References of "Rentier, Bernard"
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See detailTransmission du virus de l'hépatite C par examens médicaux invasifs
DELWAIDE, Jean ULg; Gerard, Christiane ULg; Vaira, Dolorès ULg et al

in Gastroentérologie Clinique et Biologique (1998), 22(2), 172

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See detailLow-productive alpha-herpesviridae infection in chronic lichenoid dermatoses
Nikkels, Arjen ULg; Sadzot-Delvaux, Catherine ULg; Rentier, Bernard ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1998), 196(4), 442-446

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative ... [more ▼]

BACKGROUND: Herpes simplex virus (HSV) and Varicella-zoster virus (VZV) are responsible for various atypical mucocutaneous manifestations in the immunosuppressed population. One of the causative pathomechanisms suggests an altered virus-host cell relationship. OBJECTIVE/METHODS: This report investigates by histology, immunohistochemistry and in situ hybridization the histological and virological features of 6 protracted, indolent HSV infections and 2 prolonged zoster infections. RESULTS: Histopathology revealed a lichenoid dermatitis in all patients. Specific HSV-1, HSV-2 and VZV in situ hybridization proved the viral origin of the cutaneous lesions. Immunohistochemical assessment demonstrated the intracellular presence of the HSV glycoproteins gB, gC and gD in epidermal keratinocytes which did not exhibit cytolysis. Similar findings were obtained for the VZV gE and gB. CONCLUSION: These results suggest that in some instances HSV and VZV infections may present a protracted disease course associated with a lichenoid inflammatory pattern and a non-cytolytic virus-host cell relationship. [less ▲]

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See detailPhysiopathologie et pathogenèse des douleurs zostériennes
Rentier, Bernard ULg

in Médecine et Maladies Infectieuses (1998), 28(Sp. Iss), 848-850

The origin of post-zosterian pain appears to be multiple. It implies: neuronal lesions in the central and peripheral nervous system. Young patients are less often affected than older individuals, perhaps ... [more ▼]

The origin of post-zosterian pain appears to be multiple. It implies: neuronal lesions in the central and peripheral nervous system. Young patients are less often affected than older individuals, perhaps because of damages that are caused or not to central afferences. Pain could be due to a central hyperexcitability induced and maintained by nociceptors. Antagonists of the NMDA receptor could thus prove efficient against installation of the chronic pain by interfering with neuronal discharges of the peripheral nociceptors and the induction of a hyperexcitability. [less ▲]

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See detailPrise en charge des infections à VZV
Groupe de consensus; Rentier, Bernard ULg

in Virologie (1998), 2(4), 317-323

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See detailSciences et Médecine à Liège à l'aube du troisième millénaire
Legros, Willy ULg; Rentier, Bernard ULg

in M S-Médecine Sciences (1998), 14(5), 535-536

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See detailLa régulation des cycles infectieux du virus de la varicelle et du zona
Piette, Jacques ULg; Defechereux-Thibaut de Maisières, Patricia; Baudoux-Tebache, Laurence et al

in M S-Médecine Sciences (1998), 14(5), 556-565

Varicella-zoster virus (VZV) is an Alphaherpesvirus responsible for two human diseases: primary exposure to the virus results in chicken pox (varicella) and reactivation following a period of latency in ... [more ▼]

Varicella-zoster virus (VZV) is an Alphaherpesvirus responsible for two human diseases: primary exposure to the virus results in chicken pox (varicella) and reactivation following a period of latency in dorsal lia gives rise to shingles (zoster). Interestingly, several transcripts corresponding to regulatory proteins present during the lytic cycle can be found in latently infected cells. The IE62 protein, component of the viral tegument, is a nuclear phosphoprotein. IE62 may play a crucial role in triggering and regulating the replicative cycle of VZV since it transactivates all classes of VZV genes and is able to repress or activate its own promoter. Moreover, IE62 acts in synergy with IE4, another important regulatory protein, to stimulate VZV gene promoters and IE62 is responsible for the translocation of IE4 from the cytoplasm to the nucleus. IE4 is expressed at very early times of the VZV productive cycle, Predominantly localized in the cytoplasm, IE4 activates several VZV genes, either alone or in synergy with IE62, as well as heterologous viral genes. At the molecular level, IE4 seems to act both transcriptionally and post-transcriptionally. Another major VZV protein is a 45 kDa phosphorylated protein, called IE63, which is abundantly expressed at the onset of the productive cycle. It is also defected during latency in humans and in a rat animal model an unexpected observation in Alphaherpesviruses. IE63 displays little direct effect on VZV gene promoters, it shows no inhibitory effect on the transactivating functions of IE62 but it represses the IE4 mediated activation. Studies conducted to define the mode of action of three VZV regulatory proteins playing crucial roles in the latency and reactivation of the am-rus mil not only lead to a better understanding of the virus pathogenesis but will probably help define novel therapeutic tools. [less ▲]

