References of "Rogister, Bernard"
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See detailEtude des activateurs du plasminogène et de leurs inhibiteurs dans le système nerveux en développement.
Schoenen, Jean ULg; Lefebvre, P.; Delrée, P. et al

Conference (1992)

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See detailMicroexplants cultures of the cerebellum
Rogister, Bernard ULg; Moonen, Gustave ULg

in Fedoroff, Serguei; Richardson, Anne (Eds.) Protocols for Neural cells Cultures (1992)

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See detailGrowth Factor Interactions in Cultures of Dissociated Adult Acoustic Ganglia: Neuronotrophic Effects
Lefebvre, P. P.; Van de Water, T. R.; Weber, T. et al

in Brain Research (1991), 567(2), 306-12

Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor ... [more ▼]

Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor (bFGF). Nerve growth factor (NGF) is not a survival factor for these neurons in vitro, but when used in combination with substrate bound bFGF, NGF does vigorously stimulate a neuritogenesis response by these neurons. Transforming growth factor beta (TGF beta 1) enhances the survival effect that bFGF has on these adult auditory neurons but does not by itself promote their survival in dissociated acoustic ganglion cultures. We propose that there may be complex interactions and synergy exerted by these growth factors (i.e. bFGF, NGF, TGF beta 1) during injury to the inner ear. [less ▲]

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See detailModulation of Proteolytic Activity During Neuritogenesis in the Pc12 Nerve Cell: Differential Control of Plasminogen Activator and Plasminogen Activator Inhibitor Activities by Nerve Growth Factor and Dibutyryl-Cyclic Amp
Leprince, Pierre ULg; Rogister, Bernard ULg; Delree, P. et al

in Journal of Neurochemistry (1991), 57(2), 665-74

Extracellular proteolysis is considered to be required during neuritic outgrowth to control the adhesiveness between the growing neurite membrane and extracellular matrix proteins. In this work, PC12 ... [more ▼]

Extracellular proteolysis is considered to be required during neuritic outgrowth to control the adhesiveness between the growing neurite membrane and extracellular matrix proteins. In this work, PC12 nerve cells were used to study the modulation of proteolytic activity during neuronal differentiation. PC12 cells were found to contain and release a 70-75-kDa tissue-type plasminogen activator (tPA) and a much less abundant 48-kDa urokinase-type plasminogen activator. A plasminogen activator inhibitor (PAI) activity with molecular sizes of 54 and 58 kDa was also detected in PC12 cell conditioned medium and formed high-molecular-mass complexes with released tPA. Release of PAI activity was dependent on treatment with nerve growth factor (NGF), whereas tPA synthesis and release were under control of a cyclic AMP-dependent mechanism and increased on treatment with dibutyryl-cyclic AMP [(But)2cAMP] or cholera toxin. Simultaneous treatment with NGF and (But)2cAMP resulted in increases of both tPA and PAI release and enhancement of tPA-PAI complex formation. The resulting plasminogen activator activity in conditioned medium was high in (But)2cAMP-treated cultures with short neuritic outgrowth but remained low in NGF- or NGF plus (But)2cAMP-treated cultures, where neurite extension was, respectively, large and very large. These results suggest that excess proteolytic activity may be detrimental to neuritic outgrowth and that not only PAI release but also tPA-PAI complex formation is associated with production of large and stable neuritic outgrowth. This can be understood as an involvement of PAI in the protection against neurite-destabilizing proteolytic activity. [less ▲]

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See detailKainate and Nmda Toxicity for Cultured Developing and Adult Rat Spiral Ganglion Neurons: Further Evidence for a Glutamatergic Excitatory Neurotransmission at the Inner Hair Cell Synapse
Lefèbvre, Philippe ULg; Weber, T.; Leprince, Pierre ULg et al

in Brain Research (1991), 555(1), 75-83

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory ... [more ▼]

