX, Geoffrey ; Léonard, Angélique et al
Background: The use of porous titanium particles as space filling biomaterials for intraoral bone regeneration might be of interest because of both the mechanical stability and nonresorbable properties ... [more ▼]
Background: The use of porous titanium particles as space filling biomaterials for intraoral bone regeneration might be of interest because of both the mechanical stability and nonresorbable properties. Titanium particles were recently described for bone regeneration in sinus lifts and in the treatment of periimplantitis. Nevertheless, tissue integration and 3D bone regeneration with titanium particles were poorly explored in these previous reports. Aim: The first objective of this study was to qualitatively and quantitatively assess the bone formation process, particularly the long-term behavior and 3D volume stability of subsinusal bone regeneration, using titanium or bovine hydroxyapatite granules, in a rabbit model. The second objective was to evaluate the effect of the hydration of the BHA particles with a therapeutic concentration of doxycycline solution on the osteogenesis and biomaterial resorption. Methods: Rabbits underwent a double sinus lift procedure using one of three materials: grade 1 porous titanium particles (Ti), bovine hydroxyapatite (BHA) or chemically modified bovine hydroxyapatite (BHATTC). Animals were sacrificed after 1 week, 5 weeks or 6 months. Samples were analyzed using mCT and nondecalcified histology. Results: The materials used in each of the three groups allowed an optimal bone formation; bone quantities and densities were not statistically different between the three groups. At 6 months, more stable 3D volume stability was found with TI and BHATTC (P¼0.0033). At 5 weeks and 6 months, bone to material contact (BMC) corroborating osteoconduction was significantly higher with BHA and BHATTC than with Ti (P < 0.0001). Conclusions and clinical implications: Even though the studied biomaterials displayed different architectures, they are relevant candidates for sinus lift bone augmentation before dental implants because they allow adequate 3D stability and osteogenesis. However, to recommend the clinical use of Ti, both an observation on the drilling effects of Ti particles and clinical trials are needed. [less ▲]Detailed reference viewed: 33 (0 ULg)
Physico-chemical and morphological properties of current particulated biomaterials used in alveolar bone augmentations: a review.
LAMBERT, France ; ; ROMPEN, Eric et al
in Journal of Osteology and Biomaterials (2011), 2
The efficacy of grafting materials for alveolar bone regeneration procedures has been repeatedly corroborated by clinical and scientific evidence. Although an ever growing number of biomaterials are ... [more ▼]
The efficacy of grafting materials for alveolar bone regeneration procedures has been repeatedly corroborated by clinical and scientific evidence. Although an ever growing number of biomaterials are available on the market, the origins, material characteristics, bioactivity and osteoconductive properties of these products are not always known by clinicians, hence often hampering an adequate product selection. The purpose of this contribution was to provide an overview of five different types of osteoconductive grafting materials frequently used in dentistry (Bio-Oss®, Cerasorb M™, Bone Ceramic®, Natix®, Genos®) and to summarize their physico-chemical and morphological characteristics at the macro- and micro-scale. Furthermore, the influence of these properties on the in vivo behaviour of these biomaterials is discussed. The results of this study are presented as data sheets, which may prove helpful for clinicians in the design of their treatment strategies. [less ▲]Detailed reference viewed: 43 (14 ULg)
Influence of space-filling materials in subantral bone augmentation: blood clot vs. autogenous bone chips vs. bovine hydroxyapatite
Lambert, France ; Léonard, Angélique ; Drion, Pierre et al
in Clinical Oral Implants Research (2011), 22(5), 538-545
Aim: The first objective of the present study was to compare the short- and long-term 3D volume stability of sub-sinusal bone regeneration in rabbits using different space fillers. The second objective ... [more ▼]
Aim: The first objective of the present study was to compare the short- and long-term 3D volume stability of sub-sinusal bone regeneration in rabbits using different space fillers. The second objective was to assess qualitatively and quantitatively the early bone formation process and long-term behavior of the regenerated bone. Materials and methods: Fifteen rabbits underwent a double sinus lift procedure using: blood clot (Clot), autogenous bone chips (Auto) and bovine hydroxyapatite (BHA). Animals were euthanized at 1 week, 5 weeks and 6 months. Samples were subjected to X-ray microtomography and histology. Variations in the volume of bone augmentations were calculated at different time points. Qualitative analysis was performed using 7 μm sections and quantitative histomorphometric analyses were carried out using scanning electron microscopy. Results: From baseline (100%) to 5 weeks, the augmented volumes declined to 17.3% (Clot), 57.6% (Auto) and 90.6% (BHA). After 6 months, only 19.4% (Clot) and 31.4% (Auto) of initial volumes were found, while it remained more stable in the BHA group (84%). At 1 week, an initial osteogenesis process could be observed in the three groups along the bone walls. At 5 weeks, despite a significant decline in the volume, newly formed bone density was higher with Clot and Auto than with BHA. At 6 months, bone densities were statistically similar in the three groups. However, after 6 months, the surface invaded by newly formed bone (regenerated area) was significantly higher when BHA was used as space filler. In the BHA group, the biomaterial area slightly decreased from 42.7% (1 week) to 40% (5 weeks) and 34.9% (6 months) and the density of the composite regenerated tissue (bone+BHA) reached >50% at 6 months. Conclusions and clinical implications: The three space fillers allowed bone formation to occur. Nevertheless, augmented volumes declined in the Clot and Auto groups, while they remained stable with BHA. A slowly resorbable biomaterial might be suitable in sub-sinusal bone augmentation for preventing the re-expansion process and for augmenting the density of the regenerated tissues. [less ▲]Detailed reference viewed: 99 (20 ULg)
Influence of space filling materials in sub-sinusal bone augmentation: Clot vs Autogenous bone chips vs Bovine Hydroxyapatite
Lambert, France ; Léonard, Angélique ; Drion, Pierre et al
Poster (2010, October 06)Detailed reference viewed: 63 (10 ULg)
Revisited rules of papilla level adjacent to single-tooth dental implants according recent implant designs. A retrospective study.