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See detailVaricella-zoster virus open reading frame 4 encodes an immediate-early protein with posttranscriptional regulatory properties
Defechereux, Patricia; Debrus, Serge; Baudoux, Laurence et al

in Journal of Virology (1997), 71(9), 7073-7079

Varicella-zoster virus (VZV) encodes four putative immediate-early proteins based on sequence homology with herpes simplex virus type I: the products of ORF4, -61, -62, and -63. Until now, only two VZV ... [more ▼]

Varicella-zoster virus (VZV) encodes four putative immediate-early proteins based on sequence homology with herpes simplex virus type I: the products of ORF4, -61, -62, and -63. Until now, only two VZV proteins have been described as being truly expressed with immediate-early kinetics (IE62 and IE63). The ORF4-encoded protein can stimulate gene expression either alone or in synergy with the major regulatory protein IE62. Making use of a sequential combination of transcription and protein synthesis inhibitors (actinomycin D and cycloheximide, respectively), we demonstrated the immediate-early nature of the ORF4 gene product, which can thus be named IE4. The fact that IE4 is expressed with kinetics similar to that of IE62 further underlines the possible cooperation between these two VZV proteins in gene expression. Analysis of the IE4-mediated autologous or heterologous viral gene expression at the mRNA levels clearly indicated that IE4 may have several mechanisms of action. Activation of the two VZV genes tested could occur partly by a posttranscriptional mechanism, since increases in chloramphenicol acetyltransferase (CAT) mRNA levels do not account for the stimulation of CAT activity. On the other hand, stimulation of the human immunodeficiency virus type 1 long terminal repeat-or the cytomegalovirus promoter-associated CAT activity is correlated with an increase in the corresponding CAT mRNA. [less ▲]

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See detailChronic varicella-zoster virus skin lesions in patients with human immunodeficiency virus are related to decreased expression of gE and gB
Nikkels, Arjen ULg; Rentier, Bernard ULg; Pierard, Gérald ULg

in Journal of Infectious Diseases (1997), 176(1), 261-264

The pathogenesis of chronic, verrucous varicella-zoster virus (VZV) cutaneous lesions in human immunodeficiency virus (HIV)-infected persons is unknown. It has been hypothesized that these lesions are due ... [more ▼]

The pathogenesis of chronic, verrucous varicella-zoster virus (VZV) cutaneous lesions in human immunodeficiency virus (HIV)-infected persons is unknown. It has been hypothesized that these lesions are due to an altered pattern of virus gene expression. Immediate early and late (L) gene expression in five chronic verrucous VZV lesions, four full-blown herpes zoster vesicular lesions in HIV-infected persons, and eight vesicular herpes zoster lesions in immunocompetent individuals was semiquantitatively assessed immunohistochemically using specific antibodies to the IE63, gE (L), and gB (L) proteins. All patients had evidence of IE63 expression in keratinocytes; however, gE expression was either weak or absent in keratinocytes of three verrucous lesions, and gB was either weak or absent in two. These results suggest that chronic VZV skin lesions are associated with diminished gE and gB expression. It is inferred that the VZV behavior in keratinocytes may vary from a latency-like state to a fully developed, productive infection. [less ▲]

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See detailVaricella-zoster virus immediate early proteins 4 and 62 interact with cellular transcription factors
Defechereux, Patricia; Baudoux, Laurence; Rentier, Bernard ULg et al

Poster (1997)

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See detailBinding sites analysis of the major varicella-zoster virus regulatory IE62 protein
Baudoux, Laurence; Remacle, V.; Defechereux, Patricia et al

Poster (1997)

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See detailQu'est-ce qu'un virus?
Rentier, Bernard ULg

Conference (1997)

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See detailLes recherches sur la biologie moléculaire du virus de la varicelle et du zona (VZV) ont-elles des applications cliniques ?
Rentier, Bernard ULg

in Annales de Dermatologie et de Vénéréologie (1997), 124(Suppl. 2), 4-8

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See detailDe l’acyclovir au valacyclovir: la biodisponibilité en plus de l’efficacité et de la tolérance
Rentier, Bernard ULg

in Virologics (1997), (Septembre), 10-11

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