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory neurons, we show that the afferent auditory neuronal population can be divided, on the basis of its sensitivity to the neuronotoxic effect of glutamate and its analogs, in at least 3 subpopulations, one responding to N-methyl-D-aspartate (NMDA), one responding to kainate and a third minor one unresponsive to NMDA, kainic acid and glutamate. No toxic effect of quisqualate is observed. The use of specific antagonists (kynurenate and 2-amino-5-phosphonovalerate (DAP-5) demonstrates the specificity of the receptors to the excitatory amino acids on the afferent auditory neurons. Afferent auditory neurons from adult rats can also be cultured and in these preparations only the large neurons are sensitive to glutamate, kainate and NMDA while the small neurons are not responsive, suggesting that a glutamatergic neurotransmission occurs only at this synapse between the inner hair cells and the large radial afferent auditory neurons. We also show that, in vitro, the organ of Corti releases, in response to an increased potassium concentration and in the presence of calcium, a toxic activity for the afferent auditory neurons that is antagonized by kynurenate and DAP-5. Pathophysiological implications are discussed. [less ▲]

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See detailTgf-beta1 Modulates bFGF Receptor Message Expression in Cultured Adult Auditory Neurons
Lefebvre, P. P.; Staecker, H.; Weber, T. et al

in Neuroreport (1991), 2(6), 305-8

Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular ... [more ▼]

Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular receptors for bFGF in several cell types. In this study, we show that TGFss1 is expressed in cultured adult mouse auditory neurons in response to explanation injury and acts in an autocrine fashion to increase the level of expression of bFGF receptors message in these same neurons. Based on these in-vitro results, we propose that these trophic factors (i.e. TGFss1 and bFGF) play a significant role in the response to injury by the mature auditory system. [less ▲]

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See detailGrafts of Syngenic Cultured, Adult Dorsal Root Ganglion-Derived Schwann Cells to the Injured Spinal Cord of Adult Rats: Preliminary Morphological Studies
Martin, Didier ULg; Schoenen, Jean ULg; Delree, P. et al

in Neuroscience Letters (1991), 124(1), 44-8

Highly enriched cultures of Schwann cells were obtained from adult rat dorsal root ganglia and implanted (5 x 10(5) -9 x 10(5) cells) in the spinal cord of syngenic adult rats at the site of an acute ... [more ▼]

Highly enriched cultures of Schwann cells were obtained from adult rat dorsal root ganglia and implanted (5 x 10(5) -9 x 10(5) cells) in the spinal cord of syngenic adult rats at the site of an acute compression lesion produced by a subdural inflatable microballoon. These autografts survived and invaded the host tissue, reducing central cavitation and astrocytic gliosis. They dramatically promoted ingrowth of axons, the majority of which appeared to come from the dorsal roots as judged by their neuropeptide content. Invasion of the transplants by descending, e.g. aminergic fibers, was negligible at survival times of up to 4 months. Nonetheless, autologous Schwann cells, which are readily available in the host, represent a promising material for grafts into the injured spinal cord. [less ▲]

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See detailCaractérisation et purification préliminaires de l'Astrostaine, une protéine neuronale inhibant la prolifération des astrocytes de type 1
Rogister, Bernard ULg

Doctoral thesis (1991)

In this work, we report the preliminary characterization and purification of astrostatine, a protein secreted by neuronal cells in culture and which inhibits type 1 astrocytes proliferation. This protein ... [more ▼]

In this work, we report the preliminary characterization and purification of astrostatine, a protein secreted by neuronal cells in culture and which inhibits type 1 astrocytes proliferation. This protein of a low molecular weight (14 kDa) is not active on glioma cell lines but is released by normal or tumoral neurons in culture. [less ▲]

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See detailProtéases et inhibiteurs de protéases : implications multiples dans le développement et le vieillissement cérébral
Leprince, Pierre ULg; Rogister, Bernard ULg; Delrée, Paul et al

in Revue d'Oto-Neuro-Ophtalmologie (1991), 12(13), 30-38

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See detailGrowth factors and development of the stato-acoustic system
Van De Water, Tom; Frenz, Don; Firaldez, Fernando et al

in Romand (Ed.) Development of auditory and vestibular system II (1991)

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See detailNeuronotrophic factors involvement in the regeneration of adult afferent auditory neurons.
Lefebvre, P.; Weber, T.; Delrée, P. et al

Conference (1990, November 10)

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See detailEffets de facteurs neuronotrophiques sur la régénération des neurones auditifs adultes in vitro
Lefebvre, Philippe ULg; Weber, T.; Delrée, P. et al

Conference (1990, November)

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See detailExperimental modulation of neurotransmitter phenotype in adult dorsal root ganglion neurons.
Schoenen, Jean ULg; Delrée, P.; Jammaer, R. et al

Conference (1990, June 30)

Detailed reference viewed: 6 (0 ULg)