LECLOUX, Geoffrey ; ; ROMPEN, Eric et al
Poster (2010, October)
Background: According to Choquet and Tarnow principles (2001), a papilla is always present if the distance from the base of the contact point between two crowns to the crest of the bone is 5 mm or less ... [more ▼]
Background: According to Choquet and Tarnow principles (2001), a papilla is always present if the distance from the base of the contact point between two crowns to the crest of the bone is 5 mm or less. The arrival of new designs in implantology suggested more tissue preservation and so a possible evolution for the aesthetic treatments. Aim: This study was designed to determine whether the distance from the base of the contact point to the crest of the bone would correlate with the presence or absence of the interproximal papillae adjacent to single-tooth implants using the recent implant designs. Methods: A clinical, photographical and radiographical retrospective evaluation of the papilla level around single dental implants and their adjacent teeth was performed in the anterior maxilla in 34 patients restored with 39 implants. These implants were loaded at least 6 months and present a modified profile (Implants : NobelConcept and NobelActive, Nobel Biocare ; Bone Level, Straumann. Abutments : Platform-switching and curvy). Sixty-three papillae were available for evaluation. The Jemt index, the vertical distance between the base of the contact point and the bone crest, the distance from the papilla level to the contact point were measured. The measurements were rounded off to the nearest 0,001 millimeter and used with calibration computer programs (ImageJ) to be analyzed. The statistical analyses were realized with SAS program (SAS Institute, Cary, NC, USA). Results: When the measurements from the contact point to the crest of bone was 5 mm or less, the papilla was present 100% of the time. When the distance was 6 mm, the papilla was present 96% of the time. And when the distance was 7 and 8 mm, the papilla was present 57,14% and 50% of the time. Conclusions and clinical implications: These results show the influence of the bone crest on the presence or absence of papillae between implants and adjacent teeth. The data also show a positive influence for recent designs of implant and abutment systems. This designs shift the actual critical bone distance under the contact point from 5mm to 6mm and could improve the aesthetic outcome. [less ▲]Detailed reference viewed: 48 (0 ULg)
Prise en charge pluridisciplinaire d'une parodontite juvénile: Traitement Paro-Ortho-Prothétique
LAMBERT, France ; ROMPEN, Eric
in Le point (2010), 218(Janvier -Février), 27-30Detailed reference viewed: 57 (4 ULg)
L'ostéonécrose maxillaire associée aux traitements aux bisphosphonates dans le traitement de l'ostéoporose. Consensus interdisciplinaire
; Reginster, Jean-Yves ; Rompen, Eric et al
in Louvain Medical (2010), 129(8), 305-309Detailed reference viewed: 57 (15 ULg)
One-step approach for implant placement and subantral bone regeneration using bovine hydroxyapatite: a 2- to 6-year follow-up study.
LAMBERT, France ; LECLOUX, Geoffrey ; ROMPEN, Eric
in International Journal of Oral & Maxillofacial Implants (2010)Detailed reference viewed: 64 (16 ULg)
One-piece zirconia implants : 18 months clinical outcomes.
VANHOUTTE, Vanessa ; LAMBERT, France ; ROMPEN, Eric
Conference (2009, December)
Purpose : The aim of the present study was to evaluate prospectively the clinical outcomes of a prototype one-piece zirconia implants after a -18 month follow-up. Material and methods : 20 prototype one ... [more ▼]
Purpose : The aim of the present study was to evaluate prospectively the clinical outcomes of a prototype one-piece zirconia implants after a -18 month follow-up. Material and methods : 20 prototype one-piece zirconia implants were placed and immediately restored with provisional protheses. A flapless or a minimally invasive approach was used for every implant placement. Bone levels were recorded at baseline and -1 year. Surgical, biological and prosthetic complications were also assessed. Results : The study included 15 patients. Most of the implants (90%) were placed at the anterior maxilla. Six of the implant sites were previously augmented with autogenous bone block grafts, 8 were managed with socket preservation techniques, 3 implants were immediatly placed after extraction and one implant was placed simultanously with a guided bone regeneration. Insertion torque (> 30N/cm2) was reached for all implants. The implant survival and success rates reached respectively 100% and 95%. One implant abutment fractured at placement because of an excessive insertion torque (> 50 N/cm2). No further complication occurred. Conclusion : From the preliminary results of this prospective clinical study, one-piece zirconia implants seem to success after 1 year despite they were often placed in critical clinical situtations (bone augmentations) and immediately restored. Further follow-up is needed to evaluate the long-term outcomes. [less ▲]Detailed reference viewed: 46 (0 ULg)
One-piece zirconium implant with concave transmucosal profile: an 18 month prospective study
LAMBERT, France ; ROMPEN, Eric
Poster (2009, September)Detailed reference viewed: 15 (0 ULg)
Evaluation of a technique for ridge preservation after tooth extraction 'saddle connective tissue graft and BHA'
LECLOUX, Geoffrey ; ROMPEN, Eric ; LAMBERT, France et al
Poster (2009, September)Detailed reference viewed: 40 (3 ULg)
Effect of low concentration of tetracycline solution on collagen membrane biodegradation: a rat study
LECLOUX, Geoffrey ; GRENADE, Charlotte ; et al
Poster (2009, June)Detailed reference viewed: 54 (2 ULg)
Marginal bone resorption and marginal bone level around implants in the posterior mandible: A 4-year retrospective study.
LAMBERT, France ; ; LECLOUX, Geoffrey et al
Poster (2009, June)
Long-term bone remodelling of implant placed in the posterior mandibule: a radiological study. France Lambert, Kim Vincent, Caroline Geron, Geoffrey Lecloux, Eric Rompen. Purpose: The aim of this study ... [more ▼]
Long-term bone remodelling of implant placed in the posterior mandibule: a radiological study. France Lambert, Kim Vincent, Caroline Geron, Geoffrey Lecloux, Eric Rompen. Purpose: The aim of this study was to analyse direct and long-term (4 years) marginal bone remodelling of various implant systems placed in the posterior mandibule with a single stage approach. Materials and methods: 50 partially edentulous patients received a total of 114 implants in the posterior mandibule (TE implant, Straumann®, Switzerland; Replace® Select Straight, Nobel Biocare, Sweden; Branemark System® MKIV, Nobel Biocare, Sweden). All implants were non-submerged, and loaded 8 to 12 weeks post surgery. X-rays were taken at baseline, 6 weeks, after loading and at long-term. Using a image processing program (Image J), bone losses were measured at each time point. Bone levels were also recorded using the first thread as reference point. Results: The mean bone loss reached 0.506±0.498 mm at 6 weeks, 0.798±0.599 after loading and 1.037±0.799 after 4 years. Bone losses were significatively higher on smokers and on patients displaying signs of bruxism. No statistical difference was found between the different implant types. Conclusion: 50% of the bone loss had already occurred within the 6 weeks post surgery with all implant types. Higher bone losses were often associated to risk factors such as tabacco addiction and bruxism. [less ▲]Detailed reference viewed: 33 (1 ULg)
Temperature rise during photo-activated disinfection of root canals.
; ; et al
in Lasers in Medical Science (2009), 24(1), 81-85
The aim of this study was to determine whether it is safe to use photo-activated disinfection (PAD) during root canal treatment without heating the periodontal tissues. Root canals of 30 freshly extracted ... [more ▼]
The aim of this study was to determine whether it is safe to use photo-activated disinfection (PAD) during root canal treatment without heating the periodontal tissues. Root canals of 30 freshly extracted single-rooted teeth were prepared using ProFiles up to size ISO 40 and then filled with photo-sensitiser: tolonium blue (1.2 mg/l). The 635 nm diode laser was used with the manufacturer's endo-tip. Samples were irradiated for 150 s (output power 100 mW, approximate energy density 106.16 J/cm(2)). Temperatures were recorded at working length on the external root surface. After 150 s of PAD irradiation, the average temperature rise was 0.16 +/- 0.08 degrees C. All values were lower than the 7 degrees C safety level for periodontal injury. It was concluded that, regarding the temperature increase, the use of PAD in root canals could be considered harmless for periodontal tissues. [less ▲]Detailed reference viewed: 124 (5 ULg)